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MOF-based magnetic microrobot swarms for pH-responsive targeted drug delivery

Science China Chemistry 2024年第4期67卷 1216-1223页

作者： Qinyi cao Yifan Zhang Yanping Tang Changjin Wu jizhuang Wang Dan Li College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital)Jinan UniversityHeyuan 517000China jNU-HKUST joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou 510632China Department of Chemistry The University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)hold significant potential as vehicles for drug delivery due to their expansive specific surface area,biocompatibility,and versatile ***,magnetically actuated micro/nano-robots(MNRs)offer distinct advantages,such as untethered and precise *** fusion of these technologies presents a promising avenue for achieving non-invasive targeted drug ***,we report a MOF-based magnetic microrobot swarm(MMRS)for targeted *** approach overcomes limitations associated with a single MNR,including limited drug loading and the risk of loss during *** select Zeolitic Imidazolate Framework-8(ZIF-8)as the drug vehicle for its superior loading potential and p H-sensitive *** design incorporates magnetic responsive components into the one-pot synthesis of Fe@ZIF-8,enabling collective behaviors under *** the yaw angle of alternating magnetic fields and nanoparticles'amount,the MMRSs with controllable size achieve instantaneous transformation among different configurations,including vortex-like swarms,chain-like swarms,and elliptical swarms,facilitating adaptation to environmental *** to the subcutaneous T24 tumor site,the MMRSs with encapsulated doxorubicin(DOX)automatically degrade and release the drug,leading to a dramatic reduction of the tumor in *** investigation signifies a significant advancement in the integration of biodegradable MOFs into microrobot swarms,ushering in new avenues for accurate and non-invasive targeted drug delivery.

关键词： magnetic microrobot swarm MOF nanoparticles magnetic propulsion pH-responsive drug release targeted drug delivery

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Fabrication of Molecularly Imprinted Electrospun Nanofibers with Mono-amidoxime Functional Ligand for Efficient Decontamination of Toxic Organophosphates

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Chinese journal of Polymer Science 2024年第4期42卷 446-456页

作者： Lan Wang Peng jiang Ya-Lin Niu jun-Peng cao Tian-Ying Guo Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of Chemistry and Frontier Science Center for the Creation of New Organic SubstancesNankai UniversityTianjin300071China

There is an urgent imperative to discover practical and efficacious artificial catalysts for the expeditious decontamination of toxic organophosphates. Herein, we propose a novel molecularly imprinted approach utilizing electrospun fiber scaffolds. Specifically, an amidoxime-based functional polymer (PMAOX) has been synthesized, which contains amidoxime groups that can act as nucleophiles and ligands for the formation of catalytic active sites. This polymer was blended with polyacrylonitrile (PAN), a well-processable material, to prepare a nanofiber mat using electrospinning techniques. Then, the amidoxime side groups on fiber surface were further cross-linked after the molecular coordination of templates to complete the molecularly imprinting process. This approach can not only enhance the content of functional molecularly imprinted polymers without affecting structural stability, but also combines surface MI technology to fully expose and leverage the advantages of active sites. The as prepared molecularly imprinted electrospun nanofibers MIF-Zn-PMAOX/PAN-6/4 catalyzes the degradation of paraoxon with a half-life of 32 min, and MIF-Ag-PMAOX/PAN catalyzes the degradation of parathion with a half-life of 18 min. The maximum catalytic rate evidence rate enhancements nearly 3700-fold of the self-hydrolysis. Thus, the mono-amidoxime based molecularly imprinted fibers demonstrate the versatility and superiority as self-detoxifying for organophosphates.

关键词： Organophosphateshydrolysis Electrospinning Molecular imprinting

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ELECTROCHEMICAL NOISE ANALYSIS OF PURE ALUMINUM IN SODIUM CHLORIDE SOLUTION WITH WAVELET TRANSFORM TECHNIQUE

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Acta Metallurgica Sinica(English Letters) 2002年第3期15卷 272-278页

作者： Z. Zhang, Q.D. Zhong, j.Q. Zhang, Y.L. Cheng, F.H. cao, j.M. and C.N. caoDepartment of Chemistry, Zhejiang University, Hangzhou 310027, ChinaElectrochemical Research Group, Shanghai University of Electric Power, Shanghai 200090, ChinaState Key Laboratory Dept. of Chem. Zhejiang Univ. Hangzhou 310037 China

Wavelet transforms (WT) are proposed as an alternative tool to overcome the limitations of Fourier transforms (FFT) in the analysis of electrochemical noise (EN) data. The most relevant feature of this method of analysis is its capability of decomposing electrochemical noise records into different sets of wavelet coefficients, which contain information about the time scale characteristic of the associated corrosion event. In this context, the potential noise fluctuations during the free corrosion of pure aluminum in sodium chloride solution was recorded and analyzed with wavelet transform technique. The typical results showed that the EN signal is composed of distinct type of events, which can be classified according to their scales, i.e. their time constants. Meanwhile, the energy distribution plot (EDP) can be used as 'fingerprints' of EN signals and can be very useful for analyzing EN data in the future.

关键词： electrochemical noise wavelet analysis Fourier transforms corrosion pure aluminum

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陶行知博雅教育思想及其对师范生培养的启示

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河北师范大学学报（教育科学版） 2016年第5期18卷 85-89页

作者：曹子建成都师范学院党委办四川成都611130

陶行知先生的教育思想博大精深,富含深邃的博雅教育内容。他把仁爱之心看成是教师德性养成的前提和归宿;把求真务实视为教师人格完美和立德行事的基本原则;把追求远大抱负当作教师需要谨记的信条;把提升教育者创新精神与实践能力作为改... 详细信息

陶行知先生的教育思想博大精深,富含深邃的博雅教育内容。他把仁爱之心看成是教师德性养成的前提和归宿;把求真务实视为教师人格完美和立德行事的基本原则;把追求远大抱负当作教师需要谨记的信条;把提升教育者创新精神与实践能力作为改革教育的突破口。这对当前的师范生培养具有重要的现实意义与启示。

关键词：陶行知师范生师德教师教育

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THE SUPERPLASTICITY AND DEFORMATION MECHANISM OF ULTRALIGHT BINARY Mg-8wt%Li ALLOY

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Acta Metallurgica Sinica(English Letters) 1997年第6期10卷 527-530页

作者： F.R. cao and j.Z. Cui(Department of Metalforming,P.O.B 317, Northeastern University, Shenyang 110006, China)

The maximum elongation-to-failure of 960% has been achieved in the Mg-8wt%Li alloy. It is shown by measurement of true stress-strain curve and microstructure observation that dynamic recrystallization takes place during superplastic deformation, which turns the banded grains into equiaxed grains. It is postulated by theoretical analysis that during superplastic deformation,continuous introduction of lattice dislocations into the phase interfaces contributes to the superplasticity in this *** superplastic deformation,grain growth and cavity nucleation at α phase grain boundaries have also been observed.

关键词： superplasticity magnesium-lithium alloy dynamic recrystallization grain growth cavity

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Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： jian Wang jie Chen Yaofeng Mao Yongjun Deng Wei cao Fude Nie jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical ***,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 j/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/B/Al/PTFE 3D microspheres Surface etching Reaction mechanism

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Spatial and Seasonal Variations of Mass and Chemical Composition for PM10 in Xi'an,China

Spatial and Seasonal Variations of Mass and Chemical Composi...

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十一届全国气溶胶会议暨第十届海峡两岸气溶胶技术研讨会

作者： T.Zhang j.j.cao S.X.Liu S.X.Yang SKLLQG Institute of Earth EnvironmentChinese Academy of Sciences Institute of Global Environmental Change Xi’an Jiaotong University

PM10 samples were simultaneously collected in six sampling sites during spring, summer, autumn and winter in 2010, and then their chemical composition, including elements of Ti, Mn, Fe, Zn, As and Pb, water-soluble inorganic ions of Na+, NH4+, K+, Mg2+, Ca2+, Cl-, NO3-, and SO42-, organic carbon(OC), and element carbon(EC), were determined to evaluate the PM10 levels and their chemical characteristics in Xi’an. The annual mean value of PM10 mass concentration was 302.6 μg m-3 at Shengzhengfu site(north)、293.1 μg m-3 at Weidianji site(western)、266.3 μg m-3 at Dihuansuo site(south)、223.7 μg m-3 at Chanba site(eastern) and 254.9 μg m-3 at Gaolin site(upwind zone)、211.1 μg m-3 at Heihe site(downwind zone). The CD values calculated for the urban and background stations were 0.25, 0.20, 0.17 and 0.22 during spring, summer, autumn, and winter, respectively. Low CD values reflect the similarities in the composition of the aerosol between sites. The PMF results revealed that construction dust(22.7%) contributed significantly to the detected PM10 mass, followed by secondary aerosol(22.3%), motor vehicle(18.3%), coal combustion(17.8%), soil dust(13.1%) and biomass burning(5.8%) at the urban site.

关键词： PM10 chemical composition mass balance

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北京的绿色宣言

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中国体育（中英文版） 2002年第10期 14-19页

作者： j.j.cao

Beijing Organizing Committee of the 2008 Olympic Games (BOCOG) released a draft of the Ecological Environment Protection Plan on September *** Ecological Environment Protection Plan, a part of the "Beijing Olympic Action Plan", will serve as the guideline for the city's environmental development in the next six *** draft plan, which is composed of six parts, is subject to public opinions In the following month, said BOCOG. BOCOG will revise the draft in accordance with the public opinionsand the...

关键词： II

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Improved forecasting via physics-guided machine learning as exemplified using“21·7”extreme rainfall event in Henan

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Science China Earth Sciences 2024年第5期67卷 1652-1674页

作者： Qi ZHONG Zhicha ZHANG Xiuping YAO Shaoyu HOU Shenming FU Yong cao Linguo jING China Meteorological Administration Training Center Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Zhejiang Meteorological Observatory Hangzhou 310017China Hebei Provincial Weather Modification Center Shijiazhuang 050020China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China National Meteorological Center Beijing 100081China School of Computer Science Chengdu University of Information TechnologyChengdu 610225China

As a natural disaster,extreme precipitation is among the most destructive and influential,but predicting its occurrence and evolution accurately is very challenging because of its rarity and *** the example of the“21·7”extreme precipitation event(17–21 july 2021)in Henan Province,this study explores the potential of using physics-guided machine learning to improve the accuracy of forecasting the intensity and location of extreme *** physics-guided ways of embedding physical features,fusing physical model forecasts and revised loss function are used,i.e.,(1)analyzing the anomalous circulation and thermodynamical factors,(2)analyzing the multi-model forecast bias and the associated underlying reasons for it,and(3)using professional forecasting knowledge to design the loss function,and the corresponding results are used as input for machine learning to improve the forecasting *** results indicate that by learning the relationship between anomalous physical features and heavy precipitation,the forecasting of precipitation intensity is improved significantly,but the location is rarely adjusted and more false alarms *** reasons for this are as *** anomalous features used here mainly contain information about large-scale systems and factors which are consistent with the model precipitation deviation;moreover,the samples of extreme precipitation are sparse and so the algorithm used here is ***,by combining“good and different”multi models with machine learning,the advantages of each model are extracted and then the location of the precipitation center in the forecast is improved ***,by combining the appropriate anomalous features with multi-model fusion,an integrated improvement of the forecast of the rainfall intensity and location is ***,this study is a novel exploration to improve the refined forecasting of heavy precipitation with extreme intensity and high variability,

关键词： Extreme precipitation event Refined assessment Anomalous physical features Multi-model fusion Machine learning

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Engineering hierarchical quaternary superstructure of an integrated MOF-derived electrode for boosting urea electrooxidation assisted water electrolysis

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Green Energy & Environment 2024年第4期9卷 695-701页

作者： jianjun Tian Changsheng cao Yingchun He Muhammad Imran Khan Xin-Tao Wu Qi-Long Zhu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences(CAS)Fuzhou350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China University of Chinese Academy of Sciences Beijing100049China Research Institute of Sciences and Engineering(RISE) University of SharjahSharjah27272United Arab Emirates

Controllable design of the catalytic electrodes with hierarchical superstructures is expected to improve their electrochemical ***,a self-supported integrated electrode(NiCo-ZLDH/NF)with a unique hierarchical quaternary superstructure was fabricated through a self-sacrificing template strategy from the metal–organic framework(Co-ZIF-67)nanoplate arrays,which features an intriguing well-defined hierarchy when taking the unit cells of the NiCo-based layered double hydroxide(NiCo-LDH)as the primary structure,the ultrathin LDH nanoneedles as the secondary structure,the mesoscale hollow plates of the LDH nanoneedle arrays as the tertiary structure,and the macroscale three-dimensional frames of the plate arrays as the quaternary ***,the distinctive structure of NiCo-ZLDH/NF can not only accelerate both mass and charge transfer,but also expose plentiful accessible active sites with high intrinsic activity,endowing it with an excellent electrochemical performance for urea oxidation reaction(UOR).Specially,it only required the low potentials of 1.335,1.368 and 1.388 V to deliver the current densities of 10,100 and 200 mA cm^(-2),respectively,much superior to those for typical *** NiCo-ZLDH/NF as the bifunctional electrode for both anodic UOR and cathodic HER,an energy-saving electrolysis system was further explored which can greatly reduce the needed voltage of 213 mV to deliver the current density of 100 mA cm^(-2),as compared to the conventional water electrolysis system composed of *** work manifests that it is prospective to explore the hierarchically nanostructured electrodes and the innovative electrolytic technologies for high-efficiency electrocatalysis.

关键词： Hierarchical superstructures Metal–organic frameworks Layered double hydroxides Urea oxidation reaction Hydrogen evolution reaction

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