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Combined use of chemotherapeutics and oncolytic adenovirus in treatment of AFP-expressing hepatocellular carcinoma

Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 282-287页

作者： Mao, Chen-Yu Hua, Han-Ju Chen, Ping Yu, De-Chao cao, jiang Teng, Li-Song Zhejiang Univ Sch Med Dept Surg Oncol Affiliated Hosp 1 Hangzhou 310003 Peoples R China Zhejiang Univ Sch Med Sir Run Run Shaw Inst Clin Med Key Lab Biotherapy Zhejiang Prov Hangzhou 310016 Peoples R China

BACKGROUND: Hepatocellular carcinoma (HCC) which is always refractory to most chemotherapeutic agents may result in poor survival of patients with advanced HCC. Oncolytic adenovirus is a new form for cancer gene therapy via its ability to replicate and kill tumor cells in a tumor-specific manner. In order to eradicate tumors effectively, the combination of chemotherapeutic agents and oncolytic adenovirus has been considered. This study aimed to systematically analyze the possibility of synergistic cytotoxicity of oncolytic adenoviruses in combination with chemotherapeutic agents. METHODS: Several types of human HCC cell lines were used to determine the specificity and cytotoxicity of oncolytic adenovirus Ad5-HC and Ad5-AFP (IRES) by measuring cell viability in vitro and antitumor efficiency in vivo. The cytotoxicity of Ad5-HC and Ad5-AFP (IRES) combined with chemotherapeutic agents were also assessed by the methyl thiazolyl tetrazolium assay. RESULTS: Both Ad5-HC and Ad5-AFP (IRES) were significantly cytotoxic to HCC cells with great specificity in vitro and in vivo. The combination of oncolytic adenovirus with 5-FU, doxorubicin, and paclitaxel was synergistically effective for the killing of HCC cells. CONCLUSIONS: These data suggest that oncolytic adenovirus sensitize tumors to chemotherapy and the combination therapy of chemotherapeutic agents and oncolytic adenovirus has an enhanced antitumor effect on HCC cells. (Hepatobiliary Pancreat Dis Int 2009; 8: 282-287)

关键词： hepatocellular carcinoma drug resistance oncolytic adenovirus chemotherapy

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Ruxolitinib attenuates secondary injury after traumatic spinal cord injury

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Neural Regeneration Research 2022年第9期17卷 2029-2035页

作者： Zhan-Yang Qian Ren-Yi Kong Sheng Zhang Bin-Yu Wang Jie Chang jiang cao Chao-Qin Wu Zi-Yan Huang Ao Duan Hai-Jun Li Lei Yang Xiao-Jian cao Spine Center Zhongda Hospital of Southeast UniversityNanjingJiangsu ProvinceChina Medical School Southeast UniversityNanjingJiangsu ProvinceChina Department of Orthopedics First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Orthopedics Hospital Affiliated 5 to Nantong University(Taizhou People’s Hospital)TaizhouJiangsu ProvinceChina Taizhou Clinical Medical School of Nanjing Medical University Taizhou People’s HospitalTaizhouJiangsu ProvinceChina

Excessive inflammation post-traumatic spinal cord injury(SCI)induces microglial activation,which leads to prolonged neurological ***,the mechanism underlying microglial activation-induced neuroinflammation remains poorly ***(RUX),a selective inhibitor of JAK1/2,was recently reported to inhibit inflammatory storms caused by SARS-CoV-2 in the ***,its role in disrupting inflammation post-SCI has not been *** this study,microglia were treated with RUX for 24 hours and then activated with interferon-γfor 6 *** results showed that interferon-γ-induced phosphorylation of JAK and STAT in microglia was inhibited,and the mRNA expression levels of pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,interleukin-6,and cell proliferation marker Ki67 were *** further in vivo experiments,a mouse model of spinal cord injury was treated intragastrically with RUX for 3 successive days,and the findings suggest that RUX can inhibit microglial proliferation by inhibiting the interferon-γ/JAK/STAT ***,microglia treated with RUX centripetally migrated toward injured foci,remaining limited and compacted within the glial scar,which resulted in axon preservation and less ***,the protein expression levels of tumor necrosis factor-α,interleukin-1β,and interleukin-6 were *** neuromotor function of SCI mice also *** findings suggest that RUX can inhibit neuroinflammation through inhibiting the interferon-γ/JAK/STAT pathway,thereby reducing secondary injury after SCI and producing neuroprotective effects.

关键词： functional recovery glial scar inflammation interferon-γ JAK/STAT signaling microglia Ruxolitinib spinal cord injury

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任意加速带电动态黑洞中Dirac粒子的Hawking辐射

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物理学报 2006年第6期55卷 2682-2686页

作者：曹江陵北京师范大学物理学系

在任意加速带电动态时空中,选取零标架、计算出旋系数,把四个耦合的Dirac方程中化成两个耦合的方程,采用Tortoise坐标变换将其两个耦合的方程变换成Tortoise坐标下的形式,在黑洞视界面附近化成了典型的波动方程,得到在视界面附近Dirac... 详细信息

在任意加速带电动态时空中,选取零标架、计算出旋系数,把四个耦合的Dirac方程中化成两个耦合的方程,采用Tortoise坐标变换将其两个耦合的方程变换成Tortoise坐标下的形式,在黑洞视界面附近化成了典型的波动方程,得到在视界面附近Dirac粒子的Hawking辐射温度,成功地导出了Hawking热谱公式.

关键词： Dirac方程 Hawking辐射黑洞 Tortoise坐标变换

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动态容错技术选择模型在移动Agent工作流管理系统中的应用

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上海理工大学学报 2008年第6期30卷 590-594页

作者：曹渠江姜洲上海理工大学光电信息与计算机工程学院上海200093

针对网格环境下,容错机制可保证工作流管理系统的一次性和完整性的执行特征,将移动Agent引入到工作流管理系统中,提出一个可以嵌入移动Agent工作流管理系统中的动态容错技术选择模型.在网格环境下应用这个模型增强容错功能,并允许系统... 详细信息

针对网格环境下,容错机制可保证工作流管理系统的一次性和完整性的执行特征,将移动Agent引入到工作流管理系统中,提出一个可以嵌入移动Agent工作流管理系统中的动态容错技术选择模型.在网格环境下应用这个模型增强容错功能,并允许系统通过对计算环境的感知,优化配置容错机制.

关键词：移动Agent 工作流管理系统容错机制网格计算环境

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Chinese White-Collars Balk at Marriage

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China Today 2006年第5期55卷 38-40页

作者： LIU jiang & cao YANG

CHINESE parents have always viewed their children's marriage as a crucially important event. Now, as most households in the country have just one child, they do so more than ever. While some kids have little trouble o... 详细信息

关键词：中国婚姻爱情观白领

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FRACTURE BEHAVIOUR OF SiC WHISKER REINFORCED Al COMPOSITES

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Acta Metallurgica Sinica(English Letters) 1989年第12期2卷 403-408页

作者： cao Li jiang Chiping YAO Zhongkai LEI Tingquan Harbin Institute of Technology,Harbin,China

The dynamic tensile processes of silicon carbide whisker reinforced Al composite(SiC_w/Al) with 22% V_f have been in situ observed with a scanning electron microscope equipped with a tensile *** results show that a number of microcracks have formed as the tensile stress increases to 180～190 *** form in most cases at the whisker *** frac- ture behaviour of SiC_w/Al composite observed has been explained theoretically.

关键词： composite fracture stress distribution SiC whiskers aluminum

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Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish

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Neural Regeneration Research 2020年第1期15卷 103-111页

作者： Jia-He Li Zhong-Ju Shi Yan Li Bin Pan Shi-Yang Yuan Lin-Lin Shi Yan Hao Fu-jiang cao Shi-Qing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina Department of Orthopedics the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina

Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans *** analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus *** ontology and protein-protein interaction networks were used to analyze the identified differentially expressed ***,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node *** also obtained the 10 hub genes with the highest correlation and the two modules with the highest *** results showed that spectrin may promote axonal regeneration after spinal cord injury in *** growth factor beta signaling may inhibit repair after spinal cord injury in *** adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in *** analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals.

关键词： axonal regeneration differentially expressed genes focal adhesions Gene Ontology Kyoto Encyclopedia of Genes and Genomes neural regeneration protein-protein interaction network signaling pathway spectrin tight junctions transforming growth factor beta Wnt signaling pathway

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不同性能的双亲性纳米TiO_2复合粒子改性聚偏氟乙烯超滤膜结构与性能的研究

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功能材料 2011年第1期42卷 91-95页

作者：湛含辉曹江中国矿业大学环测学院江苏徐州221008 中南大学粉末冶金研究院湖南长沙410083

利用无皂乳液聚合法合成双亲性聚丙烯酸(PAA-)g-聚甲基丙烯酸甲酯(PMMA)-g-硅烷偶联剂KH570-g-纳米TiO2复合体,通过调节亲水链中丙烯酸(AA)与甲基丙烯酸甲酯(MAA)单体的比例控制复合粒子的表面性能。利用红外光谱、接触角测定、扫描电镜... 详细信息

利用无皂乳液聚合法合成双亲性聚丙烯酸(PAA-)g-聚甲基丙烯酸甲酯(PMMA)-g-硅烷偶联剂KH570-g-纳米TiO2复合体,通过调节亲水链中丙烯酸(AA)与甲基丙烯酸甲酯(MAA)单体的比例控制复合粒子的表面性能。利用红外光谱、接触角测定、扫描电镜(SEM)等表征技术研究不同表面性能的双亲性纳米TiO2复合粒子对聚偏氟乙烯(PVDF)超滤膜结构与性能的影响。研究表明,随着亲水链中AA单体含量增多,复合体亲水性增强,改性膜亲水效果越显著,膜通量越大,但易形成大孔,截留率低,且改性膜压密性欠佳。而复合体亲水链中MMA单体含量越多,膜亲水改性效果越差,膜通量低,但膜压密性能好。两种单体最佳比例应控制在40%～60%,此时改性PVDF复合超滤膜性能优异,膜通量、截留率分别达到80mL/cm2.h和80%以上。

关键词：双亲性纳米TiO2 PVDF 超滤膜结构与性能.

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湿式离合器出油口甩出油温度预测方法

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中国公路学报 2019年第5期32卷 162-171页

作者：鲍伟曹将合肥工业大学电气与自动化工程学院安徽合肥230009

为了实现对湿式离合器出油口甩出油温度传感器的冗余校验和自我诊断,提出了一种基于粒计算约简的离合器出油口甩出油温度的模糊预测方法。首先分析出油口甩出油温度的影响因素,将主要影响因素作为预测输入量,并采用模糊推理理论预测当... 详细信息

为了实现对湿式离合器出油口甩出油温度传感器的冗余校验和自我诊断,提出了一种基于粒计算约简的离合器出油口甩出油温度的模糊预测方法。首先分析出油口甩出油温度的影响因素,将主要影响因素作为预测输入量,并采用模糊推理理论预测当前离合器出油口甩出油温度。在设计模糊预测方法的过程中,通过分析实车数据得到车辆行驶时离合器处于高滑摩功率过程和低滑摩功率过程的不同特性,分别确定相对应的隶属度函数和模糊预测规则,从而进一步提高出油口甩出油温的预测精度。为了提高模糊预测算法的实时性,基于模糊预测规则创建模糊决策表,模糊输入量和模糊输出量分别作为决策表的条件属性集与决策属性集。利用粒计算理论对模糊决策表的条件属性集进行属性约简,通过削减冗余信息有效降低模糊输入量和模糊预测规则的个数。最后利用实车采集的数据对比分析约简前后模糊预测算法的单步运行时间和预测误差等性能指标。试验结果表明:基于粒计算约简的模糊预测算法能够有效保障预测精度,同时拥有更少的模糊预测规则数和模糊输入量,有效解决了模糊预测算法占用资源较多以及实用性较差的问题。

关键词：汽车工程湿式双离合器模糊推理理论出油口甩出油温粒计算属性约简

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Testosterone is negatively associated with the severity of coronary atherosclerosis in men

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Asian Journal of Andrology 2012年第6期14卷 875-878页

作者： Li Li Chang-Yan Guo En-Zhi Jia Tie-Bing Zhu Lian-Sheng Wang Ke-jiang cao Wen-Zhu Ma Zhi-Jian Yang Department of Cardiovascular Medicine First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease （CAD） was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores （score ≤ 26 and score 〉26） using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score （r=-0. 188; P=0.000）. A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score （β=-0,110; P=0.002） after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile （highest） of testosterone compared to the first tertile （lowest） of testosterone （odds ratio （0R）=0.465; 95% confidence interval （C1）. 0.327-0.662; P=0.000）. In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.

关键词： coronary artery disease (CAD) Gensini score testosterone

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