检索结果-南通市图书馆

Genes & diseases 2023年第4期10卷 1169-1171页

作者： Robert M.Clancy carla J.Guthridge Miranda C.Marion Joel Guthridge Timothy d.Howard Peter M.Izmirly Mala Masson Jill P.Buyon Judith A.James carl d.langefeld department of Medicine Division of RheumatologyNYU Grossman School of MedicineNew YorkNY 10016USA Arthritis and Clinical Immunology Oklahoma Medical Research FoundationOklahoma CityOK 73104USA department of Biostatistics and data Science Wake Forest School of MedicineWinstone SalemNC 27101USA Center for Precision Medicine Wake Forest School of MedicineWinstoneSalemNC 27101USA department of Biochemistry Wake Forest School of MedicineWinstoneSalemNC 27101USA

The genus Streptococcus,a gram-positive bacterium,con-tains species associated with immune activation at morbid outcomes,including scarlet fever,endocarditis,meningitis,and rheumatic *** both stool and saliva,there is a pos-itive correlation between Streptococcus abundance and Sjogren’s syndrome(SS)and systemic lupus erythematosus(SLE).

关键词： lupus mother fever Streptococcus

Evaluation of Ruminal dry Matter disappearance and pH of dry Corn, High-Moisture Corn, and Rye under in Vitro Conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences 2024年第3期15卷 327-332页

作者： Warren carl Rusche Zachary Kidd Foster Smith South dakota State University Brookings South Dakota USA

An in vitro experiment was conducted to evaluate the effects of grain type on in vitro dry matter disappearance (IVdMd) and pH using ruminal fluid and a buffer reagent. Five beef cows were used for ruminal fluid collection and ruminal fluid was pooled prior to use. The cows used for ruminal fluid collection were maintained on a forage-based diet (60:40 forage to concentrate) for 28 d prior to ruminal fluid collection. Three grain types were evaluated: 1) dry corn (89% dry matter;dRC), 2) high-moisture corn (72% dry matter;HMC) and 3) rye (89% dry matter;RYE). data were analyzed as a completely randomized design. A total of twenty-one replications of each grain type were used for statistical analysis (n = 63 tubes total). IVdMd was greater (P ≤ 0.05) by 97.1% and 46.4% for RYE compared to dRC and HMC, respectively. Additionally, IVdMd was greater (P = 0.05) by 34.6% for HMC compared to dRC. Final pH was decreased (P ≤ 0.05) for RYE by 12.3% and 2.8% for RYE compared to dRC and HMC, respectively. Also, final pH was decreased (P = 0.05) by 9.8% for HMC compared to dRC. These data indicate that corn harvest method (dry vs. high-moisture) influences IVdMd and final pH and that rye has a greater disappearance of dry matter and lower final pH than corn under in vitro conditions.

关键词： Corn Grain Processing Ruminal Fermentation Rye

Caspase-3 activation as a bifurcation point between plasticity and cell death

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2012年第1期28卷 14-24页

作者： Shikha Snigdha Erica d Smith G Aleph Prieto carl W Cotman Institute for Memory Impairments and Neurological disorders University of CaliforniaIrvineIrvineCalifornia 92697-4540USA

death-mediating proteases such as caspases and caspase-3 in particular, have been implicated in neurodegenerative processes, aging and Alzheimer＇s disease. However, emerging evidence suggests that in addition to their classical role in cell death, caspases play a key role in modulating synaptic function. It is remarkable that active caspases-3, which can trigger widespread damage and degeneration, aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death. Here, we evaluate this dichotomy, and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling, able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling. We propose that temporal, spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons. This concept has implications for differential roles of caspase-3 activation across the lifespan. Specifically, we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain.

关键词： caspase-3 neurodegeneration cognition memory synaptic function

dirichlet Process Gaussian Mixture Models:Choice of the Base distribution

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2010年第4期25卷 653-664页

作者： dilan Grür carl Edward Rasmussen Gatsby Computational Neuroscience Unit University College London department of Engineering University of Cambridge Max Planck Institute for Biological Cybernetics.d-72076 Tubingen

In the Bayesian mixture modeling framework it is possible to infer the necessary number of components to model the data and therefore it is unnecessary to explicitly restrict the number of components. Nonparametric mixture models sidestep the problem of finding the ＂correct＂ number of mixture components by assuming infinitely many components. In this paper dirichlet process mixture （dPM） models are cast as infinite mixture models and inference using Markov chain Monte carlo is described. The specification of the priors on the model parameters is often guided by mathematical and practical convenience. The primary goal of this paper is to compare the choice of conjugate and non-conjugate base distributions on a particular class of dPM models which is widely used in applications, the dirichlet process Gaussian mixture model （dPGMM）. We compare computational efficiency and modeling performance of dPGMM defined using a conjugate and a conditionally conjugate base distribution. We show that better density models can result from using a wider class of priors with no or only a modest increase in computational effort.

关键词： Bayesian nonparametrics dirichlet processes Gaussian mixtures

Identifying sediment discontinuities and solving dating puzzles using monitoring and palaeolimnological records

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2016年第4期10卷 621-633页

作者： Xuhui dONG carl d. SAYER Helen BENNION Stephen C. MABERLY Handong YANG Richard W. BATTARBEE State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Nanjing 210008 China Environmental Change Research Centre Departmeni of Geography University College London London WCIE 6BT UK Aarhus Institute of Advanced Studies Aarhus University DK-8000 Aarhus C Denmark Lake Ecosystems Group Centre for Ecology & Hydrology Library Avenue Lancaster LA1 4AP UK

Palaeolimnological studies should ideally be based upon continuous, undisturbed sediment sequences with reliable chronologies. However for some lake cores, these conditions are not met and palaeolimnologists are often faced with dating puzzles caused by sediment disturbances in the past. This study chooses Esthwaite Water from England to illustrate how to identify sedimentation discontinuities in lake cores and how chronologies can be established for imperfect cores by correlation of key sediment signatures in parallel core records and with long-term monitoring data （1945-2003）. Replicated short cores （ESTH1, ESTH7, and ESTH8） were collected and subjected to loss-on-ignition, radiometric dating （210Pb, 137Cs, and 14C）, particle size, trace metal, and fossil diatom analysis. Both a slumping and a hiatus event were detected in ESTH7 based on comparisons made between the cores and the long-term diatom data. Ordination analysis suggested that the slumped material in ESTH7 originated from sediment deposited around 1805-1880 Ad. Further, it was inferred that the hiatus resulted in a loss of sediment deposited from 1870 to 1970 Ad. Given the existence of three superior 14C dates in ESTH7, ESTH 1 and ESTH7 were temporally correlated by multiple palaeolimnological proxies for age-depth model development. High variability in sedimentation rates was evident, but good agreement across the various palaeo- limnological proxies indicated coherence in sediment processes within the coring area. differences in sedimenta- tion rates most likely resulted from the natural morphology of the lake basin. Our study suggests that caution is required in selecting suitable coring sites for palaeolimno-logical studies of small, relatively deep lakes and that proximity to steep slopes should be avoided wherever possible. Nevertheless, in some cases, comparisons between a range of contemporary and palaeolimnological records can be employed to diagnose sediment distur- bances and establish a chron

关键词： sediment disturbance lake sediment chron-ology slumping hiatus Esthwaite Water

Sampling errors of the global mean sea level derived from TOPEX/Poseidon altimetry

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2011年第6期30卷 12-18页

作者： WAGNER carl National Oceanic and Atmospheric Administration National Environmental Stellite data and Information Service

Sampling errors of the global mean sea level derived from TOPEX/Poseidon （T/P） altimetry are explored using 31/ 4a of eddy-resolving numerical model outputs for sea level. By definition, the sampling errors would not exist if data were available everywhere at all times. Four problems with increasing and progressively added complexities are examined to understand the causes of the sampling errors. The first problem （P1） explores the error incurred because T/P with turning latitudes near 66° latitudes does not cover the entire globe. The second problem （P2） examines, in addition, the spatial sampling issue because samples are only available along T/P ground tracks. The third problem （P3） adds the additional complexity that sea level at any along track location is sampled only once every 10 d versus every 3 d for the model （i.e., the temporal sampling issue）. The fourth problem （P4） incorporates the full complexity with the addition of real T/P data outages. The numerical model （Los Alamos POP model Run 11） conserves the total water volume, thus generating no global mean sea level variation. Yet when the model sea level is sampled in the four problems （with P4 using the real T/P sampling）, variations occur as manifestations of the sampling errors. The results show root-mean-squares （rms） sampling errors for P1 of 0.67 （0.75） mm for 10 d （3 d） global mean sea level, 0.78 （0.86） mm for P2, 0.79 mm for P3, and 1.07 mm for P4, whereas the amplitudes of the sampling errors can be as large as 2.0 （2.7） mm for P1, 2.1 （2.7） mm for P2, 2.2 mm for P3, and 2.5 mm for P4. The results clearly show the largest source of the sampling errors to be the lack of global coverage （i.e., P1）, which the model has actually underestimated due to its own less-than-global coverage （between latitudes about 77° latitudes）. We have extrapolated that a truly global model would show the rms sampling error to be 1.14 （1.28） mm for P1, thus implying a substantially larger sampling error for P4.

关键词： sea level global warming remote sensing physical oceanography

Stellar interiors 2ed.

在线全文

学校读者我要写书评

暂无评论

丛书名： Astronomy and astrophysics library

2004年

作者： carl J. Hansen Steven d Kawaler Virginia Trimble

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Singapore

Singapore

No evidence demonstrating hepatotoxicity associated with hydroxycitric acid

作者： Michael d. Barr foreword by carl A. Trocki.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第32期15卷 4087-4089页

作者： Sidney J Stohs Harry G Preuss Sunny E Ohia Gilbert R Kaats carl L Keen Lonnie d Williams George A Burdock School of Pharmacy and Health Professions Creighton University Medical Center4967 Stillwater TrailFriscoTX 75034United States

Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations. However, while these products contain up to 20 different ingredients, some do not contain HCA. Case studies reported to date have not considered in depth the literature on the numerous animal and human studies that have been conducted on the safety and effi cacy of HCA. No HCA-associated hepatotoxicity or treatment-related adverse effects have been reported in these studies, and thus it is premature to make the assumptions presented in the recent case studies regarding Hydroxycut. If it is established in well controlled studies that the use of these formulations with and/or without HCA can result in the occurrence or progression of hepatotoxicity, additional studies should be conducted to characterize the causative factor(s).

关键词： Hydroxycitric acid Super CitriMax Hydroxycitric acid-SX Garcinia cambogia Hydroxycut Liver failure Hepatotoxicity Safety and efficacy

Predicting the distribution of the Asian tapir in Peninsular Malaysia using maximum entropy modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2012年第4期7卷 400-406页

作者： Gopalasamy Reuben CLEMENTS d.Mark RAYAN Sheema Abdul AZIZ Kae KAWANISHI carl TRAEHOLT david MAGINTAN Muhammad Fadlli Abdul YAZI Reid TINGLEY Center for Tropical Environmental and Sustainability Science and School of Marine and Tropical Biology James Cook UniversityCairnsAustralia Center for Malaysian Indigenous Studies University of MalayaKuala LumpurMalaysia WWF Malaysia Petaling JayaMalaysia durrell Institute of Conservation and Ecology University of KentCanterburyUK Malaysian Conservation Alliance for Tigers(MYCAT)Secretariat's Office Petaling JayaMalaysia Copenhagen Zoo CopenhagenDenmark department of Wldife and National Parks Peninsular Malaysia Kuala LumpurMalaysia School of Biological Sciences University of SydneySydneyAustralia

In 2008,the IUCN threat status of the Asian tapir(Tapirus indicus)was reclasified from‘vulnerable'to‘en-dangered'.The latest distribution map from the IUCN Red List suggests that the tapirs'native range is becom-ing increasingly fragmented in Peninsular Malaysia,but distribution data collected by local researchers sug-gest a more extensive geographical ***,we compile a database of 1261 tapir occurrence records within Peninsular Malaysia,and demonstrate that this species,indeed,has a much broader geographical range than the IUCN range map ***,extreme spatial and temporal bias in these records limits their utility for conservation ***,we used maximum entropy(MaxEnt)modeling to elucidate the potential ex-tent of the Asian tapir's occurrence in Peninsular Malaysia while accounting for bias in existing distribution *** MaxEnt model predicted that the Asian tapir has a wider geographic range than our fine-scale data and the IUCN range map both *** 37%of Peninsular Malaysia contains potentially suit-able tapir *** results justify a revision to the Asian tapir's extent of occurrence in the IUCN Red ***,our modeling demonstrated that selectively logged forests encompass 45%of potentially suitable tapir habitats,underscoring the importance of these habitats for the conservation of this species in Peninsular Malaysia.

关键词： ecological niche IUCN Malayan tapir mammal MaxEnt species distribution model