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Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome

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World Journal of Gastroenterology 2017年第12期23卷 2223-2233页

作者： carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit Department of General Practice Julius Centre for Health Sciences and Primary CareUniversity Medical Centre Utrecht Department of Psychiatry and Psychology St Antonius Hospital Department of Psychiatry University Medical Centre Department of Gastroenterology and Hepatology Academic Medical Centre

AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical *** The PRR is probably determined to a larger extent by patient-re

关键词： Placebo effect Psychological interventions Irritable bowel syndrome Systematic review

Inter-Network Resource Sharing in IEEE 802.22 Networks

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Communications and Network 2012年第2期4卷 111-121页

作者： carla Passiatore Pietro Camarda DEE-Politecnico di Bari v. Orabona Bari Italy

IEEE 802.22 is the first worldwide standard for Cognitive Networks (CNs) that exploits unused spectrum of the television broadcast service. An IEEE 802.22 network is also called Wireless Regional Area Network (WRAN). An open issue in cognitive 802.22 networks is represented by the resource distribution among WRANs. In this paper a protocol for radio resource management for CNs in a multichannel environment is presented and analysed. In particular, the contribution of this work is a resource sharing method to schedule the WRAN access to the available channels in a community made by two o more coexisting WRANs. The method adapts to the continuous changes of the spectrum availability due to necessity of vacating a channel in case of the incumbent primary users. Moreover, the introduced allocation scheme allows to divide the available band in a proportional way to the cognitive user spectrum demands, taking into account the issue of spatial diversity, i.e. the case where the channel coverage area is not uniform. The effectiveness of the proposed multichannel scheme is proved through simulations. The results compared favorably with other methods already known in literature and show that the proposed algorithm optimize the spectral efficiency, keeping high fairness as demonstrated computing the Jain’s index.

关键词： Cognitive Radio Resource Sharing Protocol IEEE 802.22

Mapping Glitches of Juniper Forests in Lebanon under Natural Conditions and Anthropogenic Activities

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Open Journal of Forestry 2019年第2期9卷 168-181页

作者： Ihab Jomaa carla Khater Department of Irrigation and Agrometeorology (LARI) Tal Amara Lebanon Remote Sensing Center (CNRS) Mansourieh Lebanon

In 1965, the first forest map of Lebanon was produced. It is the oldest spatial distribution representation of junipers. Landcover maps of 2002 and 2010 are the most detailed spatial distribution that spatially shows forests. Juniper forests are found in Lebanon as mainly as clear to low density coverage. High-density juniper forests are rarely found and only on Mount-Lebanon. Juniper forests are also mixed with oaks on the Eastern flank of Mount-Lebanon. Mapping juniper forests have demonstrated high degree of complexity, especially because of their low density and being mixed. The spatial representation of juniper forests was compared between the 1965 forest map and the landcover maps of 2002 and 2010. GIS environment was used to extract juniper forests from all maps. The degree of matching between juniper forests was investigated regarding the total area and spatial overlapping. Juniper forests were examined to their spatial locations, comparing the three maps. Spatial changes and anthropogenic effect were obtained, using Google Earth facilities. Google earth had satellite images acquired since 2014. Landcover maps of 2002 and 2010 have spatially matched forest map of 1965 by about 90% and 50% respectively. Spatial coverage of juniper forests were about 12,000, 26,000 and 28,000 ha on the 1965 forest map, landcover maps of 2003 and 2010 respectively. Anti-Lebanon juniper forests were not well represented on both landcover maps. Anthropogenic activities were mainly agriculture that affected juniper forests. Cultivations have replaced about 2% of the spatial coverage of 1965 Juniper forests. Quarries and urban existed inside juniper forests but in very limited areas. Juniper forests delineation did not completely match neither between the available maps, nor to the ground. Some juniper forests were not spatially represented on all maps or existing maps represented only portion of juniper forests. Juniper forest mapping requires more consideration and field investig

关键词： Conifer Forests High Mountain Forests Landcover Maps Low-Density Forests Conservation Juniperus excelsa

Bowel endometriosis: Colorectal surgeon's perspective in a multidisciplinary surgical team

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World Journal of Gastroenterology 2014年第42期20卷 15616-15623页

作者： Albert M Wolthuis Christel Meuleman carla Tomassetti Thomas D'Hooghe Anthony de Buck van Overstraeten André D'Hoore Department of Abdominal Surgery University Hospital Leuven Leuven University Fertility Centre Department of Obstetrics and Gynecology University Hospital Leuven

Endometriosis is a gynecological condition that presents as endometrial-like tissue outside the uterus and induces a chronic inflammatory reaction. Up to 15% of women in their reproductive period are affected by this condition. Deep endometriosis is defined as endometriosis located more than 5 mm beneath the peritoneal surface. This type of endometriosis is mostly found on the uterosacral ligaments, inside the rectovaginal septum or vagina, in the rectosigmoid area, ovarian fossa, pelvic peritoneum, ureters, and bladder, causing a distortion of the pelvic anatomy. The frequency of bowel endometriosis is unknown, but in cases of bowel infiltration, about 90% are localized on the sigmoid colon or the rectum. Colorectal involvement results in alterations of bowel habits such as constipation, diarrhea, tenesmus, dyschezia, and, rarely, rectal *** diagnosis must be made in case of irritable bowel syndrome,solitary rectal ulcer syndrome,and a rectal tumor.A precise diagnosis about the presence,location,and extent of endometriosis is necessary to plan surgical *** laparoscopic treatment has become the standard of *** on the size of the lesion and site of involvement,fullthickness disc excision or bowel resection needs to be performed by an experienced colorectal *** outcomes,following bowel resection for severe endometriosis,regarding pain and recurrence rate are good with a pregnancy rate of 50%.

关键词： Endometriosis Colorectal endometriosis Deeply infiltrative endometriosis Laparoscopy Diagno-sis Treatment

Impact of dental clearance on total joint arthroplasty: A systematic review

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World Journal of Orthopedics 2019年第12期10卷 416-423页

作者： Christopher Frey Sergio M Navarro Terri Blackwell carla Lidner H Del Schutte Jr Department of Orthopedic Surgery Stanford MedicineRedwood CityCA 94063United States Department of Surgery Baylor College of MedicineHoustonTX 77030United States Said School of Business University of Oxford Oxford OX11HPUnited Kingdom Comprehensive Joint Program Charleston Institute for Advanced OrthopedicsCharlestonSC 29464United States Dentistry Orange County Dental SocietyOrangeCA 92868United States

Many orthopedic surgeons require that their patients obtain dental clearance before elective total joint arthroplasty(TJA).However,there is no consensus substantiating the *** this end,a systematic review on the prevalence of dental pathology in TJA patients,risk factors for failing dental screening,and impact of dental evaluations was *** was sourced from PubMed and Scopus *** papers were sourced from the initial search,one study was extracted from the references of the original six manuscripts,and one new publication was retrieved from a second search conducted after the *** prevalence of dental pathology ranged from 8.8%to 29.4%across *** of four papers reported lower than average or improvements in postoperative infection with pre-operative dental evaluations while two found no such *** is insufficient evidence to support universal dental clearance before TJA.

关键词： Total knee arthroplasty Total hip arthroplasty Total joint arthroplasty Periprosthetic joint infection Dental screening

Systemic treatment of advanced, metastatic, medullary thyroid carcinoma

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 326-344页

作者： Antonio Matrone carla Gambale Alessandro Prete Virginia Cappagli Loredana Lorusso Valeria Bottici Rossella Elisei Department of Clinical and Experimental Medicine Endocrine UnitUniversity Hospital of PisaPisa 56124Italy

Medullary thyroid carcinoma(MTC)is a rare endocrine tumor,which arises from thyroid parafollicular C *** its ability to metastasize by blood and lymphatic vessels,it can show a more aggressive clinical behavior than differentiated thyroid *** of RET gene is the main molecular alteration involved in MTC *** the case of germline RET mutation,MTC can be inherited in an autosomal dominant way and show three different phenotypes:familial medullary thyroid carcinoma and multiple endocrine neoplasia types IIA and *** addition,in sporadic cases,somatic RET mutation remains the key molecular alteration in most of *** thyroidectomy with prophylactic or therapeutic central compartment lymph nodes dissection is the surgical treatment of *** surgical treatments and local therapies should be used in the case of single or few local or distant ***,in cases with large metastatic spread of the disease,particularly in those with significant tumor progression,additional systemic treatments are *** this review,we discuss the key points of systemic treatment in advanced,metastatic *** provide an update on the main aspects(from biological rationale to clinical experience)of each treatment,focusing our attention on the drugs used in clinical practice in the last ***,we give insights about the emerging treatments from highly selective RET inhibitors to new radionuclide therapy.

关键词： Medullary thyroid carcinoma tyrosine kinase inhibitors targeted therapy immunotherapy radionuclide therapy RET selective inhibitors

Parkinson's disease, heart disease and propolis consumption

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Journal of Integrative Medicine 2021年第5期19卷 467-468页

作者： Fulvio A.Scorza Antonio-Carlos G.de Almeida carla A.Scorza Ana C.Fiorini Josef Finsterer Disciplina de Neurociência Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP 04021-001Brazil Centro de Neurociências e Saúde da Mulher Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Departamento de Engenharia de Biossistemas Universidade Federal de Sao Joao del-Rei(UFSJ)Sao Joao del-ReiMG36307-352Brazil Departamento de Fonoaudiologia Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Brazil-Programa de Estudos Pós-Graduado em Fonoaudiologia Pontifícia Universidade Católica de Sao Paulo(PUC-SP)Sao PauloSP04021-001Brazil Klinikum Landstrasse Messerli InstituteVienna 1210Austria

It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biolog... 详细信息

关键词： Parkinson’s disease heart disease and propolis consumption

Functional lipidomics in patients on home parenteral nutrition: Effect of lipid emulsions

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World Journal of Gastroenterology 2017年第25期23卷 4604-4614页

作者： Loris Pironi Mariacristina Guidetti Ornella Verrastro Claudia Iacona Federica Agostini Caterina Pazzeschi Anna Simona Sasdelli Michele Melchiorre carla Ferreri Chronic Intestinal Failure Center Digestive Disease DepartmentSt Orsola-Malpighi Hospital Lipinutragen Srl-Lipidomics Laboratory ISOF National Council of Research

To investigate the fatty acid-based functional lipidomics of patients on long-term home parenteral nutrition receiving different intravenous lipid emulsions. METHODSA cross-sectional comparative study was carried out on 3 groups of adults on home parenteral nutrition (HPN), receiving an HPN admixture containing an olive-soybean oil-based intravenous lipid emulsion (IVLE) (OO-IVLE; n = 15), a soybean- medium-chain triacylglycerol-olive-fish oil-based IVLE (SMOF-IVLE; n = 8) or HPN without IVLE (No-IVLE; n = 8) and 42 healthy controls (HCs). The inclusion criteria were: duration of HPN ≥ 3 mo, current HPN admixtures ≥ 2 mo and HPN infusions ≥ 2/wk. Blood samples were drawn 4-6 h after the discontinuation of the overnight HPN infusion. The functional lipidomics panel included: the red blood cell (RBC) fatty acid (FA) profile, molecular biomarkers [membrane fluidity: saturated/monounsaturated FA ratio = saturated fatty acid (SFA)/monounsaturated fatty acid (MUFA) index; inflammatory risk: n-6/n-3 polyunsaturated fatty acid (PUFA) ratio = n-6/n-3 index; cardiovascular risk: sum of n-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) = n-3 index; free radical stress: sum of FA trans isomers = %trans index] and FA pathway enzyme activity estimate (delta-9-desaturase = D9D; delta-6-desaturase = D6D; delta-5-desaturase = D5D; elongase = ELO). Statistics were carried out using nonparametric tests. The amount of each FA was calculated as a percentage of the total FA content (relative%). RESULTSIn the OO-IVLE group, the percentage of oleic acid in the RBCs was positively correlated with the weekly load of OO-IVLE (r = 0.540, P = 0.043). In the SMOF-IVLE cohort, the RBC membrane EPA and DHA were positively correlated with the daily amount of SMOF-IVLE (r = 0.751, P = 0.044) and the number of HPN infusions per week (r = 0.753; P = 0.046), respectively. The SMOF-IVLE group showed the highest EPA and DHA and the lowest arachidonic acid percentages (P < 0.001). The RBC mem

关键词： Chronic intestinal failure Home parenteral nutrition Intravenous lipid emulsion Cell membrane fatty acid profile Cell membrane lipidome Functional lipidomics

Factors associated with trigger digit following carpal tunnel release

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World Journal of Orthopedics 2019年第12期10卷 454-462页

作者： Jacob Nosewicz carla Cavallin Chin-I Cheng Neli Ragina Arno W Weiss Anthony Zacharek Central Michigan University College of Medicine Mt.PleasantMI 48858United States Department of Statistics Actuarial and Data ScienceCentral Michigan UniversityMt.PleasantMI 48858United States Covenant Plastic Surgery SaginawMI 48602United States

BACKGROUND Trigger digit is a common disorder of the hand associated with carpal tunnel *** tunnel release(CTR)surgery may be a risk factor for trigger digit development;however,the association between surgical approach to CTR and postoperative trigger digit is *** To investigate patient risk factors for trigger digit development following either open carpal tunnel release(OCTR)or endoscopic carpal tunnel release(ECTR).METHODS This retrospective chart analysis evaluated 967 CTR procedures from 694 patients for the development of postoperative trigger *** were stratified according to the technique utilized for their CTR,either open or *** development of postoperative trigger digit was evaluated at three time points:within 6 mo following CTR,between 6 mo and 12 mo following CTR,and after 12 mo following ***’s penalized likelihood logistic regression was conducted to evaluate sociodemographic and patient comorbidities as potential independent risk factors for trigger *** regression models were conducted within each surgical group to reveal any potential interaction effects between surgical approach and patient risk factors for the development of postoperative trigger *** A total of 47 hands developed postoperative trigger digit following 967 CTR procedures(4.9%).In total,64 digits experienced postoperative *** long finger was most commonly *** was no significant difference between the open and endoscopic groups for trigger digit development at all three time points following ***,there were no significant independent risk factors for postoperative trigger digit;however,within group analysis revealed a significant interaction effect between gender and surgical approach(P=0.008).Females were more likely to develop postoperative trigger digit than males after OCTR(OR=3.992),but were less likely to develop postoperative trigger digit than males after ECTR(OR=0.489).CONC

关键词： Endoscopic carpal tunnel release Open carpal tunnel release,Trigger digit Carpal tunnel syndrome Stenosing tenosynovitis