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Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review

World Journal of Pediatrics 2022年第2期18卷 91-99页

作者： Javier Arredondo montero carl.s bardaji pascual.monica bronte anaut Natalia Lopez-Andres Giuseppa Antona Nerea martin-Calvo Pediatric surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Cardiovascular Translational Research Navarrabiomed(Miguel Servet Foundation)Complejo Hospitalario de Navarra(CHN)Universidad Publica de Navarra(UPNA)IdiSNAPamplonaSpain Department of Preventive medicine and Public Health Instituto de Investigacion Sanitaria de Navarra(IdiSNA).University of Navarra.PamplonaSpain CIBER Fisiopatologia de la Obesidad y Nutricion(CIBERobn) Health Institute CarlosⅢMadridSpain

Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute *** recent years,multiple biomarkers have emerged as potential diagnostic *** study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute *** We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(medline,Pubmed,Web of science and sciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion *** quality of the selected article was rated using the QUADAs2 *** extraction was performed by two independent *** The research in the medical bibliography databases resulted in 68 *** removed 26 *** the remaining 42 articles,we excluded 33 following the inclusion and exclusion *** the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and *** The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is *** sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated *** seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute *** increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated *** consider that this may be an avenue of research to explore in the future.

关键词： Acute appendicitis Children Interleukin-6 Pediatric sensitivity specificity systematic review

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Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children:a prospective validation study

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World Journal of Pediatrics 2022年第12期18卷 810-817页

作者： Javier Arredondo montero Giuseppa Antona Adriana Rivero marcotegui carl.s bardajípascual.mónica bronte anaut Raquel Ros Briones Amaya Fernández-Celis Natalia López-Andrés Nerea martín-Calvo Pediatric surgery Department Hospital Universitario de NavarraIrunlarrea 331008PamplonaSpain Clinical Analysis Department Hospital Universitario de NavarraPamplonaSpain Pathology Department Hospital Universitario de NavarraPamplonaSpain Cardiovascular Translational Research NavarraBiomed(Miguel Servet Foundation)Hospital Universitario de NavarraUniversidad Pública de Navarra(UPNA)IdiSNAPamplonaSpain school of medicine Department of Preventive Medicine and Public HealthUniversity of NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBERobn) Health Institute Carlos IIIMadridSpain Instituto de Investigación sanitaria de Navarra IdiSNAPamplonaNavarraSpain

Background serum interleukin-6(IL-6)has a moderate diagnostic performance in pediatric acute appendicitis(PAA).The evidence regarding its capacity to discern between complicated and uncomplicated PAA is *** We designed a prospective observational study to validate serum IL-6 as a marker for diagnostic classification between complicated and uncomplicated *** study included 205 patients divided into three groups:(1)patients who underwent major outpatient surgery(n=57);(2)patients with non-surgical abdominal pain(NsAP)in whom the diagnosis of PAA was excluded(n=53),and(3)patients with a confirmed diagnosis of PAA(n=95).The PAA patients were further classified as uncomplicated or complicated ***-6 concentration was determined in all patients at *** statistical analysis was performed using the mann-Whitney U test,the Fisher exact test and the Kruskall Wallis *** area under the receiver operating characteristic curves(AUC)were *** median(interquartile range,IQR)serum IL-6 values were 2 pg/mL(2.0–3.4)in group 1,3.9 pg/mL(2.4–11.9)in group 2,and 23.9 pg/mL(11.1–61.0)in group 3(Pmong the participants in group 3,those with uncomplicated PAA had median(IQR)serum IL-6 values of 17.2 pg/mL(8.5–36.8),and those with complicated PAA had 60.25 pg/mL(27.1–169)serum IL-6(PmL,the AUC for the discrimination between patients in group 2 vs.3 was 0.83[95%confidence interval(CI)0.76–0.90],with a sensitivity of 61.3%and a specificity of *** AUC for the discrimination between patients with uncomplicated and complicated PAA was 0.77(95%CI 0.68–0.86)and the cut-off point was 25.90 pg/mL,with a sensitivity and specificity of 84.6%and 65.6%,*** serum IL-6 has a good performance in discerning between complicated and uncomplicated PAA.A score including clinical and radiological variables may increase the diagnostic performance of this molecule.

关键词： Acute Appendicitis Complicated Diagnostic Interleukin-6 Pediatric Uncomplicated

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滑坡位移预测模型补充评价方法

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北京大学学报（自然科学版） 2024年第3期60卷 513-520页

作者：田原常啸寅赵文祎程楚云 bronte scheuer 邓杨兰朵马睿平张建学北京大学遥感与地理信息系统研究所北京100871 空间信息集成与3s工程应用北京市重点实验室北京100871 中国地质环境监测院北京100081

针对目前滑坡位移预测模型评价方法中总体性指标区分能力不足,以及对滑坡高风险期预测效果评价不准确等问题,设计滑坡位移预测模型快速位移期综合误差(CERDP)和峰值预测误差(PPE)两个补充评价指标以及对应的补充评价技术流程。基于滑坡... 详细信息

针对目前滑坡位移预测模型评价方法中总体性指标区分能力不足,以及对滑坡高风险期预测效果评价不准确等问题,设计滑坡位移预测模型快速位移期综合误差(CERDP)和峰值预测误差(PPE)两个补充评价指标以及对应的补充评价技术流程。基于滑坡监测数据的实例研究表明,所提补充评价指标和应用流程合理可行,可以有效地应对均方根误差(RmsE)等指标差异不显著带来的评价不准确问题,遴选出总体性能可靠,在风险时段和最高风险时点表现更好的模型,为滑坡风险管理工作提供有效的技术支持。

关键词：滑坡位移预测模型评价指标补充评价快速位移期位移峰值

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Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： Javier Arredondo montero monica bronte anaut sara Hernandez-martin Juan carl.s Lopez-Gutierrez Pediatric surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Pediatric surgery Department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the *** ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with *** treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

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简·爱 1

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丛书名：每天读一点英文名著

2013年

作者： Charlotte bronte bronte

本书是19世纪英国现实主义文学作家夏洛蒂·勃朗特的代表作。作者通过一个一波三折的爱情故事，向我们展示了简·爱这个出身贫寒却蔑视金钱、地位卑微而不轻贱、渴望爱情而不失尊严的伟大女性，以及一颗正直、高尚、纯洁，没有受到世俗... 详细信息

ISBN: (纸本)9787561178034

本书是19世纪英国现实主义文学作家夏洛蒂·勃朗特的代表作。作者通过一个一波三折的爱情故事，向我们展示了简·爱这个出身贫寒却蔑视金钱、地位卑微而不轻贱、渴望爱情而不失尊严的伟大女性，以及一颗正直、高尚、纯洁，没有受到世俗社会污染的灵魂。

关键词：英语长篇小说汉语

来源：畅想之星图书光盘版（南... 评论

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Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis:A prospective study

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World Journal of Gastroenterology 2021年第30期27卷 5112-5125页

作者： mar Riveiro-Barciela Cristina marcos-Fosch Fernando martinez-Valle Fabrizio bronte Olimpia Orozco Isidro sanz-Pérez Daniele Torres maria-Teresa salcedo salvatore Petta Rafael Esteban Antonio Craxi maria Buti Department of medicine of the UAB Hospital Universitari Vall d’HebronBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos IIIMadrid 28029Spain systemic Autoimmune Diseases Unit Internal Medicine DepartmentHospital Universitari Vall d'HebronBarcelona 08035Spain sezione di Gastroenterologia Di.Bi.M.I.SUniversity of PalermoPalermo 90133Italy Pathology Department Hospital Universitari Vall d'HebronBarcelona 08035Spain

BACKGROUND There is an increased risk of atherosclerosis in patients with chronic hepatitis C or human immunodeficiency virus,but there is scarce data on hepatitis B virus *** hypothesis of this study is that hepatitis B virus infection increases the risk of carotid plaques and subclinical atherosclerosis in naïve hepatitis B e antigen(HBeAg)negative *** To assess the rate of carotid plaques and subclinical atherosclerosis in naïve HBeAg negative subjects in comparison with a cohort of healthy *** Prospective case-control collaborative study conducted in two tertiary *** hundred and two subjects prospectively recruited at the outpatient clinic were included from may 2016 to April 2017:201 naïve HBeAg-negative hepatitis B virus-infected[49 chronic hepatitis B(CHB)and 152 inactive carriers(ICs)]and 201 healthy *** and metabolic measures,liver stiffness and carotid Doppler ultrasound were *** atherosclerosis was established on an intima-media thickness increase of≥1.2 mm and/or the presence of carotid *** distributed quantitative variables were compared with the student t test and those with a non-normal distribution with the mann-Whitney U *** variables were compared between groups using theχ2 or Fisher exact *** Carotid plaques were found more often in CHB(32.7%)than ICs(17.1%)or controls(18.4%)(P=0.048).subclinical atherosclerosis was also increased in CHB(40.8%)vsICs(19.1%)or controls(19.4%)(P=0.003).No differences in the risk of atherosclerosis were observed between controls and *** factors independently associated with the presence of carotid plaques were age[odds ratio(OR)1.43,Psubclinical atherosclerosis,age(OR 1.45,Ps(OR 1.13,P=0.028).In the subset of young subjects(s),carotid plaques(12.5%vs 1.1%,P=0.027)and subclinical atherosclerosis(12.5%vs 2.2%,P=0.058

关键词： Hepatitis B virus Carotid plaques subclinical atherosclerosis Cardiovascular risk Endothelial dysfunction Intima-media thickness

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Love and Friendship

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疯狂英语（初中天地） 2021年第12期 1-1页

作者： Emily bronte 不详

Love is like the wild *** like the *** holly is dark when the rose-briar *** which will bloom most constantly?The wild rose-briar is sweet in the *** summer blossoms scent the air;Yet wait till winter comes *** who will call the wild-briar fair?Then scorn the silly rose-wreath *** deck thee with the holly's sheen・That when December blights thy *** may still leave thy garland green.

关键词： And rose Love

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简·爱

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时代英语（初中） 2015年第3期 2-页

作者： Charlotte bronte

Charlotte bronte was born in a rural pastor’s family in Yorkshire in northern England in *** her mother’s early death,8-year-old Charlotte was sent to the Clergy Daughters’school at Cowan Bridge in Lancashire,where her two elder sisters maria and Elizabeth died one after another because of contracted *** Charlotte and her sister Emily returned *** she was 15 years old,Charlotte entered a school hosted by miss Wooller and worked as a teacher in this school several

关键词： Charlotte 简·爱 pastor Elizabeth mother 夏洛蒂·勃朗特 elder sister worked 艾米莉·勃朗特

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人脑正在想什么

人脑正在想什么

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第二十四届全国心理学学术会议

作者：徐婷 Hao-Ting Wang bronte mckeown Daniel Gutierrez-Barragan Bo-yong Park Karl-Heinz Nenning Robert Leech Elizabeth Jefferies Daniel margulies Alessandro Gozzi michael milham Jonathan smallwood University of York Istituto Italiano di Tecnologia Department of Data science Inha Unversity King's College London Centre National de la Recherche scientifque (CNRs) and Universite de Paris Queen's University

越来越多的证据表明,在很多灵长类动物中,清醒状态下脑功能通常在多个状态之间动态转换。一般认为,大脑的神经调节系统可以促使行为适应环境并改变脑的认知状态。本研究考察了人类清醒状态下大脑动态的神经调节作用,识别大脑哪些动态系... 详细信息

越来越多的证据表明,在很多灵长类动物中,清醒状态下脑功能通常在多个状态之间动态转换。一般认为,大脑的神经调节系统可以促使行为适应环境并改变脑的认知状态。本研究考察了人类清醒状态下大脑动态的神经调节作用,识别大脑哪些动态系统与人正在进行的持续思考有关。我们使用的公开的NKI-Rockland样本(年龄:18-50岁,31.78±10.34,n=337,152名男性)中静息状态功能磁共振数据集,并采用"共激活模式分析"方法确定了自然静息态下的脑动态连接。我们分析了这些不同的脑状态与神经递质图谱的关联,以及这些关联是否影响大脑神经动态、与认知问卷测量的静息态下的持续性认知。我们识别出成对的不同连接状态,并计算了其持续时间、发生率和状态间的转换矩阵。最后,我们将脑功能动态连接与多个神经递质的图谱做了关联分析,并使用元分析框架在大尺度功能空间中对脑动态进行解码。我们的研究结果表明,神经调节剂,如多巴胺和5-羟基色氨酸,对清醒脑的神经动态和持续思维模式都有重要贡献。此外,我们的研究强调了神经递质在认知功能动态变化中的重要作用,以及脑高级网络(包括额叶和默认模式网络)在其中的重要作用。

关键词：静息态功能磁共振动态认知神经调控

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