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High-fidelity replication of thermoplastic microneedles with open microfluidic channels

Microsystems & Nanoengineering 2017年第1期3卷 96-106页

作者： Zahra Faraji Rad Robert E.Nordon carl J.Anthony Lynne Bilston Philip d.Prewett Ji-Youn Arns Christoph H.Arns Liangchi Zhang Graham J.davies Graduate School of Biomedical Engineering University of New South WalesSydneyNSW 2052Australia School of Mechanical Engineering University of BirminghamBirmingham B152TTUK School of Mechanical and Manufacturing Engineering University of New South WalesSydneyNSW 2052Australia Prince of Wales Clinical School University of New South WalesSydneyNSW 2052Australia School of Petroleum Engineering University of New South WalesSydneyNSW 2052Australia

development of microneedles for unskilled and painless collection of blood or drug delivery addresses the quality of healthcare through early intervention at *** with submicron to millimeter features have been fabricated from materials such as metals,silicon,and polymers by subtractive machining or ***,to date,large-scale manufacture of hollow microneedles has been limited by the cost and complexity of microfabrication *** paper reports a novel manufacturing method that may overcome the complexity of hollow microneedle *** microneedles with open microfluidic channels are fabricated by laser *** replicas are manufactured from these templates by soft-embossing with high fidelity at submicron *** manufacturing advantages are(a)direct printing from computeraided design(CAd)drawing without the constraints imposed by subtractive machining or etching processes,(b)high-fidelity replication of prototype geometries with multiple reuses of elastomeric molds,(c)shorter manufacturing time compared to three-dimensional stereolithography,and(d)integration of microneedles with open-channel *** work will address development of open-channel microfluidics for drug delivery,fluid sampling and analysis.

关键词： drug delivery laser lithography microneedles point-of-care diagnostics soft embossing

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热液喷发机理和热泉金矿

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国外火山地质 1987年第1期 24-29页

作者： carl E. Nelson d. L. Giles 胡青邱永泉

浅部热泉环境中的金矿在时间上与热液喷发事件有关,在空间上与火口角砾岩和周围网脉带有关.这被认为可能由于突然的岩浆热流量的触发使地热储处于短暂的强超压状态,从而造成水力破碎。如果这种水力裂隙发展到地表就可能导致热液喷发。... 详细信息

浅部热泉环境中的金矿在时间上与热液喷发事件有关,在空间上与火口角砾岩和周围网脉带有关.这被认为可能由于突然的岩浆热流量的触发使地热储处于短暂的强超压状态,从而造成水力破碎。如果这种水力裂隙发展到地表就可能导致热液喷发。浅部热储的最大有效能足以引起这种喷发,特别是当流体中富含CO2时。矿化体系中含金流体最终要进入溢流通道然后涌入渗透性火口角砾岩和周围的网脉。金则被带到沸腾面之上的热泉中沉淀（高流速将沸腾面提高到距地表只有几百米的浅部）,同时大量石英、黄铁矿和冰长石开始沉淀,并伴有明显的微量元素分带。这一系列事件可能是一个连续的整体.如果这一系列事件在单个喷口反复出现,就能形成够品位的矿床.

关键词：热液有效能金矿金属矿物热泉流体对流角砾岩化热流体

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The Role of AdME in drug Safety Evaluation

The Role of ADME in Drug Safety Evaluation

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药物非临床安全性研究学术研讨会

作者： Michelle M He Lisa A.Shipley carl L.McMillian Ph.d.Research Advisor Drug Disposition Lilly Research LaboratorieDivision of Eli Lilly and Comp Ph.d.Vice President Drug Disposition Lilly Research LaboratorieDivision of Eli Lilly and Comp Ph.d.director Pathology and Investigative Toxicology Lilly Research LaboratorieDivision of Eli Lilly and Comp

Role of AdME in Safety Assessment ·delineates the Absorption,distribution, Metabolism and Excretion of drug candidates in animals and humans ·determines exposure in Toxicology Studies to establish Margins of Safety

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Assessing the sensitivity of Melanoplus frigidus （Orthoptera： Acrididae） to different weather conditions＂ A modeling approach focussing on development times

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Insect Science 2008年第2期15卷 167-178页

作者： Oliver-d. Finch Jorg Loffler Roland Pape carl-von-Ossietzky University of Oldenburg Fk V Institute of Biology and Environmental-Sciences Terrestrial Ecology D-26111 Oldenburg University of Bonn Department of Geography Meckenheimer AIlee 166 D-53115 Bonn Germany

The temperature and soil moisture conditions as well as vegetation patterns were studied to describe the habitat and to model the life cycle of Melanoplusfrigidus, a true alpine grasshopper of the Scandes. In the low alpine belt of the Norwegian Scandes the species colonizes only the warmest microhabitats with maximum soil surface temperatures of 31℃. Vegetation of these habitats consists of shrub-rich heath dominated by Vaccinium myrtillus and Calluna vulgaris. Using continuously measured temperature data, the development times for four different seasons were modeled and related to field observations. The maximum delay of adult molt was estimated to amount to 3 weeks, the delay being determined by the variation in spring temperature conditions between different years. The possibilities of using M. frigidus as an indicator organism of climate change effects on alpine zoo-coenoses of the Scandes are discussed.

关键词： alpine insects climate change indicator life history thermal effective environment

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Thin Crust Over the Marion Rise-Remelting the Ancient Gondwana Mantle

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Acta Geologica Sinica(English Edition) 2015年第A2期89卷 26-26页

作者： Réjean HEBERT carl GUILMETTE département de géologie et de génie géologique Université Laval

decade-long investigation of the Yarlung Zangbo Suture Zone （YZSZ）, southern Tibet, has revealed it＇s high complexity in terms of structure, geochronology and metamorphic and igneous histories. For instance,

关键词： CONTINENTAL rises RESEARCH GEOLOGICAL time METAMORPHIC rocks IGNEOUS rocks TRIASSIC Period AMPHIBOLITES CRUST of the earth

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Structure and Functional Implications of Chaperone Chz1 Complexed with Histones H2A.Z-H2B

Structure and Functional Implications of Chaperone Chz1 Comp...

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第十二届北京分析测试学术报告会暨展览会(BCEIA2...

作者： Zheng Zhou Hanqiao Feng d.Flemming Hansen Ed Luk Hidenori Kato daron I.Freedberg Lewis E.Kay carl Wu Yawen Bai department of Medical Genetics Biochemistry and Chemistry University of Toronto

＜正＞The packaging of the genome into chromatin is essential for normal growth,development,and differentiation of eukaryotic *** chaperones play important roles in the assembly and disassembly of nucleosomes,the fundamental structural units of *** yeast Chz1 is a recently discovered,intrinsically-disordered histone chaperone of H2A-H2B and its variant

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On the material dependency of peri-implant morphology and stability in healing bone

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Bioactive Materials 2023年第10期28卷 155-166页

作者： Stefan Bruns diana Krüger Silvia Galli d.C.Florian Wieland Jorg U.Hammel Felix Beckmann Ann Wennerberg Regine Willumeit-Romer Berit Zeller-Plumhoff Julian Moosmann Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.121502GeesthachtGermany University of Malmo Faculty of OdontologyDepartment of ProsthodonticsCarl Gustafs Vag 34Klerken20506MalmoSweden Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.121502GeesthachtGermany University of Gothenburg Institute of OdontologyDepartment of ProsthodonticsMedicinaregatan 12 f41390GoteborgSweden

The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant *** present a study in which screw implants made from titanium,polyetheretherketone and biodegradable magnesium-gadolinium alloys were implanted into rat tibia and subjected to a push-out test four,eight and twelve weeks after *** were 4 mm in length and with an M2 *** loading experiment was accompanied by simultaneous three-dimensional imaging using synchrotron-radiation microcomputed tomography at 5μm *** deformation and strains were tracked by applying optical flow-based digital volume correlation to the recorded image *** stabilities measured for screws of biodegradable alloys were comparable to pins whereas non-degradable biomaterials experienced additional mechanical ***-implant bone morphology and strain transfer from the loaded implant site depended heavily on the biomaterial *** implants stimulated rapid callus formation displaying a consistent monomodal strain profile whereas the bone volume fraction in the vicinity of magnesium-gadolinium alloys exhibited a minimum close to the interface of the implant and less ordered strain *** in our data suggest that implant stability benefits from disparate bone morphological properties depending on the biomaterial *** leaves the choice of biomaterial as situational depending on local tissue properties.

关键词： Biodegradable implant materials Bone mechanical testing Implant stability Synchrotron micro-computed tomography imaging digital volume correlation

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运用SIGRAPH—UCAd2d／3d设计汽轮机装置

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工业汽轮机 1996年第2期 26-28页

作者： carl.,KW 陈巍

德国西门子ＫＷＵ集团威塞尔汽轮机制造厂在运用ＳＩＧＲＡＰＨＵＣＡＤ２Ｄ／３Ｄ设计系统进行汽轮机轮机装置的计算机辅助设计方面已取得了很大成效。该设计系统的优势在于既可以迅速剩余做好报价准备，处理合同，也可以在汽车轮机汽... 详细信息

德国西门子ＫＷＵ集团威塞尔汽轮机制造厂在运用ＳＩＧＲＡＰＨＵＣＡＤ２Ｄ／３Ｄ设计系统进行汽轮机轮机装置的计算机辅助设计方面已取得了很大成效。该设计系统的优势在于既可以迅速剩余做好报价准备，处理合同，也可以在汽车轮机汽车的设计上具有高度的灵活性。

关键词：汽轮机 CAd

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人权的道德维度

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2018年

作者： (美)卡尔·威尔曼

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High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3d

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Bioactive Materials 2022年第7期7卷 37-52页

作者： diana Krüger Silvia Galli Berit Zeller-Plumhoff d.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht21502Germany University of Malmo Faculty of OdontologyDepartment of ProsthodonticsCarl Gustafs vag 34Klerken20506MalmoSweden Lund University Department of Clinical Sciences LundMedical Radiation PhysicsBarngatan 422242LundSweden deutsches Elektronen-Synchrotron(dESY) Notkestrasse 8522607HamburgGermany Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht21502Germany University of Gothenburg Institute of OdontologyDepartment of ProsthodonticsMedicinaregatan 12 f41390GoteborgSweden

Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal ***,they are not yet routinely applied because their degradation behavior is not fully *** this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high ***-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 ***,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and ***(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate *** results showed that Mg-5Gd degraded faster and less homogeneously than *** alloys gradually form a stable degradation layer at the interface and were surrounded by new bone *** results were correlated to in vitro data obtained from the same material and *** average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for *** results suggest that both Mg-xGd alloys are suitable as materials for bone implants.

关键词： Magnesium alloys Biodegradable implant Micro-computed tomography degradation rate degradation homogeneity Ex vivo imaging Ex vivo histology Histology vs.tomography

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