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非对称共面波导特性参数的时域反射测量

大连海事大学学报 2002年第4期28卷 1-4页

作者：房少军金红 johnston Ronald H 大连海事大学信息工程学院辽宁大连116026 加拿大卡尔加里大学电气与计算机工程系

提出了采用时域反射测量方法测量背敷金属化层非对称共面波导的特性参数.介绍了测量不连续点特性阻抗和传输线有效介电常数的原理与方法,给出了测量背敷金属化层非对称共面波导的实验结果和有关数据,对实验进行了说明,并对实验结果及其... 详细信息

提出了采用时域反射测量方法测量背敷金属化层非对称共面波导的特性参数.介绍了测量不连续点特性阻抗和传输线有效介电常数的原理与方法,给出了测量背敷金属化层非对称共面波导的实验结果和有关数据,对实验进行了说明,并对实验结果及其误差进行了分析.

关键词：特性参数非对称共面波导时域反射阶跃波特性阻抗有效介电常数测量方法

15kbar下努克片麻岩和H_2O的相关系对太古代奥长花岗岩成因的限制

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地质地球化学 1990年第2期18卷 22-27页

作者： A.D.johnston P.J.Wyllie 肖龙中国地质大学

本文报道了格陵兰西南戈特霍布地区奥长花岗质努克片麻岩的T-X(H_2O)相关系。这种片麻岩代表了太古代(30—28亿年)第二期火山活动的主要成分。我们选用压力15kbar作为奥长花岗质熔体的可能原岩所处下地壳深度的限制。在水饱和的条件下,... 详细信息

本文报道了格陵兰西南戈特霍布地区奥长花岗质努克片麻岩的T-X(H_2O)相关系。这种片麻岩代表了太古代(30—28亿年)第二期火山活动的主要成分。我们选用压力15kbar作为奥长花岗质熔体的可能原岩所处下地壳深度的限制。在水饱和的条件下,固相线～610℃和液相线～745℃之间的熔融区间为～135℃。15kbar下,H_2O饱和时大约含水15.5 wt%。H_2O不饱和时的液相线,沿从15.5wt%H_2O、～745℃,到2 wt%H_2O,1100℃的曲线轨迹延伸。H_2O含量低(7%)时,可能产生由Hb、Ga、Ep和Bi某种组合而成的镁铁质残留物,与角闪质源岩相当。在熔体H_2O含量低(<5%)时,可能的残留物由Na-P1+Qz±Ga组成,与早期的英云闪长质-奥长花岗质岩石相当。然而。

关键词：片麻岩水相奥长花岗岩太古代

Online Vaccine Information in a Knowledge Exchange Social Website (KESW)

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Open Journal of Preventive Medicine 2020年第6期10卷 151-167页

作者： Fiona Gorman Desa Yadegarians Linda Meng Nicholas Gorman Esther johnston California State University Long Beach CA USA University of California Los Angeles CA USA Keck Graduate Institute Claremont CA USA HealthPoint Seattle WA USA

Background: The potential for misinformation on usercontrolled Knowledge Exchange Social Websites (KESWs) is concerning since it can actively influence Internet users’ knowledge, attitudes, and behaviors related to childhood vaccinations. Objective: The present study examines the accuracy and predictors of health information posted to a Knowledge Exchange Social Website (KESW). Methods: A sample of 480 answers to childhood vaccination questions were retrieved and rated for accuracy. Multiple logistic regression modeling was used to examine whether answer characteristics (best answer, professional background, statistical information, source disclosure, online link, word count, vaccine stance, and tone) predict accuracy. Results: Overall, only 56.2% of the posted answers were rated as “accurate.” Accuracy varied by topics with between 52.8% - 64.3% being rated as accurate. When Yahoo Answers’ “best answers” were examined, only 49.2% rated as accurate compared to 57.7% of all other answers, a finding attributed to widespread nominations of vaccine misinformation as “best answers” for questions addressing the side effects of vaccines. For all other types of questions, “best answers” were more likely to be accurate. Regression modeling revealed that discussions of personal choices regarding childhood vaccinations predicted the accuracy of posted answers, with those who mentioned vaccinating their own children proving more likely to communicate accurate vaccine information, and those expressing vaccine hesitancy proving more likely to share factually inaccurate statements about vaccines. Conclusion: The high prevalence of misinformation on KESWs suggests that these websites may serve as a vector for spreading vaccine misperceptions. Further research is needed to assess the impact of various KESWs and to develop effective, coordinated responses by public health agencies.

关键词： Online Health Information Childhood Vaccines Immunizations Infectious Diseases Accuracy Knowledge Exchange Social Websites

An Evaluation of FaHRAS Computer Programmes’ Utility in Family History Triage of Breast Cancer

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Advances in Breast Cancer Research 2014年第2期3卷 17-21页

作者： áine Gorman Michael Sugrue Zuhair Ahmed Alison johnston Donegal Clinical and Research Academy Breast Centre North West Letterkenny Hospital Donegal Ireland

Introduction: Rapid and appropriate family risk assessment and triage of patients are essential for patients presenting to a symptomatic breast unit and international criteria for review are well established. Family History Risk Assessment Software (FaHRAS) is a computerized program, involving different modalities of risk assessment, which is available but has not been widely assessed. Aims: This study evaluated the FaHRAS software scoring of family history risk. Its analysis was compared to multi-tool family history risk assessment models in a cohort of 353 patients on a historic family history waiting list. Methods: A recent published pilot study assessed and categorized family history risk in 353 patients on a historic family history waiting list, according to international guidelines including NICE criteria, Gail and IBIS risk estimates. The current study involved a reassessment of all 353 patients using the FaHRAS software program to determine its accuracy and ease of use. Patient demographics and time required to perform the analysis were documented. Results: FaHRAS identified 73 (20.7%) patients had an IBIS family history score of 17% or greater and 89 (25.2%) patients met the NICE guidelines criteria for management beyond primary care. In the previous study, this was 79 (22.4%) and 112 (31.7%) respectively. Using the largest denominator (NICE guidelines), 264/353 (74.8%) patients could be discharged to primary care using FaHRAS. Using this largest denominator, FaHRAS also identified a total of 28 (7.9%) patients requiring referral to tertiary care while the previous study identified 3 (0.8%). Conclusion: This is one of the first studies to validate FaHRAS, which is accurate and easy to use. FaHRAS system can enable clinicians to become more efficient gatekeepers to genetic services.

关键词： Breast Cancer Risk Assessment Family History

Increasing the value of weather-related warnings

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Science Bulletin 2019年第10期64卷 647-649页

作者： Qinghong Zhang Liye Li Beth Ebert Brian Golding David johnston Brian Mills Shannon Panchuk Sally Potter Michael Riemer Juanzhen Sun Andrea Taylor Sarah Jones Paolo Ruti Julia Keller HIWeather International Coordination Office Chinese Academy of Meteorological Sciences Beijing 100081 China Deutscher Wetterdienst Research and Development Offenbach 6306乙 Germany World Weather Research Division World Meteorological Organization Geneva 1211 Switzerland Department of Atmospheric and Oceanic Sciences School of Physics Peking University Beijing 100871 China Bureau of Meteorology Melbourne Victoria 3001 Australia Met Office Exeter Devon EXI 3PB UK GNS Science/Massey University Willington 6140 New Zealand University of Waterloo and Environment and Climate Change Canada Waterloo N2L 3G1 Canada Institute of Atmospheric Physics University of Mainz Mainz 55128 Germany National Center for Atmospheric Research Boulder CO 80307-3000 USA University of Leeds Leeds LS2 9JT UK

Despite advances in forecasting and emergency preparedness, weather related disasters continue to cost many lives, to displace populations and to cause wide-spread damage. Therefore, High Impact Weather Project (HIWeather), a 10-year research project (https://***/en/resources/buHetin/hiweather-10-yearresearch- project), was established in 2016 by WM0 (World Meteorology Organization) WWRP (World Weather Research Program: https://***/pages/prog/arep/wwrp/new/wwrp_new_en. html). HIWeather aimed at achieving dramatic improvements in the effectiveness of weather-related hazard warnings, following recent advancement in numerical weather prediction at km-scale and in disaster risk reduction. The implementation plan was developed under the concept of warning chain, which comprises all components and the connections between to a successful weather-hazards warning: observations, weather forecast, hazard forecast, impact forecast, the generation of warnings and decision making (Fig. 1). A successful warning relies on information produced by the meteorological and related physical sciences, thus its effectiveness of delivery depends on applications of social, behavioral and economic sciences. The workshop of WM0 High Impact Weather Project was held in Beijing during 20-22 November of 2018, attracted a diverse and interdisciplinary group of over 70 scientists from 25 countries in the broad field of physical and social science, during which all elements of the warning chain were discussed critically.

关键词： Despite advances forecasting and emergency weather related disasters

A novel rat model of fatty organ degeneration induced by poloxamer 407

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Journal of Bio-X Research 2019年第1期2卷 41-45页

作者： Na Yin Ting Chu Yingfu Peng Yuanchun Yao Jingjing Li Bo Xiang Bo Yang Thomas P.johnston Maosheng Yang Laboratory of Disorders Genes and Department of Pharmacology Research Center of Translational Medicine Department of Pathology Jishou University School of Medicine Clinical Laboratory the First Affiliated Hospital of Jishou UniversityJishouHunan ProvinceChina Department of Pathology the First Affiliated Hospital of Jishou UniversityJishouHunan ProvinceChina Division of Pharmaceutical Sciences School of PharmacyUniversity of Missouri-Kansas CityKansas CityMOUSA

Traditional methods of inducing hyperlipidemia in animal models are either costly(genetic manipulation)or it is difficult to control for the effects of other *** example,during high-fat feeding,the amount of high-fat diet intake per animal cannot be precisely *** aim of this study was to develop an experimental model of fatty organ degeneration induced by poloxamer 407(P-407).The study was conducted in 2-month-old,male Sprague-Dawley rats that were administered intraperitoneally with either 10%(w/w)P-407(1 g/kg)or saline(10 mL/kg)for 4 *** lipid profile,organ degeneration due to fat deposition,and body mass were *** administration of P-407 resulted in significant increases in plasma triglycerides(P0.001),total cholesterol(P<0.001),high-density lipoprotein-cholesterol(P0.001),and low-density lipoprotein(P<0.001)*** contrast to the control group,fatty tissue degeneration was observed in the liver,spleen,and kidneys of P-407-treated *** correlations between fatty tissue degeneration,and the atherogenic index of plasma(P<0.001)and the ratio of total cholesterol to high-density-lipoprotein(P<0.001)were *** addition,treatment with P-407 for 3 to 4 months caused a significant reduction in body mass relative to controls(P<0.001).Thus,this study describes the development of a cost-effective experimental rat model of organ degeneration,characterized by fat accumulation in the liver,spleen,and kidneys,which could be used for the study of steatosis and related diseases arising from sustained untreated ***,both the atherogenic index of plasma and the ratio of total cholesterol to high-density lipoprotein-cholesterol can be used to predict the risk of fatty tissue degeneration in this *** study was approval of the University of Jishou Biomedical Research Ethics Committee,China.

关键词： atherogenic index of plasma fatty degeneration hyperlipidemia intraperitoneal administration poloxamer 407 rat model triglyceride

Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes

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Stroke & Vascular Neurology 2020年第2期5卷 128-137页

作者： Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne johnston Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases(NCRC-ND) BeijingChina Advanced Innovation Center for Human Brain Projection Capital Medical UniversityBeijingChina Dell Medical School University of TexasAustinTexasUSA

Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains *** Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)*** assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression *** Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was *** presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS *** CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding ***-point modified CSVD score improved the predictive power for bleeding events and *** CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 *** and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes.

关键词： intracranial bleeding Acute

Bioproduced Proteins On Demand(Bio-POD)in hydrogels using Pichia pastoris

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Bioactive Materials 2021年第8期6卷 2390-2399页

作者： Shuo-Fu Yuan Sierra M.Brooks Annalee W.Nguyen Wen-Ling Lin Trevor G.johnston Jennifer A.Maynard Alshakim Nelson Hal S.Alper Institute for Cellular and Molecular Biology The University of Texas at AustinAustinTXUSA McKetta Department of Chemical Engineering The University of Texas at AustinAustinTXUSA Department of Chemistry University of WashingtonBox 351700SeattleWAUSA

Traditional production of industrial and therapeutic proteins by eukaryotic cells typically requires large-scale fermentation *** a result,these systems are not easily portable or reusable for on-demand protein production *** this study,we employ Bioproduced Proteins On Demand(Bio-POD),a F127-bisurethane methacrylate hydrogel-based technique that immobilizes engineered Pichia pastoris for preservable,on-demand production and secretion of medium-and high-molecular weight proteins(in this case,SEAP,α-amylase,and anti-HER2).The gel samples containing encapsulated-yeast demonstrated sustained protein production and exhibited productivity immediately after lyophilization and *** hydrogel platform described here is the first hydrogel immobilization using a *** system to produce recombinant proteins of this *** results highlight the potential of this formulation to establish a cost-effective bioprocessing strategy for on-demand protein production.

关键词： Protein production Hydrogel Pichia pastoris Immobilization Lyophilization

认知与情绪过程的脑诱发电位研究——情绪的适应性假说

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心理学报 1992年第4期24卷 406-414页

作者：王晓田 Victor S.johnston Juan C.Oliver 美国新墨西哥州立大学心理系

本研究观测了30名女性被试在月经周期中的不同激素时相对图像刺激的情绪价值的主观评估和脑诱发电位反应。调节刺激的情绪价值的五类幻灯片分别为普通人像、婴儿像、皮肤病人像、男模特儿像和女模特儿像。实验发现只有脑诱发电位的P3成... 详细信息

本研究观测了30名女性被试在月经周期中的不同激素时相对图像刺激的情绪价值的主观评估和脑诱发电位反应。调节刺激的情绪价值的五类幻灯片分别为普通人像、婴儿像、皮肤病人像、男模特儿像和女模特儿像。实验发现只有脑诱发电位的P3成份随刺激的情绪价值和激素的时相而变化。被评为喜爱与不喜爱的图像(婴儿像和皮肤病人像)所诱发的P3波在幅度上均明显高于中性图像(普通人像)所致的P3反应。在高孕激素时相,对婴儿像和男模特儿像的P3反应高于在低孕激素时相对同类刺激的P3反应。高孕激素时相还伴有对各类图像性感程度评估值的降低。对各类图像喜爱程度的评估则随雌激素水平的上升而增高。上述实验结果表明,P3波敏感于刺激的情绪价值并反映了认知与情绪过程中受生理状态调节的适应性变化。

关键词：认知情绪月经周期脑诱发电位