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Prevalence and Genotyping of Human Papillomavirus among Women in the Departments of Niari and Bouenza, Republic of the Congo

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Journal of Biosciences and Medicines 2022年第1期10卷 64-77页

作者： Parfait Christy Nganga Luc Magloire Anicet Boumba candyse paola lemba tsimba Franck Gaëtan Loubanou Tchibinda Roch Bredin Bissala Nkounkou Eben Ebatetou Ataboho Ghislain Loubano-Voumbi Donatien Moukassa Faculté des Sciences de la Santé Université Marien NGOUABI Brazzaville Congo Laboratoire d’Analyses Médicales et Morphologiques H&ocirc pital Général de Loandjili Pointe-Noire Congo Zone de Recherche de Pointe-Noire Institut National de Recherche en Science de la Santé (IRSSA) Pointe-Noire Congo Faculté des Sciences et Techniques Université Marien NGOUABI Brazzaville Congo

Human papillomaviruses (HPV) are at the origin of many mucosal, benign or malignant skin pathologies. Some so-called high-risk genotypes, especially types 16 and 18, are involved in the genesis of cervical cancer, one of the most common cancers in women. To determine the prevalence of HPV infections and to identify oncogenic genotypes circulating in the departments of Niari and Bouenza. A total of 207 cervical samples collected between 2019 and 2020 were studied. Cervico vaginal smears were performed on all samples for cytological analysis, and HPV DNA detection and genotyping were performed on GeneXpert. The average age of the women who participated in this study was 43.67 ± 12.31 years in Niari and 38.29 ± 10.52 in Bouenza with age intervals ranging from 18 to 80 years. Cytological analysis of these samples reported the following prevalences: Normal diagnosed in 89.58% (186/207) cases, ASCUS in 5.31% (11/207) cases, LSIL in 2.89% (6/207) cases, and ICC in 1.93% (4/207) cases. The prevalence of HPV infection was detected in 83.54% (66/186) of women without lesions, 6.32% (5/11) of ASCUS women and 10.12% (8/10) of women with cytological abnormalities [5.06% (4/6) LSIL, and 5.06% (4/4) ICC]. In total, 79 of the 207 women in our study tested positive for one or more HPV-HR types, or 38.16%. In the department of Niari 37.5% (48/128) women tested positive for HPV, and in the department of Bouenza 39.24% (31/79) tested positive for HPV. Multiple infections ranged from two to more than three strains of HPV. No statistically significant association was observed between socio-demographic characteristics and genotyping (p > 0.05). On the other hand, HPV-HR prevalence varied significantly according to cervical cytology (p = 0.001). The results obtained show the predominance of HPV 16 in women in these two departments of Congo.

关键词： CCU HPV FCV Niari Bouenza

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