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Population pharmacokinetics of valproate in Chinese children with epilepsy

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Acta Pharmacologica Sinica 2007年第10期28卷 1677-1684页

作者： De-chun JIANG~(2,3),Li WANG~4,Yu-qin WANG~(2,6),Lin LI~3,Wei LU~5,Xiang-rong BAI~2~2 Department of Pharmacy,Xuan-wu Hospital of capital medical univer.ity,Beijing 100053,China ~4 Department of Pediatrics,Peking univer.ityFirst Hospital,Beijing 100034,China ~3 Department of Pharmacology,Xuan-wu Hospital of capital medical univer.ity,Education Ministry KeyLaboratory for Neurodegenerative Diseases,Beijing 100053,China ~5 School of Pharmaceutical science,Peking univer.ity,Beijing 100083,China ment of Pharmacy Xuan-wu Hospital of Capital Medical University Beijing 100053 China. wangyuqin8682@***.

Aim:The aim of the present study is to establish a population pharmacokinetic（PPK） model of valproate （VPA） in Chinese epileptic children to promote thereasonable use of anti-epileptic ***:Sparse data of VPA serumconcentrations from 417 epileptic children were *** patients weredivided into 2 groups:the PPK model group （n=317） and the PPK valid group（n=100）.The PPK parameter values of VPA were calculated by NONMEM soft-ware using the data of the PPK model group.A basic model and a final modelwere set *** validate the 2 models,the concentrations of PPK valid groupwere predicted by each model,*** mean prediction error （MPE）,mean squared prediction error （MSPE）,root mean squared prediction error（RMSPE）,weight residues （WRES）,and the 95% confidence intervals （95%CI） were also ***,the values between the 2 models were ***:The PPK of VPA was determined by a 1-compartment model with afirst-order absorption *** basic model was:Ka=3.09 (h-1),V/F=20.4（L）,CL/F=0.296 （L/h）.The final model was:Ka=0.251+2.24·（1-HS）(h-1),V/F=2.88+0.157·WT （L）,CL/F=0.1060.98·CO+0.0157·AGE （L/h）.For thebasic model,the MPE,MSPE,RMSPE,WRES,and the 95% CI were-23.53（-30.36,-16.70）,3728.96 （2872.72,4585.20）,39.62 （34.34,44.90）,and-0.06 （-0.14,0.02）,*** the final model,the MPE,MSPE,RMSPE,WRES,and the95% CI were-1.16 （-4.85,2.53）,1002.83 （1050.64,1143.61）,23.04 （21.12,24.96）,and0.08 （-0.04,0.20）,*** final model was more optimal than the ***:The PPK model of VPA in Chinese epileptic children wassuccessfully *** will be valuable to facilitate individualized dosageregimens.

关键词： population pharmacokinetics valproic acid epilepsy children Bayesian method NONMEM software individualized dosage regimens

Synthesis and Characterization of Polyurethane

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Journal of Wuhan univer.ity of Technology(Materials science) 2010年第6期25卷 984-986页

作者：贺纯静倪家骧 Department of Pain Xuanwu HospitalCapital Medical University

Polyurethane was synthesized by the copolymerization with isocyanate and *** structure and properties of the copolymers were characterized by infrared spectrometer（IR）,differential scanning calorimetry（DSC） and thermogravimetry（TG）.The rabbit blood samples was dripped on the polyurethane,which was prepared by drying and die,and the contact angle was measured by contact angle measurement,then infiltration phenomenon was observed by electron *** results showed that the contact angle of blood samples and polyurethane was decreased with increasing time,and the platelets on the polyurethane would gradually increase and more *** the polyurethane coating had good hydrophilic property and anticoagulant activity.

关键词： polyurethane hydrophilicity anticoagulant

Maize ZmFDR3 localized in chloroplasts is involved in iron transport

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science China(Life sciences) 2009年第9期52卷 864-871页

作者： HAN JianHui1,SONG XiuFang1,LI Peng1,YANG HuiJun2 & YIN LiPing1 1 College of Life science,capital Normal univer.ity,Beijing 100048,China 2 Department of Biological sciences,univer.ity of South Carolina,Columbia,SC 29208,USA College of Life science Capital Normal University Beijing 100048 China Department of Biological sciences University of South Carolina Columbia SC 29208 USA

Iron is an essential nutrient for plant metabolism such that Fe-limited plants display chlorosis and suffer from reduced photosynthetic efficiency. Differential display previously identified genes whose expression was elevated in Fe-deficient maize roots. Here,we describe the functional characterization of one of the genes identified in the screen,ZmFDR3 (Zea maize Fe-deficiency-related). Heterologous functional complementation assays using a yeast iron uptake mutant showed that ZmFDR3 functions in iron transport. ZmFDR3 contains a domain found in FliN-proteins of the type III secretion system and is predicted to localize to the thylakoid of plastids. Fluorescence immunocytochemistry showed that ZmFDR3 is localized in the plastids of roots,stems and leaves,with high expression found in guard cell chloroplasts. Transgenic tobacco expressing a 35S-ZmFDR3 construct contains elevated iron content,displays well arranged thylakoid membranes and has photosynthetic indices that are higher than those of the wild type. Together,these results suggest that ZmFDR3 functions in chloroplast iron transport.

关键词： ZmFDR3 iron transport iron content chloroplasts

An Earth multi-body system elasticity and plasticity dynamics model

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science China(Technological sciences) 2006年第z2期49卷 23-29页

作者： ZHANG Qingxian, BI Siwen & GONG Huili Education Ministry Key Laboratory of Three-Dimensional Information Extraction and Application, capital Normal univer.ity, Beijing 100037, China State Key Laboratory of Remote Sensing science, IRSA, Chinese Academy of sciences, Beijing 100101, China capital Normal Univ Educ Minist Key Lab Dimens Informat Extract & App Beijing 100037 Peoples R China Chinese Acad Sci IRSA State Key Lab Remote Sensing Sci Beijing 100101 Peoples R China

Research on the elasticity and plasticity dynamics of the Earth multi-body system, including the Earth multi-body system stratum-block's equivalent inertia force system and generalized inertia force, the Earth multi-body system stratum-block's equivalent inertia force system expressed with partial velocity and partial palstance, and Earth multi-body system generalized inertia force expressed with partial velocity and partial palstance. This research provides a theoretical foundation for further investigation of Earth multi-body dynamics.

关键词： Earth multi-body system, equivalent inertia force system, generalized inertia force, elasticity and plasticity, dynamics model.

A System of the Air Pollution Assessment for Mountain Area

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Systems science and Systems Engineering 1995年第1期5卷 5-8页

作者： YU Guangyi(capital Normal univer.ity,Mathematics Department, Beijing, 100037)

The purpose of this paper is to create a system of air pollusion assessment for mountain area.3),(4)It could be used for any dimensional scale area.

关键词： air pollution assessment surface approximation numerical model and algorithm interpolation polynomial.

The role of the DLPFC in inductive reasoning of MCI patients and normal agings:An fMRI study

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science China(Life sciences) 2009年第8期52卷 789-795页

作者： YANG YanHui1,3,LIANG PeiPeng2,3,LU ShengFu2,3,LI KunCheng1,3 & ZHONG Ning2,3,4 1 Xuanwu Hospital,capital medical univer.ity,Beijing 100053,China 2 The International WIC Institute,Beijing univer.ity of Technology,Beijing 100124,China 3 Beijing Municipal Lab of Brain Informatics,Beijing 100124,China 4 Department of Life science and Informatics,Maebashi Institute of Technology,Maebashi 371-0816,Japan Xuanwu Hospital Capital Medical University Beijing 100053 China The International WIC Institute Beijing University of Technology Beijing 100124 China Beijing Municipal Lab of Brain Informatics Beijing 100124 China Department of Life science and Informatics Maebashi Institute of Technology Maebashi 371-0816 Japan

Previous studies of young people have revealed that the left dorsolateral prefrontal cortex(DLPFC) plays an important role in inductive *** fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal agings,and whether the activation pattern of this region was different between MCI patients and normal *** fMRI results indicated that MCI patients had no difference from normal agings in behavior performance(reaction time and accuracy) and the activation pattern of ***,the BOLD response of the DLPFC region for MCI patients was weaker than that for normal agings,and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal *** together,these results indicated that DLPFC plays an important role in inductive reasoning of agings,and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.

关键词： mild cognitive impairment functional MRI inductive reasoning

The Existence of Supporting Prices and Economic Growth under Uncertainty

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Systems science and Systems Engineering 1998年第2期8卷 67-74页

作者： LIU Zongqian Comprehensive Techology Institute,capital normal univer.ity,100037

In our paper we will mainly construct a stochastic model from uncertainty and establish some properties on *** will next show that the existence of supporting prices and optimal paths,and obtain some results similar t... 详细信息

关键词： uncertainty state product topology probability space function space production set utility planning support prices optimal path economic growth

Tiantan International Stroke Conference (TISC) 2006:A Milestone for the Advances of Stroke in China

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中国卒中杂志 2006年第6期 457-458页

作者： Wei Zhang Liping Liu Yongjun Wang Department of Neurology,Beijing Tiantan Hospital,capital univer.ity of medical sciences,Beijing 100050,China

Tiantan International Stroke Conference (TISC) 2006 was held on June 16-18,2006 in Beijing *** International Health Exchange and Cooperation Center of Ministry of Health,International Chinese Stroke Federation, Neurol... 详细信息

关键词： A Milestone for the Advances of Stroke in China TISC

Quality evaluation for air plasma spray thermal barrier coatings with pulsed thermography

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Progress in Natural science:Materials International 2011年第4期21卷 301-306页

作者： Shi-bin ZHAO~1,Cun-lin ZHANG~2,Nai-ming WU~3,Hua-ming WANG~1 1.School of Materials science and Engineering,Beihang univer.ity,Beijing 100191,China 2.Department of Physics,capital Normal univer.ity,Beijing 100048,China 3.School of Jet Propulsion,Beihang univer.ity,Beijing 100191,China [a] School of Materials science and Engineering Beihang University Beijing 100191 China [b] Department of Physics Capital Normal University Beijing 100048 China [c] School of Jet Propulsion Beihang University Beijing 100191 China

Pulsed thermography(PT) as a non-contact non-destructive evaluation(NDE) technique was employed to examine as-sprayed air plasma spray(APS) thermal barrier coatings(TBCs) for quality *** and micro-structural characteristics play a vital role in determining the *** this paper,PT logarithmic peak second-derivative method was adopted to measure the thickness of top *** dependent thermal images were used to characterize the microstructure which was confirmed by scanning electron microscope(SEM).The results showed that there was relationship between the temperature distribution of the surface and microstructure change in *** distribution in thermal images and measurement results of thickness were in fairly good agreement with the microstructure *** can be concluded that it was possible to employ these NDE methods as quality evaluation for as-sprayed TBCs.

关键词： thermal barrier coatings(TBCs) non-destructive evaluation(NDE) pulsed thermography microstructure thickness measurement