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Laparoscopic complete mesocolic excision: West meets East

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World Journal of Gastroenterology 2014年第39期20卷 14301-14307页

作者： carina F K Chow Seon Hahn Kim division of Colorectal Surgery Departmentof SurgeryRoyal Brisbane and Women’s HospitalBrisbaneQueensland 4029 Australia department of General Surgery Mater Hospital South Brisbane Brisbane Queensland 4101 Australia department of Surgery University of Queensland Brisbane Queensland 4072 Australia Colorectal division Department of SurgeryKorea University Anam Hospital Anam-dongSeongbuk-gu Seoul 136-705 South Korea

Complete mesocolic excision is a relatively new concept in western literature. It follows the same concept of total mesorectal excision and units’ routinely performing complete mesocolic excisions have good pathological results as well as good improvements in overall survival, disease free survival and local recurrence. And yet unlike total mesorectal excision, uptake in the West has been relatively slow with many units sceptical of the true benefits gained by taking up a more technically challenging and potentially more morbid procedure when there is a paucity of literature to support these claims. This article reviews complete mesocolic excision for colon cancer, attempting to identify the risks and benefits of the technique and particularly looking at the reasons why its uptake has not been universal. It also discusses the similarities of a complete mesocolic excision to a colon resection with a d3 lymphadenectomy as well as the role of a laparoscopic approach to this technique. Considering a d3 lymphadenectomy has been the standard of care for stage II and III colon cancers in many of our Asian neighbours for over 20 years, combining this data with data on complete mesocolic excision may provide enough evidence to support or refute the need for complete mesocolic excisions. Maybe there might be lessons to be learnt from our colleagues in the east.

关键词： Complete mesocolic excision Colorectal surgery Laparoscopy Colonic neoplasms d3 lymphadenectomy

One-Stage Correction with Intra- and Extraatrial Rerouting of Anomalous Systemic and Pulmonary Venous Return and Intraventricular Repair of double Outlet Right Ventricle in a Patient with Heterotaxy Syndrome

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Congenital Heart disease 2022年第1期17卷 25-30页

作者： Helena Staehler carina Hopfner Masamichi Ono Jurgen Horer department of Congenital and Pediatric Heart Surgery German Heart Center MunichTechnische Universitat MünchenDivision of Congenital and Pediatric Heart SurgeryUniversity Hospital of MunichLudwig-Maximilians-UniversitatMunichGermany department of Pediatric Cardiology and Pediatric Intensive Care University Hospital of MunichLudwig-Maximilians-UniversitatMunichGermany

We report a very rare case of successful intracardiac correction in a patient with heterotaxy *** cardiac malformations included dextrocardia,double outlet right ventricle,pulmonary stenosis,interrupted inferior vena cava,hemiazygos continuation and total anomalous pulmonary venous ***-stage correction was *** atrial procedure consisted of intra-and extraatrial rerouting of the anomalous systemic and pulmonary venous *** hepatic veins were detached and diverted to the left atrium via an extracardiac *** correction of the double outlet right ventricle was accomplished by intraventricular redirection of the blood flow from the left ventricle to the *** right ventricular outflow was ultimately remodeled using a valved *** better perception of the complex morphology,a three-dimensional model was designed,using CT scan *** proved to be very useful for surgical planning,especially with regard to the intraatrial reconstruction of the systemic and pulmonary venous rerouting.

关键词： Heterotaxy syndrome anomalous systemic venous return anomalous pulmonary venous return azygos continuation double outlet right ventricle 3d modeling

decellularized extracellular matrix particle-based biomaterials for cartilage repair applications

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Journal of Materials Science & Technology 2023年第29期160卷 194-203页

作者： Peng Guo Nan Jiang carina Mini Gregor Miklosic Songsong Zhu Andrea J.Vernengo Matteo d’Este Sibylle Grad Mauro Alini Zhen Li AO Research Institute davos Davos 7270Switzerland department of Spine Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China State Key Laboratory of Oral diseases and National Clinical Research Center for Oral disease and West China Hospital of Stomatology Sichuan UniversityChengdu 610041China Institute for Biomechanics ETH ZürichZürich 8093Switzerland

Cartilage decellularized ExtraCellular Matrix(dECM)materials have shown promising cartilage regenera-tion capacity due to their chondrogenic ***,the limited retention of ECM components and the reduced integrity of functional ECM molecules during traditional decellularization processes im-pair the biomimicry of these *** current study aims to fabricate biomimetic materials con-taining decellularized cartilage particles that have an intact molecular structure and native composition as biomaterial inks and hydrogels for cartilage *** this,we established a novel two-fraction de-cellularization strategy for the preparation of reconstituted dECM(rdECM)particles by mixing the two-fraction components,as well as a one-fraction decellularization strategy for the preparation of biomimetic dECM(bdECM)*** acid-tyramine(THA)hydrogels containing rdECM or bdECM particles were produced and characterized via rheological test,swelling and stability evaluation,and compression *** results showed that our novel decellularization strategies preserved intact proteoglycans and collagen at a higher retention rate with adequate dNA removal compared to traditional methods of *** addition of rdECM or bdECM particles significantly increased the shear moduli of the THA bioinks while preserving their shear-thinning *** particle-embedded THA hydrogels also achieved long-term stability with a swelling ratio of 70%and high retention of glycosaminoglycans and collagen after long-term incubation,while rdECM particle-embedded THA hydrogels showed unsat-isfactory stability as self-standing *** to pure THA hydrogels,the addition of bdECM particles significantly enhanced the compression *** summary,our decellularization methods are successful in the retention of functional and intact cartilage components with high *** rdECM and bdECM particles can be supplemented in THA bioinks for biomimet

关键词： Cartilage tissue engineering decellularized extracellular matrix Proteoglycan integrity Biomimetic hydrogels Biomaterial Bioink

A look at the ASEAN-NdI: building a regional health R&d innovation network

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Infectious diseases of Poverty 2014年第1期3卷 135-144页

作者： Jaime C Montoya carina L Rebulanan Nico Angelo C Parungao Bernadette Ramirez department of Science and Technology-Philippine Council for Health Research and development(dOST-PCHRd) Taguig CityPhilippines UNICEF/UNdP/World Bank/WHO Special Programme for Research and Training in Tropical diseases(TdR) World Health OrganizationGenevaSwitzerland

Globally,there are growing efforts to address diseases through the advancement in health research and development(R&d),strengthening of regional cooperation in science and technology(particularly on product discovery and development),and implementation of the World Health Assembly Resolution 61.21(WHA61.21)on the Global Strategy and Plan of Action on Public Health,Innovation,and Intellectual Property(GSPA-PHI).As such,the Association of Southeast Asian Nations(ASEAN)is responding to this through the establishment of the ASEAN-Network for drugs,diagnostics,Vaccines,and Traditional Medicines Innovation(ASEAN-NdI).This is important in the ASEAN considering that infectious tropical diseases remain prevalent,emerging,and reemerging in the *** paper looks into the evolution of the ASEAN-NdI from its inception in 2009,to how it is at present,and its plans to mitigate public health problems regionally and even globally.

关键词： ASEAN-NdI Health research and development Infectious tropical diseases Innovation network Strategic business plan

Updating semen analysis:a subpopulation approach

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Asian Journal of Andrology 2020年第1期22卷 118-119页

作者： Almudena Garcia-Molina Anthony Valverde daznia Bompart carina Caldeira Alberto Vendrell Carles Soler Proiser R+d S.L. Scientific ParkUniversitat de ValenciaPaterna 46980ValenciaSpain department of Functional Biology and Physical Anthropology University of ValenciaBurjassot 46100ValenciaSpain Technological Institute of Costa Rica San Carlos CampusSchool of AgronomyAlajuela 223-21001Costa Rica

dear Editor,Reproductive problems affect 8%-12%of human populations worldwide;40%-50%of all infertility cases are due to the male,and up to 2%of men have suboptimal sperm quality.

关键词： dating cases infertility

Comparative analysis of ERCP,IdUS,EUS and CT in predicting malignant bile duct strictures

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World Journal of Gastroenterology 2014年第30期20卷 10495-10503页

作者： Hauke S Heinzow Sara Kammerer carina Rammes Johannes Wessling dirk domagk Tobias Meister department of Medicine B University of MünsterD-48149 MünsterGermany department of Clinical Radiology University of MünsterD-48149 MünsterGermany department of Radiology ClemenshospitalMünster University Teaching HospitalD-48153 MünsterGermany department of Medicine Ⅱ HELIOS AlbertSchweitzer HospitalG?ttingen University Teaching HospitalD-37154 NortheimGermany

AIM: To compare endoscopic retrograde cholangio-pancreatography (ERCP), intraductal ultrasound (IdUS), endosonography (EUS), endoscopic transpapillary forceps biopsies (ETP) and computed tomography (CT) with respect t... 详细信息

关键词： Intraductal ultrasound Intraductal ultrasound Bile duct strictures Endosonography Computed tomography Malignancy

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真实驾驶循环中的发动机电基合成燃料评估

同济大学学报（自然科学版） 2022年第S1期50卷 218-236页

作者：杨棋锐 Michel grill Cornelius WAGNER Markus MAUL Andre KULZER 斯图加特汽车工程与车辆发动机研究所(FKFS) 德国斯图加特70569 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

电基合成燃料(E-Fuels)是实现环境和气候目标的一个重要组成部分。其中C1含氧化合物因其具备清洁燃烧的特性而备受关注,包括氧化亚甲基醚(OME)、碳酸二甲酯(dMC)和甲酸甲酯(MeFo)。为探索新型燃料在内燃机中的潜力,对汽油和柴油燃烧、... 详细信息

电基合成燃料(E-Fuels)是实现环境和气候目标的一个重要组成部分。其中C1含氧化合物因其具备清洁燃烧的特性而备受关注,包括氧化亚甲基醚(OME)、碳酸二甲酯(dMC)和甲酸甲酯(MeFo)。为探索新型燃料在内燃机中的潜力,对汽油和柴油燃烧、排放模型进行了优化和扩展。在成功验证和标定模型后,对虚拟测试车辆进行了研究,重点关注燃料的效率潜力、排放水平和经济性。首先,基于现代汽油、柴油和天然气发动机,开发了不同概念的OME和dMC/MeFo发动机;其次,在真实驾驶循环(RdE)中对这些发动机概念在E级乘用车和40 t卡车上的应用进行了评估。结果表明,通过调整喷射策略和匹配废气再循环,OME发动机能实现最佳的热效率和极低的排放;混合燃料dMC/MeFo由于高抗爆性,结合先进的发动机技术,能达到接近柴油机的热效率,且发动机复杂性大大降低,这使得dMC/MeFo燃料在重型卡车应用中具有广阔的前景。

关键词：电基合成燃料实际驾驶排放 0d/1d仿真氧化亚甲基醚碳酸二甲酯甲酸甲酯

Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra-high field MRI and diffusion tensor metrics

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Animal Models and Experimental Medicine 2020年第2期3卷 117-129页

作者： Rodolfo G.Gatto carina Weissmann Manish Amin Ariel Finkielsztein Ronen Sumagin Thomas H.Mareci Osvaldo d.Uchitel Richard L.Magin department of Bioengineering University of Illinois at ChicagoChicagoILUSA Instituto de Fisiología Biologia Molecular y Neurociencias-IFIBYNE-CONICET University of Buenos AiresBuenos AiresArgentina department of Biochemistry National High Magnetic Field LaboratoryUniversity of FloridaGainesvilleFLUSA department of Pathology School of MedicineNorthwestern UniversityChicagoILUSA

Objective: Cell structural changes are one of the main features observed during the development of amyotrophic lateral sclerosis(ALS). In this work, we propose the use of diffusion tensor imaging(dTI) metrics to assess specific ultrastructural changes in the central nervous system during the early neurodegenerative stages of ***: Ultra-high field MRI and dTI data at 17.6 T were obtained from fixed, excised mouse brains, and spinal cords from ALS(G93 A-SOd1) ***: Changes in fractional anisotropy(FA) and linear, planar, and spherical anisotropy ratios(C_L, C_P, and C_S, respectively) of the diffusion eigenvalues were measured in white matter(WM) and gray matter(GM) areas associated with early axonal degenerative processes(in both the brain and the spinal cord). Specifically, in WM structures(corpus callosum, corticospinal tract, and spinal cord funiculi) as the disease progressed, FA, C_L, and C_P values decreased, whereas C_S values increased. In GM structures(prefrontal cortex, hippocampus, and central spinal cord) FA and C_P decreased, whereas the C_L and C_S values were unchanged or slightly smaller. Histological studies of a fluorescent mice model(YFP, G93 A-SOd1 mouse) corroborated the early alterations in neuronal morphology and axonal connectivity measured by ***: Changes in diffusion tensor shape were observed in this animal model at the early, nonsymptomatic stages of ALS. Further studies of C_L, C_P, and C_S as imaging biomarkers should be undertaken to refine this neuroimaging tool for future clinical use in the detection of the early stages of ALS.

关键词： amyotrophic lateral sclerosis animal models diffusion tensor imaging G93A-SOd1 mice ultra-high field MRI

Gossip in the gut: Quorum sensing, a new player in the hostmicrobiota interactions

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World Journal of Gastroenterology 2021年第42期27卷 7247-7270页

作者： Garance Coquant doriane Aguanno Sandrine Pham Nathan Grellier Sophie Thenet Véronique Carrière Jean-Pierre grill Philippe Seksik Centre de Recherche Saint-Antoine INSERMSorbonne UniversitéParis 75012France EPHE PSL UniversityParis 75014France department of Gastroenterology and Nutrition Saint-Antoine HospitalAPHPParis 75012France

Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers,a process known as quorum sensing(QS).This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut *** is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal *** review will examine the different QS systems and the evidence for their presence in the intestinal *** will also provide clues on the role of QS molecules that may exert,directly or indirectly through their bacterial gossip,an influence on intestinal epithelial barrier function,intestinal inflammation,and intestinal *** review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new *** understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future.

关键词： Inflammatory bowel disease Quorum sensing Gut microbiota dysbiosis Inflammation Intestinal barrier