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Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

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Regenerative Biomaterials 2023年第1期10卷 205-217页

作者： Ziqiang Wang Ya Li Chenxuan Sun Pukong cui Yuanyuan Han Tong Wu Bai Xu can Zhang Liyang Shi Jianwu Dai College of Biology Hunan UniversityChangsha 410000China State Key Laboratory of Molecular Developmental BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Transplantation of adult spinal cord tissue(aSCT)is a promising treatment for spinal cord injury(SCI)basing on various types of neural cells and matrix components inside ***,long-term systemic administration of immunosuppressors(***,TAC)is required for the survival of allogeneic tissue,which often associated with severe side effects such as infection,liver damageand renal *** this study,a triglycerol monostearate(TGM)-based TAC delivery system(***@TGM)with high drug loading concentration was developed,which possessed injectable properties as well as sustainable and immune-responsive drug release *** complete transected SCI model,locally injected TAC@TGM could reduce the infiltration of inflammation cells,enhance the survival of transplanted aSCT(***-1^(+)and NF^(+)neurons)and promote the recovery of locomotor ***,controlled release of TAC by TAC@TGM attenuated side effects of TAC on liver and kidneys compared with traditional systemic *** importantly,the developed TAC@TGM system provided a facile single dose of long-term immunosuppressive effect not just for aSCT transplantation,but also for other tissue/organ and cell transplantations.

关键词： spinal cord injury adult spinal cord tissue transplantation immune rejection controlled release tacrolimus

Pressure-induced structural transitions and metallization in ZrSe₂

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CHINESE PHYSICS B 2024年第12期33卷 126104-126104页

作者： Gao, Yiping Liu, Chenchen Tian, can Zhu, Chengcheng Huang, Xiaoli cui, Tian Jilin Univ Coll Phys State Key Lab Superhard Mat Changchun 130012 Peoples R China Ningbo Univ Sch Phys Sci & Technol Ningbo 315211 Peoples R China

High-pressure studies of two-dimensional materials have revealed numerous novel properties and physical mechanisms behind them. As a typical material of transition metal dichalcogenides (TMDs), ZrSe2 exhibits high carrier mobility, rich electronic states regulated by doping, and high potential in applications at ambient pressure. However, the properties of ZrSe2 under pressure are still not clear, especially for the structural and electrical properties. Here, we report the investigation of ZrSe2 under pressure up to 66.5 GPa by in-situ x-ray diffraction, Raman, electrical transport measurements, and first-principles calculations. Two structural phase transitions occur in ZrSe2 at 8.3 GPa and 31.5 GPa, from P-3m1 symmetry to P21/m symmetry, and finally transformed into a non-layer I4/mmm symmetry structure. Pressure-induced metallic transition is observed at around 19.4 GPa in phase II which aligns well with the results of the calculation. Our work will help to improve the understanding of the evolution of the structure and electrical transport properties of two-dimensional materials.

关键词： high pressure transition metal dichalcogenides structure phase transition electrical transport properties 61.05.cp 61.50.Ks 64.30.-t 78.30.-j

Wave propagation across fluid-solid interfaces with LBM-LSM coupling schemes

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Petroleum Science 2024年第5期21卷 3125-3141页

作者： Mu-Ming Xia Hui Zhou Chun-Tao Jiang Han-Ming Chen Jin-Ming cui can-Yun Wang Chang-Chun Yang CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and Geophysicsand Innovation Academy for Earth ScienceChinese Academy of SciencesChaoyangBeijing100029China State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)ChangpingBeijing102249China Qingdao Institute of Marine Geology China Geological SurveyQingdao266237ShandongChina AI Sonic Technology Research Center Research Institute of Tsinghua University in ShenzhenShenzhen518057GuangdongChina

Seismic wave propagation in fluid-solid coupled media is currently a popular topic. However, traditional wave equation-based simulation methods have to consider complex boundary conditions at the fluid-solid interface. To address this challenge, we propose a novel numerical scheme that integrates the lattice Boltzmann method(LBM) and lattice spring model(LSM). In this scheme, LBM simulates viscoacoustic wave propagation in the fluid area and LSM simulates elastic wave propagation in the solid area. We also introduce three different LBM-LSM coupling strategies, a standard bounce back scheme, a specular reflection scheme, and a hybrid scheme, to describe wave propagation across fluid-solid boundaries. To demonstrate the accuracy of these LBM-LSM coupling schemes, we simulate wave propagation in a two-layer model containing a fluid-solid interface. We place excitation sources in the fluid layer and the solid layer respectively, to observe the wave phenomena when seismic waves propagate to interface from different sides. The simulated results by LBM-LSM are compared with the reference wavefields obtained by the finite difference method(FDM) and the analytical solution(ANA).Our LBM-LSM coupling scheme was verified effective, as the relative errors between the LBM-LSM solutions and reference solutions were within an acceptable range, sometimes around 1.00%. The coupled LBM-LSM scheme is further used to model seismic wavefields across a more realistic rugged seabed,which reveals the potential applications of the coupled LBM-LSM scheme in marine seismic imaging techniques, such as reverse-time migration and full-waveform inversion. The method also has potential applications in simulating wave propagation in complex two-and multi-phase media.

关键词： Lattice Boltzmann method(LBM) Lattice spring model(LSM) LBM-LSM coupling Finite difference method(FDM) Fluid-solid configuration Seismic wave simulation

Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing cui Wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Major and Trace Elements of Magnetite from the Qimantag Metallogenic Belt: Insights into Evolution of Ore–forming Fluids

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Acta Geologica Sinica(English Edition) 2015年第4期89卷 1226-1243页

作者： YI Liwen GU Xiangping LU Anhuai LIU Jianping LEI Hao WANG Zhiling cui Yu ZUO Hongyan SHEN can Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitor Ministry of Education School of Geosciences and Info–Physics Central South University

Magnetite, as a genetic indicator of ores, has been studied in various deposits in the world. In this paper, we present textural and compositional data of magnetite from the Qimantag metallogenic belt of the Kunlun Orogenic Belt in China, to provide a better understanding of the formation mechanism and genesis of the metallogenic belt and to shed light on analytical protocols for the in situ chemical analysis of magnetite. Magnetite samples from various occurrences, including the ore-related granitoid pluton, mineralised endoskarn and vein-type iron ores hosted in marine carbonate intruded by the pluton, were examined using scanning electron microscopy and analysed for major and trace elements using electron microprobe and laser ablation-inductively coupled plasma-mass spectrometry. The field and microscope observation reveals that early-stage magnetite from the Hutouya and Kendekeke deposits occurs as massive or banded assemblages, whereas late- stage magnetite is disseminated or scattered in the ores. Early-stage magnetite contains high contents of Ti, V, Ga, AI and low in Mg and Mn. In contrast, late-stage magnetite is high in Mg, Mn and low in Ti, V, Ga, AI. Most magnetite grains from the Qimantag metallogenic belt deposits except the Kendekeke deposit plot in the ＂ Skarn ＂ field in the Ca＋AI＋Mn vs Ti＋V diagram, far from typical magmatic Fe deposits such as the Damiao and Panzhihua deposits. According to the （MgO＋MnO）- TiO^-AI203 diagram, magnetite grains from the Kaerqueka and Galingge deposits and the No.7 ore body of the Hutouya deposit show typical characteristics of skarn magnetite, whereas magnetite grains from the Kendekeke deposit and the No.2 ore body of the Hutouya deposit show continuous elemental variation from magmatic type to skarn type. This compositional contrast indicates that chemical composition of magnetite is largely controlled by the compositions of magmatic fluids and host rocks of the ores that have reacted with the fluids. Moreover, a co

关键词： Magnetite trace element LA-ICP-MS ore genesis Qimantag metallogenic belt

Global mitigation efforts cannot neglect emerging emitters

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National Science Review 2022年第12期9卷 82-89页

作者： can.cui Dabo Guan Daoping Wang Jing Meng Vicky Chemutai Paul Brenton Shaohui Zhang Yuli Shan Qiang Zhang Steven J.Davis Department of Earth System Science Tsinghua University The Bartlett School of Sustainable Construction University College London Department of Computer Science and Technology University of Cambridge Centre for Nature and Climate World Economic Forum School of Urban and Regional Science Shanghai University of Finance and Economics The World Bank School of Economics and Management Beihang University International Institute for Applied Systems Analysis School of Geography Earth and Environmental Sciences University of Birmingham Department of Earth System Science University of California Irvine Department of Civil and Environmental Engineering University of California Irvine

International efforts to avoid dangerous climate change have historically focused on reducing energy-related CO2emissions from countries with either the largest economies(*** EU and the USA)and/or the largest populations(*** and India).However,in recent years,emissions have surged among a different and much less-examined group of countries,raising concerns that a next generation of high-emitting economies will obviate current mitigation ***,we analyse the trends and drivers of emissions in each of the 59 countries where emissions in 2010-2018 grew faster than the global average(excluding China and India),project their emissions under a range of longer-term energy scenarios and estimate the costs of decarbonization *** emissions from these ’emerging emitters’ reach as much as 7.5 GtCO2/year in the baseline 2.5° scenari—substantially greater than the emissions from these regions in previously published scenarios that would limit warming to 1.5℃ or even 2℃.Such unanticipated emissions would in turn require non-emitting energy deployment from all sectors within these emerging emitters,and faster and deeper reductions in emissions from other countries to meet international climate ***,the annual costs of keeping emissions at the low level are in many cases 0.2%-4.1% of countries’ gross domestic production,pointing to potential trade-offs with poverty-reduction goals and/or the need for economic support and low-carbon technology transfer from historically high-emitting *** results thus highlight the critical importance of ramping up mitigation efforts in countries that to this point have been largely ignored.

关键词： emerging emiters developing countries climate change mitigation CO_2 emissions net zero

Role of Δ133p53 isoform in NF-κB inhibitor PDTC-mediated growth inhibition of MKN45 gastric cancer cells

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World Journal of Gastroenterology 2017年第15期23卷 2716-2722页

作者： Hong-Mei Zhang Xiao-Guang Sang Yan-Ze Wang can.cui Li Zhang Wan-Sheng Ji Department of Gastroenterology Affiliated Hospital of Weifang Medical University Department of Gastroenterology Shouguang People's Hospital Graduate School of Weifang Medical University

AIM To investigate the role of Δ133p53 isoform in nuclear factor-κB(NF-κB) inhibitor pyrrolidine dithiocarbamate(PDTC)-mediated growth inhibition of MKN45 gastric cancer *** The growth rate of MKN45 cells after treatment with different concentrations of only PDTC or PTDC in combination with cisplatin was detected by the CCK-8 assay. m RNA expression levels of Δ133p53, p53β, and the NF-κB p65 subunit and p65 protein levels were detected by reverse transcription-polymerase chain reaction(RT-PCR) and immunofluorescence, respectively. Growth of MKN45 cells was significantly inhibited by PDTC alone in a dose-dependent manner(P cantly in a dose-dependent manner by treatment with only PDTC(P cantly reduced in a dose-dependent manner by treatment with only PDTC or PTDC in combination with cisplatin(P 0.05). A similar tendency of change in p65 protein expression, as observed for the corresponding m RNA, was detected by immunofluorescence analysis(P cant relationship was observed between those of p65 and p53β(r = 0.076, P > 0.01).CONCLUSIONΔ133p53 isoform(not p53β) is required in PDTCinduced inhibition of MKN45 gastric cancer cells, indicating that disturbance in the cross-talk between p53 and NF-κB pathways is a promising target in pharmaceutical research for the development of treatment strategies for gastric cancer.

关键词： Gastric cancer p53 isoforms Nuclear factor-κB

In-situ electrochemical study on the eff ects of Fe(Ⅲ)on kinetics of pyrite acidic pressure oxidation

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Acta Geochimica 2024年第4期43卷 814-825页

作者： Yu Zhang can.cui Sen Lin Heping Li Lian Yang Yadian Xie Hailiang Hu Lingyun Zhou Huanjiang Wang Chunyan Li School of Chemical Engineering Guizhou Minzu UniversityGuiyang 550025China Key Laboratory of High-Temperature and High-Pressure Study of the Earth’s Interior Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Fe(Ⅲ)has been proved to be a more eff ective oxidant than dissolved oxygen at ambient temperature,however,the role of Fe(Ⅲ)in pyrite acidic pressure oxidation was rarely discussed so *** this paper,in-situ electrochemical investigation was performed using a flow-through autoclave system in acidic pressure oxidation *** results illustrated that increasing Fe(Ⅲ)concentrations led to raising in redox potential of the solution,and decreased passivation of pyrite caused by deposition of elemental *** of Fe(Ⅲ)at pyrite surface was a fast reaction with low activation energy,it was only slightly promoted by rising ***,the oxidation rate of pyrite at all investigated Fe(Ⅲ)concentrations increased obviously with rising temperatures,the anodic reaction was the rate-limiting step in the overall *** energy of pyrite oxidation decreased from 47.74 to 28.79 kJ/mol when Fe(Ⅲ)concentration was increased from 0.05 to 0.50 g/L,showing that the reaction kinetics were limited by the rate of electrochemical reaction at low Fe(Ⅲ)concentrations,while,it gradually turned to be diffusion control with increasing Fe(Ⅲ)concentrations.

关键词： Pyrite Pressure oxidation Fe(Ⅲ) In-situ electrochemistry Hydrothermal experiment

Photocatalytic Hydrogen Evolution of Keggin-type Polyoxo-tungstates and their Electrochemical Behaviors

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Chinese Chemical Letters 2006年第7期17卷 973-976页

作者： Li Qin DANG Wan Sheng YOU Xin ZHANG cui Ying HUANG Zhi Bin LEI Zhen Gang SUN can LI Institute of Chemistry for Functionalized Materials Faculty of Chemistry and Chemical Engneering Liaoning Normal University Liaoning 116029 State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Science Liaoning 116023

The photocatalytic hydrogen evolution and electrochemical behaviors of Kiggen-type XW12O40^n- （X=P, Ge and Si） are investigated. It is found that the two-electron reduced species are active for H^＋ reduction and the more negative the potential of XW12O40^（n＋2）-/（n＋1）- is, the higher the activity for hydrogen evolution is.

关键词： Polyoxotungstates photocatalysis hydrogen evolution electrochemistry.