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Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus

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World Journal of Clinical Cases 2019年第10期7卷 1111-1121页

作者： Hande Aydemir Hande Idil Tuz Nihal Piskin Guven Celebi canan kulah Furuzan Kokturk Department of Infectious Diseases and Clinical Microbiology Zonguldak Bulent Ecevit UniversityFaculty of MedicineZonguldak 67100Turkey Department of Microbiology Zonguldak Bulent Ecevit UniversityFaculty of MedicineZonguldak 67100Turkey Department of Biostatistics Zonguldak Bulent Ecevit UniversityFaculty of MedicineZonguldak 67100Turkey

BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care *** strains can develop resistance to all the antibiotics *** resistance is common and colistin resistance is rare in our *** the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our *** To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter *** During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included *** variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant *** High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter *** combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant *** the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two *** the patients with infections due to c

关键词： Acinetobacter baumannii Colistin Ventilator-associated pneumonia

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Axial gas mixing in conical spouted beds with high density particles

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Particuology 2023年第10期81卷 45-57页

作者： Neslin Dogan Murat Koksal Gorkem kulah Department of Chemical Engineering Middle East Technical UniversityAnkaraTurkey Department of Mechanical Engineering Hacettepe UniversityBeytepeAnkaraTurkey

Conical spouted beds operating with high-density particles(ρp>2500 kg/m^(3))have recently gained attention because of their potential use as nuclear fuel coaters for next-generation nuclear *** the literature,the number of axial gas mixing studies in conical and conical-cylindrical spouted beds is very limited and all axial mixing studies were carried out with relatively light particles(ρp≤2500 kg/m^(3)).Therefore,the objective of this study was to generate experimental data that can be used to explain the gas axial mixing behavior in conical spouted beds operating with both low-and high-density *** were conducted in two(γ=30°,60°)conical spouted beds with three different types of particles:zirconia(ρp=6050 kg/m^(3)),zirconia toughened alumina(ρp=3700 kg/m^(3))and glass beads(ρp=2460 kg/m^(3)).In order to be able to compare experimental data obtained at different conditions,a 1-D convection-diffusion gas mixing model originally developed by San Joséet al.(1995)was implemented to determine the axial dispersion *** results show that the axial dispersion coefficients range between m^(2)/s and m^(2)/s,increase with superficial gas velocity and are higher than the corresponding dispersion coefficients of fixed beds,lower than the dispersion coefficients of fluidized beds and in the same range with the cylindrical spouted beds reported in the *** corresponding Peclet numbers were in the range of 0.6–7.8 for all operating conditions and slightly higher Peclet numbers were obtained with glass beads indicating the relative importance of gas convective transport over gas dispersion for light particles compared to heavy particles.

关键词： Conical spouted bed Gas dispersion coefficient Axial gas mixing High-density particles

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