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Heterogeneous lamella design to tune the mechanical behaviour of a new cost-effective compositionally complicated alloy

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Journal of Materials Science & Technology 2022年第1期96卷 113-125页

作者： yu Yin Qiyang Tan Qiang sun Wangrui Ren Jingqi Zhang Shiyang Liu Yingang Liu Michael Bermingham Houwen Chen Ming-Xing Zhang School of Mechanical and Mining Engineering University of QueenslandQLD 4072Australia College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

A heterogeneous lamella(HL)design strategy was applied to manipulate mechanical properties of a new cost-effective Fe_(35)Ni_(35)Cr_(25)Mo_(5)compositionally complicated alloy(CCA).The HL structure was produced by single-step heat treatment(800℃for 1 h)after cold *** HL structure consists of alternative lamellae regions of coarse-grained FCC matrix(5-20μm),and regions containing ultra-fine grains or subgrains(200-500 nm)together with nanoprecipitates(20-500 nm)and annealing *** compared with other cost-effective CCAs,the 800℃annealed sample with HL structure demonstrated a comparable tensile property,with yield strength over 1.0 GPa and total elongation of~13%.Formation of the annealing twins and nanoprecipitates decorated HL structure was a result of the concurrent partial recrystallization and precipitation ofσphase at the shear bands with a high density of lattice defects(***-density dislocation walls and deformation twins).The latter restricted the growth of recrystallized grains,leading to the formation of ultrafine subgrains within the HL *** high yield strength resulted from the multistage hetero-deformation induced(HDI)strengthening and precipitation strengthening associated with heterogeneous lamella structures containing *** ductility was originated from the coexistence of multiple deformation mechanisms,which started with dislocation slip and formation of stacking faults at the initial stage,followed by nano-twinning at the higher strain *** HL design strategy,comprising composition and thermomechanical process designs,and the resultant microstructure tuning,open a broader window for the development of cost-effective CCAs with enhanced performance.

关键词： High entropy alloys Compositionally complicated alloys Heterogeneous lamella structure Nanoprecipitates Recrystallization Mechanical properties

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法布雷病酶替代治疗药物转换1例患者的临床分析

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中华内科杂志 2025年第2期64卷 152-156页

作者：付影张婧刘林陈楠孙祯甫山东省菏泽市立医院肾内科菏泽274000

法布雷病患者通常接受酶替代治疗(ERT)。目前,在国内上市的ERT药物有2种:阿加糖酶α和阿加糖酶β。本文报道了1例36岁的男性法布雷病患者,该患者因家系筛查确诊法布雷病,并已进入慢性肾脏病3期。患者于2022年11月启动ERT,给予阿加糖酶α... 详细信息

法布雷病患者通常接受酶替代治疗(ERT)。目前,在国内上市的ERT药物有2种:阿加糖酶α和阿加糖酶β。本文报道了1例36岁的男性法布雷病患者,该患者因家系筛查确诊法布雷病,并已进入慢性肾脏病3期。患者于2022年11月启动ERT,给予阿加糖酶α10.5 mg(0.2 mg/kg)每2周输注1次,治疗10个月后,血浆脱乙酰基三己糖酰基鞘脂醇(Lyso-GL-3)降低至23.02μg/L,但此后逐渐上升,血肌酐由143μmol/L逐渐升高至187μmol/L,估算肾小球滤过率(eGFR)从53.8 ml·min^(-1)·1.73 m^(-2)降低至38.9 ml·min^(-1)·1.73 m^(-2),患者焦虑情绪明显,疼痛等评分较前增加。综合患者生化指标和临床症状的变化,考虑阿加糖酶α疗效不佳,于2023年11月18日改用高剂量阿加糖酶β65 mg(1.0 mg/kg)每2周输注1次。转换治疗后,患者血浆Lyso-GL-3水平降低并趋于平稳,肾功能稳定,Mainz严重程度评分指数降低。目前继续规律阿加糖酶β(1.0 mg/kg,每2周1次)治疗。通过对该例患者临床特征、两种ERT药物疗效对比等进行归纳总结,为法布雷病患者ERT治疗选择提供参考依据。

关键词：法布雷病阿加糖酶β 阿加糖酶α 生物标志物

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汉英“腮(cheek)”隐喻词簇异同及其体认语言学—文化脚本理据考辨

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江苏师范大学学报(哲学社会科学版) 2025年第1期51卷 34-52,124页

作者：林玲孙毅玉林师范学院外国语学院广西玉林537000 广东外语外贸大学外国语言学及应用语言学研究中心广东广州510420

从本质上说,隐喻是一种认知和思维方式,是从一个认知域向另一个认知域的结构映射,即从“源域”向“靶域”的单向系统投射,是人类认知世界万象的主要工具。身体是人类感知世界、认识世界进而把握世界的起点和基础,是隐喻映射的常备源域,... 详细信息

从本质上说,隐喻是一种认知和思维方式,是从一个认知域向另一个认知域的结构映射,即从“源域”向“靶域”的单向系统投射,是人类认知世界万象的主要工具。身体是人类感知世界、认识世界进而把握世界的起点和基础,是隐喻映射的常备源域,由此产生的身体隐喻贯穿人类认知构建之始终。腮是人体至关重要的面部组织单位,以其为源域生发的腮隐喻在汉英语言中均广泛存在。为探讨分析腮隐喻在汉英两种语言中的使用情况,研究者诉诸CCL、BNC和COCA语料库收集汉英两种语言中的“腮/cheek”隐喻词簇,结合字典释义对比分析所有的表达后发现,汉英“腮/cheek”基于原型器官意象生发了容貌、情绪、关系、疾病、能力与品质共计六大隐喻意象,其中前四种为共有意象,后两种为不同意象,汉英“腮/cheek”隐喻词簇在语言形式、语义范围以及隐喻强度方面体现跨语言差异。该研究结合体认语言学和文化脚本理论探讨这些异同背后的深层次原因,希冀为跨文化理解和交流提供新的视角和参考。

关键词：认知隐喻腮/cheek隐喻汉英对比体认语言学文化脚本

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Transition-metal-free hydroamination/defluorination/cyclization of perfluoroalkyl alkynes with amidines

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Organic Chemistry Frontiers 2022年第1期9卷 109-116页

作者： Li-Wen sun Zi-Lun yu Xin-Long Luo Mengtao Ma Zhi-Liang Shen Xue-Qiang Chu Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China Department of Chemistry and Materials Science College of ScienceNanjing Forestry UniversityNanjing 210037China

An efficient defluorinative net-[3+3]-cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidine derivatives by using a series of perfluoroalkyl alkynes and amidines as starting materials was *** present reaction proceeded successfully under transition-metal-free conditions to form two new C–N bonds and a new heterocyclic ring through a sequence of hydroamination,defluorination,and *** desired pyrimidines could be obtained with good functional group tolerance and moderate to good ***,the distinctive fluorine effects of perfluoroalkyl substituents are vital for tuning the reactivity of alkynes for the anticipated defluorinative *** pendantπsystem would lower associated bond dissociation energy significantly compared to that of a nonactivated C(sp^(3))–F bond.

关键词： cyclization pyrimidine Transition

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线粒体移植治疗肌少症的潜力

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中国组织工程研究 2025年第13期29卷 2842-2848页

作者：李伟尹洪涛孙永晨徐卫娟孙金玲金晓东淄博市中心医院老年医学科山东省淄博市255036 淄博市中心医院神经内科山东省淄博市255036

背景:肌少症是衰老引起的骨骼肌质量和力量下降的一种综合性疾病,是老年人面临的主要健康挑战。越来越多的证据表明,线粒体功能障碍在肌少症的发病机制中起着关键作用。目的:总结线粒体质量控制失调导致肌少症的机制,探讨线粒体移植可... 详细信息

背景:肌少症是衰老引起的骨骼肌质量和力量下降的一种综合性疾病,是老年人面临的主要健康挑战。越来越多的证据表明,线粒体功能障碍在肌少症的发病机制中起着关键作用。目的:总结线粒体质量控制失调导致肌少症的机制,探讨线粒体移植可能是治疗肌少症的潜在靶点。方法:以“sarcopenia,mitochondrial dysfunction,mitochondrial quality control,mitochondrial transplantation,limitations”和“肌少症,线粒体功能障碍,线粒体质量控制,线粒体移植,局限性”为关键词,检索PubMed和CNKI数据库2009-2023年间相关文献。结果与结论:线粒体功能障碍在肌少症发病机制中发挥关键作用,线粒体移植可能通过改善线粒体生物能量学和调节线粒体相关信号通路成为治疗肌少症的可能策略。虽然部分临床前和临床研究证实线粒体移植治疗各种疾病的潜力,但关于线粒体转移的具体细节方面仍有一些亟待解决的问题。

关键词：肌少症线粒体功能障碍线粒体质量控制线粒体移植局限性

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Silver vanadate(Ag_(0.33)V_(2)O_(5))nanorods from Ag intercalated vanadium pentoxide for superior cathode of aqueous zinc-ion batteries

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Rare Metals 2022年第8期41卷 2844-2852页

作者： Zhi-Hao Su Run-Hao Wang Jiong-Hao Huang Rui sun Zhao-Xia Qin yu-Fei Zhang Hao-Sen Fan School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou510006China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou510006China

Silver vanadate(Ag_(0.33)V_(2)O_(5))nanorods were successfully synthesized by the pre-intercalation of Ag+into the interlayer of V_(2)O_(5)through a sol-gel method,which presented a favorable electrochemical performance of high capacity,rate capacity,and cycle *** ally,Ag_(0.33)V_(2)O_(5)electrode presented a high capacity of about 311 mAh·g^(-1)at the current density of0.1 A·g^(-1).It also delivered long-term cycling stability(144 mAh·g^(-1)after 500 cycles at 2 A·g^(-1)).The reasons for the superior electrochemical performance were the preintercalation Ag^+extended interlayer distance,and the introduction of elemental silver improved conductivity during charge/***,the Zn^(2+)storage mechanism was revealed by various characteristic *** prepared Ag_(0.33)V_(2)O_(5)nanorods from the sol-gel method were demonstrated as a promising cathode material for aqueous Zn^(2+)batteries.

关键词： Ag_(0.33)V_(2)O_(5)nanorods Aqueous zinc-ion battery Pre-intercalation Electron and ion transport

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COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response

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Journal of Integrative Plant Biology 2017年第2期59卷 78-85页

作者： peng wang xuan cui chunsheng zhao liyan shi guowei zhang fenglong sun xiaofeng cao li yuan qiguang xie xiaodong xu hebei key laboratory of molecular and cellular biology key laboratory of molecular and cellular biology of ministry of educationcollege of life scienceshebei normal university hebei collaboration innovation center for cell signaling Shijiazhuang 050024China state key laboratory of plant genomics and national center for plant gene research institute of genetics and developmental biologychinese academy of sciencesBeijing 100101China

Summary It was noted that circadian components function in plant adaptation to diurnal temperature cycles and freezing tolerance. Our genome-wide transcriptome analysis revealed that evening-phased COR27 and COR28 mainly repress the transcription of clockassociated evening genes PRRS, ELF4 and cold-responsive genes. Chromatin immunoprecipitation indicated that CCAI is recruited to the site containing EE elements of COR27 and COR28 promoters in a temperaturedependent way. Further genetic analysis shows COR28 is essential for the circadian function of PRR9 and PRRT. Together, our results support a role of COR27 and COR28 as nighttime repressors integrating circadian clock and plant cold stress responses.

关键词： CCA COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response EE Figure

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夜间急诊腹腔镜手术器械的超声波清洗效果及影响因素研究

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局解手术学杂志 2025年第2期34卷 121-124页

作者：孙兵姐蔡雨清袁高峰吴菊花江苏省人民医院宿迁医院消毒供应中心江苏宿迁223800

目的探讨夜间急诊腹腔镜手术器械的超声波清洗效果及影响因素。方法选取超声波清洗的698次夜间急诊腹腔镜手术器械作为研究对象,统计其超声波清洗质量不合格情况,对可能导致超声波清洗质量不合格的因素进行单因素和多因素二元Logisti... 详细信息

目的探讨夜间急诊腹腔镜手术器械的超声波清洗效果及影响因素。方法选取超声波清洗的698次夜间急诊腹腔镜手术器械作为研究对象,统计其超声波清洗质量不合格情况,对可能导致超声波清洗质量不合格的因素进行单因素和多因素二元Logistic回归方程分析。结果夜间急诊腹腔镜手术器械的698次超声波清洗中,共有55次(7.88%)清洗质量不合格。单因素及多因素二元Logistic回归分析结果显示,清洗时距手术结束时间≥10 h、管腔类手术器械、预处理不规范、清洗水质不合格和清洗介质不合格是导致夜间急诊腹腔镜手术器械超声波清洗质量不合格发生的危险因素(OR>1,P<0.05),而手工+超声波清洗为避免夜间急诊腹腔镜手术器械超声波清洗质量不合格发生的保护性因素(OR<1,P<0.05)。结论夜间急诊腹腔镜手术器械的超声波清洗质量不合格率较高,在手术结束后应尽早对其进行清洗,在超声波清洗前,尽量先进行手工清洗,尤其对于难清洗的管腔类手术器械,还应进行规范的预处理、选择合格的清洗水质和介质。

关键词：夜间急诊腹腔镜手术器械超声波清洗影响因素

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Making stereopsis related to the ability of ocular deviation:a new paradigm for assessment of intermittent exotropia

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 308-314页

作者： Jian-Bing Li Wan-Ting Kong Tao Shen Yong-Guang yuan Chong-Lin Chen Dan-Min Peng Min-Tong Liang Xuan He Dan Luo Jia-Yi Su Wei Wang Rui-Xin Wang Xin-Ping yu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510623Guangdong ProvinceChina Department of Ophthalmology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Guangzhou Xinhua University Guangzhou 510520Guangdong ProvinceChina

AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing ***:This was a prospective observational *** evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized *** with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking ***,the correlation of stereopsis were also ***:A total of 48 patients(age range:4-33y;54.17%male)participated in the *** viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at *** scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment *** expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.

关键词： intermittent exotropia stereopsis control ability

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Increased index of microcirculatory resistance in older patients with heart failure with preserved ejection fraction

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Journal of Geriatric Cardiology 2018年第11期15卷 687-694页

作者： Zhuo XU Hui-Ping GU Yang GU Wei sun Kun yu Xi-Wen ZHANG Xiang-Qing KONG Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Cardiology the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical UniversityHuai'an China

Objective To study the coronary microvascular function in older patients with heart failure with preserved ejection fraction (HFpEF) using an invasive pressure–temperature sensor guidewire. Methods Patients undergoing echocardiography and cardiac catheterization examinations for exertional dyspnea and a positive stress test were retrospectively enrolled from January 2014 to November 2017, and were allocated into the control group or HFpEF group. The HFpEF group was secondary divided into two groups according to the age of 65 years. Comparing the clinical features and values obtained in examinations between the three groups, multivariate regression analysis was used to analyze the predictors of left ventricle end diastolic pressure (LVEDP). Results There were 87 patients enrolled in this study. The older HFpEF patients (n = 32) were more likely to be female;and had the most comorbidities, such as diabetes mellitus, atrial fibrillation, and chronic kidney dysfunction (CKD) with a low estimated glomerular filtration rate (eGFR), and had a similar hypertensive prevalence as the adult HFpEF group (n = 24), whose mean LVEDP and index of microcirculatory resistance (IMR) were highest in comparison to the adult HFpEF patients and controls (n = 31). The coronary flow reserve (CFR) in the older HFpEF and adult HFpEF groups was similarly reduced. In the regression analysis, the IMR linearly correlated to LVEDP, and was the only independent predictor of LVEDP. Conclusions An increased IMR and reduced CFR were characteristics of microvascular dysfunction in older HFpEF patients. The IMR independently had a positive linear correlation with LVEDP. Microvascular rarefaction might be a subsequent pathological progression in the development of HFpEF.

关键词： Heart failure Ejection fractions Microcirculatory resistance Microvascular dysfunction

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