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Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 209-216页

作者： Cédric sima Obiang Rick Léonid Ngoua Meye Misso Guy Roger ndong Atome Joseph Privat Ondo Louis Clément Obame Engonga Edouard Nsi Emvo Laboratory of Research in Biochemistry University of Sciences and Technology of Masuku Laboratory of Natural Substances and Organometallic Synthesis University of Sciences and Technology of Masuku

Objective: To evaluate the phytochemical constituents, antimicrobial and antioxidant activities of the extracts of Distemonanthus benthamianus(D. benthamianus) stem bark and Solanum torvum(S. torvum) fruit which have been used as traditional medicinal herbs in Gabon. Methods: Plant extracts were subjected to a qualitative study(phytochemical screening) and a quantitative(dosing) study of secondary metabolites. Antioxidant activity was tested by 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid assay. Bacteria and fungi susceptibility tests were performed on Mueller Hinton medium and solid Sabouraud, respectively, using the diffusion method, while minimum inhibitory concentration, minimum fungicidal concentration and minimum bactericidal concentration were evaluated by microdilution ***: The total phenol and tannin contents were significantly higher in the water-ethanol extract compared to the other extracts of D. benthamianus and S. torvum. The water-ethanol and water-acetone extracts showed significantly higher antioxidant activity than the aqueous extracts of the two medicinal plants. However, the extracts presented weak antioxidant activities compared to standards(Vitamin C, BHA). The water-acetone and water-ethanol extracts of S. torvum showed the highest antimicrobial activity against Bacillus cereus LMG 13569 BHI, Shigella dysenteriae 5451 CIP, Shigella dysenteriae and Neisseria gonorrhoeae. Conclusions: Our results show that D. benthamianus and S. torvum can be promising sources of natural products with potential antimicrobial and antioxidant activities.

关键词： Antioxidants Phytochemical Antimicrobial Distemonanthus benthamianus Solanum torvum

Prevalence and Risk Factors Associated with Tungiasis among School-Aged Children in the City of Port Gentil, Ogooué-Maritime Province, Gabon in Central Africa

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Journal of Biosciences and Medicines 2022年第11期10卷 176-191页

作者： Thiéry ndong Mba Cédric sima Obiang Hilaire Moundounga Kenguele Arnaud Brice Pambo-Pambo Adelaïde Niéguitsila Armel Obiandong Eyivono Ulrich Nzamba Cyrille Bisseye Patrick Mickala Laboratory of Molecular and Cellular Biology (LABMC) University of Science and Technology of Masuku (USTM) Franceville Gabon Laboratory of Research in Biochemistry (LAREBIO) University of Sciences and Techniques of Masuku (USTM) Franceville Gabon Laboratory of Animal Physiology University of Science and Technology of Masuku (USTM) Franceville Gabon Laboratory of Multidisciplinary Research in Environment (LARME) University of Science and Technology of Masuku (USTM) Franceville Gabon

Background: Tungiasis is a skin infestation caused by the female sand flea called Tunga penetrans. Associated with a significant morbidity, this ectoparasite is present in all tropical regions, such as Gabon. Unfortunately, in this country, no study has ever been undertaken on this disease. However, in both urban and rural areas of this country, it causes disfigurement and mutilation of the feet or hands in infested persons, and is sometimes responsible for the school dropout of many children. It is in this context that this timely and relevant research was conducted to assess the prevalence and risk factors associated with Tungiasis in school-aged children in the city of Port Gentil, Ogooué-Maritime province, Gabon in Central Africa. Materials and Methods: This prospective and cross-sectional study took place from May 22 to August 18, 2022, in two popular and underprivileged neighborhoods of the city of Port Gentil. It consisted of a physical diagnosis of the participants, and with the help of a questionnaire submitted to their parents/guardians, numerous data were collected. Entered into an Excel 2016 spreadsheet, the data were exported to the R software in its R Commander interface, for two types of analyses. A univariate and a multivariate analysis, using logistic regression, first on socio-demographic characteristics and then on habitual and environmental behavioral characteristics, was performed and the variables in this analysis reported odds ratios and their 95% confidence intervals. The results were statistically significant at p Results: A total of 637 school-aged children with a mean age of 12.73 years and a standard deviation of 5.44, were registered and examined for this study. Among them, Tunga penetrans infestation was found in 242 children, indicating an overall prevalence of 37.99% (95% CI [0.34 - 0.41]). Univariate and multivariate analyses, using logistic regression, first according to socio-demographic characteristics and then according to risk f

关键词： Prevalence Risk Factors Tungiasis School-Aged Children Port Gentil Ogooué-Maritime Gabon

Prevalence of Pulmonary Tuberculosis and Associated Factors among Patients Admitted to the Amissa Bongo University Hospital Center in Franceville, Gabon

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Journal of Biosciences and Medicines 2023年第7期11卷 160-173页

作者： Thiéry ndong Mba Cedric sima Obiang Hilaire Moundounga Kenguele Arnaud Brice Pambo-Pambo Iris Kévin Ivala Zogo Mba Ulrich Lowens Onkassa Sah Louis-Clement Obame Engonga Cyrille Bisseye Patrick Mickala Laboratory of Molecular and Cellular Biology (LABMC) Masuku University of Science and Technology (USTM) Franceville Gabon Laboratoire de Recherche en Biochimie (LAREBIO) Masuku University of Science and Technology (USTM) Franceville Gabon Animal Physiology Laboratory Masuku University of Science and Technology (USTM) Franceville Gabon South East Regional Health Department Franceville Gabon

Background: In Gabon, the epidemiology of tuberculosis has been considerably reshaped by the AIDS virus. It is in this context that the present study was conducted to assess the prevalence of pulmonary tuberculosis and associated factors among patients at the Amissa Bongo Regional Hospital in Franceville, Gabon. Patients and Methods: This prospective, cross-sectional study was conducted in the biomedical analysis laboratory of the Amissa Bongo Regional University Hospital in Franceville from 19 June 2021 to 22 January 2022. After agreeing to take part in the study, participants were asked to fill in a questionnaire to collect their socio-demographic data and habits. Clinical signs were also observed. Sputum and gastric fluid samples were collected and examined using the Xpert MTB/RIF test and BAAR smear microscopy. Data were analysed using R software version 3.6.1. The results of the univariate and multivariate analyses were considered significant for p ≤ 0.05. Results: A total of 309 patients were included in this study, 50.81% (n = 157) men and 49.19% (n = 152) women. Of these, 98 had a positive diagnosis of pulmonary tuberculosis, giving an overall prevalence rate of 31.72%. There were 40 women or 40.82% (95% CI: [0.30 - 0.51]) and 58 men or 59.18% (95% CI: [0.48 - 0.69]). A univariate analysis of the prevalence of tuberculosis according to risk factors and clinical signs indicated a certain association between certain variables. However, an in-depth multivariate logistic regression analysis of this prevalence, according to the risk factors and clinical signs observed in the patients in the study, indicated that the age group 15 and 49 years (Adjusted OR = 47.77;95% CI: [4.4;519.7] p = 0.001*), fever (Adjusted OR = 4.83;95% CI: [1.16, 20.12] p = 0.031*), alcohol consumption (Adjusted OR = 12.2;95% CI: 12.2 [2.5;5.9] p = 0. 002*), smoking (Adjusted OR = 9.83;95% CI: [1.78;54.24] p = 0.037), HIV infection (Adjusted OR = 4.63;95% CI: [1.25;17.1] p = 0.022), cough (A

关键词： Prevalence Pulmonary Tuberculosis Ziehl-Neelsen Rapid Acid Staining GeneXpert CHURAB Franceville Gabon

长蕊木兰叶片挥发油的化学成分及其分类学意义

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西部林业科学 2019年第1期48卷 29-35页

作者：华梅司马永康马惠芬张达杨冀寅徐涛云南省林业科学院国家林业和草原局云南珍稀濒特森林植物保护和繁育实验室云南省森林植物培育与开发利用重点实验室云南昆明650201 云南大学生命科学学院云南昆明650091

采用同时蒸馏萃取法(SDE)对长蕊木兰叶片中挥发油进行提取,同时采用气相色谱/质谱(GC/MS)联用技术对挥发油中化学成分进行分析,并利用峰面积归一化法得出各化学成分在挥发油中的相对百分含量。采用文献比对分析法,将长蕊木兰叶片挥发油... 详细信息

采用同时蒸馏萃取法(SDE)对长蕊木兰叶片中挥发油进行提取,同时采用气相色谱/质谱(GC/MS)联用技术对挥发油中化学成分进行分析,并利用峰面积归一化法得出各化学成分在挥发油中的相对百分含量。采用文献比对分析法,将长蕊木兰叶片挥发油中分析得到的主要化学成分与已报到的木兰科其他属种挥发油的化学主成分进行比对分析,以探讨长蕊木兰叶片挥发油的主成分作为其化学分类指标的可能性。结果表明:从长蕊木兰叶片的挥发油中共分离出29个色谱峰,鉴定其中的26个化合物,占挥发物组成的92.92%。长蕊木兰叶片的挥发油化学成分主要由醇和烯类化合物组成,3-蒈烯相对百分含量占52.11%,为长蕊木兰叶片挥发油中相对百分含量最高的成分。其余成分还包括右旋柠檬烯(2.59%)、Tricyclo[2,2,1,0(2,6)]heptane,1,3,3-trimethyl(2.36%)、3-Thujene(9.67%)、罗勒烯(3.77%)、4-蒈烯(2.2%)、黃樟素(2.81%)、马兜铃烯(2.94%)、4-杜松二烯(4.42%)、反式-橙花叔醇(2.64%)、α-毕橙茄醇(2.14%)。长蕊木兰挥发油化学成分中3-蒈烯的相对百分含量较高,并且与木兰科其他属种挥发油的主成分不同,因此相对百分含量较高的3-蒈烯有望作为长蕊木兰中区别于木兰科其他属种的一个重要化学指标。

关键词：长蕊木兰化学分类学 GC/MS 同时蒸馏萃取法挥发油