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The Role of ADME in Drug Safety Evaluation

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The Role of ADME in Drug Safety Evaluation

药物非临床安全性研究学术研讨会

作者： Michelle M He lisa A.Shipley carl l.mcmillian Ph.D.Research Advisor Drug Disposition Lilly Research LaboratorieDivision of Eli Lilly and Comp Ph.D.Vice President Drug Disposition Lilly Research LaboratorieDivision of Eli Lilly and Comp Ph.D.Director Pathology and Investigative Toxicology Lilly Research LaboratorieDivision of Eli Lilly and Comp

Role of ADME in Safety Assessment ·Delineates the Absorption,Distribution, Metabolism and Excretion of drug candidates in animals and humans ·Determines exposure in Toxicology Studies to establish Margins of Safety

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毒理学与发现药物的相互关系

毒理学与发现药物的相互关系

药物非临床安全性研究学术研讨会

作者： carl l．mcmillian 礼来公司礼来研究实验室

毒理学参与从研发到投放市场的连续过程…目标是首次人的给药剂量(FHD)

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ADME在药品毒理学评价中的作用

ADME在药品毒理学评价中的作用

药物非临床安全性研究学术研讨会

作者： Michelle M．He lisa A．Shipley carl l．mcmillian 礼来公司礼来研究实验室礼来公司礼来研究实验室礼来公司礼来研究实验室病理及毒理学研究室

ADME 在安全性评价中的作用·描述候选药物在动物和人体内的吸收、分布、代谢和扫泄(ADME) ·在毒理学研究中测定暴露量以确定安全范围(MOS)

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A Tropical View on landau-Ginzburg Models

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Acta Mathematica Sinica,English Series 2024年第1期40卷 329-382页

作者： Michael carl Max PUMPERlA Bernd SIEBERT Alfred-Delp-Str.2 73430 AalenGermany IU Internationale Hochschule Juri-Gagarin-Ring 15299084 ErfurtGermany AnyscaleInc.2080 Addison St Ste 7BerkeleyCA 94704USA Department of Mathematics The Univ.of Texas at Austin2515 SpeedwayAustinTX 78712USA

This paper,largely written in 2009/2010,fits landau-Ginzburg models into the mirror symmetry program pursued by the last author jointly with Mark Gross since *** point of view transparently brings in tropical disks of Maslov index 2 via the notion of broken lines,previously introduced in two dimensions by Mark Gross in his study of mirror symmetry for P2.A ma jor insight is the equivalence of properness of the landau-Ginzburg potential with smoothness of the anticanonical divisor on the mirror *** obtain proper superpotentials which agree on an open part with those classically known for toric *** include mirror lG models for non-singular and singular del Pezzo surfaces,Hirzebruch surfaces and some Fano threefolds.

关键词： landau-Ginzburg model mirror symmetry tropical disk broken line wall structure scattering diagram Gross-Siebert program del Pezzo surface toric degeneration

Physical activity with or without dietary intervention for the prevention of cardiovascular diseases

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Journal of Sport and Health Science 2024年第6期13卷 753-755页

作者： carl J.lavie Salvatore Carbone leandro Slipczuk The John Ochsner Heart and Vascular Institute Ochsner Clinical Schoolthe University of Queensland School of MedicineNew OrleansLA 70121USA Department of Kinesiology and Health Sciences College of Humanities and SciencesVirginia Commonwealth UniversityRichmondVA 23284USA Montefiore Health System/Albert Einstein College of Medicine BronxNY 10461USA

We and others have published extensively on the benefits of physical activity(PA),exercise training,and cardiorespiratory fitness(CRF)to decrease the prevalence of cardiovascular diseases(CVDs)and CVD and all-cause morbidity and mortality.^(1-5)Both PA and CRF are important;however,CRF,which is mostly obtained through PA,although there is a genetic component,seems to be even more important than PA for predicting prognosis.^(1,4-6)Certainly,the wealth of data from across the world has indicated that increasing PA to enhance CRF while mitigating sedentary behavior would go a long way to lessen the world-wide obesity epidemic and reduce CVD and all-cause mortality.

关键词： mortality prevention diseases

Gouty destruction of a patellar tendon reconstruction and novel revision reconstruction technique: A case report

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World Journal of Orthopedics 2024年第7期15卷 675-682页

作者： carl C Edge Jonathan Widmeyer Omar Protzuk Maya Johnson Robert O’Connell Department of Orthopaedic Surgery Division of Sports MedicineVirginia Commonwealth University Health SystemRichmondVA 23298-0153United States Division of Sports Medicine OrthowestCarroltonGA 30117United States

BACKGROUND Gout is a disease characterized by hyperuricemia,and resultant deposition of uric acid crystals in *** typically manifested as intraarticular crystals or tophi,gout can also cause pathology at *** deposition within tendinous structures put them at risk for traumatic and degenerative ***,allografts can also be at risk of rupture in the setting of severe *** present the case of a 56-year-old female with severe gouty disease who sustained a re-rupture of a patellar tendon allograft *** SUMMARY A 56-year-old female presented to clinic after feeling her left knee pop and collapse beneath her while descending *** had a history of tophaceous gout and left patellar tendon rupture with reconstruction and multiple revisions over the course of 19 *** patient presented with pain and extensor lag.A magnetic resonance image demonstrated a ruptured patellar tendon allograft reconstruction and avulsion fracture at the tibial *** patient was treated with a novel intervention of Achilles allograft with bone block in a unique configuration with a dermal allograft incorporated into the *** was made non-weight bearing in the operative extremity in extension for the first four weeks postoperatively and was then progressed to active flexion over the course of eight *** twelve weeks,she was able to fully extend her operative knee and at five months she was resuming her normal activities and *** Failed patellar tendon reconstruction due to gouty infiltration is treated with dermal allograft augmented Achilles tendon reconstruction with bone block.

关键词： Gout Patella Reconstruction Dermal allograft Revision Case report

Evaluation of Ruminal Dry Matter Disappearance and pH of Dry Corn, High-Moisture Corn, and Rye under in Vitro Conditions

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Agricultural Sciences 2024年第3期15卷 327-332页

作者： Warren carl Rusche Zachary Kidd Foster Smith South Dakota State University Brookings South Dakota USA

An in vitro experiment was conducted to evaluate the effects of grain type on in vitro dry matter disappearance (IVDMD) and pH using ruminal fluid and a buffer reagent. Five beef cows were used for ruminal fluid collection and ruminal fluid was pooled prior to use. The cows used for ruminal fluid collection were maintained on a forage-based diet (60:40 forage to concentrate) for 28 d prior to ruminal fluid collection. Three grain types were evaluated: 1) dry corn (89% dry matter;DRC), 2) high-moisture corn (72% dry matter;HMC) and 3) rye (89% dry matter;RYE). Data were analyzed as a completely randomized design. A total of twenty-one replications of each grain type were used for statistical analysis (n = 63 tubes total). IVDMD was greater (P ≤ 0.05) by 97.1% and 46.4% for RYE compared to DRC and HMC, respectively. Additionally, IVDMD was greater (P = 0.05) by 34.6% for HMC compared to DRC. Final pH was decreased (P ≤ 0.05) for RYE by 12.3% and 2.8% for RYE compared to DRC and HMC, respectively. Also, final pH was decreased (P = 0.05) by 9.8% for HMC compared to DRC. These data indicate that corn harvest method (dry vs. high-moisture) influences IVDMD and final pH and that rye has a greater disappearance of dry matter and lower final pH than corn under in vitro conditions.

关键词： Corn Grain Processing Ruminal Fermentation Rye

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野生动物旅游者满意度构成评价与提升研究

野生动物旅游者满意度构成评价与提升研究

作者：卡尔（carl louis dela Cruz）海南师范大学

学位级别：硕士

NUMERICAl SIMUlATION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl JET

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： carl l. Gardner Steven J. Dwyer School of Mathematical and Statistical Sciences Arizona State University Tempe AZ 85287 USA

Computational gas dynamical simulations using the WENO-lF method are applied to modeling the high Mach number astrophysical jet XZ Tauri, including the effects of radiative cooling. Mach 55 simulations of the pulsed proto-jet are presented and analyzed in terms of interacting nonlinear waves： terminal Mach disks, bow shocks, and Meshkov-Richtmyer instabilities of the leading jet contact boundary.

关键词： astrophysical jets ENO. method gas dynamics