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Alpha-Stim Cranial Electrotherapy Stimulation (CES) for Anxiety Treatment: Outcomes in a United Kingdom (UK) Primary Care Practice

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Open Journal of Psychiatry 2021年第3期11卷 186-201页

作者： Chris Griffiths Chloe Leathlean David Smart Azhar Zafar cara-leigh hall Sarah Deeks Innovation and Research Department Northamptonshire Healthcare NHS Foundation Trust (NHFT) Northampton UK General Practice Alliance (GPA) Northampton UK

Background: Anxiety disorders are the most common mental disorders, typically treated with psychotherapy and medication. These treatments are not suitable for, acceptable to, or effective for everyone. Alpha-Stim AID is a Cranial Electrotherapy Stimulation (CES) treatment with evidence of effectiveness in treating anxiety disorders. Objective: The aim of this paper is to present outcomes on anxiety, depression, and quality of life of Alpha-Stim use in primary care patients in the United Kingdom’s (UK) National Health Service (NHS) who reported symptoms of anxiety. Methods: Open label patient cohort design. Self-report measures: PHQ-9 (depression), GAD-7 (anxiety) and EQ-5D-5L (health related quality of life). Twenty-three patients with symptoms of anxiety completed a six-week course of Alpha-Stim intervention. Results: Reliable improvement and remission rates respectively were 60.9% and 17.4% for the GAD-7;42.9% and 22.7% for the PHQ-9. Significant improvement and medium/large effect sizes (n2 = 0.59 and 0.56 respectively). EQ-5D-5L results showed significant improvements in quality of life. Perceived quality of life doubled with an improvement of 0.36 on the health index score, this intervention adds 3.64 Quality Adjusted Life Years (QALYs). Limitations: The study was not an RCT, there was no control group. Conclusions: Alpha-Stim AID CES can be delivered through a UK primary care practice, and can have a significant impact on symptoms of anxiety and depression, and improve quality of life in primary care patients with anxiety symptoms. Further feasibility studies in primary care and sufficiently powered RCT are required.

关键词： Alpha-Stim Primary Care Cranial Electrotherapy Stimulation Service Delivery Anxiety Depression Quality of Life Social Prescription Co-Morbidity GAD

Arbuscular mycorrhizal fungi regulate plant mineral nutrient uptake and partitioning in iron ore tailings undergoing eco-engineered pedogenesis

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Pedosphere 2024年第2期34卷 385-398页

作者： Zhen LI Songlin WU Yunjia LIU Qing YI Merinda hall Narottam SAHA Junjian WANG Yuanfang HUANG Longbin HUANG College of Land Science and Technology China Agricultural UniversityBeijing 100193China Centre for Mined Land Rehabilitation Sustainable Minerals InstituteThe University of QueenslandBrisbaneQLD 4072Australia Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Excess available K and Fe in Fe ore tailings with organic matter amendment and water-deficiencies may restrain plant colonization and growth,which hinders the formation of eco-engineered soil from these tailings for sustainable and cost-effective mine site *** mycorrhizal(AM)fungi are widely demonstrated to assist plant growth under various unfavorable ***,it is still unclear whether AM symbiosis in tailings amended with different types of plant biomass and under different water conditions could overcome the surplus K and Fe stress for plants in Fe ore tailings,and if so,by what ***,host plants(Sorghum *** ***),either colonized or noncolonized by the AM fungi(Glomus spp.),were cultivated in lucerne hay(LH,C:N ratio of 18)-or sugarcane mulch(SM,C:N ratio of 78)-amended Fe ore tailings under well-watered(55%water-holding capacity(WHC)of tailings)or water-deficient(30%WHC of tailings)*** mycorrhizal colonization,plant growth,and mineral elemental uptake and partitioning were *** indicated that AM fungal colonization improved plant growth in tailings amended with plant biomass under water-deficient *** mycorrhizal fungal colonization enhanced plant mineral element uptake,especially P,both in the LH-and SM-amended tailings regardless of water ***,AM symbiosis development restrained the translocation of excess elements(i.e.,K and Fe)from plant roots to shoots,thereby relieving their *** AM fungal roles in P uptake and excess elemental partitioning were greater in LH-amended tailings than in SM-amended *** deficiency weakened AM fungal colonization and functions in terms of mineral element uptake and *** findings highlighted the vital role AM fungi played in regulating plant growth and nutrition status in Fe ore tailings technosol,providing an important basis for involvement of AM fungi in the eco-engineered pedo

关键词： Fe stress fungal symbiosis K stress mine site rehabilitation mycorrhizal colonization plant biomass amendment plant nutrition water deficiency

Stable Isotopic Signatures of NO₃ in Waste Water Effluent and Los Angeles River

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Journal of Water Resource and Protection 2024年第1期16卷 102-122页

作者： Isaac hall Mohammad Hassan Rezaie Boroon Department of Geography Geology and Environment California State University Los Angeles California USA

A metropolitan city such as Los Angeles (LA) is an ideal study site with a very high population density, and it houses at least 3 treatment plants where sewage is treated preliminarily and then progressing to tertiary treatment before discharging into the LA River. We will gain a better understanding of the water quality in the LA River and the nitrate load in the watershed system by examining the influence of waste water treatment plants (WWTPs). The goal of this study is to pinpoint the exact source of nitrate in the LA River using the isotope signatures. We have selected sampling locations both upstream and downstream of the WWTP. This serves to monitor nitrate levels, aiding in the assessment of treatment plant effectiveness, pinpointing nitrate pollution sources, and ensuring compliance with environmental regulations. The research explores the isotopic composition of NO3 in relation to atmospheric nitrogen and Vienna Standard Mean Ocean Water, shedding light on the contributions from various sources such as manure, sewage, soil organic nitrogen, and nitrogen fertilizers. Specifically, there is a change in the δ15NAir value between the dry and wet seasons. The isotope values in the Tillman WWTP sample changed between dry and wet seasons. Notably, the presence of nitrate originating from manure and sewage is consistent across seasons, emphasizing the significant impact of anthropogenic and agricultural activities on water quality. This investigation contributes to the broader understanding of nitrogen cycling in urban water bodies, particularly in the context of wastewater effluent discharge. The findings hold implications for water quality management and highlight the need for targeted interventions to mitigate the impact of nitrogen-containing compounds on aquatic ecosystems. Overall, the study provides a valuable framework for future research and environmental stewardship efforts aimed at preserving the health and sustainability of urban water resources. This

关键词： Metropolitan City Los Angeles Treatment Plants Sewage Treatment Nitrate Source Isotope Signatures Water Quality

SMILE soft X-ray Imager flight model CCD370 pre-flight device characterisation

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Earth and Planetary Physics 2024年第1期8卷 25-38页

作者： S.Parsons D.J.hall O.Hetherington T.W.Buggey T.Arnold M.W.J.Hubbard A.Holland Centre for Electronic Imaging the Open UniversityMilton KeynesMK76AAUK

Throughout the SMILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their *** order to understand the changes of the CCD370s within the soft X-ray Imager,an initial characterisation of the devices has been carried out to give a baseline performance *** CCDs have been characterised,the two flight devices and the flight spa *** has been carried out at the Open University in a bespo ke cleanroom measure ment *** results show that there is a cluster of bright pixels in the flight spa re which increases in size with tempe *** at the nominal ope rating tempe rature(-120℃) it is within the procure ment ***,the devices meet the specifications when ope rating at -120℃ in 6 × 6 binned frame transfer science *** se rial charge transfer inefficiency degrades with temperature in full frame *** any charge losses are recovered when binning/frame transfer is implemented.

关键词： CCD soft X-ray imager characterisation SMILE

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科学新闻 2024年第2期 63-64页

作者： Rebecca Lengnick-hall 倪伟波华盛顿大学布朗学院

在妈妈被诊断出患有癌症的3个月后，她被送进了重症监护室（ICU）。就在我即将和项目负责人因一项帮助我过渡到教师职位的资助而见面的10分钟前，我得知了这个消息。在最后一刻取消见面是不专业的。但当我疯狂地把东西扔进行李箱时，我...

在妈妈被诊断出患有癌症的3个月后，她被送进了重症监护室（ICU）。就在我即将和项目负责人因一项帮助我过渡到教师职位的资助而见面的10分钟前，我得知了这个消息。在最后一刻取消见面是不专业的。但当我疯狂地把东西扔进行李箱时，我知道自己无法全身心投入。所以，我给项目负责人发了封邮件，解释了情况。她立即回信，让我专注于家庭。后来，当我妈妈离开重症监护室时，我仍然心烦意乱，无法见面。项目负责人重述了一遍她的信息：“未来几周的总体目标就是做一个好女儿，研究可以再等等。”她的话成为了我的人生路标。自从妈妈2020年被诊断出癌症以来，她完成了每

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面向电铲自主装卸的矿用自卸车斗型优化

吉林大学学报（工学版） 2024年第5期54卷 1227-1236页

作者：谭晓丹王勇澎 Robert hall 徐天爽黄庆学吉林大学机械与航空航天工程学院长春130022 太原重型机械集团有限公司矿山采掘装备及智能制造国家重点实验室太原030024 南达科他州矿业理工大学采矿工程与管理学院拉皮德城57701 太原理工大学机械与运载工程学院太原030024

针对现有电铲自主装卸功能在料堆重构、环境感知、目标识别等领域存在技术难度的现状,从降低自主装卸作业任务难度的角度出发,本文提出了一种以载荷均衡分布为目标的矿用自卸车斗型优化方法。首先,构建了一种基于差分迭代的装卸后自卸... 详细信息

针对现有电铲自主装卸功能在料堆重构、环境感知、目标识别等领域存在技术难度的现状,从降低自主装卸作业任务难度的角度出发,本文提出了一种以载荷均衡分布为目标的矿用自卸车斗型优化方法。首先,构建了一种基于差分迭代的装卸后自卸车斗内料堆的轮廓重构方法,并对料堆质心位置进行计算;其次,建立并验证了模拟电铲装卸过程的离散元仿真方法;再次,利用离散元仿真实验,研究了不同斗型结构参数对斗内料堆质心位置的影响;最后,以横向载荷均布为目标,以纵向载荷分布、行驶安全性、斗容变化为约束对斗型进行优化。结果表明:优化后的斗型与原斗型相比,在保持装载能力和行驶安全性的前提下,极端装卸位置时的载荷分布均匀性显著提升,并具有更大的合理装卸面积和更高的作业效率。

关键词：机械设计及理论自主装卸矿用自卸车载荷分布斗型优化

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The CCD instrument background of the SMILE SXI

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： M.W.J.Hubbard O.Hetherington D.J.hall T.W.Buggey S.Parsons T.Arnold A.Holland C.Pagani S.Sembay Centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The ESA and CAS SMILE mission orbit is highly elliptical and will pass through multiple radiation *** Soft X-ray Imager(SXI)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the CCDs(Charge-Coupled Devices)that form the focal plane array of the SXI were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic Cosmic Rays(GCRs).It was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the GCRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

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教老年老鼠学新把戏

商业周刊（中文版） 2024年第2期 52-57页

作者： cara Giaimo Justin J.Wee(摄影) 杜然(译) 不详

在缅因州巴港的杰克逊实验室里,实验员每天都要仔细查看他们饲养的几组特殊的小鼠。这些小鼠都已存活了600余天,大致相当于人类的60岁;有些甚至远不止这个数。有几只可能需要帮助才能够到饮水器,但其中许多小鼠都是我们人类希望老去后... 详细信息

在缅因州巴港的杰克逊实验室里,实验员每天都要仔细查看他们饲养的几组特殊的小鼠。这些小鼠都已存活了600余天,大致相当于人类的60岁;有些甚至远不止这个数。有几只可能需要帮助才能够到饮水器,但其中许多小鼠都是我们人类希望老去后的样子,用该实验室的科学主任纳迪娅·罗森塔尔(Nadia Rosenthal)的话说。

关键词：罗森塔尔缅因州实验员杰克逊实验室饮水器小鼠

我们在举办可持续活动时学到的5件事加拿大旅游目的地分享了一些关于如何可持续举办活动的见解

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中国会展 2024年第2期 62-63页

作者： Guy hall 不详

创造一个有影响力的活动不是一件小事。这是一项复杂的任务,需要细致的计划、协调和执行。然而,最近,人们越来越意识到会议行业可持续发展的重要性。将环境、社会和经济方面的可持续性纳入活动已成为规划师的关键考虑因素。2023年初,加... 详细信息

创造一个有影响力的活动不是一件小事。这是一项复杂的任务,需要细致的计划、协调和执行。然而,最近,人们越来越意识到会议行业可持续发展的重要性。将环境、社会和经济方面的可持续性纳入活动已成为规划师的关键考虑因素。2023年初,加拿大旅游局的商业活动团队在安大略省滑铁卢举办了“创新加拿大”活动。这次独家活动让来自世界各地的客户有机会亲眼目睹加拿大在先进制造业的创新和领导地位。这也是加拿大目的地的第一个碳中和活动,他们强调尽可能负责任地接待他们的客户。

关键词：旅游目的地先进制造业考虑因素碳中和安大略省行业可持续发展可持续性商业活动