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Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure

Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 55-62页

作者： Xiu-Hua Wang Ling-Zhi Dou can gu Xiao-Qing Wang School of Nursing Central South University Second Hospital of Xiangya Central South University

Objective:To investigate the alteration of plasma levels of omentin-1 and visfatin in elderly patients with coronary heart disease(CHD)and heart ***:Plasma omentin-1 and visfatin levels were measured in 90 subjects(29 stable angina pectoris(SAP)cases,30 unstable angina pectoris(UAP)cases and 31 age-and sex-matched healthy controls(age≥60 years)by enzyme-linked immunosorbent assay *** to the New York Heart Association classification.59 CHDs were divided into three groups:functional I class,11 cases;functional II/III class,36 cases;and functional IV class,12 ***:The plasma level of omentin-1in CHO patients was significantly lower than thai of the control ***-lin SAP group and UAP group were significantly lower compared to the control group(there was no statistical significance between UAP group and SAP group;P>0.05).The plasma level of visfatin in CHD patients was significandy higher than that of the control ***,visfatin in SAP group and UAP group were all significantly higher compared to the control group,while there was no statistical significance between UAP group,and SAP *** plasma omentin-1 level was negatively correlated with SBP(r=-0.264,P<0.05),positively correlated with HDL-c level(r=0.271,P<0.05);the plasma visfatin level was positively correlated with TC(r=0.292,P<0.05),negatively correlated with HDL-c level(r=-0.266,P<0.05).There was a negative correlation between plasma omentin-1 and visfatin levels(r=-0.280,P<0.05).Moreover,multiple linear stepwise regression analysis showed that omentin-1 and visfatin levels might be affected by HDL-c *** regression analysis showed that visfatin could be an independent risk factor of ***:Decreased levels of omentin-1 and increased levels of visfatin may be involved in the occurrence and development of ***-1 and visfatin,independently,may be protective and pro-inflammatory ***,both omentin-1 and visfatin may

关键词： Coronary heart disease Omenlin-1 Visfatin NYHA class Stable angina pectoris Unstable angina pectoris

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Accurate mirror-based camera pose estimation with explicit geometric meanings

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Science China(Technological Sciences) 2014年第12期57卷 2504-2513页

作者： LI Xin LONG gu can guO Peng Yu LIU Jin Bo ZHANG Xiao Hu YU Qi Feng College of Aerospace Science and Engineering National University of Defense Technology Hunan Key Laboratory of Videometrics and Vision Navigation

An accurate closed form solution is proposed to estimate camera pose by several mirrored reference object images acquired via a planar mirror under different unknown poses. Compared with state-of-the-art methods, our method is more accurate when there are more than three images and has explicit geometric meanings. This method also properly handles cases in which some of the mirror poses are parallel. The central idea is to minimize an error metric based on all reflections of rotation, which enables the camera rotation to be estimated directly by SVD of sum of mirrored camera rotations. After that, the camera translation is computed by solving a large system of linear equations to minimize object space collinearity error. Both synthesized data and real data experiments show the advantages of our approach.

关键词： pose estimation planar mirror reflection geometric meaning SVD

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Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 482-485页

作者： Shengbo Yang can gu guiying Zhang Jian Kang Haiquan Wen QianJin Lu Jinhua Huang Department of Dermatology Third Xiangya HospitalCentral South University School of Nursing Central South University Department of Dermatology Second Xiangya HospitalCentral South University

Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook ***:Human fibrosarcoma HT-1080 cells were treated with different doses of triptolide for 72 *** the expression and activity of matrix metalloproteinase(MMP)-2 and -9 were measured and the invasiveness of triptolide-treated HT-1080 cells was compared with that of anti-MMP-9- treated HT-1080 ***:18 nmol/L triptolide inhibited the gene expression and activity of MMP-9,but not those of MMP-2,in HT-1080 *** addition,both 18 nmol/L triptolide and 3μg/mL anti-MMP-9 significantly reduced the invasive potential of HT-1080 cells,by about 50%and 35%, respectively,compared with the *** there was no significant difference between the effect of 18 nmol/L triptolide and that of anti-MMP-9 on invasive potential of HT-1080 cells. Conclusions:These data suggest that triptolide inhibits tumor cell invasion partly by reducing MMP-9 gene expression and activity.

关键词： Triptolide Matrix metalloproteinase Fibrosarcoma Neoplasm metastasis

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Relationship between brain—derived neurotrophic factor and cognitive function of obstructive sleep apnea/hypopnea syndrome patients

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 906-910页

作者： Wei-Hong Wang guo-Ping He Xu-Ping Xiao can gu Hua-Ying Chen Medical College of Hunan Normal University School of Nursing Central South University First Affiliated Hospital Hunan Normal University

Objective:To determine the relationship between the blood serum brain-derived neurotrophic factor（BDNF） level and cognitive function deterioration in patients with obstructive sleep apnea/ hypopnea syndrome（OSAHS）,and to explore the possible mechanism of cognitive impairment. Methods:Twenty-eight male OSAHS patients and 14 normal males（as controls） were enrolled in the *** and the Montreal cognitive assessment（MoCA） were conducted. The blood serum BDNF levels were measured using ***:The OSAHS group had significantly decreased blood serum BDNF levels compared with the control group（t=-10.912, P=0.000）.The blood serum BDNF level of the subjects was significantly positively associated with the MoCA score（r=0.544,P=0.000）,significantly negatively associated with the apneahypopnea index（AHI） and shallow sleep（S1+S2）（AHI:r=-0.607,P=0.000;S1+S2:r =-0.768,P= 0.000）,and significantly positively associated with the lowest SaO2（LSO）,slow wave sleep（S3+S4）, and rapid eye movement sleep（REM）（LSO:r=0.566,P = 0.000;S3+S4:r=0.778,P=0.000;REM: r=0.575,P=0.000）.Conclusions:OSAHS patients have significantly decreased blood serum BDNF levels compared with the *** hypoxia as well as the deprivation of slow wave sleep and REM may lead to the decreased serum BDNF level of OSAHS *** decreased blood serum BDNF level may contribute to the cognitive impairment in OSAHS.

关键词： Obstructive sleep apnea/hypopnea syndrome Cognitive function Brain-derived neurotrophic factor Sleep

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农村消化性溃疡病人治疗依从性分析及健康需求调查

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中南大学学报（医学版） 2006年第6期31卷 960-961页

作者：谷灿何国平中南大学护理学院长沙410013

目的:调查农村消化性溃疡患者治疗依从性及健康需求情况,为防治消化性溃疡提供依据。方法:采用问卷调查形式,从药物治疗、定期复查、生活方式改善3个维度收集资料,并对患者进行健康需求调查。结果:共调查116例,其中生活方式改善的依从... 详细信息

目的:调查农村消化性溃疡患者治疗依从性及健康需求情况,为防治消化性溃疡提供依据。方法:采用问卷调查形式,从药物治疗、定期复查、生活方式改善3个维度收集资料,并对患者进行健康需求调查。结果:共调查116例,其中生活方式改善的依从比例最低,为4.3%(5例),药物治疗和定期复查依从比例均为7.8%(9例)。逐步回归分析提示,影响药物治疗依从性的因素为经济收入。需要消化性溃疡咨询的患者为105例(90.5%),需要饮食指导的患者为98例(84.5%),需要定期体格检查的患者为93例(80.2%)。结论:农村消化性溃疡患者对不同医嘱的依从性均很低,需加强健康宣教。

关键词：消化性溃疡治疗依从性健康需求农村社区

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Increased 5-hydroxymethylcytosine and Ten-eleven Translocation Protein Expression in Ultraviolet B-irradiated HaCaT Cells

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Chinese Medical Journal 2017年第5期130卷 594-599页

作者： Dan Wang Jin-Hua Huang Qing-Hai Zeng can gu Shu Ding Jian-Yun Lu Jing Chen Sheng-Bo Yang Department of Dermatology Third Xiangya Hospital Central South University Changsha Hunan 410013 China Department of Community Nursing Xiangya School of Nursing Central South University Changsha Hunan 410013 China

Background： DNA hydroxymethylation refers to a chemical modification process in which 5-methylcytosine （5mC） is catalyzed to 5-hydroxymethylcytosine （5hmC） by ten-eleven translocation （TET） family proteins. Recent studies have revealed that aberrant TETs expression or 5hmC level may play important roles in the occurrence and development of various pathological and physiological processes including cancer and aging. This study aimed to explore the relation between aberrant DNA hydroxymethylation with skin photoaging and to investigate the levels of TETs, 5mC, and 5hmC expression 24 h after 40 mJ/cm^2 and 80 mJ/cm^2 doses of ultraviolet B （UVB） irradiation to HaCaT cells. Methods： To explore whether aberrant DNA hydroxymethylation is also related to skin photoaging, 40 mJ/cm^2 and 80 mJ/cm^2 doses of UVB were chosen to treat keratinocytes （HaCaT cells）. After 24 h of UVB irradiation, 5mC and 5hmC levels were determined by immunohistochemistry （IHC） and immunofluorescence （IF）, and at the same time, the expression levels of matrix metalloproteinase 1 （MMP-1） and TETs were assessed by reverse transcription-polymerase chain reaction or Western blot analysis. Results： After 40 mJ/cm^2 and 80 mJ/cm^2 doses of UVB exposure, both IHC and IF results showed that 5hmC levels increased significantly, while the 5mC levels did not exhibit significant changes in HaCaT cells, compared with HaCat cells without UVB exposure. Moreover, compared with HaCat cells without UVB exposure, the levels ofTET1, TET2, and TET3 mRNA and protein expression were significantly upregulated （mRNA： P = 0.0022 and 0.0043 for TET1; all P 〈 0.0001 for TET2; all P = 0.0006 for TET3; protein： P = 0.0012 and 0.0006 tbr TET 1 ; all P = 0.0022 for TET2; and all P = 0.0002 for TET3）, and the levels of MMP- 1 mRNA expression increased dose dependently in 40 mJ/cm^2 and 80 mJ/cm^2 UVB-irradiated groups. Conclusion： UVB radiation could cause increased 5hmC and TET expression, which might become a novel biomarker in

关键词： 5-hydroxymethylcytosine 5-methylcytosine DNA Hydroxymethylation Ten-eleven Translocation Ultraviolet B

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智慧型健康小屋在正常高值血压职业人群血压管理中的应用效果

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中华健康管理学杂志 2021年第1期15卷 49-53页

作者：马俊向亚利谷灿中南大学湘雅护理学院长沙410013 中山大学附属第五医院健康管理中心珠海510009

目的探讨智慧型健康小屋在正常高值血压职业人群血压管理的干预效果。方法2019年5月7至17日在中南大学湘雅三医院签约的体检单位中随机抽取的一家企业单位内招募到的符合纳排标准的共154例正常高值血压在职人员按照Excel中的Random函数... 详细信息

目的探讨智慧型健康小屋在正常高值血压职业人群血压管理的干预效果。方法2019年5月7至17日在中南大学湘雅三医院签约的体检单位中随机抽取的一家企业单位内招募到的符合纳排标准的共154例正常高值血压在职人员按照Excel中的Random函数随机分为试验组与对照组,试验组给予基于智慧型健康小屋的精准健康管理方案,对照组给予传统的纸质宣传册的健康管理,干预时间为8周。采用成组t检验比较两组人群的血压、自我管理能力各维度及总分间的差异,采用配对t检验比较干预前后各组血压、自我管理能力各维度及总分间的差异。结果干预前两组各指标差异均无统计学意义,干预8周后,试验组自我管理总分、自我管理行为、自我管理认知及自我管理环境得分均明显高于对照组[(107.75±9.21)比(97.38±6.99),(53.27±5.81)比(48.59±4.93),(33.44±4.27)比(31.63±3.42),(21.04±3.14)比(17.16±2.30)](均P<0.01);试验组人群收缩压、舒张压均较对照组有更明显的下降[(124.01±4.60)比(126.88±3.52),(78.41±5.93)比(80.53±4.89)](均P<0.05)。结论基于智慧型健康小屋的健康管理方式能够显著提高正常高值血压职业人群的自我管理能力,降低该人群的血压。

关键词：健康管理正常高值血压职业人群

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HIV阳性女性宫颈癌筛查现状及其影响因素的研究进展

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中国护理管理 2019年第5期19卷 748-753页

作者：张瑶王菁菁谷灿中南大学湘雅护理学院

本文综述国内外HIV阳性女性宫颈癌的筛查现状、筛查指南以及影响因素的研究进展,为我国尽快开展相关研究,建立宫颈癌筛查指南,降低HIV阳性女性宫颈癌的发病率和死亡率提供科学依据。

关键词： HIV 宫颈癌宫颈癌筛查综述

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中国数字安全治理探析

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信息安全与通信保密 2021年第11期19卷 48-56页

作者：顾璨上海赛博网络安全产业创新研究院上海200003

当前数据安全问题已经成为世界各国面临的共同挑战,如何做好我国数据安全治理是当下我们需要重点研究的一项课题。通过研究数据安全治理在隐私保护和数据权概念下的治理理念,结合包括政务、企业和金融在内的不同行业的数据安全需求,我... 详细信息

当前数据安全问题已经成为世界各国面临的共同挑战,如何做好我国数据安全治理是当下我们需要重点研究的一项课题。通过研究数据安全治理在隐私保护和数据权概念下的治理理念,结合包括政务、企业和金融在内的不同行业的数据安全需求,我国可以从数据安全治理框架和数据安全能力成熟度模型框架两方面着手开展数据安全体系建设。在此过程中,一方面,应提升我国数据安全治理能力;另一方面,要积极开展数据安全治理的全球合作。

关键词：数据安全治理数据安全需求治理能力全球合作

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基于声阵列技术的汽车噪声源识别及贡献量分析

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振动工程学报 2010年第6期23卷 630-635页

作者：邓江华顾灿松刘献栋李宏庚中国汽车技术研究中心汽车工程研究院天津300162 北京航空航天大学交通科学与工程学院北京100086 上汽通用五菱汽车股份有限公司广西柳州545007

将统计最优声阵列技术运用于汽车噪声源(内部和外部)识别中,采用改进的远场声全息技术以弥补传统远场声全息识别精度低的缺点;研究了基于近场声全息技术的声贡献量分析方法,从而为低噪声优化设计提供方向;运用统计最优波束形成算法进行... 详细信息

将统计最优声阵列技术运用于汽车噪声源(内部和外部)识别中,采用改进的远场声全息技术以弥补传统远场声全息识别精度低的缺点;研究了基于近场声全息技术的声贡献量分析方法,从而为低噪声优化设计提供方向;运用统计最优波束形成算法进行中高频声源识别,并将DAMAS方法用于后处理以提高识别精度,通过上述方法以探索一种新的声源识别及控制技术。最后将以上方法运用于某型轿车的声源识别和声贡献量分析中。

关键词：改进远场声全息声源识别统计最优声阵列贡献量

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