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Sustained-release drug delivery systems for the treatment of glaucoma

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International Journal of Ophthalmology(english edition) 2021年第1期14卷 148-159页

作者： Natasha P.Kesav cara e.capite.a young Monica K.ertel Leonard K.Seibold Malik Y.Kahook Department of Ophthalmology University Hospitals Cleveland Medical CenterClevelandOH 44106USA Department of Ophthalmology University of Colorado School of MedicineCO 80045USA

Glaucoma,a leading cause of irreversible blindness,affects more than 64 million people worldwide and is expected to grow in number due to the aging global population and enhanced methods of *** topical therapies are often effective when used as prescribed,the drawbacks of current medical management methods include poor patient adherence,local and systemic side effects,and in some cases,limited therapeutic *** ocular drug delivery platforms promise to deliver differentiated drug formulations with targeted delivery leveraging patient-independent *** platforms are in various stages of development with promising pre-clinical and clinical *** Bimatoprost Sustained Release (SR) intracameral implant was approved in the United States in March of 2020,making it the first long-term injectable therapy available for the treatment of *** review aims to provide an update on novel sustained release drug delivery systems that are available today as well as those that might be commercialized in coming years.

关键词： glaucoma drug delivery sustained release

Refractive outcomes among glaucoma patients undergoing phacoemulsification cataract extraction with and without Kahook Dual Blade goniotomy

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eye and Vision 2019年第1期6卷 236-241页

作者： erin G.Sieck cara e.capite.a young Rebecca S.epstein Jeffrey R.SooHoo Mina B.Pantcheva Jennifer L.Patnaik Anne M.Lynch Malik Y.Kahook Leonard K.Seibold Department of Ophthalmology University of Colorado School of Medicine1675 Aurora Court F731AuroraCO 80045USA

Background:Glaucoma patients undergoing phacoemulsification alone have a higher rate of refractive surprise compared to patients without *** risk is further increased with combined filtering ***,there are few and conflicting reports on the effect of combined phacoemulsification and micro-invasive glaucoma surgery(MIGS).Here,we look at refractive outcomes of glaucoma patients undergoing phacoemulsification with and without Kahook Dual Blade(KDB)***:Retrospective chart review of 385 glaucomatous eyes of 281 patients,which underwent either phacoemulsification alone(n=309)or phacoemulsification with KDB goniotomy(n=76,phaco-KDB)at the University of *** main outcome was refractive surprise defined as the difference in target and postoperative refraction spherical equivalent greater than±0.5 Diopter(D).Results:Refractive surprise greater than±0.5 D occurred in 26.3%of eyes in the phaco-KDB group and 36.2%in the phacoemulsification group(p=0.11).Refractive surprise greater than±1.0 D occurred in 6.6%for the phacoKDB group and 9.7%for the phacoemulsification group(p=0.08).There was no significant difference in risk of refractive surprise when pre-operative IOP,axial length,keratometry or performance of KDB goniotomy were assessed in univariate ***:There was no difference between refractive outcomes of glaucomatous patients undergoing phacoemulsification with or without KDB goniotomy.

关键词： Kahook Dual Blade goniotomy refractive surprise glaucoma cataract

INTO THe DARK ABYSS eXPLORING SOUTH CHINA'S eXPANSIVe UNDeRGROUND RIVeR SYSTeM

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城市漫步（GBA版） 2019年第10期 34-43页

作者： Matthew Bossons Rachel Berkley cara Chu Wai-ching Vincent Lou 不详

On June 23,2018,12 young Thai boys and their assistant football coach wandered into a karst cave in northern Thailand,near the border with *** happened next would captivate the world and lead to a complex and daring international rescue operation:The 10.3-kilometer-long Tham Luang cave flooded,trapping the boys in total blackness nearly 2.5 kilometers from the cave entrance.

关键词： karst happen black

NTO THe DARK ABYSS eXPLORING SOUTH CHINA’S eXPANSIVe UNDeRGROUND RIVeR SYSTeM

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城市漫步（上海版、英文） 2020年第1期 38-47页

作者： Matthew Bossons via Rachel Berkley(images) cara Chu Wai-ching Vincent Lou 不详

关键词： karst happen black