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Non-coding RNAs and gastric cancer

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World Journal of Gastroenterology 2014年第18期20卷 5411-5419页

作者： Pei-Fei Li sheng-can Chen Tian Xia Xiao-Ming Jiang Yong-Fu Shao Bing-Xiu Xiao Jun-Ming Guo Department of Biochemistry and Molecular Biology Zhejiang Provincial Key Laboratory of PathophysiologyNingbo University School of Medicine

Non-coding RNAs(ncRNAs)play key roles in development,proliferation,differentiation and *** ncRNA expression is associated with gastric cancer occurrence,invasion,and ***,aberrant expression of microRNAs(miRNAs)is significantly related to gastric cancer tumor stage,size,differentiation and *** interrupt cellular signaling pathways,inhibit the activity of tumor suppressor genes,and affect the cell cycle in gastric cancer *** miRNAs,including miR-21,miR-106a and miR-421,could be potential markers for the diagnosis of gastric *** non-coding RNAs (lncRNAs),a new research hotspot among cancerassociated ncRNAs,play important roles in epigenetic,transcriptional and post-transcriptional *** gastric cancer-associated lncRNAs,such as CCAT1,GACAT1,H19,and SUMO1P3,have been *** addition,Piwi-interacting RNAs,another type of small ncRNA that is recognized by gastroenterologists,are involved in gastric carcinogenesis,and piR-651/823represents an efficient diagnostic biomarker of gastric cancer that can be detected in the blood and gastric *** interfering RNAs also function in posttranscriptional regulation in gastric cancer and might be useful in gastric cancer treatment.

关键词： Non-coding RNA MicroRNA Piwi-interacting RNA Long non-coding RNA Small interfering RNA Gastric cancer

Total Synthesis of Phakellistatin 13 by Solution Method

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Chinese Chemical Letters 2006年第8期17卷 995-998页

作者： Qing Feng JIANG You Jun ZHOU Jian Zhong YAO Jia Guo LU Ju ZHU Chun Quan sheng can Hui ZHENG Bing YAO Department of Medicinal Chemistry School of Pharmacy Second Military Medical University Shanghai 200433

Phakellistatin 13 is a good antitumor lead compound isolated from halobios. It was synthesized first time by solution method in combination of stepwise coupling and segment condensation. Final deprotection and cyclization were achieved according to our designed method, which was different from the reported process. The spectral data of synthetic product is consisted with literatureal data of natural product. Total synthesis of phakellistatin 13 is a significant achievement to further study of its derivatives and developing novel antitumor drugs.

关键词： Phakellistatin 13 solution-phase synthesis cyclopeptide.

Spin-orbit coupling adjusting topological superfluid of mass-imbalanced Fermi gas

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Chinese Physics B 2022年第9期31卷 208-216页

作者： Jian Feng Wei-Wei Zhang Liang-Wei Lin Qi-Peng Cai Yi-Cai Zhang sheng-can Ma Chao-Fei Liu School of Science Jiangxi University of Science and TechnologyGanzhou 341000China School of Physics and Electronic Engineering Guangzhou UniversityGuangzhou 510006China

Topological superfluid state is different from the normal superfluid one due to the excitation energy gap on the *** to obtain the topological superfluid state by using spin-orbit coupling to control the s-waves paired mass-imbalanced Fermi gas is a recent novel *** this paper,we study the topological superfluid phase diagram of two-dimensional mass-imbalanced Fermi gas with Rashba spin-orbit coupling at zero *** find that due to the competition among mass imbalance,pairing interaction and spin-orbit coupling,there is a double-well structure in the thermodynamic potential,which affects the properties of the ground state of the *** comprehensively give the phase diagrams of the system on the plane of spin-orbit coupling and chemical potential,and the phase diagrams on the plane of the reduced mass ratio and two-body binding *** study not only points out the stable region of topolog-ical superfluid state of mass-imbalanced Fermi gas,but also provides a detailed theoretical basis for better observation of topological superfluid state in experiments.

关键词： topological superfluid mass-imbalanced spin-orbit coupling Fermi gas

非药物干预在阿尔茨海默病临床前期的应用现状与展望

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中华神经医学杂志 2020年第4期19卷 325-329页

作者：韩璎盛灿首都医科大学宣武医院神经内科北京100053

阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍为特征的中枢神经系统退行性疾病,也是引起老年痴呆最常见的病因。流行病学调查显示,全球约4700万人罹患痴呆,预计到2050年,痴呆患者将增加至1.31亿[1].中国60岁以上... 详细信息

阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍为特征的中枢神经系统退行性疾病,也是引起老年痴呆最常见的病因。流行病学调查显示,全球约4700万人罹患痴呆,预计到2050年,痴呆患者将增加至1.31亿[1].中国60岁以上老年人痴呆的患病率为5.30%[2]。近年来,国内外开展的一系列靶向清除或减少P-淀粉样蛋白(Ap)沉积的临床试验并未显著改善AD患者的认知功能,甚至出现各种副作用[3].

关键词：阿尔茨海默病临床前期非药物干预

Organic Phosphorus in Shallow Lake Sediments in Middle and Lower Reaches of the Yangtze River Area in China

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Pedosphere 2008年第3期18卷 394-400页

作者： JIN Xiang-can WANG sheng-Rui CHU Jian-Zhou WU Feng-Chang State Environmental Protection Key Laboratory for Lake Pollution Control Research Center of Lake Eco-EnvironmentChinese Research Academy of Environmental Sciences Beijing 100012 （China） Colleges of Resource and Environment Hebei Agriculture University Baoding 071001 （China） State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang550002 （China）

Thirteen sediment core samples(0-10 cm) were taken from the seven lakes in the middle and lower reaches of the Yangtze River to determine the contents and distributions of organic phosphorus(P) fractions in the sediments of the shallow lakes in the *** organic P fractions in the sediments were in the order of moderately labile organic P(MLOP) > moderately resistant organic P(MROP) > highly resistant organic P(HROP) > labile organic P(LOP),with average proportional ratios of 13.2:2.8:1.3:***,MLOP,and MROP were significantly related to the contents of total organic carbon(TOC),water-soluble P(WSP),algal-available P(AAP),NaHCO3-extractable P(Olsen-P),total P(TP),organic P(OP),and inorganic P(IP).However,HROP was significantly related to OP and weakly correlated with TOC,WSP,AAP,Olsen-P,TP or *** suggested that organic P,especially LOP and MLOP in sediments,deserved even greater attention than IP in regards to lake *** terms of organic P,sediments were more hazardous than soils in lake *** OP concentrations were higher in moderately polluted sediment than those in heavily polluted sediment,LOP and MLOP were higher in the heavily polluted sediment,which indicated that heavily polluted sediment was more hazardous than moderately polluted sediment in lake eutrophication.

关键词： bioavailability chemical extracted phosphorus lake sediment middle and lower reaches of the Yangtze River area organic phosphorus fractions

VSC-HVDC输电系统的电磁暂态建模与仿真

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高电压技术 2007年第11期33卷 94-99页

作者：郑超盛灿辉魏强盛浩中国电力科学研究院北京100085 河南电力试验研究院郑州450052 北京四方继保自动化股份有限公司北京100085

基于电压源换流器(VSC)的新型直流输电(VSC-HVDC)系统技术优点很多,建立能够准确描述VSC-HVDC动态特性的详细模型及仿真算法对该项输电技术的深入研究具有重要意义,还可为含有VSC-HVDC的电力系统机电、电磁混合仿真奠定基础。为此首先... 详细信息

基于电压源换流器(VSC)的新型直流输电(VSC-HVDC)系统技术优点很多,建立能够准确描述VSC-HVDC动态特性的详细模型及仿真算法对该项输电技术的深入研究具有重要意义,还可为含有VSC-HVDC的电力系统机电、电磁混合仿真奠定基础。为此首先分析了VSC-HVDC的工作原理;利用隐式梯形积分法建立了双端VSC-HVDC的详细电磁暂态仿真模型,并利用一阶惯性环节模拟锁相环测量了VSC交流母线电压相位的动态特性;鉴于对应VSC-HVDC电磁暂态模型的差分方程为右端项含有待求变量的隐式方程,提出了相应的迭代求解数值计算算法。在VSC交流母线电压幅值和相位突变的条件下,通过与PSCAD/EMTDC中所建VSC-HVDC仿真电路电磁暂态响应的对比,验证了VSC-HVDC电磁暂态模型及其数值计算算法的正确性。

关键词：电压源换流器新型直流输电锁相环隐式梯形积分电磁暂态建模电磁暂态仿真

论供给侧结构性改革对全要素生产率的影响——基于粤港澳大湾区9市纺织服装行业的经验证据

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云南社会科学 2019年第6期 58-64页

作者：谢圣远卢灿生深圳大学经济学院

利用2000-2016年粤港澳大湾区9市纺织服装行业面板数据分析供给侧改革对行业效率的影响,结果表明,纺织服装行业改革后“补短板”成效明显,工资水平上升,创新能力增强,能源消耗下降,全要素生产率总体得到提高。“去产能、去库存、降成本... 详细信息

利用2000-2016年粤港澳大湾区9市纺织服装行业面板数据分析供给侧改革对行业效率的影响,结果表明,纺织服装行业改革后“补短板”成效明显,工资水平上升,创新能力增强,能源消耗下降,全要素生产率总体得到提高。“去产能、去库存、降成本和补短板”均对全要素生产率的提高产生了较为显著影响。粤港澳大湾区纺织服装行业应进一步发挥区域产业竞争优势,打造广深莞纺织服装行业创新走廊;利用供给侧结构性改革的机遇,发挥大湾区纺织服装行业的改革引领效应。

关键词：供给侧改革全要素生产率粤港澳大湾区纺织服装行业

Study on the Relationship Between the Growth and Development Speed and the Expression of GH and IGF-1 in Children

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Chinese Journal of Biomedical Engineering(English Edition) 2023年第1期32卷 25-31,46页

作者： QUE Yong-xiang ZHANG Ling-zhao ZHANG sheng-can YOU Qiu-xia Department of Children's Health Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan Fujian 364000China Department of Obstetrica Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan Fujian 364000China Longyan Disease Prevention and Control Center Longyan Fujian 364000China Department of Laboratory Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan Fujian 364000China

Objective:To investigate the relationship between the growth and development speed and the expression of growth hormone(GH)and insulin-like growth factor-1(IGF-1)in ***:A total of 78 healthy children who received physical examination in our hospital from December 2020 to December 2022 were randomly selected by cluster sampling,which were divided into three groups according to the standard deviation unit curve of height and weight,namely,the delayed group(n=11),the normal group(n=51)and the tachycardia *** venous blood was collected in the early morning to detect the levels of GH and IGF-1 from the three groups of children according to the relevant operation *** correlation analysis was performed betweenΔheight,Δweight and GH,IGF-1 in all ***:Overall analysis showed that there were significant differences in height and weight among the three groups of children on the day of enrollment,at 3,6,9 and 12months after enrollment(Pcantly higher than those on the day of enrollment,and the difference was statistically significant(Pcantly higher than those in tardy group on the day of enrollment,at 3,6,9 and 12months after enrollment(Pcant differences inΔheight andΔweight among the three groups(Pcant differences in the levels of GH and IGF-1 among the three groups on the da

关键词： growth and development of children height weight growth hormone(GH) insulin-like growth factor-1(IGF-1)

Recovery of Palladium From Simulated High-Level Liquid Waste by Solvent Extraction

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Recovery of Palladium From Simulated High-Level Liquid Waste...