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Frontiers of COVID-19-related myocarditis as assessed by cardiovascular magnetic resonance

World Journal of Clinical Cases 2022年第20期10卷 6784-6793页

作者： Yi Luo Ben-Tian Liu Wei-Feng Yuan can-xian zhao The First People’s Hospital of Longquanyi District Chengdu 610100Sichuan ProvinceChina Department of Radiology Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Medical Imaging Chengdu Second People’s HospitalChengdu 610011Sichuan ProvinceChina

Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** some patients,COVID-19 is complicated with *** detection of myocardial injury and timely intervention can significantly improve the clinical outcomes of COVID-19 *** endomyocardial biopsy(EMB)is currently recognized as the‘gold standard’for the diagnosis of myocarditis,there are large sampling errors,many complications and a lack of unified diagnostic *** addition,the clinical methods of treating acute and chronic COVID-19-related myocarditis are *** magnetic resonance(CMR)can evaluate the morphology of the heart,left and right ventricular functions,myocardial perfusion,capillary leakage and myocardial interstitial fibrosis to provide a noninvasive and radiation-free diagnostic basis for the clinical detection,efficacy and risk assessment,and followup observation of COVID-19-related ***,for the diagnosis of COVID-19-related myocarditis,the Lake Louise Consensus Criteria may not be fully ***-19-related myocarditis is different from myocarditis related to other viral infections in terms of signal intensity and lesion location as assessed by CMR,which is used to visualize myocardial damage,locate lesions and quantify pathological changes based on various ***,the standardized application of CMR to timely and accurately evaluate heart injury in COVID-19-related myocarditis and develop rational treatment strategies could be quite effective in improving the prognosis of patients and preventing potential late-onset effects in convalescent patients with COVID-19.

关键词： COVID-19 Myocarditis Cardiovascular magnetic resonance Inflammation Diagnosis Infection

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Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： can-can Zhang Jun-Long Yang Ya-Jiang Huang Guang-xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

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Highly Hydrolysis-Resistant Polyimide Fibers Prepared by Thermal Crosslinking with Inherent Carboxyl Groups

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Chinese Journal of Polymer Science 2024年第2期42卷 247-255,I0010页

Easy hydrolysis in alkaline environments limits the use of polyimide fibers in environmental protection. The hydrolysis resistance levels of polyimide fibers can be improved by crosslinking of the macromolecular chains. In this work, crosslinked polyimide fibers(CPI fibers) were produced by intrinsic carboxyl decarboxylation for the first time. The thermal stability of the polyimide fibers containing the intrinsic carboxyl groups(PIC fibers) was studied, and the temperature of the decarboxylation-crosslinking reaction was determined to be 450 ℃. The PIC fibers were hotdrawn to initiate thermal crosslinking of the carboxyl groups and molecular chain orientation at high temperature. The CPI fibers had high tensile strengths(0.72-1.46 GPa) and compressive strengths(401-604 MPa). The oriented macromolecules and chemically crosslinked structure improved the tightness of the molecular chains and endowed the CPI fibers with excellent hydrolytic resistance. The CPI-50 fiber did not dissolve in a 0.5 wt% NaOH solution during heating at 90 ℃ for 10 h, and the tensile strength retention reached 87% when treated in 0.5 wt% NaOH solutions at 90 ℃ for 1 h, providing a guarantee for its application in alkaline corrosive environments.

关键词： Polyimide Carboxyl group Crosslinking Hydrolysis-resistance

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The deep mantle upwelling beneath the northwestern South China Sea:Insights from the time-varying residual subsidence in the Qiongdongnan Basin

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Geoscience Frontiers 2021年第6期12卷 223-235页

作者： Zhong-xian zhao Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 511458China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China Key Laboratory of Marine Mineral Resources Ministry of Natural ResourcesGuangzhou 510760China

Deep hot mantle upwelling is widely revealed around the Qiongdongnan Basin on the northwestern South China Sea margin. However, when and how it influenced the hyper-extended basin is *** resolve these issues, a detailed analysis of the Cenozoic time-varying residual subsidence derived by subtracting the predicted subsidence from the backstripped subsidence was performed along a new seismic reflection line in the western Qiongdongnan Basin. For the first time, a method is proposed to calculate the time-varying strain rates constrained by the faults growth rates, on basis of which, the predicted basement subsidence is obtained with a basin-and lithosphere-scale coupled finite extension model, and the backstripped subsidence is accurately recovered with a modified technique of backstripping to eliminate the effects of later episodes of rifting on earlier sediment thickness. Results show no residual subsidence in 45–28.4 Ma. But after 28.4 Ma, negative residual subsidence occurred, reached and remained ca. -1000 m during 23–11.6 Ma, and reduced dramatically after 11.6 Ma. In the syn-rift period(45–23 Ma), the residual subsidence is ca. -1000 m, however in the post-rift period(23–0 Ma),it is positive of ca. 300 to 1300 m increasing southeastwards. These results suggest that the syn-rift subsidence deficit commenced at 28.4 Ma, while the post-rift excess subsidence occurred after 11.6 *** with previous studies, it is inferred that the opposite residual subsidence in the syn-and post-rift periods with similar large wavelengths(>10^(2) km) and km-scale amplitudes are the results of transient dynamic topography induced by deep mantle upwelling beneath the central QDNB, which started to influence the basin at ca. 28.4 Ma, continued into the Middle Miocene, and decayed at ca.11.6 Ma. The initial mantle upwelling with significant dynamic uplift had precipitated considerable continental extension and faulting in the Late Oligocene(28.4–23 Ma). After ca. 11.6 Ma, s

关键词： Residual subsidence Deep mantle upwelling Strain rate Qiongdongnan Basin Northwestern South China Sea margin

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Two-dimensional linear connected-k system with trinary states and its reliability

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Journal of Systems Engineering and Electronics 2011年第5期22卷 866-870页

作者： xian zhao Wei zhao Weijuan Xie School of Management and Economics Beijing Institute of Technology Beijing 100081 P. R. China

Existing studies about two-dimensional consecutivek-out-of-n： F system is dealt with two states （either component or system）： working or failure. A new model for two-dimensional linear consecutive-k-out-of-n： F system is proposed, in which the components and systems can be at any of the three states： full working, derating working, and failure. Furthermore, two engineer- ing concrete instances of the new system are given. By using the finite Markov chain imbedding approach, the system reliability is presented in a unified formula with the product of matrices for the case of independent and identically distributed component states which can be extended to the independent but non-identical case easily. Finally, an example is given to illustrate the effectiveness of the above approach and tractability of various problems.

关键词： reliability two-dimensional systems trinary states

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Efficient Difference Schemes for the Caputo-Tempered Fractional Diffusion Equations Based on Polynomial Interpolation

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Communications on Applied Mathematics and Computation 2021年第1期3卷 1-40页

作者： Le zhao can Li Fengqun zhao Department of Applied Mathematics Xi’an University of TechnologyXi’an 710054China

The tempered fractional calculus has been successfully applied for depicting the time evolution of a system describing non-Markovian diffusion *** related governing equations are a series of partial differential equations with tempered fractional *** the polynomial interpolation technique,in this paper,we present three efficient numerical formulas,namely the tempered L1 formula,the tempered L1-2 formula,and the tempered L2-1_(σ)formula,to approximate the Caputo-tempered fractional derivative of orderα∈(0,1).The truncation error of the tempered L1 formula is of order 2-α,and the tempered L1-2 formula and L2-1_(σ)formula are of order 3-α.As an application,we construct implicit schemes and implicit ADI schemes for one-dimensional and two-dimensional time-tempered fractional diffusion equations,***,the unconditional stability and convergence of two developed difference schemes with tempered L1 and L2-1_(σ)formulas are proved by the Fourier analysis ***,we provide several numerical examples to demonstrate the correctness and effectiveness of the theoretical analysis.

关键词： Caputo-tempered fractional derivative Polynomial interpolation Implicit ADI schemes Stability

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五味子甲素改善氧化应激引起的内皮功能障碍

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中国药理学通报 2025年第1期41卷 122-130页

作者：侯惠民张文文赵卫萍赵鑫朴贤美寒地心血管疾病国家重点实验室哈尔滨医科大学药学院药理学教研室黑龙江省生物医药工程重点实验室—省部共建国家重点实验室培育基地心血管药物研究教育部重点实验室黑龙江哈尔滨150086

目的探究五味子甲素(schizandrin A,SchA)对氧化应激引起内皮功能障碍的拮抗作用及其作用机制。方法选用人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)作为研究对象,采用MTT实验检测SchA对HUVECs活力的影响;通过流... 详细信息

目的探究五味子甲素(schizandrin A,SchA)对氧化应激引起内皮功能障碍的拮抗作用及其作用机制。方法选用人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)作为研究对象,采用MTT实验检测SchA对HUVECs活力的影响;通过流式细胞技术检测细胞中ROS的含量;试剂盒检测HUVECs中MDA、CAT的含量以及细胞上清液中NO、ET-1的含量;Western blot实验检测细胞中SOD1、p-eNOS/eNOS蛋白以及Nrf2/Keap1/HO-1通路蛋白的表达情况;免疫荧光实验检测细胞Nrf2的入核情况。结果SchA通过激活Nrf2/Keap1/HO-1信号通路逆转LPS或缺氧诱导的HUVECs内ROS和MDA含量的升高及SOD1和CAT含量的下降;SchA逆转LPS诱导的HUVECs中p-eNOS和eNOS蛋白表达的降低及逆转细胞培养液中NO含量的下降和ET-1含量的升高;Nrf2抑制剂ML385逆转SchA对氧化应激及内皮功能障碍的拮抗作用。结论SchA拮抗LPS及缺氧诱导的氧化应激,SchA通过上调Nrf2/Keap1/HO-1信号通路改善氧化应激引起的内皮功能障碍。

关键词： SchA 氧化应激内皮功能障碍 Nrf2/Keap1/HO-1信号通路 HUVECs LPS

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Theoretical Design of Defects as a Driving Force for Ion Transport in Li_(3)OBr Solid Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 143-153页

作者： Xingyun Luo Yanlu Li xian zhao State Key Lab of Crystal Materials and Institute of Crystal Materials Shandong UniversityJinan 250100China Center for Optics Research and Engineering Shandong UniversityQingdao 266237China

Due to ever-increasing concerns about safety issues in using Li ionic batteries,solid electrolytes have extensively *** Li-rich antiperovskite Li_(3)OBr has been considered as a promising solid electrolyte candidate,but it still suffers challenges to achieve a high ionic conductivity owing to the high intrinsic symmetry of the crystal ***,we presented a design strategy that introduces various point defects and grain boundaries to break the high lattice symmetry of Li_(3)OBr crystal,and their effect and microscopic mechanism of promoting the migration of Li-ion were explored *** has been found that Li_(i)are the dominant defects responsible for the fast Li-ion diffusion in bulk Li_(3)OBr and its surface,but they are easily trapped by the grain boundaries,leading to the annihilating of the Frenkel defect pair V'_(Li)+Li_(i),and thus limits the V'_(Li)diffusion at the grain *** V_(Br)defect near the grain boundaries can effectively drive V'_(Li)across the grain boundary,thereby converting the carrier of Li^(+)migration from Li,in the bulk and surface to V'_(Li)at the grain boundary,and thus improving the ionic conductivity in the whole Li_(3)OBr *** work provides a comprehensive insight into the Li^(+)transport and conduction mechanism in the Li_(3)OBr *** opens a new way of improving the conductivity for all-solid-state Li electrolyte material through the defect design.

关键词： defects density functional theory ionic migration solid electrolyte

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Graph convolutional network for axial concentration profiles prediction in simulated moving bed

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Chinese Journal of Chemical Engineering 2024年第9期73卷 270-280页

作者： can Ding Minglei Yang Yunmeng zhao Wenli Du Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

The simulated moving bed(SMB)chromatographic separation is a continuous compound separation process based on the differences in adsorption capacity exhibited by distinct constituents of a mixture on the fluid phase and stationary *** prediction of axial concentration profiles along the beds in a unit is crucial for the operating optimization of *** the correlation shared by operating variables of SMB has an enormous impact on the operational state of the device,these correlations have been long overlooked,especially by the data-driven *** study proposes an operating variable-based graph convolutional network(OV-GCN)to enclose the underrepresented correlations and precisely predict axial concentration profiles prediction in *** OV-GCN estimates operating variables with the Spearman correlation coefficient and incorporates them in the adjacency matrix of a graph convolutional network for information propagation and feature *** with Random Forest,K-Nearest Neighbors,Support Vector Regression,and Backpropagation Neural Network,the values of the three performance evaluation metrics,namely MAE,RMSE,and R^(2),indicate that OV-GCN has better prediction accuracy in predicting five essential aromatic compounds'axial concentration profiles of an SMB for separating p-xylene(PX).In addition,the OV-GCN method demonstrates a remarkable ability to provide high-precision and fast predictions in three industrial case *** the goal of simultaneously maximizing PX purity and yield,we employ the non-dominated sorting genetic algorithm-II optimization method to perform multi-objective optimization of the PX purity and *** outcome suggests a promising approach to extracting and representing correlations among operating variables in data-driven process modeling.

关键词： Chromatography Prediction Operating variables Graph convolutional network Optimization

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Oscillation Period of Two-Level Systems Driven by Time-Dependent Fields

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Chinese Physics Letters 1999年第12期16卷 917-918页

作者： zhao xian-geng CCAST(World Laboratory) P.O.Box 8730Beijing 100080 Institute of Applied Physics and Computational Mathematics Beijing 100088 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

We study the dynamics of two-level systems under the influence of time-dependent external fields. An oscillation period describing the transition between two states is obtained analytically by the use of perturbation theory, from which the results for any special case can be derived. We illustrate two examples to show the advantage of our theory, in which the phenomenon of localization/delocalization can be addressed uniformly by oscillation period.

关键词： oscillation uniformly perturbation

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