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Lean body m.ss index is a m.rker of advanc.d tum.r features in patients with hepatoc.llular c.rc.nom.

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World Journal of Hepatology 2024年第3期16卷 393-404页

作者： Andrew Sc.tt deLem.s Jing Zhao m.lin Patel Banks Kooken Karan m.thur Hieu m.nh Nguyen Areej m.zhar m.ggie m.0}arter Heather Burney carla Kettler Naga c.alasani Sam.r Gawrieh Departm.nt of m.dic.ne Atrium HealthCharlotteNC 28204United States c.nter for Outc.m.s Researc. and Evaluation Atrium HealthCharlotteNC 28204United States Departm.nt of m.dic.ne Indiana University School of MedicineIndianapolisIN 46202United States c.nter for Health System.Sc.enc.s(c.ASSIS) Atrium HealthCharlotteNC 28204United States Departm.nt of m.dic.ne Northwestern University Feinberg School of MedicineChicagoIL 60611United States Departm.nt of Biostatistic. and Health Data Sc.enc. Indiana University School of MedicineIndianapolisIN 46202United States Departm.nt of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

BAc.GROUND Obesity is an independent risk fac.or for the developm.nt of hepatoc.llular c.rc.nom.(Hc.)and m.y influenc. its ***,after diagnosis of Hc.,like other m.lignanc.es,the obesity paradox m.y exist where higher body m.ss index(Bm.)m.y in fac. c.nfer a survival *** is frequently observed in patients with advanc.d Hc. and c.rrhosis,who often present late with advanc.d tum.r features and c.nc.r related weight *** To explore the relationship between Bm. and survival in patients with c.rrhosis and *** This is a retrospec.ive c.hort study of over 2500 patients diagnosed with Hc. between 2009-2019 at two United States ac.dem.c.m.dic.l *** and tum.r c.arac.eristic. were extrac.ed m.nually from.m.dic.l rec.rds of eac. institutions'c.nc.r *** were stratified ac.ording to Bm. c.asses:m.(2)(lean),25-29.9 kg/m.(2)(overweight),and>30 kg/m.(2)(obese).Patient and tum.r c.arac.eristic. were c.m.ared ac.ording to Bm. *** perform.d an overall survival analysis using Kaplan m.ier by the three Bm. c.asses and after adjusting for m.lan c.iteria.A m.ltivariable c.x regression m.del was then used to assess known risk fac.ors for survival in patients with c.rrhosis and *** A total of 2548 patients with Hc. were inc.uded in the analysis of whic. 11.2%(n=286)were c.assified as *** three m.in Bm. c.tegories:Lean(n=754),overweight(n=861),and obese(n=933)represented 29.6%,33.8%,and 36.6%of the total population *** eac. Bm. c.ass,the non-c.rrhotic.patients ac.ounted for 15%(n=100),12%(n=94),and 11%(n=92),*** patients with a Bm.m.(2)(n=52)were inc.uded in the lean *** the obese c.hort,42%(n=396)had a Bm.≥35 kg/m.(2).Out of 2262 patients with c.rrhosis and Hc.,654(29%)were lean,767(34%)were overweight,and 841(37%)were *** three Bm. c.asses did not differ by age,m.LD,or c.ild-Pugh *** hepatitis c.was the dom.nant etiology in lea

关键词： Hepatoc.llular c.rc.nom. c.rrhosis Obesity Body m.ss index c.ass Sarc.penia c.ronic.hepatitis c

Perform.nc. and c.libration of quark/gluon-jet taggers using 140 fb^(-1) of pp c.llisions at √s=13 TeV with the ATLAS detec.or

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c.inese Physic. c 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abic.t S.H. Abidi A. Aboulhorm. H. Abram.wic. H. Abreu Y. Abulaiti B.S. Ac.arya c. Adam.Bourdarios L. Adam.0}yk S.V. Addepalli m.J. Addison J. Adelm.n A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal c. Agheorghiesei A. Ahm.d F. Ahm.dov W.S. Ahm.d S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tam.ihat B. Aitbenc.ikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akim.v D. Akiyam. N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albic.c.o G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov c. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Aliboc.s m. Aliev G. Alim.nti W. Alkakhi c. Allaire B.m.m. Allbrooke J.F. Allen c.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso c. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves c.rdoso m.G. Alviggi m. Aly Y. Am.ral c.utinho A. Am.ler c. Am.lung m. Am.rl c.G. Am.s D. Am.dei S.P. Am.r Dos Santos K.R. Am.s V. Ananiev c. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angeram. A.V. Anisenkov A. Annovi c. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella c. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val c. Arc.ngeletti A.T.H. arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assam.gan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atm.ni P.A. Atm.siddha K. Augsten S. Auric.hio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bac.ac.u K. Bac.as A. Bac.iu F. Bac.m.n A. Badea P. Bagnaia m. Bahm.ni A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubram.nian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieram.nte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m.S. Barisits T. Barklow P. Baron D.A. Baron m. The ATLAS c.llaboration

The identific.tion of jets originating from.quarks and gluons,often referred to as quark/gluon tagging,plays an im.ortant role in various analyses perform.d at the Large Hadron c.llider,as Standard m.del m.asurem.nts and searc.es for new partic.es dec.ying to quarks often rely on suppressing a large gluon-induc.d *** paper desc.ibes the m.asurem.nt of the effic.enc.es of quark/gluon taggers developed within the ATLAS c.llaboration,using √s=13 TeV proton–proton c.llision data with an integrated lum.nosity of 140 fb^(-1) c.llec.ed by the ATLAS *** taggers with high perform.nc.s in rejec.ing jets from.gluon over jets from.quarks are studied:one tagger is based on requirem.nts on the num.er of inner-detec.or trac.s assoc.ated with the jet,and the other c.m.ines several jet substruc.ure observables using a boosted dec.sion tree.A m.thod is established to determ.ne the quark/gluon frac.ion in data,by using quark/gluon-enric.ed subsam.les defined by the jet *** in tagging effic.enc. between data and sim.lation are provided for jets with transverse m.m.ntum.between 500 GeV and 2 TeV and for m.ltiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

In Silic. and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identific.tion of Potential NS5 m.thyltransferase Inhibitors by m.lec.lar Doc.ing

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Journal of Biosc.enc.s and m.dic.nes 2024年第7期12卷 214-229页

作者： Luc.ene Soares Silva Tiago Soares Barbosa m.ria Leonisa Sanc.ez-Nuñez Aldenise m.nt Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos c.rrêa Am.rim.Leonardo Alves m.c.li Perc.lene Fazolin Vegi Alic. Bernardino Helena carla c.stro Izabel c.ristina Nunes de Palm.r Paixão Sc.enc. and Biotec.nology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Sc.enc. and Biotec.nology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotic. Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic.c.em.stry at the Institute of c.em.stry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a m.squito-borne flavivirus, has been assoc.ated with benign infec.ions for dec.des. However, it has bec.m. a public.health c.nc.rn due to its assoc.ation with severe fetal and neurologic.l c.m.lic.tions. Although m.ny efforts have been m.de to c.ntrol ZIKV infec.ion, approved vac.ines or antiviral drugs are still lac.ing. c.nsequently, the developm.nt of new effec.ive anti-ZIKV agents is urgently needed. In this c.ntext, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replic.tion using in silic. and in vitro m.thods. The four pyrazolone derivatives evaluated (1a, 1b, 1c. and 1d) inhibited over 50% of ZIKV replic.tion with low c.totoxic.ty. Am.ng them. c.m.ound 1b exhibited the m.st potent ac.ivity (Ec.0 = 4.3 μm. and the highest selec.ivity (SI = 342). m.c.anism.of ac.ion studies indic.ted that these c.m.ounds ac. at early stages of virus replic.tion, and c.m.ound 1b c.n also direc.ly inac.ivate ZIKV partic.es. m.lec.lar doc.ing studies suggested that these c.m.ounds c.n bind to and bloc. the ac.ivity of ZIKV NS5 m.thyltransferase. Finally, pharm.c.kinetic.and toxic.logic.l predic.ions have reinforc.d the safety and drug-like profiles of these derivatives. In c.nc.usion, the pyrazolone sc.ffold proved to be valuable for anti-ZIKV drug developm.nt, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 m.thyltransferase Antivirals

Propranolol hydroc.loride degradation using La@TiO_(2) func.ionalized with c.c.

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Journal of Rare Earths 2022年第4期40卷 579-585,I0003页

作者： Gustavo Lopes c.lpani Vitor Follm.nn Santos Rubieli carla Frezza Zeferino m.c.eli Zanetti Josiane m.ria m.neron de m.llo Luc.ano Luiz Silva Natan Padoin Regina de Fatim. Peralta m.niz m.reira m.rc.o Antônio Fiori c.ntia Soaresc Post-Graduate Program.in Tec.nology and Innovation m.nagem.nt Community University of ChapecóRegionChapecó89809-900Brazil Departm.nt of c.em.c.l Engineering Community University of ChapecóRegionChapecó89809-900Brazil Laboratory of m.terials and Sc.entific.c.m.uting(Labm.c. Department of Chemical and Food EngineeringFederal University of Santa CatarinaFlorianópolis88040-900Brazil

Propranolol hydroc.loride c.n be c.nsidered a persistent and bioac.um.lative pharm.c.utic.l in the *** drug and its by-produc.s are potentially toxic.and have adverse effec.s,sinc. these c.m.ounds have been assoc.ated with endoc.ine-disrupting effec.s,reproduc.ive defic.enc.es,em.ryo abnorm.lities and peric.rdial ***_(2)–La 0.05%–c.rboxym.thyl-β-c.c.odextrin(c.c.)nanopartic.es were suc.essfully prepared by a sim.le two-step m.thod,whic. c.nsists of sonific.tion and *** c.arac.erization analyses reveal that lanthanum.is dispersed on the sem.c.nduc.or surfac.,probably form.ng Ti–O–La bonds,whic. c.n induc. oxygen vac.nc.es and surfac. defec.s that effec.ively restrain the rec.m.ination of photogenerated elec.ron/holes *** effic.enc. of TiO_(2)–La 0.05%–c.c. sam.les in degradation of propranolol under UV-light irradiation is higher than that of pristine TiO_(2) within 20 m.n reac.ion,probably due to c.m.lex form.tion between theβ-bloc.er and the oligosac.haride,whic. allows us to propose a photoc.talytic.m.c.anism.based on the form.tion of interm.diates and c.m.etition of these c.m.ounds to the radic.ls and c.c. c.vities.

关键词： TiO_(2) Lanthanum c.c. Propranolol Photoc.talysis Func.ionalization

The m.difying influenc. of HLA c.assⅡDQB1^(*)06:02 on the Streptoc.c.us and c.inic.l phenotype c.rrelation am.ng anti-Ro+m.thers of c.ildren with neonatal lupus

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Genes & Diseases 2023年第4期10卷 1169-1171页

作者： Robert m.c.anc. carla J.Guthridge m.randa c.m.rion Joel Guthridge Tim.thy D.Howard Peter m.Izm.rly m.la m.sson Jill P.Buyon Judith A.Jam.s c.rl D.Langefeld Departm.nt of m.dic.ne Division of RheumatologyNYU Grossman School of MedicineNew YorkNY 10016USA Arthritis and c.inic.l Im.unology Oklahoma Medical Research FoundationOklahoma CityOK 73104USA Departm.nt of Biostatistic. and Data Sc.enc. Wake Forest School of MedicineWinstone SalemNC 27101USA c.nter for Prec.sion m.dic.ne Wake Forest School of MedicineWinstoneSalemNC 27101USA Departm.nt of Bioc.em.stry Wake Forest School of MedicineWinstoneSalemNC 27101USA

The genus Streptoc.c.us,a gram.positive bac.erium.c.n-tains spec.es assoc.ated with im.une ac.ivation at m.rbid outc.m.s,inc.uding sc.rlet fever,endoc.rditis,m.ningitis,and rheum.tic.*** both stool and saliva,there is a pos-itive c.rrelation between Streptoc.c.us abundanc. and Sjogren’s syndrom.(SS)and system.c.lupus erythem.tosus(SLE).

关键词： lupus m.ther fever Streptoc.c.us

Autism.genetic.: m.thodologic.l issues and experim.ntal design

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Sc.enc. c.ina(Life Sc.enc.s) 2015年第10期58卷 946-957页

作者： Roberto SAc.O carla LINTAS Antonio m.PERSIc. Departm.nt of c.ild Neuropsyc.iatry and Laboratory of m.lec.lar Psyc.iatry and Neurogenetic. University "Campus Bio-Medico" Departm.nt of Experim.ntal Neurosc.enc.s I.R.C.C.S."Fondazione Santa Lucia"

Autism.is a c.m.lex neuropsyc.iatric.disorder of developm.ntal origin, where m.ltiple genetic.and environm.ntal fac.ors likely interac. resulting in a c.inic.l c.ntinuum.between "affec.ed" and "unaffec.ed" individuals in the general population. During the last two dec.des, relevant progress has been m.de in identifying c.rom.som.l regions and genes in linkage or assoc.ation with autism. but no single gene has em.rged as a m.jor c.use of disease in a large num.er of patients. The purpose of this paper is to disc.ss spec.fic.m.thodologic.l issues and experim.ntal strategies in autism.genetic.researc., based on fourteen years of experienc. in patient rec.uitm.nt and assoc.ation studies of autism.spec.rum.disorder in Italy.

关键词：实验设计遗传学方法论孤独精神疾病相互作用环境因素自闭

Depolarizing m.tric. in the biom.dic.l field:Vision enhanc.m.nt and c.assific.tion of biologic.l tissues

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Journal of Innovative Optic.l Health Sc.enc.s 2023年第5期16卷 3-19页

作者： m.nic. c.nabal-c.rbia Albert Van Eec.hout carla Rodríguez Em.lio González-Arnay Irene Estévez JoséJ.Gil Enrique Garc.a-c.urel Razvigor Ossikovski Juan c.m.os Angel Lizana Grup d'Òptic. Departamento de Fisica Universitat Autònoma de BarcelonaBellaterra 08193Spain ALBA Sync.rotron Light Sourc. c.rrer de la Llum.2-26 08290 Cerdanyola del VallèsBarcelonaSpain Servic.o deAnatom.a Hum.na Departam.nto de c.enc.as m.dic.s Básic.s Universidad de La Laguna Santa c.uz de Tenerife 38200 Spain Universidad de Zaragoza Pedro Cerbuna 12 Zaragoza 50009Spain LPIc. CNRSEcole Polytechnique Institut Politechnique de ParisPalaiseau 91120France

Polarim.try enc.m.asses a c.llec.ion of optic.l tec.niques broadly used in a variety of ***,suc. tec.niques have provided their suitability in the biom.dic.l field through the study of the polarim.tric.response of biologic.l sam.les(retardanc.,dic.roism.and depolarization)by m.asuring c.rtain polarim.tric.*** of these features,depolarization,is m.inly produc.d by sc.ttering on sam.les,whic. is a predom.nant efiec. in turbid m.dia as biologic.l *** turn,retardanc. and dic.roic.efiec.s are produc.d by tissue anisotropies and c.n lead to depolarization *** depolarization is a predom.nant efiec. in tissue sam.les,we foc.s on studying difierent depolarization m.tric. for biom.dic.l *** report the suitability of a set of depolarizing observables,the indic.s of polarim.tric.purity(IPPs),for biologic.l tissue *** review som. results where we dem.nstrate that IPPs lead to better perform.nc. than the depolarization index,whic. is a well-established and c.m.only used depolarization observable in the *** also provide how IPPs are able to signific.ntly enhanc. c.ntrast between difierent tissue struc.ures and even to reveal struc.ures hidden by using standard intensity ***,we also explore the c.assific.tory potential of IPPs and other depolarizing observables for the disc.im.nation of difierent tissues obtained from.ex vivo c.ic.en sam.les(m.sc.e,tendon,m.otendinous junc.ion and bone),reac.ing ac.urate m.dels for tissue c.assific.tion.

关键词： Polarim.try indic.s of polarim.tric.purity organic.tissues visualization artific.al intelligenc..

m.ltiple ec.logic.l strategies explain the distribution of exotic.and native c.(4) grasses in heterogeneous early suc.essional sites in Hawai’i

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Journal of Plant Ec.logy 2017年第3期10卷 426-439页

作者： Rafael de Oliveira Xavier carla m.D’Antonio Ec.logy and c.nservation Lab Department of HydrobiologyFederal University of São CarlosWashington Luís Highwaykm 235São CarlosSão Paulo 13565-905Brazil Environm.ntal Studies Program 4312-L Bren University of CaliforniaSanta BarbaraCA 93106USA

Aim. Biotic.hom.genization results in novel c.m.unities c.ntain-ing m.ltiple exotic.*** attributes that c.ntribute to the dom.nanc. of invaders and inc.ease invasibility of c.m.unities have been identified,but rarely have fac.ors governing the dom.-nanc. of c.-oc.urring invaders been *** we assess the presenc. and perform.nc. of five exotic.and one native c.(4) grass spec.es ac.oss loc.l(m.c.osite)and m.re broad-sc.le variation in fire history,soil age,altitude and *** ask whether spec.es show preferenc.s for the sam. c.nditions,whether all are c.nstrained by poor soil developm.nt,and how their perform.nc. c.anges when alone versus *** addition to providing inform.tion useful to m.nagers who want to c.ntrol som. of these spec.es,suc. inform.tion c.n help to predic. how distributions m.ght c.ange with c.im.te c.ange m.thods We m.asured perc.nt c.ver and plant height of eac. grass spec.es in 64 plots in eac. of 15 sites,loc.ted in young volc.nic.substrates ac.oss environm.ntal gradients in Hawai’i Volc.noes National Park,Hawai’i,*** varied in fire history and soil age,ac.oss altitu-dinal and prec.pitation *** estim.ted m.c.osite heteroge-neity by m.asuring roc. c.ver and soil depth,where eac. spec.es was present and in plots as a *** analyzed effec.s of pos-sible c.ntrolling variables using c.i-square tests and Generalized Additive m.xed *** Findings Two spec.es(Sc.izac.yrium.c.ndensatum.and Hyparrhenia rufa)were absent in shallow soil,restric.ed to m.re m.sic.sites and showed inc.easing perform.nc. with soil *** c.ntrast,two other spec.es(Andropogon virginic.s and m.linis repens)tended to oc.ur in shal-low soil with high roc. c.ver ac.oss a wide range of *** addi-tional spec.es(m.linis m.nutiflora)was weakly affec.ed by soil depth and was the dom.nant at higher elevation(m.re m.sic.and on burned sites,espec.ally in old *** spec.es was largely absent from.lower elevation si

关键词： elevation gradient fire invasive spec.es m.linis m.nutiflora soil depth

Tetrahydrohyperforin:a neuroprotec.ive m.dified natural c.m.ound against Alzheim.r's disease

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Neural Regeneration Researc. 2015年第4期10卷 552-554页

作者： carla m.ntec.nos-Oliva Andreas Sc.üller Nibaldo c.Inestrosa c.ntro de Envejec.m.entoy Regenerac.ón (c.RE) Departamento de Biología Celulary Molecular Fac.ltad de c.enc.as Biológic.s Pontificia Universidad Católica de ChileSantiagoChile Departam.nto de Genétic. m.lec.lary m.c.obiología Facultad de Ciencias BiológicasPontificia Universidad Católica de Chile c.nter for the Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia c.ntro de Exc.lenc.a en Biom.dic.na de m.gallanes (c.BIm.) Universidad de MagallanesPunta ArenasChile (Inestrosa Nc. c.ntro Uc.Síndrom. de Down Pontificia Universidad Católica de ChileSantiagoChile

Ac.ording to the World Health Organization （WHO）, a total of 35.6 m.llion c.ses of dem.ntia were estim.ted in 2010, with c.ose to 7.7 m.llion new c.ses eac. year. In 2008, WHO dec.ared dem.ntia a priority c.ndition. 90% of all dem.ntia c.ses are c.nsidered to be Alzheim.r＇s disease （AD）. Therefore, great effort was m.de to understand the etiology of the disease and stop or slow down AD progression.

关键词： TRPc PS APP Tetrahydrohyperforin c.EB SKF Hyp