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Survey of hepatitis b virus infection for liver cancer screening in China:A population-based,cross-sectional study

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Chinese Medical Journal 2024年第12期137卷 1414-1420页

作者： Yongjie Xu Changfa Xia He Li Maomao cao Fan Yang Qianru Li Mengdi cao Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Office of National Cancer regional Medical Centre in Liaoning Province The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China

background:Hepatitis b virus(HbV)infection is the primary cause of hepatocellular carcinoma(HCC)in *** target population for HCC screening comprises individuals who test positive for hepatitis b surface antigen(HbsAg).However,current data on the prevalence of HbV infection among individuals who are eligible for HCC screening in China are *** aimed to assess the seroepidemiology of HbV infection among Chinese individuals eligible for HCC screening to provide the latest evidence for appropriate HCC screening strategies in ***:Questionnaires including information of sex,age,ethnicity,marital status,educational level,source of drinking water,as well as smoking and alcohol consumption history and serum samples were collected from females aged 45-64 years and males aged 35-64 years in 21 counties from 4 provinces in eastern and central China between 2015 and ***-linked immunosorbent assay methods were used to detect the serum HbV marker ***:A total of 603,082 individuals were enrolled,and serum samples were collected for analysis from January 1,2015 to December 31,*** prevalence of HbsAg positive in the study population was 5.23%(31,528/603,082).The prevalence of HbsAg positive was greater in males than in females(5.60%[17,660/315,183]vs 4.82%[13,868/287,899],χ^(2)=187.52,Prly participants exhibited a greater prevalence of HbV infection than younger participants(χ^(2)=41.73,Pbirth cohort analysis revealed an overall downward trend in HbV prevalence for.b.th males and *** born in more recent cohorts exhibited a lower prevalence of HbV infection as compared to those born ***:The current prevalence of HbV infection remains above 5%in populations eligible for HCC screening in *** efforts should be made to increase the accessibility of HCC screening among individuals with HbV infection.

关键词： Hepatitis b virus Liver cancer screening China Hepatitis b surface antigens Early detection of cancer

Construct a 3D microsphere of HMX/b/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： Jian Wang Jie Chen Yaofeng Mao Yongjun Deng Wei cao Fude Nie Jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(b),severely limit their practical ***,multi-component 3D microspheres of HMX/b/Al/PTFE(HbA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HbA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HbA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HbA-P).Meanwhile,HbA also shows enhanced energy output and reactivity than 3D microspheres of HMX/b/PTFE(Hb)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HbA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and b_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/b/Al/PTFE 3D microspheres Surface etching reaction mechanism

b-COPNA resin formation from ethylene tar light fractions:Process development and mechanical exploration by molecular simulation

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Chinese Journal of Chemical Engineering 2024年第6期70卷 118-129页

作者： Hongyan Shen Lingrui Cui Xingguo Wei Yuanqin Zhang Lian Cen Jun Xu Fahai cao Engineering research Center of Large Scale reactor East China University of Science and TechnologyShanghai 200237China

An efficient utilization strategy of ethylene tar(ET),the main by-product of the ethylene cracking unit,is urgently required to meet demands for modern petrochemical *** the other hand,condensed polynuclear aromatic resin of moderate condensation degree(b-COPNA)is a widely used carbon material due to its superb processability,the production of which is,however,seriously limited by the high cost of raw *** such context,an interesting strategy was proposed in this study for producing b-COPNA resin using crosslinked light fractions of ethylene tar(ETLF,boiling pointby molecular simulation.1,4-benzenedimethanol(PXG)was first selected as the crosslinking agent according to the findings of molecular *** effects of operating conditions,including reactions temperature,crosslinking agent,and catalyst content on the softening point and yield of b-COPNA resin products were then investigated to optimize the *** reaction mechanism of resin production was studied by analyzing the molecular structure and transition state of ETLF and crosslinking *** was shown that PXG exhibited a superior capacity of withdrawing electrons and a higher electrophilic reactivity than other crosslinking *** addition to the highest yield and greatest heat properties,PXG-prepared resin contained the most condensed *** corresponding optimized conditions of resin preparation were 180℃,1:1.9(PXG:ETLF),and 3%(mass)of catalyst content with a resin yield of 78.57%.It was the electrophilic substitution reaction that occurred between the ETLF and crosslinking agent molecules that were responsible for the resin formation,according to the experimental characterization and molecular ***,it was confirmed that the proposed strategy and demonstrated process can achieve a clean and high value-added utilization of ETLF via b-COPNA resin preparation,bringing huge economic value to the current petrochemical industry.

关键词： Ethylene tar Crosslinking COPNA resin Molecular simulation Transient state

reevaluation by the CrISPr/Cas9 knockout approach revealed that multiple pluripotency-associated lncrNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit

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Science China Life Sciences 2024年第10期67卷 2198-2212页

作者： Zhen Li Xuefei Li Jingxia Lin Yangming Wang Huiqing cao Jiajian Zhou Institute of Molecular Medicine College of Future TechnologyPeking University Dermatology Hospital Southern Medical University beijing Advanced Center of rNA biology (bEACON) Peking University

Many long noncoding rNAs(lncrNAs) have been identified through sirNA-based screening as essential regulators of embryonic stem cell(ESC) pluripotency. However, the biological and molecular functions of most lncrNAs remain unclear. Here, we employed CrISPr/Cas9-mediated knockout technology to explore the functions of 8 lncrNAs previously reported to promote pluripotency in mouse ESCs. Unexpectedly, all of these lncrNAs were dispensable for pluripotency maintenance and proliferation in mouse ESCs when disrupted individually or in combination. Single-cell transcriptomic analysis also showed that the knockout of these lncrNAs has a minimal impact on pluripotency gene expression and cell identity. We further showed that several small hairpin rNAs(shrNAs) previously used to knock down lncrNAs caused the downregulation of pluripotency genes in the corresponding lncrNA-knockout ESCs, indicating that off-target effects likely responsible for the pluripotency defects caused by these shrNAs. Interestingly, linc1343-knockout and linc1343-knockdown ESCs failed to form cystic structures and exhibited high expression of pluripotency genes during embryoid body(Eb) differentiation. by reintroducing rNA products generated from the linc1343 locus, we found that two snorNAs, Snora73a and Snora73b, but not lncrNAs, could rescue pluripotency silencing defects during Eb differentiation of linc1343 knockout ESCs. Our results suggest that the 8 previously annotated pluripotency-regulating lncrNAs have no overt functions in conventional ESC culture; however, we identified snorNA products derived from an annotated lncrNA locus as essential regulators for silencing pluripotency genes.

关键词： long noncoding rNAs embryonic stem cells CrISPr/Cas9 snorNAs stem cell differentiation

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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κb Signaling Pathway

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Current Medical Science 2024年第1期44卷 232-240页

作者： Zhi-bin ZHU Meng-jie LIU Jing WANG Zhou SHU Jie cao Department of Stomatology Chengdu Seventh People's HospitalChengdu 610044China Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune ***,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain *** study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in *** In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κb(NF-κb)pathway components was measured using qrT-PCr and Western *** in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating *** SC significantly blocked the activation of NF-κb signaling in TNF-α-stimulated HaCaT *** addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse *** reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin *** The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.

关键词： secoemestrin C(SC) psoriasis tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kb(NF-kb) inflammation

Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles

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Food Science and Human Wellness 2024年第3期13卷 1303-1310页

作者： Qile Xia Yan Liang Ailing cao Yan cao Luyun Cai Key Laboratory of Post-Harvest Handling of Fruits Food Science InstituteZhejiang Academy of Agricultural SciencesHangzhou 310021China Ningbo research Institute College of Biosystems Engineering and Food ScienceZhejiang UniversityNingbo 315100China School of biological and Chemical Engineering Zhejiang Engineering Research Center for Intelligent Marine Ranch EquipmentNingboTech UniversityNingbo 315100China College of Food Science and Engineering Bohai UniversityJinzhou 121013China Hangzhou Customs District Hangzhou 310007China

In this paper,tannic acid(TA)and Fe~(3+)were added to form a layer of metal-polyphenol network structure on the surface of the nanoparticles which were fabricated by zein and carbon quantum dots(CQDs)encapsulating phlorotannins(PTN).pH-responsive nanoparticles were prepared successfully(zein-PTN-CQDs-Fe-~Ⅲ).Further,the formation of composite nanoparticles was confirmed by a series of characterization *** zeta-potential and Fourier transform infrared spectroscopy data proved that electrostatic interaction and hydrogen bonding are dominant forces to form *** encapsulation efficiency(EE)revealed that metal-polyphenol network structure could improve the EE of *** analysis and differential scanning calorimetry experiment indicated the thermal stability of zein-PTN-CQDs-Fe~Ⅲnanoparticles increased because of metal-polyphenol network *** pH-responsive nanoparticles greatly increased the release rate of active substances and achieved targeted release.

关键词： Metal Phlorotannins Nanoparticles pH-responsive Characterization

Stromal cell decidualization and embryo implantation: a vulner.b.e step leading to successful pregnancy

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reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang Sudini r.Fernando Suranga P.Kodithuwakku Dandan cao William S.b.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell rNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation recurrent pregnancy loss repeated implantation failure

Adsorption limitation investigation on olefins for Cu–bTC

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Friction 2024年第4期12卷 606-617页

作者： Xiao YANG Yunbo WANG Weihua cao ruizheng JIANG Guoxin XIE Yuying cao Xiaowen QI School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Key Laboratory of Self-Lubricating Spherical Plain bearing Technology of Hebei Province Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Tr.b.logy in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Aviation Key Laboratory of Science and Technology on Generic Technology of Self-Lubricating Spherical Plain bearing Yanshan UniversityQinhuangdao 066004China

To utilize Cu-benzene-1,3,5-tricarboxylate(Cu-bTC)adsorbed lubricant oils in the self-lubricating field,the adsorption properties of Cu-bTC on different 1-olefins must be *** this work,1-hexene,1-octene,1-nonene,1-decene,1-undecene,and 1-dodecene were studied by the Monte Carlo method and *** adsorption limit of Cu-bTC for n-olefins was determined as 1-undecene by the adsorption *** suggested a limit for even straight-chain molecules to the adsorption of *** maximum ratio of the olefin length of the largest pore diameter(L/D)of Cu-bTC was approximately ***,theoretical calculations(radial distr.b.tion function(rDF))and experiments(infrared(Ir)spectra)confirmed the interaction of n-olefin adsorbates and the Cu-bTC framework occurred between the-CH=of olefins and the Cu and O atoms of the Cu-bTC *** work adds to the understanding and investigation of the adsorption of liquid lubricants using Cu-bTC as a metal-organic framework(MOF).

关键词： metal-organic framework(MOF) Cu-benzene-1,3,5-tricarboxylate(Cu-bTC) Monte Carlo method adsorption properties 1-olefins

Primary anaplastic lymphoma kinase-positive large b-cell lymphoma of the left bulbar conjunctiva: A case report

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World Journal of Clinical Cases 2024年第3期12卷 657-664页

作者： Xiao-Hong Guo Chu-bin Li Hui-Hui cao Gen-Yuan Yang Department of Pathology Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000Guangdong ProvinceChina Endoscopy Center Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000Guangdong ProvinceChina

bACKGrOUND Anaplastic lymphoma kinase(ALK)-positive large b-cell lymphoma(LbCL)is an aggressive and rare variant of diffuse ***,we report an uncommon case of stage IE extranodal ALK-positive LbCL initially originating in the bulbar *** SUMMArY A 63-year-old woman presented with a mass in the left bulbar conjunctiva that had persisted for six months,accompanied by swelling and pain that had per-sisted for 3 *** examination revealed an 8 mm slightly elevated pink mass in the lower conjunctival sac of the left ***,the tumor was com-posed of large immunoblastic and plasmablastic large lymphoid cells with scattered anaplastic or multinucleated large ***,the neoplastic cells were positive for ALK,CD10,CD138,Kappa,MUM1,bOb.1,OCT-2,CD4,CD45,EMA,CD79a,CD38,and AE1/AE3,and negative for CD20,PAX5,Lambda,bCL6,CD30 and all other T-cell *** results of gene rearrangement tests showed monoclonal IGH/IGK/IGL and TCrD *** in situ hybridization studies did not reveal any bCL2,bCL6 or MYC ***,Epstein-barr virus was not detected by in situ hybridization in the *** on the histopathological and imaging examinations,the neoplasm was classified as stage IE ALK-positive *** further treatments were *** the 6,15,and 21 mo postoperative follow-up visits,the patient was in good condition,without obvious *** case represents the first example of primary extranodal ALK-positive LbCL presenting as a bulbar conjunctival mass,which is extremely rare and shares morphological and immunohistochemical features with a variety of other neo-plasms that can result in *** Awareness of the condition presented in this case report is necessary for early and accurate diagnosis and appropriate treatment.

关键词： Anaplastic lymphoma kinase Large b-cell lymphoma Conjunctiva Immunoglobulin/T-cell receptor gene Immunohistochemistry Case report