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Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review

World Journal of Clinical Cases 2014年第6期2卷 172-193页

作者： Robbie SR Woods Esther M O'Regan Susan Kennedy cara martin John J O'Leary Conrad Timon Department of Otolaryn-gology Royal Victoria Eye and Ear Hospital Department of Histopa-thology St. James’s Hospital Department of Histopathology Royal Victoria Eye and Ear Hospital Molecular Pathology Research Coombe Women and Infants University Hospital

Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities.

关键词： Human papillomavirus Human papillomavirus Oropharynx Oropharyngeal Squamous cell carcinoma Head and neck Oncology

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Brain Rattled, Heart Shackled: Ictal Asystole in a Patient without Prior History of Epilepsy or Arrhythmia

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World Journal of Cardiovascular Diseases 2022年第4期12卷 228-235页

作者： Joseph Berger martin Sayegh Anish D. Thomas cara Sherman Vikas Agrawal Jay V. Doshi Internal Medicine Department St. John’s Riverside Hospital Yonkers New York USA Lake Erie College of Osteopathic Medicine Erie Pennsylvania USA Neurology Department St. John’s Riverside Hospital Yonkers New York USA Cardiac Electrophysiology Department St. John’s Riverside Hospital Yonkers New York USA

We present a case of ictal asystole in an 81-year-old female, with no prior history of epileptic activity, or cardiac history suggestive of arrhythmia, who suffered several seemingly unrelated epileptic and asystolic episodes prior to finally having a witnessed seizure followed by an asystolic event. Following this event, all atrioventricular (AV) nodal blockers, and medications with potential seizure threshold lowering activity were stopped, and anti-epileptic medication was optimized. Due to the wishes of the patient’s family, no invasive interventions were ***, the patient continued to be medically treated with anti-epileptic therapy and had no further asystolic events. Unfortunately, the patient’s overall clinical status deteriorated, and she subsequently passed during her hospital stay after being made do not resuscitate and do not intubate (DNR/DNI) by the family and then subsequently comfort care. Prior to her passing, however, she had remained free of epileptic events for 10 days and free of asystolic events for 21 days.

关键词： Seizure Epilepsy Asystole Cardiac Arrest Ictal Asystole Arrhythmia Cardiac Pacing Electroencephalogram Ertapenem

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Refining murine heterotopic heart transplantation:A model to study ischemia and reperfusion injury in donation after circulatory death hearts

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Animal Models and Experimental Medicine 2021年第3期4卷 283-296页

作者： Mohammed Quader Renee Cholyway Niluka Wickramaratne Oluwatoyin Akande martin Mangino Eleonora Mezzaroma Adolfo GMauro Qun Chen Alexander Kantlis Stefano Toldo Division of Cardiothoracic Surgery Pauley Heart CenterVirginia Commonwealth UniversityRichmondVAUSA School of Pharmacy Virginia Commonwealth UniversityRichmondVAUSA Division of Cardiology Pauley Heart CenterVirginia Commonwealth UniversityRichmondVAUSA

Heart transplantation is a lifesaving procedure,which is limited by the availability of donor *** hearts from donors after circulatory death,which have sustained global ischemia,requires thorough studies on reliable and reproducible models that developing researchers may not have *** combining the most recent lit-erature and our recommendations based on observations and trials and errors,the methods here detail a sound in vivo heterotopic heart transplantation model for rats in which protective interventions on the ischemic heart can be studied,and thus al-lowing the scientific community to advance organ preservation *** gathered from reproducible animal models allow for successful translation to clinical studies.

关键词： animal models cardiovascular biology cardiovascular disorders reproducibility

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