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Geoscience and high-level nuclear waste disposal： the Nordic scene

Episodes 2008年第1期31卷 168-175页

作者： Alan Geoffrey Milnes Michael B. Stephens carl-henric wahlgren Luesa Wikstroem GEA Consulting Grand-Rue 7C 2035 Corcelles （NE） Switzerland. Geological Survey of Sweden Box 670 75128 Uppsala Sweden. Posiva Oy 27160 Olkiluoto Finland.

In Norden, two countries, Sweden and Finland, are actively engaged in site investigations for the location of deep repositories for spent nuclear fuel from power-producing nuclear reactors. These investigations are being carried out in crystalline rocks of the Fennoscandian Shield. In Sweden, a long history of site selection has led to the identification and investigation of two sites, Forsmark and Laxemar/Simpevarp, based on a strategy of combining favourable bedrock with consent by the local population. Surface-based geoscientific investigations of the two candidates, with extensive deep drilling, are now drawing to a close. A proposal as to which of the sites would be most suitable for the development of a deep repository will be submitted to the governmental regulatory authorities in 2009. In Finland, the site selection process was shorter and less politically controversial, and led to a "Decision in Principle" by the Finnish parliament, in May 2001, to develop a deep repository at the Olkiluoto site. The access tunnel to an underground rock characterisation facility at 400-500 m depth is at present under construction, accompanied by extensive geoscientific investigations in the subsurface. An application for a construction licence for a deep repository will be submitted in 2012. Although all sites are located in Precambrian crystalline rocks, the Swedish sites both lie in relatively homogeneous granitic rocks, whilst the Finnish site is located in an heterogeneous migmatite complex. The Nordic approach to high-level nuclear waste disposal in crystalline rock will be the theme of a Topical Symposium at the 33rd International Geological Congress at Oslo, in August 2008, and the three sites mentioned above will be the focus of Congress Excursion no. 14.

关键词：地球科学原子核核污染北欧地区

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Impact of weather conditions and building design on contaminant infiltration from crawl spaces in Swedish schools-Numerical modeling using Monte carlo method

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Building Simulation 2022年第5期15卷 845-858页

作者： Fredrik Domhagen Paula wahlgren carl-Eric Hagentoft Department for Architecture and Civil Engineering Division of Building TechnologyChalmers University of TechnologySE-41296GothenburgSweden

Some Swedish school buildings built in the 1960s and 1970s experience indoor air quality problems,where the contaminants are suspected to come from the crawl space underneath the *** poor indoor air quality causes discomfort among pupils and *** an exhaust fan to maintain a negative pressure difference in the crawl space relative to indoors or increasing the ventilation in the classroom are two examples of common measures taken to improve the indoor air ***,these measures are not always effective,and sometimes the school building has to be *** relation between pressure distribution,contaminant concentration in the classroom,outdoor temperature,wind,mechanical ventilation,and air leakage distribution is complex.A better understanding of these relations is crucial for making decisions on the most efficient measure to improve the indoor air *** this paper,a model for contaminant infiltration from the crawl space is used together with the Monte carlo method to study these *** are performed for several cases where different building shapes,building orientations,shielding conditions,and geographical locations are *** show,for example,that for a building with an imbalanced ventilation system,air is leaking from the crawl space to the classroom for the majority of cases and that concentration levels in the classroom are usually the highest during mild and calm days.

关键词： airtightness air permeability Monte carlo method infiltration model crawl space indoor air quality

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Molecular identity, expression and functional analysis of interleukin-1α and its isoforms in rat testis

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Asian Journal of Andrology 2004年第2期6卷 149-153页

作者： T. Sultana K. V. Svechnikov K. Gustafsson A. wahlgren E. Tham G. Weber O. Soder Pediatric Endocrinology Unit Department of Woman and Child Health Centre for Molecular Medicine and Tumor Biochemistry Karolinska Institute and Hospital S-17176 Stockholm Sweden Department of Biological and Biomedical Sciences Faculty of Health Sciences Aga Khan University Karachi- 74800 Pakistan Department of Chemistry and Biomedical Sciences Vniversity of Kalmar SE-391 82 Kalmar Sweden

Interleukin-1α (IL-1α) is a proinflammatory cytokine that has also been found to act as a paracrine mediator involved in the regulation of testicular functions. The present review provides an overview of the role of IL 1α in testicular physiology. Bioactive IL-1α isolated from adult rat testis was found to consist of three distinct immunoreactive protein species with apparent sizes of 45, 24 and 19 kDa. These isoforms showed bioactivity in a thymocyte proliferation and steroidogenesis assays with different biopotencies. The background of the molecular heterogeneity and processing, secretion and regulation of the isoforms of testicular IL-1α are discussed. All three isoforms have been found to be secreted into the testis tubular lumen and interstitial space. We have provided evidence that IL-1α is a paracrine factor that may be of importance in, e.g., the regulation of Leydig cell steroidogenesis. Pathophysiologically, testicular IL-1α may contribute to testicular relapse of acute lymphocytic leukemia in boys.

关键词： IL-1α spermatogenesis testis Sertoli celis Leydig celis calpain

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Are you suffering from a large arterial occlusion?Please raise your arm!

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Stroke & Vascular Neurology 2018年第4期3卷 215-221页

作者： Charith Cooray Michael V Mazya Matteo Bottai Jan F Scheitz Azmil H Abdul-Rahim Tiago Prazeres Moreira Robert Mikulik Antonin Krajina Miroslava Nevsimalova Danilo Toni Nils wahlgren Niaz Ahmed Department of Clinical Neurosciences Karolinska InstitutetStockholmSweden Department of Neurology Karolinska University HospitalStockholmSweden Unit of Biostatistics Institute of Environmental MedicineKarolinska InstitutetStockholmSweden Center for Stroke Research Berlin and Department of Neurology Charité-Universitätsmedizin BerlinBerlinGermany Stroke Research Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK International Clinical Research Center and Neurology Department St.Anne's University Hospital in Brno and Masaryk UniversityBrnoCzech Republic Department of Radiology University HospitalHradec KraloveCzech Republic Comprehensive Cerebrovascular Center HospitalČeskéBudějoviceCeske BudejoviceCzech Republic Emergency Department Stroke Unit Department of Neurology and PsychiatryHospital Policlinico Umberto I'Sapienza'UniversityRomeItaly

Background and purpose Triage tools to identify candidates for thrombectomy are of utmost importance in acute *** prognostic tool has yet gained any widespread *** compared the predictive value of various models based on National Institutes of Health Stroke Scale(NIHSS)subitems,ranging from simple to more complex models,for predicting large artery occlusion(LAO)in anterior circulation *** Patients registered in the SITS international Stroke Register with available NIHSS and radiological arterial occlusion data were *** compared 2042 patients harbouring an LAO with 2881 patients having no/distal *** binary logistic regression,we developed models ranging from simple 1 NIHSS-subitem to full NIHSS-subitems *** and specificities of the models for predicting LAO were *** The model with highest predictive value included all NIHSS subitems for predicting LAO(area under the curve(AUC)0.77),yielding a sensitivity and specificity of 69%and 76%,*** second most predictive model(AUC 0.76)included 4-NIHSS-subitems(level of consciousness commands,gaze,facial and arm motor function)yielding a sensitivity and specificity of 67%and 75%,*** simplest model included only deficits in arm motor-function(AUC 0.72)for predicting LAO,yielding a sensitivity and specificity of 67%and 72%,*** Although increasingly more complex models yield a higher discriminative performance for predicting LAO,differences between models are not *** grade of arm dysfunction along with an established stroke-diagnosis model may serve as a surrogate measure of arterial occlusion-status,thereby assisting in triage decisions.

关键词： occlusion specificity diagnosis

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Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis

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World Journal of Gastroenterology 2008年第28期14卷 4576-4579页

作者： Gudrun Scheving Thorsteinsson Maria Magnussson Lena M Hallberg Nils Gunnar wahlgren Fredrik Lindgren Petter Malmborg Thomas H Casswall Department of Pediatrics Karolinska University Hospital and CLINTECKarolinska InstitutetStockholm Se-141 86Sweden Pediatric Coagulation Unit Karolinska University Hospital and CLINTECKarolinska InstitutetStockholm Se-141 86Sweden Division of Radiology Karolinska University Hospital and Karolinska InstitutetStockholm Se-141 86Sweden Clinical Neuroscience Unit Karolinska University Hospital and Karolinska InstitutetStockholm Se-141 86Sweden Division of Paediatric Gastroenterology Hepatology & NutritionKarolinska University Hospital and CLINTECKarolinska InstitutetSe-141 86 StockholmSweden

The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor .

关键词：炎症肠炎肠溃疡静脉血栓形成老年

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恶性疟原虫抗原变异机理的研究(英文)

恶性疟原虫抗原变异机理的研究(英文)

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“科技增强国力，青年开创未来——携手走向辉煌的新世纪”中国科协第三届青年学术年会

作者：陈启军 Mats wahlgren 李德昌盖欣尹继刚杨举 Microbiology and Tumor Biology Center Karolinska InstituteSweden 长春农牧大学

恶性疟原虫(Plasmodium falciparum)是一种致病力最强,对人类危害最为严重的一种寄生原虫。由于该虫寄生的红细胞表面抗原(PfEMP1)不断发生抗原变异,从而逃避了人体免疫系统对寄生在红细胞内的虫体的特异性免疫清除作用。搞清该虫抗原... 详细信息

恶性疟原虫(Plasmodium falciparum)是一种致病力最强,对人类危害最为严重的一种寄生原虫。由于该虫寄生的红细胞表面抗原(PfEMP1)不断发生抗原变异,从而逃避了人体免疫系统对寄生在红细胞内的虫体的特异性免疫清除作用。搞清该虫抗原变异的分子机理是制定疟疾防治措施的一个重要环节。本文报导单细胞RT-PCR技术在这方面的研究成果。借助单细胞显微操作系统,将发育不同时期的虫体从培养基内取出,以反转录PCR法将单个虫体转录的PfEMP1-mRNA扩增出来。结果发现,在侵入红细胞初期,疟原虫将分布在各染色体上的PfEMP1基因激活并转录。但当虫体发育到后期时,通过一种特异的选择机制,恶性疟原虫从其所转录的所有PfEMP1-mRNA分子中选择一个对虫体免疫逃避最为有效的mRNA作最后表达。因此,多基因同时激活与转录,选择其中的单个基因进行最后表达是恶性疟原虫抗原变异的分子机理。

关键词： PfEMP1 malaria single cell RT-PCR aatigenic variation

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机械血栓清除术治疗急性缺血性卒中的欧洲卒中组织-Karolinska专家共识(2014/2015更新版)

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中国脑血管病杂志 2017年第1期14卷 51-55页

作者： wahlgren N Moreira T Michel P 吴川杰(译) 李传辉(译) 闫峰(译) 吉训明(译) 不详首都医科大学宣武医院神经外科北京100053

自1996年,Karolinska卒中共识/更新（Karolinska Stroke Update,KSU）会议每两年举行一次。自2014年起,该会议成为欧洲卒中组织（European Stroke Organization,ESO）的官方会议。ESO-KSU会议项目委员会批准最终项目,该项目的核心由共... 详细信息

自1996年,Karolinska卒中共识/更新（Karolinska Stroke Update,KSU）会议每两年举行一次。自2014年起,该会议成为欧洲卒中组织（European Stroke Organization,ESO）的官方会议。ESO-KSU会议项目委员会批准最终项目,该项目的核心由共识会议组成,每次会议关注一个卒中临床研究方向的最新研究结果。参会者在大会主席和秘书的协调下起草共识。

关键词：推荐共识急性卒中治疗机械血栓清除术血管内

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Minutes of the 5th Meeting of the International Networ for Young Researchers in Male Fertility

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Asian Journal of Andrology 2012年第5期14卷 796-796页

作者： Alexandra Amara Aida wahlgren Frank Tiittelmann Karel De Gendt Martin Blomberg Jensen Mirja Nurmio Michelle Welsha Jan-Bernd Stukenborg Center for Neuroscience and Cell Biology University of Coimbra Coimbra 3004-517 Portugal IDIBAPS University of Bamelona Barcelona 08036 Spain pediatric Endocrinology Unit Department of Women's and Children's Health Karolinska Institutet and University Hospital Stockholm 17176 Sweden Institute of Human Genetics University of Munster MQnster 48149 Germany Laboratory of Experimental Medicine and Endocrinology Catholic University of Leuven Leuven 3000 Belgium Department of Growth and Reproduction Rigshospitalet University of Copenhagen Copenhagen 2100 Denmark Departments of Physiology and Paediatrics University of Turku Turku 20520 Finland and aThe University of Glasgow Glasgow G12 8QQ Scotland

The International Network for Young Researchers in Male Fertility （INYRMF; http：//***） is committed to establish global networks among young （early stage） scientists in testicular research and to promote collaboration and exchange of methodologies and expertise. We provide a more informal way of commu- nication than many other congresses and meetings and promote online discussions on the homepage and during our annual meetings.

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卒中发作后3．5—4h内溶栓疗效分析

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中国处方药 2010年第9期9卷 57-57页

作者： Ahmed N wahlgren N Grond M

2008年9月，ECASSⅢ和SITS—ISTR观察性研究报告了静脉用阿替普酶溶栓的时间窗从脑卒中发作后3h放宽到4．5h的疗效和安全性。本研究旨在评估放宽的时间窗的执行情况、治疗的效果以及SITS～ISTR研究记录患者的安全性以及功能转归。

关键词：疗效分析发作后脑卒中酶溶栓执行情况功能转归安全性时间窗

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急性缺血性卒中的机械取栓治疗：ESO、ESMINT、ESNR和EAN共同支持的2014／2015 ESO-卡罗林斯卡卒中更新会议共识声明

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国际脑血管病杂志 2016年第1期24卷 1-12页

作者： Nils wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁徐格林不详南京军区南京总医院神经内科 210002

这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织（European Stroke Organisation, ESO）-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排，在2015年利用新的临床试验数据对该声明进... 详细信息

这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织（European Stroke Organisation, ESO）-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排，在2015年利用新的临床试验数据对该声明进行了更新。2015年2月，在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订，然后通过电子邮件交换意见，最终版本得到各学会的认可。推荐意见与原始版本一致，证据等级更新到2015年2月20日为止，在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论，与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见，得到欧洲卒中组织ESO、欧洲神经微创治疗学会（European Society of Minimally Invasive Neurological Therapy, ESMINT）、欧洲神经放射学学会（European Society of Neuroradiology, ESNR）和欧洲神经病学学会（European Academy of Neurology, EAN）的支持。

关键词：推荐共识声明急性卒中治疗机械取栓血管内

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