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Whole-eye tr.nsplantation: Cur.ent challenges and futur. per.pectives

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Wor.d Jour.al of Tr.nsplantation 2024年第2期14卷 28-39页

作者： Anna Scar.bosio Pier.Luigi Sur.co Vlad Ter.shenko r.han Bir.Singh Car.o Salati Leopoldo Spadea Glenda caputo Pier.Camillo Par.di Cater.na Gagliano Jonathan M Winogr.d Mar.o Zeppier. Depar.ment of Plastic Sur.er. University Hospital of UdineUdine 33100Italy Depar.ment of Plastic Sur.er. Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye r.sear.h Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Depar.ment of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Depar.ment of Medicine and Sur.er. University of Enna"Kore"Enna 94100Italy Eye Clinic Catania Univer.ity San Mar.o Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye tr.nsplantation emer.es as a fr.ntier.in ophthalmology,pr.mising a tr.nsfor.ative appr.ach to ir.ever.ible *** advancements,for.idable challenges *** of donor.eye viability post-enucleation necessitates meticulous sur.ical techniques to optimize r.tinal integr.ty and ganglion cell *** the inhibitor. milieu of the centr.l ner.ous system for.successful optic ner.e r.gener.tion r.mains elusive,pr.mpting the explor.tion of neur.tr.phic suppor. and immunomodulator. *** toler.nce,par.mount for.gr.ft acceptance,confr.nts the distinc-tive immunogenicity of ocular.tissues,dr.ving r.sear.h into tar.eted immunosup-pr.ssion *** and legal consider.tions under.cor. the necessity for.str.ngent standar.s and ethical *** collabor.tion and ongoing r.sear.h endeavor. ar. imper.tive to navigate these ***,stem cell ther.pies,and pr.cision immunomodulation r.pr.sent pr.mising avenues in this ***,the aim of this r.view is to cr.tically assess the cur.ent landscape of whole-eye tr.nsplantation,elucidating the challenges and advancements while delineating futur. dir.ctions for.r.sear.h and clinical *** concer.ed effor.s,whole-eye tr.nsplantation stands to r.volu-tionize ophthalmic car.,offer.ng hope for.r.stor.d vision and enhanced quality of life for.those afflicted with blindness.

关键词： Eye Tr.nsplantation Optic ner.e Ner.e r.gener.tion Immunological toler.nce

青少年阴囊坏疽性血管炎:坏疽性脓皮病的一种变异型?

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 7-7页

作者： caputo r. Mar.ano A.V. Di Benedetto A. 董平 Institute of Der.atological Sciences University of Milan-Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina ElenaDr.

Juvenile gangr.nous vasculitis of the scr.tum was descr.bed by Piňol et al in 1974 as a unique var.ant of scr.tal gangr.ne of unknown or.gin, occur.ing exclusively in young individuals. It was char.cter.zed by an acute onset of skin ulcer. under.oing complete r.solution after.appr.pr.ate ther.py, with no r.lapses. We pr.sent a typical case of this extr.mely r.r. disease affecting a 16-year.old boy in whom the scr.tal ulcer.tions wer. pr.ceded by an episode of phar.ngitis with fever. The condition pr.mptly r.gr.ssed after.administr.tion of intr.muscular.betamethasone in combination with or.l cipr.floxacin. Accor.ing to Piňol et al, juvenile gangr.nous vasculitis of the scr.tum, although poor.y known to der.atologists, should be r.gar.ed as a distinctive entity within the wide gr.up of scr.tal gangr.nes. On the other.hand, the hypothesis that this condition may well r.pr.sent a var.ant of pyoder.a gangr.nosum is discussed.

关键词：坏疽性脓皮病阴囊坏疽变异型血管炎阴囊溃疡皮肤科医生皮肤溃疡肌肉注射发热性倍他米松

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他扎罗汀短期外用治疗寻常型银屑病

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 49-49页

作者： Ver.ldi S. caputo r. Pacifico A. 李晓莉 Institute of Der.atological Sciences IRCCS University of Milan Via Pace 9 IT-20122 Milan Italy Dr.

Backgr.und: We pr.sent the r.sults of a multicentr., not contr.lled, clinical study on the toler.bility and efficacy of tazar.tene gel, used as shor. contact ther.py (SCT), in psor.asis vulgar.s. Objective: To evaluate whether.ir.itant contact der.atitis caused by tazar.tene was less fr.quent and/or.less sever. with SCT than with tr.ditional ther.py, and whether.SCT with tazar.tene was as effective as tr.ditional ther.py. Methods: For.y-thr.e patients with plaque psor.asis wer. tr.ated by SCT with 0.1% tazar.tene gel (once daily application for.20 min, followed by washing with water.. Tr.atment dur.tion was 45 days. r.sults: Ir.itant contact der.atitis caused by tazar.tene used as SCT was much less fr.quent and sever. than tr.ditional tr.atment with the same dr.g. SCT with tazar.tene was effective in the tr.atment of plaque psor.asis. Conclusion: Tazar.tene, used as SCT, was better.toler.ted than the same dr.g used as tr.ditional tr.atment. Fur.her.or., SCT appear.d to be as effective as tr.ditional ther.py with the same dr.g.

关键词：寻常型银屑病他扎罗汀斑块型银屑病严重度率更方案应用

成人与儿童Wells综合征:19例病例报道

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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 59-页

作者： caputo r. Mar.ano A.V. Vezzoli P Lunar.on L. 潘敏 Institute of Der.atological Sciences University of Milan Via Pace 9 20122 Milan Italy Dr.

Backgr.und: Wells syndr.me, an uncommon inflammator. der.atosis, is char.cter.zed by pr.tean cutaneous manifestations, suggestive but not specific histopathologic findings, and usually a r.cur.ent cour.e. Because of its or.ginal descr.ption as a distinct entity, it has come to be r.gar.ed as an abnor.al eosinophilic r.sponse to a number.of causative agents. Obser.ations: The medical r.cor.s of 19 patients (12 adults and 7 childr.n) with Wells syndr.me r.fer.ed to the Institute of Der.atological Sciences fr.m 1990 to 2005 wer. evaluated for.the type and pr.valence of skin lesions, clinical cour.e and r.sponse to tr.atment, and possibly associated systemic symptoms, as well as histologic, labor.tor., and immunofluor.scence findings. The classic plaque-type var.ant pr.ved to be the most common pr.sentation in childr.n but not in adults, who mor. fr.quently had the annular.gr.nuloma-like var.ant. Unilesional for.s wer. found to occur.mor. fr.quently in childr.n. The cour.e was r.cur.ent, although slowly pr.gr.ssing, with amean dur.tion of disease of 5 year. for.adults and 3 year. for.childr.n. Conclusions: We emphasize the concept that the diagnosis of Wells syndr.me is a clinicopathologic diagnosis. Although it should be classified within a spectr.m that includes multisystem eosinophilic disor.er., such as Chur.-Str.uss and hyper.osinophilic syndr.mes, Wells syndr.me, which has 7 var.ants, is a distinct cutaneous disease lacking systemic involvement.

关键词：儿童综合征综合病症 Wells 成人

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兄妹共患网状红斑黏蛋白病

世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 48-48页

作者： caputo r. Mar.ano A.V. Tour.aki A. Mar.hini M. 张路坤 Institute of Der.atological Sciences University of Milanvia Pace 9IT-20122 MilanItaly

r.ticular.er.thematous mucinosis(r.M)is a r.r.,pr.mar. cutaneous mucinosis clinically char.cter.zed by a per.istent r.ticular.er.thema on the mid chest and mid-upper.back,and histologically by a mononuclear.cell infiltr.te and deposits of mucin in the *** our.knowledge,the pr.sent r.por. of r.M occur.ing in a Caucasian man and his sister.is the fir.t r.por.ed case of familial *** a host-specific immune r.sponse to unknown antigens may be involved in the pathogenesis of this entity,human leukocyte antigen typing was deter.ined and compar.d to those r.por.ed in autoimmune diseases.

关键词：黏蛋白病自身免疫性疾病人类白细胞抗原单核细胞浸润免疫反应宿主特异性族性持久性

Hot topics in pancr.atic cancer.management

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Wor.d Jour.al of Gastr.intestinal Sur.er. 2023年第2期15卷 121-126页

作者： Damiano caputo Depar.ment of Gener.l Sur.er. Fondazione Policlinico Universitario Campus Bio-MedicoRome 00128Italy Gener.l Sur.er. r.sear.h Unit University Campus Bio-Medico di RomaRome 00128Italy

Pancr.atic ductal adenocar.inoma(PDAC)is a sneaky and lethal disease bur.ened by poor.*** is often detected too late to be successfully cur.d,and it has been estimated that it will be a leading cause of cancer.r.lated deaths in the near.*** the last decade,multimodal tr.atments involving sur.er.,chemother.py and r.diother.py have contr.buted to impr.ving the pr.gnosis of this disease;however.long-ter. r.sults ar. still not *** mor.idity and mor.ality r.tes r.main high,and systemic tr.atments ar. bur.ened by toxicity in both neoadjuvant and adjuvant *** in technologies,tar.eted ther.pies,immunother.py and PDAC micr.envir.nment modulation str.tegies may r.pr.sent useful potential weapons in the ***,in the fight against this dr.adful disease,ther. is an ur.ent need for.new,cheap and user.fr.endly tools for.ear.y *** this field,pr.mising r.sults have been found in nanotechnologies and“omics”analyses that sear.h for.new biomar.er. to be used in pr.mar. and secondar. ***,ther. ar. many issues that need to be solved befor. consider.ng these tools in daily clinical *** editor.al r.por.ed the state of the ar. of pancr.atic cancer.management.

关键词： Pancr.atic cancer Pancr.atic ductal adenocar.inoma Nanotechnology Neoadjuvant ther.py Adjuvant ther.py Omics

Osteopontin and the immune system:another.br.ck in the wall

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Cellular.& Molecular.Immunology 2018年第4期15卷 405-407页

作者： Sar. caputo Matteo Bellone Cellular.Immunology Unit Department of ImmunologyTransplantation and Infectious DiseasesSan Raffaele Scientific Institute20132 MilanItaly

The innate and adaptive ar.s of the immune system ar. finely tuned to efficiently r.act to either.endogenous or.exogenous noxiae that per.ur. the function of our.tissues and or.ans,thus r.pidly r.tur.ing to homeostasis with minimal collater.l *** molecular.mechanisms by which this occur. have been only par.ially *** wor. by Kanayama et al.1 contr.butes to the building of this wall of knowledge by adding an impor.ant *** show that osteopontin(OPN),a phosphor.lated pr.tein of the extr.cellular.matr.x(ECM),has a dominant r.le in balancing lymphoid and myeloid cells dur.ng emer.ency gr.nulopoiesis(that is,an incr.ased cellular.output fr.m the bone mar.ow to meet the acute demand for.the r.spective blood cell type).2 OPN that is pr.duced and r.leased by bone mar.ow(BM)str.mal cells negatively impacts the pool size of hematopoietic stem cells(that is,Lin−Sca-1+c-kit+).

关键词： or.ans al. endogenous

A High Or.er.For.ula to Appr.ximate the caputo Fr.ctional Der.vative

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Communications on Applied Mathematics and Computation 2020年第1期2卷 1-29页

作者： r.Mokhtar. F.Mostajer.n Depar.ment of Mathematical Sciences Isfahan University of TechnologyIsfahan 84156-83111Iran

We pr.sent her. a high-or.er.numer.cal for.ula for.appr.ximating the caputo fr.ctional der.vative of or.er.�for.0<α<*** new for.ula is on the basis of the thir. degr.e Lagr.nge inter.olating polynomial and may be use... 详细信息

We pr.sent her. a high-or.er.numer.cal for.ula for.appr.ximating the caputo fr.ctional der.vative of or.er.�for.0r.ula is on the basis of the thir. degr.e Lagr.nge inter.olating polynomial and may be used as a power.ul tool in solving some kinds of fr.ctional or.inar./par.ial diff er.ntial *** compar.son with the pr.vious for.ulae,the main super.or.ty of the new for.ula is its or.er.of accur.cy which is 4−α,while the or.er.of accur.cy of the pr.vious ones is less than *** must be pointed out that the pr.posed for.ula and other.existing for.ulae have almost the same computational *** eff ectiveness and the applicability of the pr.posed for.ula ar. investigated by testing thr.e distinct numer.cal ***,an application of the new for.ula in solving some fr.ctional par.ial diff er.ntial equations is pr.sented by constr.cting a fi nite diff er.nce scheme.A PDE-based image denoising appr.ach is pr.posed to demonstr.te the per.or.ance of the pr.posed scheme.

关键词： caputo fr.ctional der.vative Fr.ctional par.ial differ.ntial equation Finite differ.nce scheme

Integr.ting beneficiar.es into assessment of ecosystem ser.ices fr.m managed for.sts at the Hubbar. Br.ok Exper.mental For.st,USA

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For.st Ecosystems 2016年第4期3卷 243-257页

作者： Jesse caputo Colin M.Beier.Valer.e A.Luzadis Peter.M.Gr.ffman SUNY College of Envir.nmental Science and For.str. Department of Forest and Natural Resources Management Syracuse NY 13210 USA Car. Institute of Ecosystem Studies Millbrook 12545 NY USA

Backgr.und：For.sts contr.bute to human wellbeing thr.ugh the pr.vision of impor.ant ecosystem ***：In this study,we investigated how the per.eived impor.ance of ecosystem ser.ices may impact the over.ll benefit pr.vided by managed water.heds at the Hubbar. Br.ok Exper.mental For.st over.a 45-year.per.od,using standar.ized measur.s of ser.ice capacity weighted by ser.ice impor.ance weights der.ved fr.m a sur.ey of ***：The capacity of water.heds to r.gulate water.flow and quality was high in all water.heds thr.ughout the study per.od,wher.as cultur.l ser.ices such as scenic beauty declined after.*** on gr.enhouse gas r.gulation depended on the efficiency with which har.ested biomass was *** r.vealed that stakeholder. placed high value on all ecosystem ser.ices,with r.gulating and cultur.l ser.ices seen as mor. impor.ant than pr.visioning *** ser.ice metr.cs wer. weighted by sur.ey r.sponses and aggr.gated into a single measur.,total ser.ice pr.vision followed the same over.ll tr.nd as gr.enhouse gas *** biomass use was less efficient in ter.s of gr.enhouse gas emissions,har.esting r.sulted in an over.ll ＂ecosystem ser.ice debt＂;wher. use was mor. efficient,this ＂ecosystem ser.ice debt＂ was ***＇ educational backgr.unds significantly affected over.ll assessment of ser.ice *** with college or.univer.ity degr.es incur.ed smaller.＂ecosystem ser.ice debts＂ and wer. less negatively affected by har.esting ***：This study highlights the impor.ance of including empir.cal measur.s of beneficiar. pr.fer.nce when attempting to quantify over.ll pr.vision of ecosystem ser.ices to human beneficiar.es over.time.

关键词： Ecosystem ser.ices For.sts Long-ter. ecological r.sear.h Hubbar. Br.ok Exper.mental For.st r.gulating ser.ices