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数据生命周期视角下政府跨域协作数据治理及其运行逻辑

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东北大学学报（社会科学版） 2020年第3期22卷 56-63页

作者：李月曹海军东北大学文法学院辽宁沈阳110169

数字政府时代,高效的数据治理是实现政府跨域协作、解决复杂棘手问题的重要工具。以数据生命周期理论为视角分析发现,在政府跨域协作场景下,数据需求的满足过程与主体内部数据生命周期之间产生矛盾,使数据规划阶段的前置治理失效,数据... 详细信息

数字政府时代,高效的数据治理是实现政府跨域协作、解决复杂棘手问题的重要工具。以数据生命周期理论为视角分析发现,在政府跨域协作场景下,数据需求的满足过程与主体内部数据生命周期之间产生矛盾,使数据规划阶段的前置治理失效,数据采集与处理成本增加,最终导致数据利用阶段的供给迟滞。为确保跨域协作中数据的自由流动、全局一致以及安全可靠,应突破个体层次的数据生命周期模型,转向面向协作整体的跨域协作数据生命周期治理逻辑,通过数据规划、数据汇聚、数据联通、数据利用以及数据增值五个阶段,完成数据价值的实现与增长。

关键词：数据治理政府跨域协作数据生命周期治理逻辑

赓续百年目标:共同富裕的因由寻绎、意蕴索隐和路径构想

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云南社会科学 2022年第1期 54-61,187,188页

作者：曹海军梁赛东北大学文法学院民政部研究基地东北大学城乡社区建设研究院

治国之道,富民为始。党的十九届五中全会以来,随着全面建成小康社会的胜利,“共同富裕”从头部边缘跃向众星中央,从远景目标稳向实践实操,成为接续第二个百年奋斗目标的航标指针,有其内在的理论逻辑、历史逻辑和现实逻辑。贯彻新发展理... 详细信息

治国之道,富民为始。党的十九届五中全会以来,随着全面建成小康社会的胜利,“共同富裕”从头部边缘跃向众星中央,从远景目标稳向实践实操,成为接续第二个百年奋斗目标的航标指针,有其内在的理论逻辑、历史逻辑和现实逻辑。贯彻新发展理念、构建新发展格局、推动高质量发展谋求的是更高层级、更加全面、更具创新的共同富裕,是对中国共产党百年共同富裕的认识和经验的承嬗离合。共同富裕并非同时富裕、同等富裕和杀富济贫、平均贫富,而是安富恤贫和差别富裕,这决定在把握共同富裕价值基准时要从“共同”“异中同”“同中异”三个维度解构盖全无贫、盖均无贫、无贫有别的意蕴。探赜共同富裕的实现途径要摒弃“唯发展”和“唯平等”就是共同富裕的片面思想,要以合法性、稳定性和实效性为护翼,将始点、过程和结果的校正意识贯穿于分配、协同、保障的基础制度安排和统筹、关系、补偿的内在机制创新以及生活、精神、环境、社会、公共服务的联动措施细化等顶层设计全过程,扎实推动共同富裕落地生根、落在实处。

关键词：共同富裕差别富裕高质量发展第二个百年目标

基于系统动力学的社交网络舆情应对策略仿真分析——以“亚布力事件”为例

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东北大学学报（社会科学版） 2019年第1期21卷 57-63页

作者：曹海军李明东北大学文法学院辽宁沈阳110169

在信息技术高速发展的背景下,社交网络平台不断涌现并得以广泛使用。它在给生活带来便利的同时却也导致了社交网络舆情的产生,如何有效应对社交网络舆情是政府面临的新挑战。对与社交网络舆情关联度较高的多主体因素进行分析后,采用Vens... 详细信息

在信息技术高速发展的背景下,社交网络平台不断涌现并得以广泛使用。它在给生活带来便利的同时却也导致了社交网络舆情的产生,如何有效应对社交网络舆情是政府面临的新挑战。对与社交网络舆情关联度较高的多主体因素进行分析后,采用Vensim PLE软件构建社交网络舆情多主体应对模型,并结合具体案例"亚布力事件"进行仿真分析。结果表明:社交网络舆情受舆情事件、媒体、网民、政府多个主体及其相关因素的共同影响,政府可通过提升舆情事件导控能力、规范和引导媒体行为、积极疏导网民情绪及提高信息透明度等举措有效应对社交网络舆情。

关键词：系统动力学社交网络舆情社交网络平台仿真分析

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大学课程高深性:立论基础与实践反思

大学教育科学 2017年第5期 57-61页

作者：唐德海曹如军广西民族大学教育科学学院淮阴师范学院教育科学学院

大学人才培养目标是确立大学课程高深性的理论基础,国际教育标准分类是印证大学课程高深性的实践依据。为确保培养高级专门人才的质量要求,大学课程管理应深化对课程高深性的认识与理解,并以高深性的维系为思路重构课程体系和课程实施... 详细信息

大学人才培养目标是确立大学课程高深性的理论基础,国际教育标准分类是印证大学课程高深性的实践依据。为确保培养高级专门人才的质量要求,大学课程管理应深化对课程高深性的认识与理解,并以高深性的维系为思路重构课程体系和课程实施路径。

关键词：大学课程培养目标课程管理变革高深性理论实践

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社会网络分析在医疗和公共卫生中的应用

中国公共卫生 2020年第3期36卷 398-403页

作者：曹海军陈宇奇东北大学文法学院辽宁沈阳110169

社会网络分析的应用拓宽了医疗与公共卫生的研究范式和实验场域,促进了流行病学、医疗与公共卫生服务、卫生系统等研究的纵深发展。公共卫生突发事件及流行病防疫加速了社会网络分析在医疗卫生领域的普及,从系统论角度出发研究公共卫生... 详细信息

社会网络分析的应用拓宽了医疗与公共卫生的研究范式和实验场域,促进了流行病学、医疗与公共卫生服务、卫生系统等研究的纵深发展。公共卫生突发事件及流行病防疫加速了社会网络分析在医疗卫生领域的普及,从系统论角度出发研究公共卫生问题已经得到科研人员的广泛认可,研究成果呈现逐年递增趋势。当前,社会网络分析主要被应用于医疗信息沟通、公共卫生行为、交际网络、医疗卫生系统研究等领域,其中疫病传播网络、医护网络与医疗系统网络的研究成为领域内聚焦的热门议题。社会网络在公共卫生领域的应用前景广阔,网络计量模型的拓展应用以及非正式网络的研究将是未来极具现实意义与探索价值的选题。本文运用文献计量的相关方法,梳理了2010-2019年全球该领域的发展趋势与概况。

关键词：公共卫生社会网络分析疫病防疫医疗系统

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基于组合模型的软件可靠性预计方法

系统工程与电子技术 2013年第12期35卷 2661-2664页

作者：韩坤吴纬曹军海陈守华装甲兵工程学院技术保障工程系北京100072 北京特种车辆研究所北京100072

为了提高软件可靠性预计精度和稳定性,本文提出基于组合模型的软件可靠性预计方法。构建组合模型的过程包括选取基模型和确定各基模型的权值。选取基模型时依据的准则有生命周期阶段、模型用户需求、故障数据类型、故障趋势匹配、模型... 详细信息

为了提高软件可靠性预计精度和稳定性,本文提出基于组合模型的软件可靠性预计方法。构建组合模型的过程包括选取基模型和确定各基模型的权值。选取基模型时依据的准则有生命周期阶段、模型用户需求、故障数据类型、故障趋势匹配、模型假设吻合和模型预计偏好,并在此基础上阐述了基模型选取算法。基模型权值的确定采用序列似然比方法。最后,引用一组软件故障数据,用于检验此组合模型的预计效果。通过与单个模型的对比,显示组合模型预计结果更为可信。

关键词：计算机软件软件可靠性预计组合模型基模型选择权值确定

Research progress of slippage characteristic and gas film stability enhancement methods on biomimetic hydrophobic surfaces

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Journal of Hydrodynamics 2024年第1期36卷 87-101页

作者： Meng-zhuo Zhang hai-bao Hu Liu-zhen Ren Lu-yao Bao jun Wen Luo Xie School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China

The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophobic surfaces(HS)and the gas-liquid interface(GLI)of superhydrophobic surfaces(SHS)in recent years,but also introduces some innovative methods that can effectively improve the gas film stability and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,by MD and multibody dissipative particle dynamics(MDPD)method,the slippage behavior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hybrid slip boundary condition model to describe the slippage characteristic on *** addition,we found through experiment that a three-dimensional backflow will appear on the GLI under the interfacial adsorption of surfactants,and the backflow direction will reverse with the change of GLI ***,we put forward the wettability step structure and gas injection method to enhance the stability and drag reduction effect of the gas film on SHS.

关键词： Hydrophobic surface superhydrophobic surface interfacial slip underwater drag reduction

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

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Asian Journal of Andrology 2024年第2期26卷 165-174页

作者： hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-jun Huo Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionEducation Ministry of ChinaCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Maternal-Fetal Medicine Institute Department of Obstetrics and GynaecologyShenzhen Baoan Women's and Children's HospitalJinan UniversityShenzhen 518100China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various *** mitochondrial protease complex(ClpXP),which consists of caseinolytic mitochondrial matrix peptidase X(ClpX)and caseinolytic protease P(ClpP)and mediates the degradation of misfolded,damaged,and oxidized proteins,is essential for maintaining mitochondrial *** has been implicated in meiosis regulation,but its precise role is currently *** this study,we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X(Clpx^(cKO))mouse model to investigate the function of ClpX in *** found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the ***,it caused asynapsis of homologous chromosomes and impaired meiotic recombination,resulting in meiotic arrest in the zygotene-to-pachytene transition *** loss of ClpX compromised the double-strand break(DSB)repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolog 1(RAD51)to DSB *** dysfunction may be due to an insufficient supply of energy from the aberrant mitochondria in Clpx^(cKO) spermatocytes,as discerned by electron ***,ubiquitination signals on chromosomes and the expression of oxidative phosphorylation subunits were both significantly attenuated in Clpx^(cKO) *** together,we propose that ClpX is essential for maintaining mitochondrial protein homeostasis and ensuring homologous chromosome pairing,synapsis,and recombination in spermatocytes during meiotic prophase I.

关键词： ClpX homologous chromosome meiosis mitochondrial recombination synapsis

Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer

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Chinese Chemical Letters 2024年第8期35卷 443-448页

作者： Yiran Tao Chunlei Dai Zhaoxiang Xie Xinru You Kaiwen Li jun Wu hai Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Guangdong Provincial Clinical Research Center for Urological Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Traditional therapies such as surgery and endocrine therapy no longer meet the clinical needs in prostate cancer treatment,and more effective treatments are urgently *** studies have reported that targeted inhibition of the transcription factor cyclin dependent kinase 7(CDK7)could effectively suppress prostate cancer ***,the toxicity of CDK7 inhibitors such as THZ1 is the main limitation of the clinical *** this work,we synthesized Cys8E(C8E)nanoparticles(NPs)loaded with THZ1(C8E@THZ1),a novel GSH-targeting and stimuli-responsive nano-delivery platform,and investigated its anti-tumor potential and biosafety *** vitro,C8E@THZ1 potently inhibited the proliferation and promoted the apoptosis of prostate cancer *** tumor-bearing mice,C8E@THZ1 inhibited tumors by up to 85%,while the damage of THZ1 to liver function was effectively *** results confirmed that inhibition of CDK7 can effectively block the progression of prostate cancer,and that Cys8E NPs is a highly prospective delivery platform to promote the clinical application of CDK7 inhibitors.

关键词： Prostate cancer Nanoparticles CDK7 THZ1 THZ1@Cys8E NPs