检索结果-南通市图书馆

Scatter Search Based Particle Swarm Optimization Algorithm for Earliness/Tardiness Flowshop Scheduling with Uncertainty

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2016年第3期13卷 285-295页

作者： jia-can Geng Zhe Cui Xing-Sheng Gu Key Laboratory of Advanced Control and Optimization for Chemical Process Ministry of EducationEast China University of Science and Technology

Considering the imprecise nature of the data in real-world problems, the earliness/tardiness （E/T） fiowshop scheduling problem with uncertain processing time and distinct due windows is concerned in this paper. A fuzzy scheduling model is established and then transformed into a deterministic one by employing the method of maximizing the membership function of middle value. Moreover, an effective scatter search based particle swarm optimization （SSPSO） algorithm is proposed to minimize the sum of total earliness and tardiness penalties. The proposed SSPSO algorithm incorporates the scatter search （SS） algorithm into the frame of particle swarm optimization （PSO） algorithm and gives full play to their characteristics of fast convergence and high diversity. Besides, a differential evolution （DE） scheme is used to generate solutions in the SS. In addition, the dynamic update strategy and critical conditions are adopted to improve the performance of SSPSO. The simulation results indicate the superiority of SSPSO in terms of effectiveness and efficiency.

关键词： Earliness/tardiness (E/T) scheduling fuzzy modeling scatter search (SS) particle swarm optimization (PSO).

Online detection of bursty events and their evolution in news streams

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 340-355页

作者： Wei CHEN Chun CHEN Li-jun ZHANC can WANG jia-jun BU Zhejiang Laboratory of Service Robot Zhejiang Universit) Hangzhou 310027 China

Online monitoring of temporally-sequenced news streams for interesting patterns and trends has gained popularity in the last *** this paper,we study a particular news stream monitoring task:timely detection of bursty events which have happened recently and discovery of their evolutionary patterns along the ***,a news stream is represented as feature streams of tens of thousands of features(i.e.,*** news story consists of a set of keywords.).A bursty event therefore is composed of a group of bursty features,which show bursty rises in frequency as the related event *** this paper,we give a formal definition to the above problem and present a solution with the following steps:(1) applying an online multi-resolution burst detection method to identify bursty features with different bursty durations within a recent time period;(2) clustering bursty features to form bursty events and associating each event with a power value which reflects its bursty level;(3) applying an information retrieval method based on cosine similarity to discover the event's evolution(i.e.,highly related bursty events in history) along the *** extensively evaluate the proposed methods on the Reuters Corpus Volume *** results show that our methods can detect bursty events in a timely way and effectively discover their *** power values used in our model not only measure event's bursty level or relative importance well at a certain time point but also show relative strengths of events along the same evolution.

关键词： Online event detection Event’s evolution News stream Affinity propagation

A facile synthesis of the oxazolidinone antibacterial agent linezolid

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2013年第3期24卷 230-232页

作者： Yan-Wu Li Yan Liu Yun-can jia jian-Yong Yuan Institute of Life Science & Pharmacy College Chongqing Medical University

A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coup... 详细信息

关键词： LinezolidSynthesisGoldberg coupling reaction

LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第5期7卷 696-706页

作者： Xingxian Guo jiangxia Pu Ziqi Tang can jia Fan Yang Tianyi Liu Yinyuan Ding Centre for Lipid Research&Chongqing Key Laboratory of Metabolism on Lipid and Glucose Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education)Department of Infectious DiseasesInstitute for Viral HepatitisThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina

Background: LDL receptor-related protein-1(LRP1) is a cell-surface receptor that functions in diverse physiological pathways. We previously demonstrated that hepatocyte-specific LRP1 deficiency(hLRP1KO) promotes diet-induced insulin resistance and increases hepatic gluconeogenesis in mice. However, it remains unclear whether LRP1 regulates hepatic ***: Insulin signaling, glycogenic gene expression, and glycogen content were assessed in mice and HepG2 cells. The pcDNA 3.1 plasmid and adeno-associated virus serotype 8 vector(AAV8) were used to overexpress the truncated β-chain(βΔ) of LRP1 both in vitro and in ***: On a normal chow diet, hLRP1KO mice exhibited impaired insulin signaling and decreased glycogen content. Moreover, LRP1 expression in HepG2 cells was significantly repressed by palmitate in a dose-and time-dependent manner. Both LRP1 knockdown and palmitate treatment led to reduced phosphorylation of Akt and GSK3β, increased levels of phosphorylated glycogen synthase(GYS), and diminished glycogen synthesis in insulin-stimulated HepG2 cells, which was restored by exogenous expression of the βΔ-chain. By contrast, AAV8-mediated hepatic βΔ-chain overexpression significantly improved the insulin signaling pathway, thus activating glycogenesis and enhancing glycogen storage in the livers of high-fat diet(HFD)-fed ***: Our data revealed that LRP1, especially its β-chain, facilitates hepatic glycogenesis by improving the insulin signaling pathway, suggesting a new therapeutic strategy for hepatic insulin resistance-related diseases.

关键词： glycogenesis i nsulin resistance i nsulin signaling pathway LRP1

Recent activity of Chihe segment of Tanlu fault zone

在线全文

学校读者我要写书评

暂无评论

Acta Seismologica Sinica(English Edition) 2004年第6期17卷 678-685页

作者： YAO Da-quan(姚大全) LIU jia-can(刘加灿) Earthquake Administration of Anhui Province Hefei 230031 China Earthquake Administration of Anhui Province Hefei 230031 China

By means of differentiation of remote sensing image, field seismo-geological survey, analysis on drilling explora- tion materials, sampling and dating of rock samples, combined with seismicity and microscopic tectonic analysis, this paper studies the recent activity of Chihe segment of the Tanlu fault zone. The result indicates that the Chihe fault segment undergoes the deformation alternately in the mode of stick slip and creep during Late Quaternary, and its recent activity is mainly creep.

关键词： Tanlu fault zone Chihe segment structure resolution recent activity

同方期刊数据库

A sampling method based on URL clustering for fast web accessibility evaluation

在线全文

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2015年第6期16卷 449-456页

作者： Meng-ni ZHANG can WANG jia-jun BU Zhi YU Yu ZHOU Chun CHEN College of Computer Science and Technology Zhejiang University Hangzhou 310027 China

When evaluating the accessibility of a large website, we rely on sampling methods to reduce the cost of evaluation. This may lead to a biased evaluation when the distribution of checkpoint violations in a website is skewed and the selected samples do not provide a good representation of the entire website. To improve sampling quality, stratified sampling methods first cluster web pages in a site and then draw samples from each cluster. In existing stratified sampling methods, however, all the pages in a website need to be analyzed for clustering, causing huge I/O and computation costs. To address this issue, we propose a novel page sampling method based on URL clustering for web accessibility evaluation, namely URLSamp. Using only the URL information for stratified page sampling, URLSamp can efficiently scale to large websites. Meanwhile, by exploiting similarities in URL patterns, URLSamp cluster pages by their generating scripts and can thus effectively detect accessibility problems from web page templates. We use a data set of 45 web sites to validate our method. Experimental results show that our URLSamp method is both effective and efficient for web accessibility evaluation.

关键词： Page sampling URL clustering Web accessibility evaluation

社会流动视角下宋代“贫富无定势”现象解析——基于洪迈《夷坚志》的探讨

在线全文

学校读者我要写书评

暂无评论

郑州大学学报（哲学社会科学版） 2019年第2期52卷 80-88,128页

作者：贾灿灿南通大学文学院江苏南通226019

洪迈《夷坚志》对宋代市井生活百态的描绘,为我们研究宋代"贫富无定势"现象提供了生动的事例,可补正史之未备。在《夷坚志》的记载中,举凡官吏、士人、村民、商人、工匠、医卜杂类,甚至流民、乞丐都有致富的可能。宋代由贫而富的上行流... 详细信息

洪迈《夷坚志》对宋代市井生活百态的描绘,为我们研究宋代"贫富无定势"现象提供了生动的事例,可补正史之未备。在《夷坚志》的记载中,举凡官吏、士人、村民、商人、工匠、医卜杂类,甚至流民、乞丐都有致富的可能。宋代由贫而富的上行流动渠道,有经营工商业、行医占卜、婚姻及以不义、不仁起富的非法手段。子孙不肖、贪利忘义、谋财害命的人更有可能贫困如初,而那些注重子孙培养、仁义守信、乐善好施的人更容易获得长久的富足。与魏晋、隋唐相比,后致性规则在宋代社会流动规则中越来越凸显,至少在《夷坚志》中表现趋势如此,它折射出的是宋人渴望畅通社会流动渠道,形成合理、有序的社会流动,只有遵守社会秩序,才能获得长久的富贵。宋代贫富之间的社会流动,意味着宋代社会人们经济地位的升与降处于随时变化之中。此书所描绘出的宋代"贫富无定势"的种种微观流动景象,从一个侧面反映出两宋社会的开放和多元化的发展倾向。

关键词：宋代 “贫富无定势” 社会流动《夷坚志》

骨质疏松研究热点:骨髓间充质干细胞分化命运

在线全文

学校读者我要写书评

暂无评论

第二军医大学学报 2017年第4期38卷 397-404页

作者：陈晓苏佳灿第二军医大学长海医院创伤骨科上海200433 中韩生物医学工程中心上海201802

骨质疏松症是一种常见的代谢性骨病,以骨量减少、骨密度降低和骨微结构破坏为特征,容易发生脆性骨折,其发病率逐年增高。骨质疏松症发病与骨平衡的破坏有关,一方面破骨细胞活性增强、骨吸收加快,另一方面成骨细胞功能衰减、骨形成不足,... 详细信息

骨质疏松症是一种常见的代谢性骨病,以骨量减少、骨密度降低和骨微结构破坏为特征,容易发生脆性骨折,其发病率逐年增高。骨质疏松症发病与骨平衡的破坏有关,一方面破骨细胞活性增强、骨吸收加快,另一方面成骨细胞功能衰减、骨形成不足,最终导致净骨量丢失。成骨不足与骨髓间充质干细胞分化方向密切相关。在骨质疏松症患者中,骨髓间充质干细胞向脂肪方向分化增多,向成骨方向分化减少,其分化命运受BMP/Smad、Wnt、Notch、Hedgehog等多条信号通路调控,并涉及转录调控、转录后调控和表观遗传等多种调控机制,是目前研究的热点与焦点。未来研究可集中于寻找决定骨髓间充质干细胞分化方向的关键因子和间充质干细胞移植,为骨质疏松症的治疗提供新思路。

关键词：骨质疏松间充质干细胞细胞分化信号通路微RNAs 表观遗传学

在线全文

学校读者我要写书评

暂无评论

纳米孔硅灰石载药抗菌止血材料的研究

无机化学学报 2011年第4期27卷 625-630页

作者：陈于徐灿苏佳灿李文锐上海市第二军医大学附属长海医院上海200433

采用溶胶-凝胶法,以聚氧乙烯-聚氧丙烯-聚氧乙烯三嵌段共聚物(P123)为模板剂,合成了纳米孔硅灰石(np-WT),用np-WT载盐酸万古霉素研制了一种新型的载药抗菌止血材料,并对其止血性能进行了研究。结果表明:np-WT具有排列有序的纳米孔道结构... 详细信息

采用溶胶-凝胶法,以聚氧乙烯-聚氧丙烯-聚氧乙烯三嵌段共聚物(P123)为模板剂,合成了纳米孔硅灰石(np-WT),用np-WT载盐酸万古霉素研制了一种新型的载药抗菌止血材料,并对其止血性能进行了研究。结果表明:np-WT具有排列有序的纳米孔道结构,其孔径在2 nm左右,高比表面积的np-WT能够明显地缩短体外部分凝血活酶时间(APTT)和凝血酶原时间(PT)。载药np-WT能够在磷酸缓冲溶液(PBS)中缓慢地释放药物,载药np-WT对其凝血性能没有明显的影响。载药np-WT对大肠杆菌有很好的抗菌作用,细胞毒性实验表明:载药np-WT无细胞毒性。载药np-WT具有很好的止血性能,能够阻止兔背部伤口的流血和缩短其流血时间。

关键词：纳米孔硅灰石止血药物缓释抗菌生物相容性