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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios car.os perez muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of cardiology Hospital Arnau de VilanovaValenciaSpain Department of car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.ose of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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Coupling textural and stable-isotope variations in fluvial stromatolites:Comparison of Pleistocene and recent records in NE Spain

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Journal of Palaeogeography 2019年第2期8卷 150-169页

作者： C.Arenas M.C.osácar L.Auqué C.Sancho Department of Earth Sciences University of Zaragoza Geotransfer Group and Institute for Research on Environmental Sciences of Aragón(IUCA)

Textural and stable isotopic features of two middle Pleistocene fluvial stromatolite profiles are compared to a recent stromatolite,both formed in the River Piedra system(NE Spain),to test the reliability of climatic,hydrologic and depositional information derived from ancient *** Pleistocene stromatolites formed in a multi-domed,highly-inclined *** recent stromatolite also formed in a highly-inclined cascade of the River Piedra,the sedimentary conditions of which were periodically examined between the years 2000 and *** Pleistocene stromatolites are formed of an alternation of 1) thin large-crystal laminae(type A),with elongated crystals up to 1 mm long,and 2) thick small-crystal laminae(type B),consisting of cyanobacterial fan-and bushshaped *** textural and isotopic comparison with the recent stromatolite shows that each A–B couplet corresponds to one *** type-A laminae are comparable to the macrocrystalline laminae that occur in the cool-period deposits of the recent stromatolite,and the type-B laminae are comparable to the warm-period deposits of the recent *** temperatures(Tw),calculated from δ^(18)O_(calcite) and present measures of δ^(18)O_(water),were similar in the Pleistocene and recent specimens,and close to the measured river ***,the Pleistocene stromatolites formed not far from isotopic equilibrium,as did the recent *** Pleistocene δ^(18) O_(calcite) biannual oscillation is wider in amplitude than in the recent stromatolite,which suggests larger differences in Tw through the year in the Pleistocene than at *** Pleistocene δ^(13)C_(calcite) does not show any pattern;and the values are slightly higher than the recent *** co-evolution of δ^(18)O and δ^(13)C is parallel in the Pleistocene stromatolites,matching the recent stromatolite *** results and their comparison with other ancient examples prove that textural and isotopic features in ancient stromatolites

关键词： Tufa Recent and ancient stromatolites Stable isotopes Biotic and abiotic laminae Intra-annual and inter-annual water temperature variations

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The emotional structuring of the Andean territory: Mapping embodied narratives in Coporaque, Peru

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Frontiers of Architectural Research 2023年第5期12卷 985-998页

作者： Gonzalo Ríos-Vizcarra Luis Enrique Calatayud-Rosado Aleixandre Brian Duche-perez Víctor Cano-Ciborro Faculty of Architecture and Civil and Environmental Engineering Universidad Católica de Santa MaríaArequipa 04001Peru Faculty of Social Sciences and Technologies and Humanities Universidad Católica de Santa MaríaArequipa 04001Peru The Higher Technical School of Architecture of Madrid Polytechnic University of MadridMadrid 28040Spain

This research explores the subject of territory,understood based on the life world of Andean inhabitants of the Colca Valley(Arequipa,Peru),who are descendants of ancient local Indigenous groups that,since prehistoric times,have known how to adapt to the rugged geographical reality of the *** a phenomenological approach,which assesses the subjective experience,it was possible to corroborate the existence of routine patterns of spatiality that preserve the emotional essence of past territorial conceptions,which have prevailed despite the hegemonic impositions systematically forced upon the land ever since the Spanish conquest in the 16th *** carrying out coexistence fieldwork in situ,five layers of territorial sense have been registered,which,besides being very useful in order to optimize and give coherence to their agricultural and animal husbandry tasks,are periodically represented through verbal and corporal narratives,which have been mapped in this work in order to make their dynamics of symbolization visible and to conclude in the existence of an emotional Andean territory.

关键词： Life world Territory Affection Andean Colca valley Phenomenology Narratives

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Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter

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World Journal of Gastroenterology 2013年第24期19卷 3723-3725页

作者： Raphael JF Felizardo Niels os Cmara Division of Nephrology Department of Medicine Federal University of Sao PauloSao Paulo CEP 05508-900 Brazil Department of Immunology Institute of Biomedical Sciences University of S o PauloSao Paulo CEP 05508-900 Brazil

Ochratoxin A (OTA) is a secondary metabolite of Asper-gillus and Penicillium, microorganisms that can be haz-ardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular car-cinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. In a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods.

关键词： Ochratoxin A Mycotoxin Food contamination Hepatocellular carcinoma Liver cancer Egypt

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Sexual Function in Pregnant Women in the Public Health System

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 764-774页

作者： Candice Cezimbra Miranda Amanda Vilaverde perez Bruno Ribeiro Bossardi Luiza Cabreira Brust Fernanda Santos Grossi Edimárlei Gonsales Valério Janete Vettorazzi Maria Celeste osório Wender PostgraduationProgram in Health Sciences: Gynecology and Obstetrics Universidade Federal do Rio Grande do Sul (UFRGS). Rua Ramiro Barcelos Santa Cecilia Porto Alegre RS Brazil FAMED UFRGS Rua Ramiro Barcelos Santa Cecilia Porto Alegre RS Brazil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) UFRGS Rua Ramiro Barcelos Santa Cecilia Porto Alegre RS Brazil Service of Obstetrics and Gynecology Hospital de Clínicas de Porto Alegre (HCPA) Rua Ramiro Barcelos Santa Cecília Porto Alegre RS Brazil

Introduction: Pregnancy is a unique situation and involves changes in sexuality. The aim is to evaluate sexual function and satisfaction in pregnant women under prenatal care provided by the public health system. Method: Cross-sectional study with pregnant women receiving ambulatory care in the public health system in the Southern region of Brazil conducted between November 2014 and September 2015. Results: 283 pregnant women were studied. The mean age was 27.7 ± 6.3 years;64% were white and 31.1% were nulliparous. In the total sample, 8.50% were in the first trimester of pregnancy, 37.4% were in the second trimester, and 54.1% were in the third trimester. The rate of global sexual dysfunction (score 26 points) was 55.5%, following the application of The Female Sexual Function Index (FSFI). Sexual dysfunction was significantly more prevalent in the third trimester (62%) compared to the first (33.3%) and second (50.9%) trimesters (p = 0.015). There was a significant difference in all domains, except in the desired domain, according to the trimester. Pregnant women in the third trimester showed significantly lower scores compared to those in the first trimester in the domains with significance. Conclusion: The prevalence of sexual dysfunction among pregnant women in the public system was high. Knowing that more than 50% of the pregnant women presented sexual dysfunction, it is essential to approach sexuality during prenatal care involving the couple.

关键词： Sexual Dysfunction Pregnancy Female Sexual Function Index Sexuality Sexual Function

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Impact of multidrug resistance on the management of bacterial infections in cirrhosis

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World Journal of Clinical Cases 2023年第3期11卷 534-544页

作者： car.os Terra Ângelo Zambam de Mattos Marcelo Souza Chagas Andre Torres Denusa Wiltgen Barbara muniz Souza Renata Mello perez Gastroenterology-Liver Unit State University of Rio de JaneiroRio de Janeiro 20551-030Rio de JaneiroBrazil Liver Unit Casa de Saúde São José-Rede Santa CatarinaRio de Janeiro 22271-080Rio de JaneiroBrazil Alliance of Brazilian Centers for Cirrhosis car The ABC GroupRio de Janeiro 20551-030Rio de JaneiroBrazil Liver Unit Federal Hospital of LagoaRio de Janeiro 22470-050Rio de JaneiroBrazil Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Internal Medicine Federal Hospital of LagoaRio de Janeiro 22470-050Rio de JaneiroBrazil Department of Internal Medicine Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Brazil Hepatology Division Federal University of Rio de JaneiroRio de Janeiro 21941-617Rio de JaneiroBrazil IDOR D’Or Institute for Research and EducationRio de Janeiro 22281-100Rio de JaneiroBrazil

Patients with cirrhosis have an increased risk of infection and differently from other complications,that over the years are improving in their outcomes,infections in cirrhotic patients are still a major cause of hospitalization and death(up to 50%in-hospital mortality).Infections by multidrug-resistant organisms(MDRO)have become a major challenge in the management of cirrhotic patients with significant prognostic and cost-related *** one third of cirrhotic patients with bacterial infections is infected with MDR bacteria and their prevalence has increased in recent *** infections have a worse prognosis compared to infections by non-resistant bacteria because they are associated with lower rate of infection *** adequate management of cirrhotic patients with infections caused by MDR bacteria depends on the knowledge of some epidemiological aspects,such as the type of infection(spontaneous bacterial peritonitis,pneumonia,urinary tract infection and spontaneous bacteremia),bacteriological profile of antibiotic resistance at each health care unit and site of infection acquisition(community acquired,healthcare associated or nosocomial).Furthermore,regional variations in the prevalence of MDR infections determine that the choice of empirical antibiotic therapy must be adapted to the local microbiological *** treatment is the most effective measure to treat infections caused by ***,optimizing antibiotic prescribing is critical to effectively treat these *** of risk factors for multidrug resistance is essential to define the best antibiotic treatment strategy in each case and the choice of an effective empirical antibiotic therapy and its early administration is cardinal to reduce *** the other hand,the supply of new agents to treat these infections is very ***,specific protocols that include preventive measures must be implemented in order to limit the negative impact of this sev

关键词： Cirrhosis Infection multidrug-resistance Bacterial Antibiotics Microbiota

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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando perez de Prado cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain cardiology Department Hospital Universitario San JuanAlicanteSpain cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain cardiology Department Hospital Universitario Puerta del MarCadizSpain cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain cardiology Department Hospital Universitario de CrucesBilbaoSpain cardiology Department Hospital Regional Universitario de MálagaMalagaSpain cardiology Department Hospital Universitario Puerta de HierroMadridSpain cardiology Department Hospital Alvaro CunqueiroVigoSpain cardiology Department Hospital Juan Ramon JimenezHuelvaSpain cardiology Department Hospital Universitario de BadajozBadajozSpain cardiology Department Hospital Universitario Lucus AugustiLugoSpain cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain cardiology Department Hospital Santa CruzLisboaPortugal cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain cardiology Department Hospital Universitario Miguel ServetZaragozaSpain cardiology Department Hospital Germans Trias i PujolBadalonaSpain cardiology Department Hospital de MeridaMeridaSpain cardiology Department Hospital São BernardoSetúbalPortugal cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain cardiology Department Hospital do Espirito SantoEvoraPortugal cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal cardiology Department Hospital de CabueñesGijonSpain cardiology Department Hospital Garcia de OrtaAlmadaPortugal cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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The Security of Platelet-rich Plasma in Sports-relatedInjuries

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Journal of Health Science 2014年第8期2卷 363-369页

作者： Leticia Rivero Gonzalez Gabriel Lupon Escobar LluisTil perez Sara Estevez Sarmiento Fuerteventura Hospital Clinica Roca Sports Medical Unit Gran Canaria Hospital Universitario Insular de Gran Canaria LasPalmas de Gran Canaria Las Palmas 35016 Spain Sports Medicine Consorci Sanitari de Terrassa (CST) in Olympic Training Center (CAR) Sant Cugat del Vall~s 08173 Spain Sports Medicine FC Barcelona Barcelona 08028 Spain Hospital Universitario Insular de Gran Canaria Las Palmas de Gran Canaria Las Palmas 35016 Spain

Platelet-rich plasma （PRP） therapy in orthopedics and sports medicine has seen an expansion in use since 2003. Theobjective of this study is to not only review evidence of clinical effectiveness but also to evaluate its security and detect any disparitybetween its use and its popularity. A prospective, descriptive study, which included 104 athletes were performed. Minor adverse effectswere recorded and these were self-limited. Although there is a lack of more detailed studies which compare other factors, PRP therapyhas been shown to have positive results in relation to certain lesions.

关键词： Sports medicine, growth factors, muscles, tendons, ligaments, platelet-rich plasma.

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Factors associated with H pylori epidemiology in symptomatic children in Buenos Aires,Argentina

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World Journal of Gastroenterology 2006年第33期12卷 5384-5388页

作者： Cinthia Goldman Andrés Barrado Mariana Janjetic Norma Balcarce Eduardo Cueto Rua Masaru oshiro María L Calcagno Margarita Martinez Sarrasague Julián Fuda Ricardo Weill Marcela Zubillaga Guillermo I perez-perez José Boccio Radioisotopes Laboratory and Laboratory of Stable Isotopes Applied to Biology and Medicine Physics Department School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina Laboratory of Stable Isotopes Applied to Biology and Medicine Physics Department School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina Gastroenterology Unit Hospital de nios "Superiora Sor María Ludovica" La Plata Argentina Health Center Di Matteo San Fernando Buenos Aires Argentina Mathematics Department School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina Agrarian Industries Department School of Agronomy University of Morón Buenos Aires Argentina Departments of Medicine and Microbiology New York University School of Medicine New York United States

AIM： To determine prevalence of H pylori infection in symptomatic children in Buenos Aires, Argentina, and to investigate factors associated with HpyloH positivity. METHODS： A total of 395 children with upper gastrointestinal symptoms referred to the Gastroenterology Unit of the Children Hospital ＂Sor Maria Ludovica＂ were evaluated for the presence of H py/or/by the ^13C-Urea Breath Test （^13C-UBT）. A questionnaire was applied to the recruited population. RESULTS： Prevalence of H pylo H infection was 40.0% in this population （mean age 9.97 ± 3.1 years）. The factors associated with H py/or/positivity were number of siblings （P 〈 0.001）, presence of pet cats （P = 0.03） and birds （P = 0.04） in the household, and antecedents of gastritis among family members （P = 0.01）. After multivariate analysis, number of siblings [Odds ratio （OR） = 1.39; 95% CI, 1.20-1.61] and contact with pet cats （OR = 1.76; 95% CI, 1.00-3.09） remained as variables associated with H pylori infection. CONCLUSION： The prevalence of H pylori infection in children with upper gastrointestinal symptoms in Argentina was similar to that reported in developed countries. Children from families with a higher crowding index and presence of pet cats have a higher risk of being colonized with Hpylori.

关键词： H pylori Children Epidemiology Urea breathtest Prevalence

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Comparative Analysis of carbon Monoxide Modeling from Vehicular Sources in Puebla City,Mexico

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Journal of Environmental Protection 2015年第1期6卷 77-83页

作者： Sthephany Sedeno-Cisneros Maria Auxilio osorio-Lama Miguel Angel Valera-perez Rene Bernardo Elias Cabrera-Cruz Faculty of Chemical Engineering Praiseworthy Autonomous University of PueblaPueblaMexico Institute of Sciences Praiseworthy Autonomous University of PueblaPueblaMexico Faculty of Engineering“Arturo Narro Siller” Autonomous University of TamaulipasTampicoMexico

The results of dispersion modeling of carbon monoxide are reported in this paper. The results of applying the technique of Rapid Assessment of Sources of Environmental Pollution (RASEP) database and the Air Monitoring State System in the City of Puebla, México, were employed. Concentrations of carbon monoxide emitted by cars inferred by RASAP technique with those reported by the environmental monitoring station “Nymphs”, were compared. The date of 21 June 2005-2010 was selected during the peak hour traffic flow. The dispersion of carbon monoxide was modeled by software DISPER and SCRI software, in order to infer the exposure levels of carbon monoxide in the study area. The estimated and monitored concentrations were evaluated with the Mexican regulations for population’s health protection. Regarding the dispersion model, SCRI was discarded for the target validation because it only allows modeling on specific areas. Moreover, the modeling software allowed DISPER simulations with linear sources of car exhaust, so this advantage is considered appropriate to continue using this program. Both estimates obtained by RASEP, as modeled by DISPER and recorded by the monitoring system exceed the maximum permissible limits of NOM-021-SSA1-1993 getting an impermissible for the area of influence of the assessment monitoring station. The DISPER software has potential use for such evaluations, but more work is required on the system for their inferences can be validated by reproducible physical and chemical measurements.

关键词： Environmental Pollutants Assessment carbon Monoxide Puebla

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