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Fetal Bradyarrhythmias:Etiopathogenesis,Diagnosis and Treatment:Between Literature Review and Experience of a Tertiary Center

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Congenital Heart Disease 2021年第4期16卷 309-331页

作者： Elio Caruso Silvia Farruggio salvatore Agati Corrado Di Mambro Mediterranean Pediatric Cardiology Center“Bambino Gesù”San Vincenzo Hospital Contrada SirinaTaormina98039Italy

Fetal arrhythmias reach up around 10%of the total third-level perinatal cardiology *** bradycardia is defined as a baseline fetal heart rate(FHR)of less than 110 bpm sustained for at least 10 *** overall incidence of malignant fetal bradyarrhythmias,such as complete atrioventricular block(AVB)and channellopathies,is relatively rare,1:5000 pregnancies,but represents a serious emergency for the gynecologist,neonatologists,and pediatric *** complete AVB is strongly associated with maternal connective tissue disease,but it can be also associated with congenital heart disease and usually with a poorer prognosis with high risk of fetal hydrops and ***,the treatment of severe fetal bradyarrhythmias is principally pharmacological and aims to increase the FHR,besides an early resolution of underlying causes,when possible,and a promptly management of fetal heart *** electrostimulation nowadays is an experimental pioneering method,reserved for limited selected cases.

关键词： Fetal arrhythmias hydrops bradyarrhythmia atrioventricular block

Thermal Radiation Modelling in Tunnel Fires

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Advances in Applied Mathematics and Mechanics 2011年第3期3卷 327-353页

作者： Paolo Ciambelli Maria Grazia Meo Paola Russo salvatore Vaccaro Department of Industrial Engineering University of Salernovia Ponte don Melillo 84084 Fisciano(SA)Italy

Modelling based on Computational Fluid Dynamics(CFD)is by now effectively used in fire research and hazard *** on the scenario,radiative heat transfer can play a very important role in enclosure combustion events such as tunnel *** this work,the importance of radiation and the effect of the use of different approaches to account for it were ***,small-scale tunnel fire simulations were performed and the results compared with experimental data,then realistic full-scale scenarios were *** results show up the capability of CFD modelling to reproduce with good approximation tunnel *** proved to be noteworthy mainly when the scale of the fire is relatively *** the various approaches employed to simulate radiation,the use of the Discrete Transfer model gave the most accurate results,mainly when the absorption-emission characteristics of the combustion products were taken into ***,the suitability of the use of CFD in quantitative Fire Hazard Analysis is discussed.

关键词： CFD radiation modelling fire hazard analysis tunnel fires

Sexual outcomes after partial penectomy for penile cancer： results from a multi-institutional study

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Asian Journal of Andrology 2017年第1期19卷 57-61页

作者： salvatore Sansalone Mauro Silvani Rosario Leonardi Giuseppe Vespasiani Valerio Iacovelli Department of Experimental Medicine and Surgery - Urology Tor Vergata University of Rome 00133 Rome Italy Department of Urology Biella General Hospital 13900 Biella Italy Musumeci GECAS Clinic Gravina di catania 95127 Catania Italy.

Penile cancer is an uncommon malignancy. Surgical treatment is inevitably mutilating. Considering the strong impact on patients＇ sexual life we want to evaluate sexual function and satisfaction after partial penectomy. The patients in this study （n = 25） represented all those who attended our institutions and were diagnosed and treated for penile cancer from October 2011 to November 2013. All patients underwent partial penectomy and followed-up （mean： 14 months; range： 12-25）. Sexual presurgical baseline was estimated using the International Index of Erectile Dysfunction 15 （IIEF-15）. Sexual outcomes of each patient were estimated considering four standardized and validated questionnaires. We analyzed the means and ranges of IIEF-15 including erectile function （IIEF-1-5 and -15）, orgasmic function （IIEF-9 and -10）, sexual desire （IIEF-11 and -12）, intercourse satisfaction （IIEF-6-8）, and overall satisfaction （IIEF-13 and -14）. Then, we also used Quality of Erection Questionnaire （QEQ）, Erectile Dysfunction Inventory of Treatment Satisfaction （EDITS） and Self-Esteem and Relationship （SEAR） to evaluate the sexual function and satisfaction of our patients. The final results showed that penile cancer leads to several sexual and psychosexual dysfunctions. Nevertheless, patients who undergo partial penectomy for penile cancer can maintain the sexual outcomes at levels slightly lower to those that existed in the period before surgery.

关键词： partial penectomy penectomy penile cancer penile tumor sexual outcomes

A review of electromagnetic processing of materials(EPM):Heating,sintering,joining and forming

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Journal of Materials Science & Technology 2021年第10期69卷 239-272页

作者： Mattia Biesuz Theo Saunders Daoyao Ke Michael J.Reece Chungfeng Hu salvatore Grasso Southwest Jiaotong University School of Materials Science and EngineeringChengdu 611756China Queen Mary University of London Mile End Road.El 4NS LondonUK University of Trento Department of Industrial EngineeringVia Sommarive 938123 TrentoItaly

Electricity is an efficient form of energy,and the growing interest in electricity-assisted manufacturing is motivated by its inherent energy saving and reduced environmental *** this,Electromagnetic Processing of Materials(EPM)allows the fabrication of materials with new compositions,metastable phases and nanograined microstructures that cannot be obtained using conventional heating processes using *** review covers EPM for the manufacture of ceramic and metal bulk components,with a specific focus on the effects of electric fields and electromagnetic radiations on processing in a wide spectrum of frequencies ranging from DC(f=0 Hz)to visible light(f=10^(14)–10^(15)Hz).The manuscript is divided into two *** first part provides a comprehensive overview of the interactions between matter and electric field/current,including heating phenomena(resistive Joule,induction,dielectric heating,electric arcs)and athermal effects(electromigration,electroplasticity,electrochemical reactions,ponderomotive force and others).The second part is focused on the technological application of the techniques,covering heat treatments,joining,sintering and *** distinct physical phenomena are involved in EPM:resistive Joule and induction heating,electrochemical reactions,electroplasticity,electric arcs and electromagnetic heating based on radio and microwave frequencies(mainly used for heating dielectric materials;i.e.,dielectric heating)or on the IR/visible light(IR heating and lasers).

关键词： Field-assisted sintering Electroplasticity Joining Welding Induction heating Arc melting

Massive feature extraction for explaining and foretelling hydroclimatic time series forecastability at the global scale

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Geoscience Frontiers 2022年第3期13卷 79-99页

作者： Georgia Papacharalampous Hristos Tyralis Ilias G.Pechlivanidis salvatore Grimaldi Elena Volpi Department of Engineering Roma Tre UniversityVia V.Volterra 6200146 RomeItaly Department of Water Resources and Environmental Engineering School of Civil EngineeringNational Technical University of AthensHeroon Polytechneiou 515780 ZographouGreece Hellenic Air Force General Staff Hellenic Air ForceMesogion Avenue 227-23115561 CholargosGreece Swedish Meteorological and Hydrological Institute 60176 NorrköpingSweden Department for Innovation in Biological Agro-food and Forest SystemsUniversity of TusciaViterboItaly Department of Mechanical and Aerospace Engineering Tandon School of EngineeringNew York UniversityBrooklynNY10003United States

Statistical analyses and descriptive characterizations are sometimes assumed to be offering information on time series *** the scientific interest suggested by such assumptions,the relationships between descriptive time series features(e.g.,temporal dependence,entropy,seasonality,trend and linearity features)and actual time series forecastability(quantified by issuing and assessing forecasts for the past)are scarcely studied and quantified in the *** this work,we aim to fill in this gap by investigating such relationships,and the way that they can be exploited for understanding hydroclimatic forecastability and its *** this end,we follow a systematic framework bringing together a variety of–mostly new for hydrology–concepts and methods,including 57 descriptive features and nine seasonal time series forecasting methods(i.e.,one simple,five exponential smoothing,two state space and one automated autoregressive fractionally integrated moving average methods).We apply this framework to three global datasets originating from the larger Global Historical Climatology Network(GHCN)and Global Streamflow Indices and Metadata(GSIM)*** these datasets comprise over 13,000 monthly temperature,precipitation and river flow time series from several continents and hydroclimatic regimes,they allow us to provide trustable characterizations and interpretations of 12-month ahead hydroclimatic forecastability at the global *** first find that the exponential smoothing and state space methods for time series forecasting are rather equally efficient in identifying an upper limit of this forecastability in terms of Nash-Sutcliffe efficiency,while the simple method is shown to be mostly useful in identifying its lower *** then demonstrate that the assessed forecastability is strongly related to several descriptive features,including seasonality,entropy,(partial)autocorrelation,stability,(non)linearity,spikiness and heterogeneity features

关键词： Exponential smoothing Predictability Statistical hydrology Time series analysis Time series clustering Time series forecasting

Synthesis and property characterization of ternary laminar Zr_(2)SB ceramic

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Journal of Advanced Ceramics 2022年第5期11卷 825-833页

作者： Qiqiang ZHANG Shuai FU Detian WAN Yiwang BAO Qingguo FENG salvatore GRASSO Chunfeng HU Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Green Building Materials China Building Materials AcademyBeijing 10000China

In this paper,Zr_(2)SB ceramic with purity of 82.95 wt%(containing 8.96 wt%ZrB_(2)and 8.09 wt%zirconium)and high relative density(99.03%)was successfully synthesized from ZrH_(2),sublimated sulfur,and boron powders by spark plasma sintering(SPS)at 1300℃.The reaction process,microstructure,and physical and mechanical properties of Zr_(2)SB ceramic were systematically *** results show that the optimum molar ratio to synthesize Zr_(2)SB is n(ZrH_(2)):n(S):n(B)=1.4:1.6:*** average grain size of Zr_(2)SB is 12.46μm in length and 5.12μm in width,and the mean grain sizes of ZrB2 and zirconium impurities are about 300 *** terms of physical properties,the measured thermal expansion coefficient(TEC)is 7.64×10^(-6) K^(-1) from room temperature to 1200℃,and the thermal capacity and thermal conductivity at room temperature are 0.39 J·g^(-1)·K^(-1)and 12.01 W·m^(-1)·K^(-1),*** room temperature electrical conductivity of Zr_(2)SB ceramic is measured to be 1.74×10^(6)Ω^(-1)·m^(-1).In terms of mechanical properties,Vickers hardness is 9.86±0.63 GPa under 200 N load,and the measured flexural strength,fracture toughness,and compressive strength are 269±12.7 MPa,3.94±0.63 MPa·m1/2,and 2166.74±291.34 MPa,respectively.

关键词： Zr_(2)SB spark plasma sintering(SPS) reaction path microstructure properties

Dispersive liquid-liquid microextraction,an effective tool for the determination of synthetic cannabinoids in oral fluid by liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第3期11卷 292-298页

作者： Pierpaolo Tomai Alessandra Gentili Roberta Curini Rossella Gottardo Franco Tagliaro salvatore Fanali Department of Chemistry Sapienza UniversityP.le Aldo Moro 500185RomeItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly and Institute of Translational Medicine and BiotechnologySechenov First Moscow State Medical UniversityMoscowRussia Teaching Committee of Ph.D.School in Natural Science and Engineering University of Verona VeronaItaly

In the present work,dispersive liquid-liquid microextraction(DLLME)was used to extract six synthetic cannabinoids(JWH-018,JWH-019,JWH-073,JWH-200,or WIN 55,225,JWH-250,and AM-694)from oral fluids.A rapid baseline separation of the analytes was achieved on a bidentate octadecyl silica hydride phase(Cogent Bidentate C18;4.6 mm×250 mm,4μm)maintained at 37℃,by eluting in isocratic conditions(water:acetonitrile(25:75,V/V)).Detection was performed using positive electrospray ionization-tandem mass *** parameters affecting DLLME(pH and ionic strength of the aqueous phase,type and volume of the extractant and dispersive solvent,vortex and centrifugation time)were optimized for maximizing *** particular,using 0.5 mL of oral fluid,acetonitrile(1 mL),was identified as the best option,both as a solvent to precipitate proteins and as a dispersing solvent in the DLLME *** select an extraction solvent,a low transition temperature mixture(LTTM;composed of sesamol and chlorine chloride with a molar ratio of 1:3)and dichloromethane were compared;the latter(100μL)was proved to be a better extractant,with recoveries ranging from 73%to 101%by vortexing for 2 *** method was validated according to the guidelines of Food and Drug Administration bioanalytical methods:intra-day and inter-day precisions ranged between 4%and 18%depending on the spike level and analyte;limits of detection spanned from 2 to 18 ng/mL;matrixmatched calibration curves were characterized by determination coefficients greater than ***,the extraction procedure was compared with previous methods and with innovative techniques,presenting superior reliability,rapidity,simplicity,inexpensiveness,and efficiency.

关键词： Microextraction techniques Dispersive liquid-liquid microextraction Illicit drugs Synthetic cannabinoids Silica C-based column

Characterization of volatile organic compounds in grafted tomato plants upon potyvirus necrotic infection

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Journal of Integrative Agriculture 2023年第8期22卷 2426-2440页

作者： Roberta SPANò Mariarosaria MASTROCHIRICO Francesco LONGOBARDI salvatore CERVELLIERI Vincenzo LIPPOLIS Tiziana MASCIA Department of Soil Plant and Food SciencesUniversity of Bari“Aldo Moro”Via Amendola 165/ABari 70126Italy Department of Chemistry University of Bari“Aldo Moro”Via Orabona 4Bari 70126Italy National Research Council(CNR) Institute of Sciences of Food Production(ISPA)Via Amendola 122/OBari 70126Italy

A headspace solid-phase microextraction-gas chromatography-mass spectrometry(HS-SPME/GC-MS)method was used to study the volatile organic compounds(VOCs)associated with the differential immune response of tomato plants infected with the recombinant strain of potato virus Y(PVY^(C)-to),necrogenic to *** was carried out in UC82(UC),a virus susceptible tomato variety,comparing the same UC plants grafted or not onto a virus tolerant tomato ecotype,Manduria(Ma);the three types of samples used for the GC-MS analysis were mock-inoculated UC/Ma plants,UC/Ma+PVY^(C)-to and UC+PVY^(C)-to plants;the VOCs obtained were *** from symptomatic PVY^(C)-to-infected UC plants showed a VOCs composition enriched in alcohols,fatty acid derivates,benzenoids,and salicylic acid derivatives,while in mock-inoculated UC/Ma plants VOCs were mainly characterized by methyl ester *** VOC profile was in line with RNAseq data analyses,denoting that PVY^(C)-to viral RNA accumulation and disease symptoms induce the specific transcriptional activation of genes involved in VOCs ***,principal component analysis highlighted that VOCs of PVY^(C)-to-infected and mock-inoculated grafted plants were much closer each other than that of symptomatic PVY^(C)-to-infected non-grafted UC *** results suggest that VOCs profiles of tomato plants are related to the viral RNA accumulation,disease intensity and graft-derived tolerance to PVY^(C)-to infection.

关键词： tomato potyvirus VOCs defense grafted plants

Encapsulated peracetic acid as a valid broad‑spectrum antimicrobial alternative,leading to beneficial microbiota compositional changes and enhanced performance in broiler chickens

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2128-2142页

作者： salvatore Galgano Leah Conway Nikki Dalby Adrian Fellows Jos G.MHoudijk Monogastric Science Research Centre Scotland’s Rural CollegeWest Mains RoadEdinburgh EH93JGScotlandUK Aga2tech Ltd HalifaxUK Centre for Innovation Excellence in Livestock YorkUK

Background Antimicrobial alternatives are urgently needed,including for poultry production *** this study,we tested the potential broad-range antimicrobial alternative peracetic acid,delivered in feed via the hydrolysis of encapsulated precursors through a 28-day study using 375 Ross 308 broiler *** tested two peracetic acid concentrations,30 and 80 mg/kg on birds housed on re-used litter,and we evaluated the impact of both levels on gut microbial communities,bacterial concentration,antimicrobial resistance genes relative abundance and growth performance when compared to control birds housed on either clean or re-used *** Body weight gain and feed conversion ratio improved in peracetic acid fed *** d 28,birds given 30 mg/kg of peracetic acid had a decreased Firmicutes and an increased Proteobacteria abundance in the jejunum,accompanied by an increase in Bacillus,Flavonifractor and Rombustia in the caeca,and a decreased abundance of tetracycline resistance *** given 80 mg/kg of peracetic acid had greater caecal abundance of macrolides lincosamides and streptogramins resistance *** performance on clean litter was reduced compared to reused litter,which concurred with increased caecal abundance of Blautia,decreased caecal abundance of Escherichia/Shigella,Anaerostipes and Jeotgalicoccus,and greater gene abundance of vancomycin,tetracycline,and macrolides resistance *** Peracetic acid could be used as a safe broad-spectrum antimicrobial alternative in *** precursors were able to reduce the bacterial concentration in the jejunum whilst promoting the proliferation of probiotic genera in the caeca,especially at the low peracetic acid concentrations tested,and improve growth ***,our findings offer further insights on potential benefits of rearing birds on re-used litter,suggesting that the latter could be associated with better performance and reduced antimicrobial resistance

关键词： Antimicrobial alternative Antimicrobial resistance Broiler chicken Microbiota Peracetic acid Performance 16S rRNA gene