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Construction of Circular Economy Industrial System

Chinese Journal of Population,Resources and Environment 2007年第4期5卷 26-30页

作者： cao man ye wenhu Research Center for China Sustainable Development Peking University Beijing 100871 China

It is difficult to realize the transformation from traditional economy industrial system to circular economy industrial system. Regarding primary raw materials as the indicators, the industrial system has been specified according to the divergence among the indicators and the circular utilization modes. In comparison with the association among industrial systems, the relationship among industrial sub-systems is named as industrial cross-linking in this paper. The industrial system which could completely utiLize and recycle the indicators shouM be increased and strengthened, and the circular economy industrial system with complete industrial association and industrial cross-linking should also be constructed. Taking the development of circular agricultural system basing on the traditional agricultural system as an example, the traditional agricultural products are regarded as the indicators which have been divided into foodstuff and crop straws which are used to produce food and articles for use, Like fertilizer, energy and papers etc. The way to construct the circular agricultural industrial system is to increase the industrial systems that could utilize the products generated from crop straws, feces and other castoffs and transform the wastewater and other trucks into environmental friendly products. It has also been pointed out that the construction of circular economy industrial system is conducive to the foundation of circular industrial economics and the establishment of the construction layout of circular economy and the application schemes. Suggestions to the theoretical and practical work of the next step have also been brought forward in this paper.

关键词： circular economy industrial system industrial structure construction

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Thermodynamic Resolution of Pharmaceutical Precursor Modafinil Acid on the Basis of Chiral-at-Metal Strategy

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Chinese Journal of Chemistry 2021年第6期39卷 1483-1490页

作者： man-Li cao Jun-Ling Zhu Zhong-Lan Zhi Bao-Hui ye Su-Yang Yao Xiu-Lian Zhang Department of Chemistry Guangdong University of EducationGuangzhouGuangdong 510303China MOE Key Laboratory of Bioinorgonic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong 510275China

Chiral-at-metal strategy was developed to resolve the essential sulfoxide pharmaceutical intermediates R-modafinil acid and its ana-logues with high yields and ee *** efficient resolution process was achieved based on the diastereoselective discrimination caused by hydrogen bond and intramolecular π-π interaction between chiral-at-metal center and the coordinated chiral sulfoxide ***,the chiral Ir(lll)receptor can be reused with complete retention of their configurations and without the loss of reaction activity and *** work provides a new access to synthesize R-modafinil acid as well as its analogues and develops the application of chiral-at-metal strategy in chiral resolution.

关键词： Chiral resolution Chiral-at-metal complexes Modafinil acid Chiral pharmaceutical Ir(III)complexes

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Synergistic effects of plant hormones on spontaneous late-ripening mutant of'Jinghong'peach detected by transcriptome analysis

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Food Quality and Safety 2022年第1期6卷 68-80页

作者： man Zhang Tingting Du Yarui Yin Hongyan cao Zhihua Song Mao ye Yating Liu Yanhong Shen Libin Zhang Qing Yang Dong Meng Junkai Wu Hebei Normal University of Science and Technology QinhuangdaoChina Hebei Key Laboratory of Horticultural Germplasm Excavation and Innovative Utilization QinhuangdaoChina The College of Forestry Beijing Forestry UniversityBeijingChina Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beiling Forestry UniversityBeilingChina

Objectives:Peach(Prunus persica L.)is an ancient fruit tree that originated from *** is the climacteric fruit belonging to genus Prunus in family ***,which is produced during ripening,accelerates fruit softening,and therefore peaches cannot be stored for a long *** and Methods:To study the mechanism of fruit late ripening,transcriptome analysis of the fruit of a late-ripening mutant of'Jinghong'peach was performed to identify genes and pathways involved in fruit late ***:A total of 1805,1511,and 2309 genes were found to be differentially expressed in W2_vs_M1,W3_vs_M2,and W3_vs_M3,*** enrichment analysis of the differentially expressed genes showed they were related to carotenoid biosynthesis,starch and sucrose metabolism plant hormone signal transduction,flavonoid biosynthesis,and *** expression trends of ripening-related genes that encode transcription factors and plant hormone signal transduction-related genes that encode enzymes were ***:It will help to elucidate the transcriptional regulatory network of fruit development in the spontaneous late-ripening mutant of‘Jinghong’peach and provide a theoretical basis for understanding the molecular regulatory mechanism of fruit ripening.

关键词： Peach late-ripening bud mutation transcriptome analysis plant hormones

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Endoscopic extraction of a submucosal esophageal foreign body piercing into the thoracic aorta:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2484-2490页

作者： Zhi-cao Chen Gui-Quan Chen Xiao-Chun Chen Chang-ye Zheng Wei-Dong cao Gang-Hao Deng Department of Gastroenterology Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina Department of Radiology Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina Department of Cardiovascular Surgery Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina

BACKGROUND Aorto-esophageal injury is a rare but life-threatening complication of esophageal foreign bodies,which typically requires open *** best way to treat patients with this condition remains *** date,few reports have described an aortic wall directly penetrated by a sharp foreign ***,we present a rare case of a fishbone completely embedded in the esophageal muscularis propria and directly piercing the aorta,which was successfully treated by endoscopy and thoracic endovascular aortic repair(TEVAR).CASE SUMMARY We report the case of a 71-year-old man with a 1-d history of retrosternal pain after eating *** abnormal findings were observed by the emergency *** tomography showed a fishbone that had completely pierced through the esophageal mucosa and into the *** patient refused to undergo surgery for personal reasons and was *** days after the onset of illness,he was readmitted to our *** examination showed a nodule with a smooth surface in the middle of the *** ultrasonography confirmed a fishbone under the *** performing TEVAR,we incised the esophageal mucosa under an endoscope and successfully removed the *** patient has remained in good condition for 1 *** Incising the esophageal wall under endoscope and extracting a foreign body after TEVAR may be a feasible option for cases such as ours.

关键词： Endoscopy Esophageal foreign body Esophageal perforation Aortic penetration Case report

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Attenuation of periostin in retinal Müller glia by TNF-α and IFN-γ

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 212-218页

作者： Ying-Qian Peng man-Jing cao Shigeo Yoshida Lu-Si Zhang Hui-Lan Zeng Jing-Ling Zou Yoshiyuki Kobayashi Takahito Nakama Jing-Ming Shi Song-Bai Jia ye-Di Zhou Department of Ophthalmology the Second Xiangya Hospital Central South University Hunan Clinical Research Center of Ophthalmic Disease Department of Ophthalmology Kyushu University Graduate School of Medical Sciences Department of Ophthalmology Kurume University School of Medicine

AIM: To investigate the regulation and mechanisms of periostin expression in retinal Müller glia, and to explore the relevance to retinal neovascularization. METHODS: The oxygen-induced retinopathy(OIR) mouse model and the human Moorfield/Institute of Ophthalmology-Müller 1(MIO-M1) cell line were used in the study. Immunofluorescence staining was used to determine the distribution and expression of periostin and a Müller glial cell marker glutamine synthetase(GS). Cytokines TNF-α and IFN-γ were added to stimulate the MIO-M1 cells. ShRNA was used to knockdown periostin expression in MIO-M1 cells. Quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR) was conducted to assess the mRNA expression of periostin. RESULTS: Immunofluorescence staining showed that periostin was expressed by MIO-M1 Müller glia. GS-positive Müller glia and periostin increased in OIR retinas, and were partially overlaid. The stimulation of TNF-α and IFN-γ reduced the mRNA expression of periostin significantly and dose-dependently in MIO-M1 cells. Knockdown of periostin reduced mRNA expression of vascular endothelial growth factor A(VEGFA) in MIO-M1 cells, while VEGFA expression was not changed in periostin knock-out OIR retinas. CONCLUSION: Müller glia could be one of the main sources of periostin in the retina, and might contribute to the pathogenesis of retinal neovascularization. Proinflammatory cytokines TNF-α and IFN-γ attenuate the periostin expression in retinal Müller glia, which provides a potential and novel method in treating retinal neovascular diseases.

关键词： TNF-α IFN-γ periostin Müller glia retinal neovascularization

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Octreotide-induced acute life-threatening gallstones after vicarious contrast medium excretion:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7484-7489页

作者： Zong-Hong Han Zhong-Ming He Wen-Hua Chen cao-ye Wang Qi Wang Department of Interventional Radiology The First People’s Hospital of ChangzhouChangzhou 213003Jiangsu ProvinceChina

BACKGROUND Octreotide is widely used for the treatment of acromegaly,neuroendocrine tumors,and secretory ***,long-term octreotide treatment can increase the incidence of *** contrast medium excretion(VCME)through the hepatobiliary system is well ***,few studies have reported octreotide-induced acute gallstones following *** SUMMARY A 69-year-old man presented with left lower back pain and hematuria caused by a *** patient had a history of polycystic kidney *** occurred following renal artery embolization for a ruptured polycystic *** 5 d of treatment with octreotide,the patient developed acute gallstones and intrahepatic cholestasis which further induced pancreatitis and *** was discharged after hemodialysis,antibiotics,and supportive *** For patients with a high-risk of VCME,octreotide should be cautiously administered and carefully monitored.

关键词： Octreotide Gallstones Contrast medium Case report

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Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

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Military Medical Research 2024年第5期11卷 625-642页

作者： Meng-Yuan Jiang Wan-Rong man Xue-Bin Zhang Xiao-Hua Zhang Yu Duan Jie Lin Yan Zhang Yang cao De-Xi Wu Xiao-Fei Shu Lei Xin Hao Wang Xiao Zhang Cong-ye Li Xiao-Ming Gu Xuan Zhang Dong-Dong Sun Department of Cardiology Xijing HospitalAir Force Medical UniversityXi’an710032China Department of Basic Medicine Air Force Medical UniversityXi’an710032China Department of Physiology and Pathophysiology Air Force Medical UniversityXi’an710032China Institute for Hospital management Research Chinese PLA General HospitalBeijing100853China

Background Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, which impairs myocardial function. Adipsin may play an important protective role in the pathogenesis of DCM. The aim of this study is to investigate the regulatory effect of Adipsin on DCM lipotoxicity and its molecular *** high-fat diet (HFD)-induced type 2 diabetes mellitus model was constructed in mice with adipose tissue-specific overexpression of Adipsin (Adipsin-Tg). Liquid chromatography-tandem mass spectrometry (LC–MS/MS), glutathione-S-transferase (GST) pull-down technique, Co-immunoprecipitation (Co-IP) and immunofluorescence colocalization analyses were used to investigate the molecules which can directly interact with Adipsin. The immunocolloidal gold method was also used to detect the interaction between Adipsin and its downstream *** expression of Adipsin was significantly downregulated in the HFD-induced DCM model (P < 0.05). Adipose tissue-specific overexpression of Adipsin significantly improved cardiac function and alleviated cardiac remodeling in DCM (P < 0.05). Adipsin overexpression also alleviated mitochondrial oxidative phosphorylation function in diabetic stress (P < 0.05). LC–MS/MS analysis, GST pull-down technique and Co-IP studies revealed that interleukin-1 receptor-associated kinase-like 2 (Irak2) was a downstream regulator of Adipsin. Immunofluorescence analysis also revealed that Adipsin was co-localized with Irak2 in cardiomyocytes. Immunocolloidal gold electron microscopy and Western blotting analysis indicated that Adipsin inhibited the mitochondrial translocation of Irak2 in DCM, thus dampening the interaction between Irak2 and prohibitin (Phb)-optic atrophy protein 1 (Opa1) on mitochondria and improving the structural integrity and function of mitochondria (P < 0.05). Interestingly, in

关键词： Diabetic cardiomyopathy Mitochondrial translocation Mitochondrial function Fatty acidβ-oxidation

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Human parvovirus B19-associated early postoperative acquired pure red cell aplasia in simultaneous pancreas-kidney transplantation:A case report

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World Journal of Clinical Cases 2021年第8期9卷 1968-1975页

作者： Hui Wang Ying-Xin Fu Wen-Li Song Zhen Wang Gang Feng Jie Zhao ye-Qi Nian Yu cao Department of Kidney and Pancreas Transplant Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Acquired pure red cell aplasia(aPRCA)related to human parvovirus B19(HPV B19)is rarely reported in simultaneous pancreas-kidney transplantation(SPKT)recipients;there has yet to be a case report of early postoperative *** this current study,we report the case of a Chinese patient who experienced the disease in the early postoperative *** SUMMARY A 63-year-old man,with type 2 diabetes and end-stage renal disease,received a brain dead donor-derived *** treatment consisted of tacrolimus,prednisone,enteric-coated mycophenolate sodium(EC-MPS),and thymoglobulin combined with methylprednisolone as *** hemoglobin(Hb)level declined due to melena at postoperative day(POD)3,erythropoietinresistant anemia persisted,and reticulocytopenia was diagnosed at POD *** bone marrow aspirate showed decreased erythropoiesis and the presence of giant pronormoblasts at POD *** next-generation sequencing(mNGS)of a blood sample identified HPV B19 infection at POD ***-MPS was withdrawn;three cycles of intravenous immunoglobulin(IVIG)infusion therapy were administered;and tacrolimus was switched to *** HPV B19-associated aPRCA resolved completely and did not relapse within the 1-year follow-up *** diminution in mNGS reads was correlated with Hb and reticulocyte count *** HPV B19-associated aPRCA can occur at an early period after *** effective therapy regimen includes IVIG infusion and adjustment of the immunosuppressive ***,mNGS can be used for the diagnosis and to reflect disease progression.

关键词： Anemia Human parvovirus B19 Intravenous immunoglobulin Metagenomic Next-generation sequencing Pancreas transplantation Case report

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Creutzfeldt-Jakob disease presenting as Korsakoff syndrome caused by E196A mutation in PRNP gene:A case report

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World Journal of Clinical Cases 2023年第25期11卷 5982-5987页

作者： Yong-Kang Zhang Jia-Rui Liu Kang-Li Yin Yuan Zong Yu-Zhen Wang ye-Min cao Diagnosis and Treatment Center of Vascular Disease Shanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China

BACKGROUND Prion diseases are a group of degenerative nerve diseases that are caused by infectious prion proteins or gene *** humans,prion diseases result from mutations in the prion protein gene(PRNP).Only a limited number of cases involving a specific PRNP mutation at codon 196(E196A)have been *** coexistence of Korsakoff syndrome in patients with Creutzfeldt-Jakob disease(CJD)caused by E196A mutation has not been documented in the existing *** SUMMARY A 61-year-old Chinese man initially presented with Korsakoff syndrome,followed by rapid-onset dementia,visual hallucinations,akinetic mutism,myoclonus,and *** patient had no significant personal or familial medical *** resonance imaging of the brain revealed extensive hyperintense signals in the cortex,while positron emission tomography/computed tomography showed a diffuse reduction in cerebral cortex *** biochemical and microorganism testing of the cerebrospinal fluid(CSF)yielded normal *** for thyroid function,human immunodeficiency virus,syphilis,vitamin B1 and B12 levels,and autoimmune rheumatic disorders were *** and CSF tests for autoimmune encephalitis and autoantibody-associated paraneoplastic syndrome yielded negative results.A test for 14-3-3 protein in the CSF yielded negative ***-genome sequencing revealed a diseasecausing mutation in *** patient succumbed to the illness 11 months after the initial symptom *** Korsakoff syndrome,typically associated with alcohol intoxication,also manifests in CJD *** with CJD along with PRNP E196A mutation may present with Korsakoff syndrome.

关键词： Prion disease Creutzfeldt-Jakob disease Korsakoff syndrome PRNP gene 14-3-3 proteins Case report

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循环经济产业体系论纲

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中国人口·资源与环境 2006年第3期16卷 48-50页

作者：曹曼叶文虎北京大学中国持续发展研究中心北京100871

循环经济的核心是物质在产业间和产业与环境间的循环流动,发展循环经济要落实到具体的产业和企业上,需搞清具有物质循环利用关系的产业及其间的关系。为区别传统经济产业间的关系,避免走入用传统产业理论指导循环经济建设的误区,本文提... 详细信息

循环经济的核心是物质在产业间和产业与环境间的循环流动,发展循环经济要落实到具体的产业和企业上,需搞清具有物质循环利用关系的产业及其间的关系。为区别传统经济产业间的关系,避免走入用传统产业理论指导循环经济建设的误区,本文提出产业体系和循环经济产业体系的概念,并将若干与某种生产要素有关的产业相互联系、相互制约而构成的整体称为产业体系,以物质要素循环利用关系为纽带的产业体系称为循环经济产业体系。根据物质在环境社会系统中的流动模式,将循环经济产业体系中的产业分成物资产业、人的产业和环境产业三大类。要在传统(线性)经济的基础上发展循环经济,需理性地按生态学原理规范经济活动,重点强化废弃物再生和回用的环境产业,使之同物资产业和人的产业相协调。产业体系是对产业结构概念的发展,循环经济产业体系是循环经济理论和建设的重要内容,构建循环经济理论体系、出台有关法律法规和产业政策,是循环经济建设工作的重点。

关键词：产业体系循环经济组成形成机理

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