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Efficacy and safety of Yangxue Qingnao Granules in treatment of migraine:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第2期12卷 335-345页

作者： Bo Zhou Gui-Shu Wang Yu-Ning Yao Tong Hao Huan-Qin Li Ke-gang cao Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Infectious Disease Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Institute for Brain Disorders Beijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China

BACKGROUND Yangxue Qingnao Granules(YXQN)is a Chinese patent medicine that has been commonly used in the clinical treatment of *** To assess the efficacy and safety of YXQN alone for the treatment of *** We searched 10 databases to identify relevant randomized controlled trials(RCTs)published before September *** review authors independently searched and screened the literature,extracted the data,and assessed the methodological quality of the studies using criteria from ROB 2.0,and analyzed the data using Review Manager 5.4 *** A total of 12 RCTs including 767 participants with migraine met the selection *** divided these studies into comparisons of YXQN with placebo,routine treatment drugs,and other Chinese patent *** meta-analysis showed the following:(1)Efficacy:The YXQN group outperformed the placebo group[relative risk(RR)=0.29,95%confidence interval(95%CI):0.15–0.43,P<0.00001],routine treatment group(RR=0.18,95%CI:0.09–0.27,P<0.0001),and Chinese patent medicine group(RR=0.27,95%CI:0.13–0.41,P<0.001);(2)frequency of headache:There was a significant difference between YXQN vs placebo[mean difference(MD)=-1.25,95%CI:-1.60 to-0.90,P<0.00001],routine treatment drugs(MD=-0.85,95%CI:-1.15 to-0.56,P<0.00001),and Chinese patent medicine(MD=-0.91,95%CI:-1.35 to-0.46,P<0.0001);(3)headache duration:We found great heterogeneity between studies,with no differences between YXQN and placebo(MD=-0.61,95%CI:-1.53 to-0.31,P=0.19)and routine treatment drugs(MD=-0.22,95%CI:-0.89 to 0.46,P<0.53).YXQN was more effective than other Chinese patent medicines in reducing headache duration(MD=-1.24,95%CI:-1.70 to-0.77,P<0.00001);and(4)headache severity:There was no significant difference between YXQN vs placebo(MD=-1.67,95%CI:-3.52 to 0.19,P=0.08),routine treatment drugs(MD=-0.53,95%CI:-2.02 to 0.96,P=0.68),and other Chinese patent medicines(MD=-0.49,95%CI:-2.83 to 1.85,P=0.68).Mild gastrointestinal adverse reactions were reported

关键词： Meta-analysis Migraine Yangxue Qingnao Granules Traditional Chinese patent medicine

Chronic social defeat stress‑induced depression reduces BCG efficacy by promoting regulatory T‑cell levels in mice

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Animal Diseases 2024年第2期4卷 115-126页

作者： Rohit Tyagi Xi Chen Atika Dhar Bing Yang Wei Zhou Aikebaier Reheman Yingying Lei gang cao National Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China National Institute of Immunology New Delhi 110067India College of Animal Science and Technology Tarim UniversityAlar 843300China Bio‑Medical Center Huazhong Agricultural UniversityWuhan 430070China

Despite the initial successes of the Bacillus Calmette-Guerin(BCG)vaccine in children,its efficacy against tuberculosis is highly *** is a lack of understanding about how mental conditions influence BCG ***,we used the chronic social defeat stress(CSDS)model to explore the effects of depression on BCG vaccination *** observed higher lung and spleen bacterial loads and a lower organ index in depressed compared to BCG ***,a relatively lower T cell protective efficacy was observed in both compared to control and BCG mice via a mycobacterium growth inhibition assay(MGIA).Cytokine expression of IL-12p40,IL-1β,IL-17,TNF-αand IFN-γwas reduced,whereas the expression of IL-10 and IL-5 was increased in the spleen of both compared to BCG ***,the proportions of CD4^(+)IFN-γ^(+),CD8^(+)IFN-γ^(+)T lymphocytes and CD4^(+)effector/central memory T cells were reduced in the splenocytes of the depressed BCG *** promotes CD4^(+)regulatory T cells(Treg)and myeloid-derived suppressor cell(MDSC)generation in depressed mice,contributing to the reduced pro-inflammatory immune response upon BCG *** study provides insight into the decreased protective immunity by BCG vaccination attributable to depression in mice.

关键词： BCG Vaccine efficacy Treg Immune suppression Depression

Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 758-771页

作者： Xin Han Yan Ning Xinyue Dou Yiwen Wang Qiyuan Shan Kao Shi Zeping Wang Chuan Ding Min Hao Kuilong Wang Mengyun Peng Haodan Kuang Qiao Yang Xianan Sang gang cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou311400China

Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying *** vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw *** ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-QTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)*** note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and *** interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through *** conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.

关键词： Liver fibrosis SIRT3 Cornus officinalis AMPK Caspase6

考虑地震事件内空间相关性的区域概率地震危险性分析

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工程力学 2024年第S01期41卷 117-128页

作者：丁佳伟吕大刚曹正罡哈尔滨工业大学结构工程灾变与控制教育部重点实验室黑龙江哈尔滨150090 哈尔滨工业大学土木工程学院智能防灾减灾工业与信息化部重点实验室黑龙江哈尔滨150090

一次地震事件不同地点的地震动强度参数与结构响应参数之间是空间相关的,相关的地震效应将导致地震损失急剧集中与积累,从而造成灾难性事件,但是现有的区域尺度地震风险评估并没有考虑地震动的空间相关性。该文采用地统计学方法表征地... 详细信息

一次地震事件不同地点的地震动强度参数与结构响应参数之间是空间相关的,相关的地震效应将导致地震损失急剧集中与积累,从而造成灾难性事件,但是现有的区域尺度地震风险评估并没有考虑地震动的空间相关性。该文采用地统计学方法表征地震事件内地震动强度参数的空间相关性,提出了理论半变异函数的几何稳健估计方法,并采用加权最小二乘法实现对短距离空间相关性的准确高效评估。以新潟越冲地震为例,基于指数半变异函数模型,采用加权最小二乘法对几何稳健估计半变异函数值进行拟合,得到了PGA、PGV和0 s~10 s谱加速度的空间相关性函数,提出了变程b值的预测模型,结果表明:相比于短周期谱加速度,长周期谱加速度的空间相关性衰减速率更小,且在T=0.45 s处存在拐点。将所开发的空间相关性模型应用于区域概率地震危险性分析,采用Monte Carlo方法实现了空间相关随机场的区域地震动强度参数的模拟,改进了传统区域地震危险性分析的方法,发现绝大多数情况下考虑空间相关性的年超越概率大于未考虑空间相关性的年超越概率,表明考虑空间相关性对于建筑群落及基础设施风险评估、韧性城市建设等具有重要的指导意义。

关键词：事件内残差空间相关性几何稳健估计加权最小二乘法半变异函数区域危险性分析

Electric field dependence of spin qubit in a Si-MOS quantum dot

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Chinese Physics B 2024年第6期33卷 248-253页

作者：马荣龙倪铭周雨晨孔真真王桂磊刘頔罗刚曹刚李海欧郭国平 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Beijing Superstring Academy of Memory Technology Beijing 100176China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Origin Quantum Computing Company Limited Hefei 230026China

Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum ***, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.

关键词： silicon-based quantum computing valley electric-dipole spin resonance

不同力程排斥相互作用胶体粒子系统的摩擦特性

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物理学报 2024年第15期73卷 141-146页

作者：段浩炀杨柯欣曹义刚郑州大学物理学院:中原之光实验室郑州450001

利用朗之万分子动力学,数值研究了无序点钉扎衬底上二维胶体粒子系统的摩擦特性.本文考虑了三种不同的模型胶体粒子系统,每种系统中胶体粒子之间的相互作用均被模拟为两种不同力程的排斥势.研究发现:每种模型系统均存在两个最大静摩擦力... 详细信息

利用朗之万分子动力学,数值研究了无序点钉扎衬底上二维胶体粒子系统的摩擦特性.本文考虑了三种不同的模型胶体粒子系统,每种系统中胶体粒子之间的相互作用均被模拟为两种不同力程的排斥势.研究发现:每种模型系统均存在两个最大静摩擦力(第一最大静摩擦力f_(c1)^(d)和第二最大静摩擦力f_(c2)^(d));力程相近的短程排斥相互作用之间的干涉会导致粒子间排斥增强,从而导致f_(c1)^(d)的明显降低和f_(c2)^(d)以上沿外场驱动力方向上运动有序的加强.本文的研究结果有助于揭示具有不同力程相互作用胶体粒子系统的摩擦机制.

关键词：摩擦胶体塑性流动运动有序

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双Λ超核同位旋标量巨共振性质的相对论研究

物理学报 2024年第4期73卷 105-112页

作者：温静孙帅曹李刚张丰收北京师范大学核科学与技术学院射线束技术教育部重点实验室北京100875 北京市科学技术研究院辐射技术研究所北京100875 兰州重离子加速器国家实验室原子核理论研究中心兰州730000

基于相对论平均场理论(RMF),采用TM1以及有效超子−核子和超子−超子相互作用,首先研究了^(16)O和^(18)ΛΛO的单粒子能级受超子的影响情况,发现超子的加入使得核子能级能量降低.其次基于相对论无规位相近似方法(RRPA),自洽地计算了^(16)O... 详细信息

基于相对论平均场理论(RMF),采用TM1以及有效超子−核子和超子−超子相互作用,首先研究了^(16)O和^(18)ΛΛO的单粒子能级受超子的影响情况,发现超子的加入使得核子能级能量降低.其次基于相对论无规位相近似方法(RRPA),自洽地计算了^(16)O和^(18)ΛΛO同位旋标量巨单极和四极共振态.发现相比于16O各巨共振的响应函数,超核的响应函数会发生改变.研究表明:这种改变主要来自于超子的加入导致的核子单粒子能级的改变,以及超子粒子−空穴组态跃迁的贡献,而超子−超子剩余相互作用对单极和四极共振在低能区的响应函数的影响比较小,特别对高能区的响应函数基本没有影响.

关键词：双Λ超核巨共振相对论无规位相近似

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油田分层测试工艺及数智化技术

油气井测试 2024年第2期33卷 65-71页

作者：赵增权曹刚曹钰宣中国石油集团渤海钻探工程有限公司井下技术服务分公司天津300283 中国石油大庆油田有限责任公司第一采油厂黑龙江大庆163001

为解决油田传统注入井分层测试工艺效率低、精度差和成本高的问题,研究了一种基于油田数智化推进发展的新技术。该技术整合了智能管柱测调技术、预制电缆以及智能配水器和封隔器等技术,实现了对注入井的分层测试过程的自动化和智能化;... 详细信息

为解决油田传统注入井分层测试工艺效率低、精度差和成本高的问题,研究了一种基于油田数智化推进发展的新技术。该技术整合了智能管柱测调技术、预制电缆以及智能配水器和封隔器等技术,实现了对注入井的分层测试过程的自动化和智能化;通过使用由智能管柱组成的多功能装置,实时监测和采集地质资料;借助可视化界面展示测试数据,增强了数据分析和管理的可视化程度;通过远程控制可实时检测和重新设定每层注水量、查看注水层位的压力和温度,以及进行封隔器密封性检测等;井口智能校准自检仪还能定期对井下仪器参数进行重新标定和校准。该技术为智能化测试技术在油田行业的应用提供了新的思路和方向。

关键词：智能管柱测调数智化技术注入井分层测试优化实时检测自动化测试

自拟癣良方对咪喹莫特诱导小鼠银屑病的治疗作用及机制研究

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军事医学 2024年第3期48卷 219-224页

作者：李金隆曹德森曹岗浙江中医药大学药学院杭州310053 解放军总医院医学工程科北京100853

目的观察自拟癣良方对咪喹莫特诱导小鼠类银屑病的治疗作用并探讨其作用机制。方法BALB/c小鼠随机分为正常组、模型组及口服外涂组,每组10只。采用背部涂布5%咪喹莫特乳膏诱导建立BALB/c小鼠银屑病模型,考察自拟癣良方对银屑病的治疗作... 详细信息

目的观察自拟癣良方对咪喹莫特诱导小鼠类银屑病的治疗作用并探讨其作用机制。方法BALB/c小鼠随机分为正常组、模型组及口服外涂组,每组10只。采用背部涂布5%咪喹莫特乳膏诱导建立BALB/c小鼠银屑病模型,考察自拟癣良方对银屑病的治疗作用。于咪喹莫特乳膏诱导前,以及诱导后第3、7、10及12天,通过光声成像技术,观察小鼠皮肤血管分布和迂曲变化,评价自拟癣良方对血管异常新生的影响。采用苏木素-伊红染色,评价实验小鼠皮肤局部病理变化。采用酶联免疫吸附试验检测小鼠皮肤组织及血清中肿瘤坏死因子α(TNF-α)、白细胞介素-17(IL-17)及白细胞介素-6(IL-6)等细胞因子含量变化。通过流式细胞术,考察小鼠脾脏中Treg、Th1、Th17等细胞因子含量。结果与模型组相比,口服外涂组银屑病面积与严重性指数(PASI)评分显著下降(P<0.01),口服外涂组皮肤中TNF-α、IL-17及IL-6含量显著下调(P<0.01),口服外涂组Treg、Th17及Th1细胞比例明显下降(P<0.05),口服外涂组小鼠皮肤组织病理学(Baker法)评分明显降低(P<0.05)。结论自拟癣良方对银屑病具有良好治疗作用,可通过免疫抑制作用抑制银屑病皮损。

关键词：银屑病小鼠中药光声成像免疫抑制