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miniSCIDOm: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino m.Reimold E.Beyreuther f.-E.Brack f.Kroll J.Pawelke J.D.Schilz m.Schneider U.Schramm m.E.P.Umlandt K.Zeil T.Ziegler J.metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOm detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

Re-evaluating monazite as a record of metamorphic reactions

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Geoscience frontiers 2022年第2期13卷 237-254页

作者： Kyle P.Larson Sudip Shrestha John m.Cottle carl Guilmette T.Alex Johnson H.Daniel Gibson félix Gervais Department of Earth Environmental and Geographic SciencesUniversity of British Columbia Okanagan3247 University WayKelownaBC V1V 1V7Canada fipke Laboratory for Trace Element Research University of British Columbia Okanagan3247 University WayKelownaBC V1V 1V7Canada Department of Earth Science University of CaliforniaSanta BarbaraSanta BarbaraCA 93106-9630USA Géologie et Génie Géologique UniversitéLavalQuébec CityQuebecCanada Department of Earth Sciences Simon Fraser University8888 University DriveBurnabyBC V5A 1S6Canada Départment des Génies Civil Géologique et des MinesPolytechnique MontréalMontréalQC H3T 1J4Canada

This study presents a re-examination of historical specimens(DG136 and DG167)from the monashee complex in the southeastern Canadian Cordillera that are critical to the current understanding of rare earth element(REE)distribution between garnet and monazite(and other accessory minerals)during ***-hundred and fifty-one new monazite petrochronology spot analyses on 29 different grains across two specimens outline detailed(re)crystallization *** element data collected from the same ablated volume,interpreted in the context of new phase equilibria modelling that includes monazite,xenotime and apatite,link ages to specific portions of the pressure-temperature(P-T)paths followed by the *** linkages are further informed by garnet Lu-Hf geochronology and xenotime *** clockwise P-T paths indicate prograde metamorphism was ongoing by ca.80 ma in both *** structurally deeper specimen,DG136,records peak P-T conditions of~755-770℃and 8.8-10.4 kbar,interpreted to coincide with(re-)crystallization of low Y monazite at~75-70 ***-rim garnet isopleths from DG167 cross in the observed peak assemblage field at~680℃ and 9.3 *** conditions are interpreted to correspond with low Y monazite(re-)crystallisation at~65 *** specimens record decompression along their retrograde path coincident with high Y 70-55 ma and 65-55 ma monazite populations in DG136 and DG167,*** findings broadly agree with those initially reported~20 years ago and confirm early interpretations using trace elements in monazite as generally reliable markers of metamorphic *** phase equilibria modelling and in situ petrochronological analysis,however,provide additional insight into monazite behaviour during anatexis and the effects of potential trace element buffering by REE-bearing phases such as apatite.

关键词： monazite petrochronology Phase equilibria modelling Geochronology P-T-t paths

Nanoencapsulation of Antioxidant-Rich fraction of Roasted moringa oleiferaL. Leaf Extract: Physico-Chemical Properties and in VitroRelease mechanisms

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food and Nutrition Sciences 2021年第9期12卷 915-936页

作者： Pierre Nobossé Edith N. fombang Damanpreet Singh carl m. f. mbofung Department of food Science and Nutrition National School of Agro-Industrial Sciences ENSAI University of Ngaoundere Ngaoundere Adamawa Region Cameroon Pharmacology and Toxicology Laboratory CSIR-Institute of Himalayan Bioresource Technology Palampur Himachal Pradesh India

Nanocapsules (NC) of antioxidant rich fraction of roasted moringa leaves were prepared using emulsion coacervation technique with alginate (ALG) and/or chitosan (CTS) as biopolymers. NC were characterized based on par... 详细信息

Nanocapsules (NC) of antioxidant rich fraction of roasted Moringa leaves were prepared using emulsion coacervation technique with alginate (ALG) and/or chitosan (CTS) as biopolymers. NC were characterized based on particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency (EE) and loading capacity (LC). Substituting CTS with ALG in NC caused a reduction in particle size and PDI, and enhanced EE. mean particle size dropped from 1209 nm in 1:3 to 413 nm in 3:1 ALG/CTS-NC;PDI decreased from 0.9% to 0.2% and zeta potential from -5.4 to -28.1 mV. The font-family:"">highest EE (87.6%) and LC (13%) were obtained with ALG-CTS-NC (3:1). ALG-NC were spherical while both CTS and ALG-CTS-NC were ovoid. ALG and ALG-CTS-NC were oil/water emulsions while CTS-NC formed water/oil emulsions. 60% and 70% of bioactives in ALG-CTS-NC (3:1) were released in simulated gastric and intestinal fluids respectively after 400 min. Release of antioxidants from NC is concentration-dependent (first order model) and involves simultaneously diffusion (Higuchi model), swelling (korsmeyer-Peppas model) and erosion (Hixson-Crowell model) mechanisms.

关键词： Nanoencapsulation Roasted moringa Leaf Extract Liquid-Liquid Partitioning Antioxidant Activity Phenolic Compounds Physico-Chemical Properties Release mechanisms

Effect of Pure Culture fermentation on Biochemical Composition of moringa oleiferaLam Leaves Powders

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food and Nutrition Sciences 2013年第8期4卷 851-859页

作者： Noumo Ngangmou Thierry Tatsadjieu Ngouné Léopold montet Didier f. mbofung carl moses Nationnal School of Agro-Industrial Sciences Ngaoundéré Cameroon UmR 95 Qualisud CIRAD Montpellier France University Institute of Technology Ngaoundéré Cameroon

This study was carried out to determine the effect of the age of the leaves and fermentation on in vitro protein digestibility and biochemical properties of leaves powder of moringa oleifera. A 6 × 2 × 2 factorial design with two ages of the leaves (one and seven-month-old leaves), six times of fermentation and two fermentation temperatures was used for this purpose. One and seven-month-old fresh leaves were dried at 45 ℃ for 24 h, crushed to 1000 μm then fermented at 30℃ and 37℃ for 120 hours with Lactobacillus plantarum A6 at 108 CfU/g. Samples were withdrawn every 24 hours for physico-chemical analyses. Results showed that 7 month-old leaves were richer in iron, proteins, polyphenols and phytates than one month old leaves. The phytates content dropped from 66.92% and 61.95% in the seven and one month-old leaves powders respectively fermented at 37℃, and from 54.15% and 67.95% in the seven and one month-old leaves powders respectively fermented at 30℃. Protein content increased by 26.34% and 24.48% for the 1and 7-month-old leaves powders respectively fermented at 37℃, and by 13.06% and 13.97% for the 1and 7month-old leaves powders respectively, fermented at 30℃. Iron availability increased from 35.97% to 40.57% and 20.74% to 30.98% for the 1and 7-month-old leaves powders respectively, fermented at 37℃ and from 35.97% to 39.79% and 20.76% to 23.72% for the 1and 7-month-old leaves powders respectively, fermented at 30℃. There was a negative correlation between pH, total and reducing sugar contents, time as well as fermentation temperature, whereas there was a positive correlation between total protein content and pepsic digestibility of protein and fermentation time. from these results, fermentation of m. oleifera leaf powder by Lactobacillus plantarum A6 increases protein content, pepsic digestibility of protein and availability of iron and reduces the phytates content of these powders.

关键词： moringa Oleifera Leaf Powder fermentation Lactobacillus Plantarum A6 Availability Protein Digestibility

The Potential Application of Syzygium aromaticumand Cymbopogon citratusEssential Oils as Natural Preservatives of Beef Patties

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food and Nutrition Sciences 2015年第3期6卷 374-385页

作者： fabrice Bruno Siewe Pierre Désiré mbougueng Léopold Ngoune Tatsadjieu Thierry Ngangmou Noumo carl m. f. mbofung Department of food Science and Nutrition National School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon Department of Process Engineering National School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon Department of food Engineering and Quality Control University Institute of Technology University of Ngaoundere Ngaoundere Cameroon College of Technology University of Bamenda Bamenda Cameroon

The effect of essential oils from Syzygium aromaticum and Cymbopogon citratus on the lipid oxidation and microbial growth in beef patties was investigated in the present study. Essential oils were incorporated into the beef patties at 0.1% and 0.2% (w/w). The beef patties were then inoculated with cultures of E. coli and S. aureus and stored at 4°C. The control patties were processed without essential oil but inoculated with E. coli or S. aureus. The proximate composition, lipid oxidation and microbial counts were carried out after 7, 14, 21 and 28 days. Results showed that the incorporation of essential oils in beef patties did not significantly (P S. aromaticum at 0.2% reduced the E. coli growth by 1.48 log CfU/g and that of S. aureus by 6.52 log CfU/g while the incorporation of C. citratus at 0.2% reduced the E. coli growth by 1.21 log CfU/g and that of S. aureus by 1.4 log CfU/g after 28 days of storage. The pH measurement during the storage period showed a slight drop during the first 7 days of storage and an increase during the last 21 days in all samples. The sensory test of the beef patties showed that the consumers accepted patties formulated with the two essential oils. But the one made with 0.1% essential oil of S. aromaticum was the most accepted. The analysis of the color of beef patties between 0 and 28 days of storage revealed that the incorporation of essential oils retarded the degradation of the color of patties. Results obtained in the present study indicate the possibility of exploiting Syzygium aromaticum and Cymbopogon citratus essential oils to protect beef patties against lipid oxidation and microbial growth.

关键词： S. aromaticum C. citratus Essential Oil Beef Patties Lipid Oxidation microbial Stability Escherichia coli Staphylococcus aureus

Proximate Composition, mineral and Vitamin Content of Some Wild Plants Used as Spices in Cameroon

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food and Nutrition Sciences 2012年第4期3卷 423-432页

作者： Armand Abdou Bouba Nicolas Yanou Njintang Harquin Simplice foyet Joel Scher Didier montet carl moses f. mbofung Department of Agriculture Livestock and By-Products University of Maroua Maroua Cameroon Department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon Department of food Science and Nutrition University of Ngaoundere Ngaoundere Cameroon Laboratoire d’Ingénierie et des Biomolécules (LiBio) Nancy-Université Nancy France

The aim of this work was to contribute to our knowledge of the proximate composition, mineral and vitamin content of 20 edible wild plants used as spices in Cameroon. The plant species were collected from 3 different markets in the West Region of Cameroon and analysed for their content of crude proteins, and lipid, ash, moisture, available sugars, total phenols, carotenoids, minerals (Ca, Zn, K, Na, mg, Al, mn, Cu and Se), and vitamins (A, E and C) as well as for their pH and colour. Results revealed that all the plants were low in moisture (7.7 to 10.5 g/100 g) but high in ash content (7.7 to 10.5 g/100 g). Hua gabonii (bark) (1594.5 mg/100 g) was relative source of calcium, Echinops giganteus (206.4 mg/100 g) exhibited the highest level of iron and Scorodophleus zenkeri (310.0 μg/100 g) the highest level of selenium. Generally all the plants were found to contain low levels of Zn, Cu and mg. Wide variations were observed for the pro- teins and available sugars among the samples. The lipid content of some of the plants were surprisingly relatively high as was the case with monodora myristica (53.4 g/100 g), Xylopia aethiopica (33.7 g/100 g), fagara leprieuri (32.1 g/100 g), and Aframomum daniellii (23.1 g/100 g). All the plants were rich in phenols, carotenoids, vitamin E and C. They are dark in colour and in solution they tended to provoke a fair acidification.

关键词： Spices Proximate Composition minerals Vitamins

Assessing nest attentiveness of Common Terns via video cameras and temperature loggers

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Avian Research 2020年第3期11卷 284-301页

作者： Jeffery D.Sullivan Paul R.marbán Jennifer m.mullinax David f.Brinker Peter C.mcGowan carl R.Callahan Diann J.Prosser Natural Systems Analysts Winter ParkFL 32789USA marine Estuarineand Environmental Sciences ProgramUniversity of MarylandCollege ParkMD 20742USA Department of Environmental Science and Technology University of Maryland1443 Animal Sciences BldgCollege ParkMD 20742USA Department of Natural Resources Maryland Natural Heritage ProgramAnnapolisMD 21401USA Chesapeake Bay field Office U.S.Fish and Wildlife ServiceAnnapolisMD 21401USA U.S.Geological Survey Patuxent Wildlife Research CenterLaurelMD 20708USA.

Background:While nest attentiveness plays a critical role in the reproductive success of avian species,nest attentiveness data with high temporal resolution is not available for many ***,improvements in both video monitoring and temperature logging devices present an opportunity to increase our understanding of this aspect of avian ***:To investigate nest attentiveness behaviors and evaluate these technologies,we monitored 13 nests across two Common Tern(Sterna hirundo)breeding colonies with a paired video camera-temperature logger approach,while monitoring 63 additional nests with temperature loggers *** occurred from may to August of 2017 on Poplar(Chesapeake Bay,maryland,USA)and Skimmer Islands(Isle of Wight Bay,maryland,USA).We examined data respective to four times of day:morning(civil dawn‒11:59),Peak(12:00‒16:00),Cooling(16:01‒civil dusk),and Night(civil dusk‒civil dawn).Results:While successful nests had mostly short duration off-bouts and maintained consistent nest attentiveness throughout the day,failed nests had dramatic reductions in nest attentiveness during the Cooling and Night periods(pment due to predation pressure from a Great Horned Owl(Bubo virginianus).Incubation appeared to ameliorate ambient temperatures during Night,as nests were significantly warmer during Night when birds were on versus off the nest(pmeanwhile,off-bouts during the Peak period occurred during higher ambient temperatures,perhaps due to adults leaving the nest during the hottest periods to perform belly ***,temperature logger data alone had limited ability to predict nest attentiveness status during shorter bouts,with results highly dependent on time of day and bout *** our methods did not affect hatching success(p>0.05),video-monitored nests did have significantly lower clutch sizes(pf iButtons and video ca

关键词： Common Tern iButton Nest attentiveness Sterna hirundo Temperature logger Video monitoring

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marketing = 6th ed.

Observation of a single protein by ultrafast X-ray diffraction

丛书名：当代全美mBA经典教材书系

2003年

作者： Charles W. Lamb Joseph f. Hair carl mcDaniel.

"北大光华管理学院ImBA、mBA推荐用书"--Cover.

ISBN: (数字)730105971X

ISBN: (纸本)730105971X

"北大光华管理学院ImBA、mBA推荐用书"--Cover.

关键词： marketing.

来源：畅想之星图书光盘版（南... 评论

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.mancuso Tommaso mazza carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper michael meyer filipe R.N.C.maia Laboratory of molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XfEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic multi-User CryoEm facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden max Planck Institute for the Structure and Dynamics of matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast