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FRONTIERS OF MEDICINE 2024年第4期18卷 752-756页

作者： Chen, Yihui cao, qiaozhi Peng, Cong Zhou, Bingjing Jiang, Yu Chen, Xiang Li, Jie Cent South Univ Xiangya Hosp Dept Dermatol Changsha 410008 Peoples R China Cent South Univ Xiangya Hosp Hunan Key Lab Skin Canc & Psoriasis Changsha 410008 Peoples R China Cent South Univ Xiangya Hosp Natl Clin Res Ctr Geriatr Disorders Changsha 410008 Peoples R China Furong Lab Changsha 410008 Peoples R China

Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China

关键词： DOUBLE-BLIND PLACEBO ADOLESCENTS ABROCITINIB ADULTS

止痒消疹颗粒联合第2代抗组胺药治疗慢性荨麻疹的临床疗效

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中南大学学报（医学版） 2024年第2期49卷 175-181页

作者：张丽杨波曹巧芝彭聪陈明亮粟娟陈翔李捷中南大学湘雅医院皮肤病医院(皮肤科) 长沙410008 国家老年疾病临床医学研究中心(湘雅医院) 长沙410008 芙蓉实验室长沙410008 中南大学湘雅医院中医科长沙410008

目的:慢性荨麻疹呈反复发作的慢性经过,其一线用药为第2代抗组胺药,治疗选择有限,且抗组胺药的疗效存在个体差异,并不能满足所有患者的需求。本研究旨在探索止痒消疹颗粒联合抗组胺药治疗慢性荨麻疹患者的临床疗效和安全性。方法:回顾... 详细信息

目的:慢性荨麻疹呈反复发作的慢性经过,其一线用药为第2代抗组胺药,治疗选择有限,且抗组胺药的疗效存在个体差异,并不能满足所有患者的需求。本研究旨在探索止痒消疹颗粒联合抗组胺药治疗慢性荨麻疹患者的临床疗效和安全性。方法:回顾性收集2020年4月至2021年3月就诊于中南大学湘雅医院,且诊断为慢性荨麻疹的患者的临床资料。接受常规的第2代抗组胺药治疗的患者为对照组,在常规的第2代抗组胺药治疗的基础上联合使用止痒消疹颗粒治疗的患者为观察组。比较治疗前和治疗4周后2组7日荨麻疹活动度评分(Weekly Urticaria Activity Score,UAS7)及皮肤病生活质量指数(Dermatology Life Quality Index,DLQI)的差异,采用症状积分下降指数(Symptom Score Reduce Index,SSRI)评价并比较2种治疗方案的疗效。结果:治疗4周后,2组的UAS7均明显降低(分别P=0.001,P0.05);但是在根据DLQI计算SSRI来疗效评价时,对照组和观察组的有效率分别为33.33%和46.88%,2组间疗效的差异有统计学意义(P<0.001)。2组均有3例患者存在嗜睡的药物不良反应。结论:止痒消疹颗粒联合第2代抗组胺药可有效降低慢性荨麻疹患者的疾病活动度,且对生活质量的改善优于单用第2代抗组胺药。

关键词：止痒消疹颗粒慢性荨麻疹抗组胺药临床疗效

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度普利尤单抗对中重度特应性皮炎的疗效与安全性分析

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中华医学杂志 2024年第30期104卷 2810-2816页

作者：王佳怡周冰静曹巧芝彭聪陈明亮陈翔李捷中南大学湘雅医院皮肤科皮肤肿瘤与银屑病重点实验室国家老年疾病临床医学研究中心长沙

目的分析度普利尤单抗对中重度特应性皮炎(AD)的疗效与安全性。方法回顾性分析2020年8月至2022年11月在中南大学湘雅医院皮肤科接受度普利尤单抗治疗的中重度AD患者的临床资料, 共259例。分别在治疗前、治疗后第2、4、16、24周采用湿疹... 详细信息

目的分析度普利尤单抗对中重度特应性皮炎(AD)的疗效与安全性。方法回顾性分析2020年8月至2022年11月在中南大学湘雅医院皮肤科接受度普利尤单抗治疗的中重度AD患者的临床资料, 共259例。分别在治疗前、治疗后第2、4、16、24周采用湿疹面积和严重程度指数评分(EASI)、特应性皮炎评分(SCORAD)、瘙痒峰值数字评分(NRS)、以患者为导向的湿疹测量评分(POEM)和皮肤病学生活质量指数(DLQI)评估患者疗效, 同时记录治疗期间发生的不良反应。比较治疗前后不同时间点的评分变化和实验室指标变化。结果 259例患者的年龄为(35.4±25.9)岁, AD病程[M(Q1, Q3)]为4.00(2.00, 9.00)年, 男性占64.1%(166例)。度普利尤单抗治疗第2、4、16、24周的EASI、SCORAD、POEM、DLQI和NRS评分与治疗前相比均下降(均P<0.001)。第16周时EASI50、EASI75和EASI90构成分别为91.0%(101/111)、71.2%(79/111)和40.5%(45/111), 第24周时构成分别为95.0%(76/80)、80.0%(64/80)和45.0%(36/80)。第24周的基础总IgE水平(P=0.005)和嗜酸性粒细胞(EOS)计数(P<0.001)与治疗前相比降低。54(20.9%)例患者出现不良事件, 主要表现为面颈部顽固性红斑(5.0%, 13例)和结膜炎(1.9%, 5例)。结论度普利尤单抗可有效改善中重度AD的皮疹面积、皮疹严重程度和瘙痒程度等, 提高患者生活质量, 并且不良反应发生率较低。

关键词：皮炎, 特应性度普利尤单抗白细胞介素4 白细胞介素13 生物制剂治疗效果药物不良反应

Comprehensive analysis of advanced glycation end-products in commonly consumed foods:presenting a database for dietary AGEs and associated exposure assessment

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Food Science and Human Wellness 2024年第4期13卷 1917-1928页

作者： qiaozhi Zhang Huatao Li Ruixing Zheng Lili cao Shufen Zhang Shuifeng Zhang Huadong Sheng Yuhao Jiang Yanbo Wang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Ningbo Academy of Product and Food Quality Inspection(Ningbo Fibre Inspection Institute) Ningbo 315048China National Pre-packaged Food Quality Supervision and Inspection Center(Zhejiang) Zhejiang Fangyuan Test Group Co.Ltd.Hangzhou 310018China

Advanced glycation end-products(AGEs)are a group of heterogeneous compounds formed in heatprocessed foods and are proven to be detrimental to human ***,there is no comprehensive database for AGEs in foods that covers the entire range of food categories,which limits the accurate risk assessment of dietary AGEs in human *** this study,we first established an isotope dilution UHPLCQq Q-MS/MS-based method for simultaneous quantification of 10 major AGEs in *** contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations.Nε-Carboxymethyllysine,methylglyoxal-derived hydroimidazolone isomers,and glyoxal-derived hydroimidazolone-1 are predominant AGEs found in most *** amounts of AGEs were high in processed nuts,bakery products,and certain types of cereals and meats(>150 mg/kg),while low in dairy products,vegetables,fruits,and beverages(<40 mg/kg).Assessment of estimated daily intake implied that the contribution of food groups to daily AGE intake varied a lot under different eating patterns,and selection of high-AGE foods leads to up to a 2.7-fold higher intake of AGEs through daily *** presented AGE database allows accurate assessment of dietary exposure to these glycotoxins to explore their physiological impacts on human health.

关键词： Advanced glycation end-products Maillard reaction Processed foods Dietary database Exposure assessment

Complex transmission matrix retrieval for a highly scattering medium via regional phase differentiation

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Photonics Research 2024年第5期12卷 876-883页

作者： qiaozhi HE RONGJUN SHAO YUAN Qu LINXIAN LIU CHUNXU DING JIAMIAO YANG School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

Accurately measuring the complex transmission matrix(CTM) of the scattering medium(SM) holds critical significance for applications in anti-scattering optical imaging, phototherapy, and optical neural networks. Noninterferometric approaches, utilizing phase retrieval algorithms, can robustly extract the CTM from the speckle patterns formed by multiple probing fields traversing the SM. However, in cases where an amplitude-type spatial light modulator is employed for probing field modulation, the absence of phase control frequently results in the convergence towards a local optimum, undermining the measurement accuracy. Here, we propose a high-accuracy CTM retrieval(CTMR) approach based on regional phase differentiation(RPD). It incorporates a sequence of additional phase masks into the probing fields, imposing a priori constraints on the phase retrieval algorithms. By distinguishing the variance of speckle patterns produced by different phase masks, the RPD-CTMR can effectively direct the algorithm towards a solution that closely approximates the CTM of the SM. We built a prototype of a digital micromirror device modulated RPD-CTMR. By accurately measuring the CTM of diffusers, we achieved an enhancement in the peak-to-background ratio of anti-scattering focusing by a factor of 3.6, alongside a reduction in the bit error rate of anti-scattering image transmission by a factor of 24. Our proposed approach aims to facilitate precise modulation of scattered optical fields, thereby fostering advancements in diverse fields including high-resolution microscopy, biomedical optical imaging, and optical communications.

关键词： matrix phase holds

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Understanding the initial use stage of cement mortar lining in drinking water distribution systems:Silicon and aluminum as stability indicators

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Journal of Environmental Sciences 2024年第1期135卷 495-505页

作者： qiaozhi Liu Yuan Zhuang Guiwei Li Yao Zhang Marc A.Edwards Baoyou Shi Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Civil and Environmental Engineering Virginia TechBlacksburgVA 24061USA

The cement mortar lining(CML)of commonly used ductile iron pipes can severely deteriorate the drinking water quality at the initial stage of use,but the behavioral characteristics of different elements release from the CML in this stage is still *** this study,dynamic immersion experiments with new cement mortar lined ductile iron pipe reactors were conducted under different feed water hardness and alkalinity *** results showed that the release of alkaline substances from the CML at the initial stage of use could strongly influence the pH of water,which consequently greatly impacted the release/precipitation behaviors of calcium,aluminum and *** pH and aluminum concentration of the effluent water could reach 11.5 and 700μg/L within 24 hr of hydraulic retention time,respectively,under conditions of relatively lower hardness and *** to the pH elevation,calcium carbonate precipitation could occur even at much lower feed water *** the aluminum and silicon could keep release from the CML in soluble form at different hardness and alkalinity levels,and their release rate depended on the amount of calcium carbonate ***,aluminum and silicon were more suitable as indicators of the corrosion intensity at the initial stage of CML use rather than the traditional calcium carbonate precipitation *** feed water hardness and alkalinity levels for mitigating the initial intense corrosion of CML were proposed:hardness>40 mg/L(CaCO_(3)),alkalinity>100 mg/L(CaCO_(3)).

关键词： Cement mortar lining Hardness Alkalinity Elemental release Drinking water supply

Full-polarization angular spectrum modeling of scattered light modulation

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Photonics Research 2024年第3期12卷 485-490页

作者： RONGJUN SHAO CHUNXU DING YUAN QU LINXIAN LIU qiaozhi HE YUEJUN WU JIAMIAO YANG School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

The exact physical modeling for scattered light modulation is critical in phototherapy,biomedical imaging,and free-space optical *** particular,the angular spectrum modeling of scattered light has attracted considerable attention,but the existing angular spectrum models neglect the polarization of photons,degrading their ***,we propose a full-polarization angular spectrum model(fpASM)to take the polarization into *** model involves a combination of the optical field changes and free-space angular spectrum diffraction,and enables an investigation of the influence of polarization-related factors on the performance of scattered light *** establishing the relationship between various model parameters and macroscopic scattering properties,our model can effectively characterize various depolarization *** a demonstration,we apply the model in the time-reversal data transmission and anti-scattering light *** method allows the analysis of various depolarization scattering events and benefits applications related to scattered light modulation.

关键词： scattered angular spectrum

Transient stimulated Raman scattering spectroscopy and imaging

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Light(Science & Applications) 2024年第4期13卷 654-663页

作者： qiaozhi Yu Zhengjian Yao Jiaqi Zhou Wenhao Yu Chenjie Zhuang Yafeng Qi Hanqing Xiong National Biomedical Imaging Center College of Future TechnologyPeking UniversityBeijing 100871China Biomedical Engineering Department College of Future TechnologyPeking UniversityBeijing 100871China

Stimulated Raman scattering(SRS)has been developed as an essential quantitative contrast for chemical imaging in recent ***,while spectral lines near the natural linewidth limit can be routinely achieved by state-of-the-art spontaneous Raman microscopes,spectral broadening is inevitable for current mainstream SRS imaging *** is because those SRS signals are all measured in the frequency *** is a compromise between sensitivity and spectral resolution:as the nonlinear process benefits from pulsed excitations,the fundamental time-energy uncertainty limits the spectral ***,the spectral range and acquisition speed are mutually *** we report transient stimulated Raman scattering(T-SRS),an alternative time-domain strategy that bypasses all these fundamental conjugations.T-SRS is achieved by quantum coherence manipulation:we encode the vibrational oscillations in the stimulated Raman loss(SRL)signal by femtosecond pulse-pair sequence excited vibrational wave packet *** Raman spectrum was then achieved by Fourier transform of the time-domain SRL *** all Raman modes are impulsively and simultaneously excited,T-SRS features the natural-linewidth-limit spectral line shapes,laser-bandwidth-determined spectral range,and improved ***~150-fs laser pulses,we boost the sensitivity of typical Raman modes to the sub-mM *** all-plane-mirror high-speed time-delay scanning,we further demonstrated hyperspectral SRS imaging of live-cell metabolism and high-density multiplexed imaging with the natural-linewidth-limit spectral resolution.T-SRS shall find valuable applications for advanced Raman imaging.

关键词： scattering excited mutually

Comparison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy

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Food Science and Human Wellness 2024年第2期13卷 668-680页

作者： Gang Yu Yuhao Jiang Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong Sheng Yanbo Wang qiaozhi Zhang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Fangyuan Test Group Co. Ltd.Hangzhou 310018China Key Laboratory of Biosafety Detection for Zhejiang Market Regulation Hangzhou 310018China Zhejiang Liziyuan Food Co. LtdJinhua 321031China

Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic ***,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely *** this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food *** outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut *** showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed *** C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were *** study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy.

关键词： Food allergy Mouse models Epicutaneous sensitization Th2 response Gut microbiota

Dietary polyphenols reduced the allergenicity ofβ-lactoglobulin via non-covalent interactions:a study on the structure-allergenicity relationship

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Food Science and Human Wellness 2024年第5期13卷 2617-2628页

作者： Chi Zhang qiaozhi Zhang Huatao Li Zhouzhou Cheng Shiyu Fan Hujun Xie Zhongshan Gao Yan Zhang Linglin Fu School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310018China Allergy Research Center Zhejiang UniversityHangzhou 310018China Hebei Food Inspection and Research Institute Hebei Food Safety Key LaboratoryKey Laboratory of Special Food Supervision Technology for State Market RegulationHebei Engineering Research Center for Special Food Safety and HealthShijiazhuang 050227China

Studies showed that complexation of polyphenols with milk allergens reduced their immunogenic ***,the relationship between structures of polyphenols and their hypoallergenic effects on milk allergens in association with physiological and conformational changes of the complexes remain *** this study,polyphenols from eight botanical sources were extracted to prepare non-covalent complexes withβ-lactoglobulin(β-LG),a major allergen in *** dominant phenolic compounds bound toβ-LG with a diminished allergenicity were identified to investigate their respective role on the structural and allergenic properties ofβ-*** from Vaccinium fruits and black soybeans were found to have great inhibitory effects on the IgE-and IgG-binding abilities ofβ-*** the fourteen structure-related phenolic compounds,flavonoids and tannins with larger MWs and multi-hydroxyl substituents,notably rutin,EGCG,and ellagitannins were more potent to elicit changes on the conformational structures ofβ-LG to decrease the allergenicity of complexedβ-*** analysis further demonstrated that a destabilized secondary structure and protein depolymerization caused by polyphenol-binding were closely related to the allergenicity property of formed *** study provides insights into the understanding of structure-allergenicity relationship ofβ-LG-polyphenol interactions and would benefit the development of polyphenol-fortified matrices with hypoallergenic potential.

关键词： Cow’s milk allergy β-Lactoglobulin Protein-polyphenol interaction Allergenicity Conformational structure

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