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Le.e.遗传性视神经病变患者氧化应激诱导的细胞凋亡反应

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 4-5页

作者： Battisti C. Formichi P. cardaioli e. A. Fe.e.ico 张磊 De.t. of Ne.rol. and Be.av. Scie.ce. Policlinico Le Scotte V. le Bracci 2 53100 Siena Italy Prof.

Obje.tive.: Le.e.’s he.e.itary optic ne.ropathy (LHON)is a mate.nally inhe. ite. dise.se.in which acute.or subacute.bilate.al visual loss occurs pre.e.e.tia lly in young me.. Ove. 95%of LHON case. are.associate. with one.of thre. mitoch ondrial DNA (mtDNA) point mutations, but only 50%of me. and 10%of wome. who ha rbour a pathoge.e.ic mtDNA mutation de.e.op optic ne.ropathy. This incomple.e.pe.ne.rance.and pre.e.e.ce.for me. sugge.ts that additional ge.e.ic (nucle.r or mit ochondrial) and/or e.vironme.tal factors must modulate.phe.otype.e.pre.sion in L HON. A role.for re.ctive.oxyge. spe.ie. (ROS) in mitochondrial dise.se., se.onda ry to mtDNA mutations, or as a re.ult of the.dire.t e.fe.t of ROS cytotoxicity, has be.n implicate. in many mitochondrial disorde.s, including LHON. The.purpo se.of this study was toinve.tigate.the.role.of oxidative.stre.sinduce. apoptosis in LHON. Me.hods: The.2-de.xyDribose.induce. apoptotic re.ponse.of pe.iphe.ral blood lymphocyte. from six patie.ts with LHON and six he.lthy subje.ts was i nve.tigate. using light microscopy, flow cytome.ry, agarose.ge. e.e.trophore.is, and the.me.sure.e.t of mitochondrial me.brane.pote.tial. Re.ults: Ce.ls of pati e.ts with LHON had a highe. rate.of apoptosis than those.of controls and the.e.w as e.ide.ce.of mitochondrial involve.e.t in the.activation of the.apoptotic casc ade. Conclusions: The.e.diffe.e.ce. in oxidative.stre.s induce. apoptosis are.in line.with the.hypothe.is that re.ox home.stasis could play a role.in the.e.pre. sion of ge.e.ic mutations in diffe.e.t individuals and could re.re.e.t a pote.ti al targe. in the.de.e.opme.t of ne. the.ape.tic strate.ie..

关键词：遗传性视神经病 Le.e. 凋亡反应氧化应激视神经病变线粒体膜电位因子影响活性氧遗传性疾病外显率

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Pate.t forame. ovale.closure.in ove.-60-ye.rs old patie.ts with diastolic dysfunction

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Journal of Ge.iatric Cardiology 2008年第1期5卷 3-6页

作者： Gianluca Rigate.li Fabio De.l'Avvocata Paolo cardaioli Massimo Giordan Gabrie.e.Braggion Loris Roncon Se.tion of Adult Conge.ital and Structural He.rt Dise.se Cardiovascular Diagnosis and Endoluminal Interventions Rovigo General Hospital Rovigo Italy

Background Pate.t forame. ovale.(PFO)-re.ate. stroke.is a possible.and not e.sily manage.ble.occurre.ce.in ≤60-ye.rs-old patie.ts due.to the.pre.e.ce.of diffe.e.t comorbiditie. and in particular of diastolic dysfunction which is conside.e. as a contraindication to PFO *** grade.of diastolic dysfunction for which PFO closure.is contraindicate. and whe.he. the.e.are.change. in diastolic dysfunction class afte. closure.have.not be.n inve.tigate. in de.p *** We.prospe.tive.y e.rolle. patie.ts who we.e.re.e.re. to our ce.tre.ove. a 12 months pe.iod for PFO transcathe.e. closure.having e.hocardiographic de.onstration of diastolic dysfunction (≤Ⅲ class diastolic dysfunction).e.hocardiography was sche.ule. at 1,6 and 12 months in orde. to asse.s change. in hae.odynamic parame.e.s of le.t ve.tricle.*** Thirte.n out of 80 patie.ts re.e.re. to our ce.tre.(16.2%,me.n age.65 + 6.4 ye.rs) ove. a 24-month pe.iod we.e.e.rolle. in the.study (Table.1).e.ghte.n Amplatze. PFO Occlude. 25 mm and one.35 mm,two Amplatze. 25/25 mm Cribriform Occlude. and two 25 nun Pre.e.e.Occlusion Syste. we.e.succe.sfully implante. with no intraope.ative.*** collate.al findings on ICe.8/12 patie.ts (66.7 %) had hype.trophy of the.inte.atrial se.tum (thickne.s of the.rims ＞ 1.2 mm) probably imputable.to hype.te.sive.*** patie.ts de.e.ope. atrial fibrillation during the.first month post-implantation,all succe.sfully tre.te. with antiarrhythmic *** a me.n follow-up of 40±4.3 months le.t ve.tricle.pe.formance.indice. (e.e.tion fraction and e.d-diastolic volume. and diastolic dysfunction parame.e.s (e.A,de.e.e.ation time.diastolic dysfunction class) did not change.*** The.pre.e.t study sugge.ts that PFO transcathe.e. closure.may be.safe.y pe.forme. in age. patie.ts with diastolic dysfunction class 1-2.(J Ge.iatr Cardio12008;5:3-6.)

关键词： pate.t forame. ovale e.de.ly diastolic dysfunction transcathe.e. closure

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