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A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCt detecting malaria

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Microsystems & Nanoengineering 2020年第1期6卷 1316-1333页

作者： Sthitodhi Ghosh Kashish Aggarwal Vinitha t.u thinh Nguyen Jungyoup Han Chong H.Ahn Department of Electrical Engineering and Computer Science Microsystems and BioMEMS LaboratoryUniversity of CincinnatiCincinnatiOH 45221USA Mico BioMed uSA Inc. 10999 Reed Hartman HighwaySTE 309CCincinnatiOH 45242USA

there has been a considerable development in microfluidic based immunodiagnostics over the past few years which has greatly favored the growth of novel point-of-care-testing(POCt).However,the realization of an inexpensive,low-power POCt needs cheap and disposable microfluidic devices that can perform autonomously with minimum user *** work,for the first time,reports the development of a new microchannel capillary flow assay(MCFA)platform that can perform chemiluminescence based ELISA with lyophilized chemiluminescent *** new MCFA platform exploits the ultra-high sensitivity of chemiluminescent detection while eliminating the shortcomings associated with liquid reagent handling,control of assay sequence and user *** functionally designed microchannels along with adequate hydrophilicity produce a sequential flow of assay reagents and autonomously performs the ultra-high sensitive chemiluminescence based ELISA for the detection of malaria biomarker such as *** MCFA platform with no external flow control and simple chemiluminescence detection can easily communicate with smartphone via uSB-OtG port.using a custom-designed optical *** use of the smartphone for display,data transfer,storage and analysis,as well as the source of power allows the development of a smartphone based POCt analyzer for disease *** paper reports a limit of detection(LOD)of 8 ng/mL by the smartphone analyzer which is sensitive enough to detect active malarial *** MCFA platform developed with the smartphone analyzer can be easily customized for different biomarkers,so a hand-held POCt for various infectious diseases can be envisaged with full networking capability at low cost.

关键词： POCt smart capillary

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Laser Surface texturing of Co–Cr–Mo Alloy for Biomedical Applications:A Case Study for the Effects of Process Parameters on Surface Properties

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Journal of Bionic Engineering 2023年第5期20卷 1967-1984页

作者： Şefika Kasman İbrahim can uçar Sertan Ozan Department of Mechanical Engineering Dokuz Eylul UniversityIzmir35397Turkey Department of Mechanical Engineering Yozgat Bozok UniversityYozgat66100Turkey

this study presents a comprehensive approach to applying texturing processes created by engraving on the surface of CoCr28Mo alloy workpieces using a 20 W pulsed nanosecond fiber *** hatch strategy and distance,frequency,and scan speed were control parameters for texturing *** effectiveness of the parameters in terms of roughness and contact angle of the texturized surface was *** roughness and contact angle were analyzed using variance analysis to identify each variable's *** has been determined that the roughness of the texture defined by the hatch strategy plays a decisive role in the wettability behavior of the surface;however,the scan speed,frequency,and hatch distance which are among the laser surface texturing conditions are influential in the roughness and contact *** scan speed and hatch distance while decreasing frequency resulted in smoother surfaces,increasing the contact *** having rough surfaces produced with different processing conditions exhibit a super hydrophilic *** contact angle is most sensitive to the hatch distance;however,the frequency has the least influence on the contact *** most and least efficient surface roughness parameters are revealed to be scan speed and hatch distance,respectively.

关键词： Laser surface texturing Co-Cr-Mo alloy Surface roughness Wettability Bionic

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Geoelectrical survey over perched aquifers in the northern part of upper Sakarya River Basin,türkiye

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Journal of Groundwater Science and Engineering 2022年第4期10卷 335-352页

作者： can Ertekin Emin u ulugergerli Aegean Regional Directorate of Mineral Research and Exploration İzmirTürkiye Çanakkale Onsekiz Mart.university Department of Geological EngineeringTerzioğlu CampusÇanakkaleTürkiye Çanakkale Onsekiz Mart.university Engineering FacultyDepartment of Geophysical EngineeringTerzioğlu CampusÇanakkaleTürkiye

In this study,a groundwater exploration survey was conducted using the DC Resistivity(DCR)method in a hydrogeological setting containing a perched *** data were gathered and an electrical tomography section was recovered using conventional four-electrode inst.uments with a Schlumberger array and a two-dimensional(2D)inversion *** proposed scheme was tested over a synthetic threedimensional(3D)subsurface model before deploying it in a field *** proposed method indicated that gathering data with simple four-electrode inst.uments at stations along a line and 2D inversion of datasets at multiple stations can recover depth intervals of the studied aquifer in the hydrogeological setting even if it has a 3D *** this study,2D inversion of parallel profiles formed a pseudo-3D volume of the subsurface resistivity st.uctures and mapped out multiple resistive(>25 ohm·m)bodies at shallow(between 50-100 m)and deep sections(>150 m).In general,the proposed method is convenient to encounter geological units that have limited vertical and spatial extensions in any direction and presents resistivity contrast from groundwater-bearing geologic materials.

关键词： Groundwater Perched Aquifer DC Resistivity Inversion Sakarya River türkiye

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Casting properties of AStM A128 Gr.E1 steel modified with Mn-alloying and titanium ladle treatment

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China Foundry 2021年第3期18卷 199-206页

作者： uğur Gürol Erdal Karadeniz OzanÇoban Süleyman can Kurnaz Gedik Welding Company Ankara Caddesi34906İstanbulTurkey Sakarya university Engineering FacultyDepartment of Metallurgical&Materials EngineeringEsentepe Campus54187SakaryaTurkey Sakarya university Engineering FacultyDepartment of Mechanical EngineeringEsentepe Campus54187SakaryaTurkey Istanbul Gedik university Engineering FacultyDepartment of Metallurgical&Materials Engineering34876IstanbulTurkey

this work aims to produce a high manganese steel with more refined austenite grains and better wear resistance without sacrificing the t.ughness and tensile properties by Mn alloying and ti ladle treatment in comparision to AStM A128 Gr.E1 steel (1.0C-13Mn) that is mostly used in the mining *** 1.0C-17Mn-xti alloys (x=0,0.05 and 0.1,in wt.%) were prepared.A relationship was established between the microst.uctures and mechanical properties of the as-cast and solution annealed *** ti content increases the stable ti(CN) phase on and beside the grain boundaries and decreases up to 37% the austenite grain size of the as-cast alloy with 0.10wt.% ***,after solution annealed,optimized titanium content (0.05wt.%) results in significant improvements in wear resistance,hardness,elongation,yield and tensile strengths by 44%,31%,30%,8% and 12%,respectively,except 9% decrease in impact t.ughness compared to AStM A 128 Gr.E1 steel without *** results show that 1.0C-17Mn-0.05ti alloy can be used for parts exposed to high load wear and applied in conditions where relatively high tensile properties with sufficent ductility is needed.

关键词： high manganese steel hadfield steel ladle treatment grain refinement microst.ucture mechanical properties

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. the Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic t-lymphocyte antigen-4 (CtLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the cancer Genome Atlas Program (tCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the tarBase, miRtarBase, and miRBase databases. the regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. the expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' utR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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u-can日语能力测试N1模拟试题集 1

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2010年

作者：日本u-can日语能力测试研究会编

本书对新的日语能力测试的出题内容进行了详细分析，针对性地提出了有效对策，并精心编制了实战试题，以帮助参加日语能力测试的考生，切实提高其日语水平和应试能力。

ISBN: (纸本)9787100074315

关键词：日语习题水平考试

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Institute of Energy Process Engineering and Chemical Engineering (IEC), tu Bergakademie Freiberg: towards a Circular Carbon Economy

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Clean Energy 2019年第4期3卷 316-323页

作者： Freiberg, t.u Bergakademie Reiche Zeche Fuchsmuehlenweg 9 Freiberg 09599 Germany

1 History of the Institute of Energy Process Engineering and Chemical Engineering(IEC)the history of IEC dates back to 1918,when the Lignite Foundation of the State of Saxony was founded to develop pro-cesses and technologies for lignite utilization in *** 1919,the precursor department of IEC with a focus on the thermochemical conversion of lignite was established.

关键词： Saxon IEC Carbon

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u-can日语能力测试N2模拟试题集 1

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2010年

作者：日本u-can日语能力测试研究会编

ISBN: (数字)9787100074308

ISBN: (纸本)9787100074308

关键词：日语习题水平考试

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Highly Improved Creep Resistance in Polypropylene through thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： can-can Zhang Jun-Long Yang Ya-Jiang Huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. this st.uctural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(trGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% trGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(tEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of trGO's influence on PP's creep behavior. It was observed that when trGO content exceeded 1.0 wt%, an effective particle network st.ucture formed within the PP matrix. this homogeneously dispersed trGO-formed particle network st.ucture restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without st.uctural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. this research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, t.us extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

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Anatomy of a eustatic event during the turonian (Late Cretaceous) hot greenhouse climate

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Science China Earth Sciences 2017年第1期60卷 20-29页

作者： Bilal u. HAQ Brian t. HuBER Department of Paleobiology MRC-121Smithsonian InstitutionWashington D C 20013USA Sorbonne ISTEP Pierre&Marie Curie UniversityParis 75005France

Sequence stratigraphic studies consider relative change in sea level(as regulated by eustasy,local tectonics and sediment supply)as the main builder of the stratigraphic *** has generally been considered as a consequence of the growth and decay of continental ice sheets that would explain large,rapid changes in sea level,even during periods of relative global climatic ***,such a mechanism has become increasingly difficult to envision during times of extreme global warmth such as the turonian,when the equator-to-pole temperature gradient was very low and the presence of polar ice seems *** paper investigates the timing and extent of sea level falls during the late Cenomanian through turonian,especially the largest of those events,sequence boundary Ktu4,which occurred during the middle to late turonian peak of the Cretaceous hot greenhouse *** conclude that the amplitude of the widespread third-order sea level fall in the middle turonian that is centered at^91.8 Ma varies at different locations depending on the influence of dynamic topography on local tectonics and regional climatic *** volume variations seem unlikely as a mechanism for controlling sea level at this ***,this causal factor cannot be ruled out completely since Antarctic highlands(if they existed in the Late Cretaceous)could sequester enough water as ice to cause eustatic *** ascertain this requires detailed tomographic imaging of Antarctica,followed by geodynamic modeling,to determine whether high plateaus could have existed to accumulate ephemeral ice *** mechanisms for sea level change,such as transference between ground water(a small amplitude shorter time scale effect)and the ocean and entrainment and release of water from the mantle to the oceanic reservoir(a potentially large amplitude and longer time scale process),are intriguing and need to be explored further to prove their efficacy at third-order time scales.

关键词： Eustatic event turonian Hot greenhouse climate

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