检索结果-南通市图书馆

Can CT Perfusion Guide Patient Selection for Treatment of Delayed Cerebral Ischemia?

Advances in Computed Tomography 2013年第1期2卷 4-12页

作者： Pina C. Sanelli Rachel Gold Nikesh Anumula Austin Ferrone carl E. johnson joseph P. Comunale Apostolos j. Tsiouris Howard Riina Halinder Mangat Axel Rosengart Alan Z. Segal Department of Neurological Surgery Weill Cornell Medical College New York USA Department of Neurology Weill Cornell Medical College New York USA Department of Radiology Weill Cornell Medical College New York USA

Purpose: To evaluate qualitative and quantitative CT perfusion (CTP) for different treatment options of delayed cerebral ischemia (DCI) in aneurysmal SAH. Methods: Retrospective study of consecutive SAH patients enrolled in a prospective IRB-approved clinical trial. Qualitative analysis of CTP deficits were determined by two blinded neuroradiologists. Quantitative CTP was performed using standardized protocol with region-of-interest placement sampling the cortex. DCI was assessed by clinical and imaging criteria. Patients were classified into treatment groups: 1) hypertension-hemodilution-hypervolemia (HHH);2) intra-arterial (IA) vasodilators and/or angioplasty;3) no treatment. Mean quantitative CTP values were compared using ANOVA pairwise comparisons. Receiver operating characteristic (ROC) curves, standard error (SE) and optimal threshold values were calculated. Results: Ninety-six patients were classified into three treatment groups;21% (19/96) HHH, 34% (33/96) IA-therapy and 46% (44/96) no treatment. DCI was diagnosed in 42% (40/96);of which 18% (7/40) received HHH, 80% (32/40) IA-therapy, and 2% (1/40) no treatment. CTP deficits were seen in 50% (48/96);occurring in 63% (12/19) HHH, 94% (31/33) IA-therapy, and 11% (5/44) no treatment. Presence of CTP deficits had 83% sensitivity, 89% specificity, 90% positive predictive and 81% negative predictive values for treatment. Mean quantitative CTP values revealed significant differences in CBF (p mL/100 gm/min (89% specificity, 71% sensitivity) for determining treatment. Conclusion: These initial findings of significant differences in CTP deficits for different treatment groups suggest that CTP may have a potential role in guiding patient selection for treatment of DCI.

关键词： CT Perfusion Aneurysmal Subarachnoid Hemorrhage Delayed Cerebral Ischemia Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

诺贝尔的囚徒第1版

引用

2004年

作者：（美）卡尔·杰拉西（carl Djerassi）黄群译

本书是20世纪的一部经典小说。它真实地描写了科学家的生活和道德观念。

ISBN: (数字)7530640623

ISBN: (纸本)7530640623

本书是20世纪的一部经典小说。它真实地描写了科学家的生活和道德观念。

关键词：长篇小说美国现代

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Taxonomic species recognition should be consistent

引用

National Science Review 2022年第12期9卷 17-18页

作者： Stephen j.O'Brien Shu-jin Luo Guy Harvey Oceanographic Center Halmos College of Arts and Sciences Nova Southeastern University The State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University

Criteria for species naming have been contentious since the time of carl *** no clear’right or wrong’convention for species naming,biologists strive to simply convince their *** NSR compendium offers detailed guidance [1-6] that adds quantitative genomic inference to the *** taxonomic assemblages (***,fish,fungi,insects,terrestrial and marine invertebrates,plants,bacteria) are sufficiently distinctive that any generalization is fraught with natural exceptions.

关键词： PHYLOGEOGRAPHY

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Model evaluation for the prediction of solubility of active pharmaceutical ingredients(APIs) to guide solid–liquid separator design

引用

Asian journal of Pharmaceutical Sciences 2018年第3期13卷 265-278页

作者： Kuveneshan Moodley jürgen Rarey Deresh Ramjugernath Thermodynamics Research Unit School of Engineering University of KwaZulu-Natal Howard College Campus Industrial Chemistry Carl von Ossietzky University Oldenburg

The assumptions and models for solubility modelling or prediction in systems using nonpolar solvents, or water and complex triterpene and other active pharmaceutical ingredients as solutes aren't well studied. Furthermore, the assumptions concerning heat capacity effects(negligibility, experimental values or approximations) are explored, using non-polar solvents(benzene), or water as reference solvents, for systems with solute melting points in the range of 306–528 K and molecular weights in the range of 90–442 g/mol. New empirical estimation methods for the Δ_(fus)C_(pi) of APIs are presented which correlate the solute molecular masses and van der Waals surface areas with Δ_(fus)C_(pi). Separate empirical parameters were required for oxygenated and non-oxygenated solutes. Subsequently, the predictive capabilities of the various approaches to solubility modelling for complex pharmaceuticals,for which data is limited, are analysed. The solute selection is based on a principal component analysis, considering molecular weights, fusion temperatures, and solubilities in a non-polar solvent, alcohol, and water, where data was available. New NRTL-SAC parameters were determined for selected steroids, by regression. The original UNIFAC, modified UNIFAC(Dortmund), COSMO-RS(OL), and COSMO-SAC activity coefficient predictions are then conducted, based on the availability of group constants and sigma profiles. These are undertaken to assess the predictive capabilities of these models when each assumption concerning heat capacity is employed. The predictive qualities of the models are assessed, based on the mean square deviation and provide guidelines for model selection, and assumptions concerning phase equilibrium, when designing solid–liquid separators for the pharmaceutical industry on process simulation software. The most suitable assumption regarding Δ_(fus)C_(pi) was found to be system specific, with modified UNIFAC(Dortmund) performing well in benzene as a solvent system,

关键词： Solubility Solid–Liquid Equilibrium Model prediction Active pharmaceutical ingredients

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

飞机尾流控制的SPIV实验研究

飞机尾流控制的SPIV实验研究

引用

第七届全国实验流体力学学术会议

作者：黄烁桥申功炘 Robert Konrath carl F.v.Carmer Kompenhans jürgen 航空工程与科学学院流体所北京航空航天大学 Institute of Aerodynamics and Flow Technology Germany Aerospace Center(DLR)GottingenGermany

利用简化的飞机模型,通过改变尾翼的迎角及展弦比,试图建立一种能加速自我消亡的尾流涡系统。本实验在拖曳水槽中进行,运用SPIV系统进行测量,获得了一系列空间切面的2D/3C数据,给出两种不同尾翼情况下的SPIV观测结果,并与无尾翼情况作... 详细信息

利用简化的飞机模型,通过改变尾翼的迎角及展弦比,试图建立一种能加速自我消亡的尾流涡系统。本实验在拖曳水槽中进行,运用SPIV系统进行测量,获得了一系列空间切面的2D/3C数据,给出两种不同尾翼情况下的SPIV观测结果,并与无尾翼情况作了对比:若没有尾翼,翼尖涡能单独地存在很长时间,而如果选用合适的尾翼设置,由于尾翼涡和翼尖涡相互作用触发出的Rayleigh-Ludwieg不稳定性(The Rayleigh-Ludwieg instability),尾迹涡的涡核可以在飞机下游约35个展长位置处就破裂掉;另外,为了有效地使尾迹涡破裂,必须使Rayleigh-Ludwieg不稳定性的"触发"发生在翼尖涡完全发展后,触发时间的控制可通过调整尾翼迎角及展弦比来实现。

关键词：尾流涡 SPIV Rayleigh-Ludwieg不稳定性

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Growth and form of Quercus robur and Fraxinus excelsior respond distinctly different to initial growing space: results from 24-year-old Nelder experiments

引用

journal of Forestry Research 2013年第1期24卷 1-14页

作者： Christian Kuehne Patrick Pyttel Edgar Kublin jürgen Bauhus Institute of Silviculture University of FreiburgD-79085 Freiburg i.Br.Germany. Faculty of Forests and Forestry University of Applied Sciences Wei- henstephan-TriesdorfHans-Carl-von-Carlowitz-Platz 3D-85354 FreisingGermany Department of Biometry and Informatics Forest Research Station Baden-WürttembergPostfach 708D-79007 FreiburgGermany

Initial growing space is of critical importance to growth and quality development of individual trees. We investigated how mortality, growth （diameter at breast height, total height）, natural pruning （height to first dead and first live branch and branchiness） and stem and crown form of 24-year-old pedunculate oak （Quercus robur [L.]） and European ash （Fraxinus excelsior [L.]） were affected by initial spacing. Data were recorded from two replicate single-species Nelder wheels located in southern Germany with eight initial stocking regimes varying from 1,020 to 30,780 seedlings·ha？1. Mortality substantially decreased with increasing initial growing space but significantly differed among the two species, averaging 59% and 15% for oak and ash plots, respectively. In contrast to oak, the low self-thinning rate found in the ash plots over the investigated study period resulted in a high number of smaller intermediate or suppressed trees, eventually retarding individual tree as well as overall stand development. As a result, oak gained greater stem dimensions throughout all initial spacing regimes and the average height of ash significantly increased with initial growing space. The survival of lower crown class ashes also appeared to accelerate self-pruning dynamics. In comparison to oak, we observed less dead and live primary branches as well as a smaller number of epicormic shoots along the first 6 m of the lower stem of dominant and co-dominant ashes in all spacing regimes. Whereas stem form of both species was hardly affected by initial growing space, the percentage of brushy crowns significantly increased with initial spacing in oak and ash. Our findings suggest that initial stockings of ca. 12,000 seedlings per hectare in oak and 2,500 seedlings per hectare in ash will guarantee a sufficient number of at least 300 potential crop trees per hectare in pure oak and ash plantations at the end of the self-thinning phase, respectively. If the problem of epicormic shoots a

关键词： spacing trial stocking self-thinning intraspecific competition qualification spatially explicit modelling generalized additive model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immunotherapy as maintenance treatment in metastatic triple negative breast cancer

引用

journal of Cancer Metastasis and Treatment 2021年第1期7卷 315-322页

作者： Tira j.Tan jack j.Chan Rebecca A.Dent Division of Medical Oncology National Cancer CentreSingapore 169610Singapore.

Metastatic triple negative breast cancer(mTNBC)is an aggressive disease associated with a poor prognosis as compared to other subtypes of breast *** advances have been made in recent years with new approvals for PARP inhibitors for those patients who harbor germline BRCA mutations and immune checkpoint inhibitors for patients with programmed death ligand-1(PD-L1)expressing *** therapies are associated with favorable toxicity profiles and improved health-related quality of life when compared with *** therapy,now recognized as the mainstay for patients with ovarian malignancies,takes advantage of the benefit of low-intensity therapies to suppress a disease over a prolonged period of time following maximal response to induction *** strategy has been little explored in the treatment of ***,we briefly discuss the evidence to date lending credence to this treatment paradigm and examine the potential role of immunotherapy as maintenance in the management of mTNBC.

关键词： Triple negative breast cancer maintenance therapy immunotherapy PARP inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

附录G 微型太阳敏感器

引用

控制工程（北京） 2004年第4期 101-116页

作者： carl Christian Liebe Sohrab Mobasser Youngsam Bae Chris j.Wrigley jeffrey R.Schroeder Ayanna M.Howard

微型太阳敏感器样机已经在美国加利福尼亚理工学院喷气推进实验室(jPL)研制出来。此样机包含一块很薄的硅片。硅片上镀铬和金,带有数百个小针孔,安放在一个有源像源敏感器(APS)的图象探测器顶面,与探测器表面距离为900μm。当太阳照射... 详细信息

微型太阳敏感器样机已经在美国加利福尼亚理工学院喷气推进实验室(jPL)研制出来。此样机包含一块很薄的硅片。硅片上镀铬和金,带有数百个小针孔,安放在一个有源像源敏感器(APS)的图象探测器顶面,与探测器表面距离为900μm。当太阳照射掩膜时,在APS图像探测器上形成太阳图像。精确地确定探测器上太阳图像的位置,就可以算出太阳角——其工作原理与日晷相像。封装后的微型太阳敏感器质量为11g,体积为4.2cm^3,功耗为30mW。微型太阳敏感器的精度优于1′,最大视场角为160°。

关键词：硅片微型大视场封装图像太阳敏感器功耗探测器日晷形成

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small incision lenticule extraction (SMILE) history, fundamentals of a new refractive surgery technique and clinical outcomes

引用

Eye and Vision 2014年第1期1卷 9-20页

作者： Dan Z Reinstein Timothy j Archer Marine Gobbe London Vision Clinic 138 Harley StreetLondon W1G 7LAUK Department of Ophthalmology Columbia University Medical CenterNew YorkNYUSA Centre Hospitalier National d’Ophtalmologie ParisFrance

This review summarizes the current status of the small incision lenticule extraction(SMILE)*** the early work by Sekundo et *** Shah et al.,SMILE has become increasingly *** accuracy of the creation of the lenticule with the VisuMax femtosecond laser(carl Zeiss Meditec)has been verified using very high-frequency(VHF)digital ultrasound and optical coherence tomography(OCT).Visual and refractive outcomes have been shown to be similar to those achieved with laser in situ keratomileusis(LASIK),notably in a large population reported by Hjortdal,Vestergaard et *** in terms of the change in corrected distance visual acuity(CDVA)has also been shown to be similar to *** was expected that there would be less postoperative dry eye after SMILE compared to LASIK because the anterior stroma is disturbed only by the small incision,meaning that the anterior corneal nerves should be less affected.A number of studies have demonstrated a lower reduction and faster recovery of corneal sensation after SMILE than *** studies have also used confocal microscopy to demonstrate a lower decrease in subbasal nerve fiber density after SMILE than *** potential biomechanical advantages of SMILE have been modeled by Reinstein et *** on the non-linearity of tensile strength through the *** have reported a similar change in Ocular Response Analyzer(Reichert)parameters after SMILE and LASIK,however,these have previously been shown to be unreliable as a representation of corneal *** options after SMILE are *** addition applications of the SMILE procedure are also discussed including the potential for cryo-preservation of the lenticule for later reimplantation(Mohamed-Noriega,Angunawela,Lim et al.),and a new procedure referred to as endokeratophakia in which a myopic SMILE lenticule is implanted into a hyperopic patient(Pradhan et al.).Finally,studies reporting microdistortions in Bowman’s layer and cor

关键词： Small incision lenticule extraction(SMILE) Laser in situ keratomileusis(LASIK) Lenticule Cap Dry eye Corneal sensation Corneal innervation Corneal biomechanics Endokeratophakia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

引用

Hepatoma Research 2016年第1期2卷 36-41页

作者： Adam Hauch carl Winkler Eric Katz Peter W.Lundberg Mary Killackey Anil S.Paramesh Luis A.Balart Nathan j.Shores Martin Moehlen Ward Miller Douglas P.Slakey joseph F.Buell Bob H.Saggi Tulane Transplant Institute Tulane University School of MedicineNew OrleansLA 70112USA Department of Gastroenterology Section of HepatologyTulane University School of MedicineNew OrleansLA 70112USA

Aim:Portal vein thrombosis(PVT)in the liver transplant recipient poses many ***,the risk factors and effects on outcomes of PVT are not ***:This study analyzed the experience with PVT in liver transplant program from 2007 to *** included the effectiveness of PVT diagnostics and its risk factors using logistical *** primary endpoints were Kaplan-Meir patient and graft *** secondary endpoints were the length of stay(LOS),transfusion rate,and overall *** predictors of survival were identified using a Cox’s proportional hazards ***:Two hundred and sixteen consecutive liver transplant recipients were examined,and 30(13.8%)had either a total or partial *** hundred and five patients had imaging within 1 year of liver transplantation with only 7(23.3%)of the 30 PVTs identified *** sensitivity(4.8-50%)and negative predictive values(10.5-22.2%)were ***,age significantly predicted PVT[P=0.037/hazard ratio(HR)=0.95].Ninety-day-patient and graft survival for PVT was similar at 6 months,although 1-year survival was significantly lower.“Occult”PVT was not associated with inferior *** for end-stage liver disease score>25(P=0.001,HR=0.49/P=0.004,HR=0.52)and age>60 years(P=0.017,HR=0.64/P=0.013,HR=0.67)were significant predictors of patient and graft *** the transfusion rate was significantly greater with PVT,LOS,and morbidity were ***:Older recipients had a greater likelihood of *** studies were not effective at excluding PVT,and occult diagnosis did not affect the *** was not an independent predictor of mortality or graft loss,but was associated with greater blood loss but not increased LOS or morbidity.

关键词： Advanced age graft survival patient survival post-transplant outcomes resource utilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：