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Spatiotemporal microRNA profile in peripheral nerve regeneration:miR-138 targets vimentin and inhibits Schwann cell migration and proliferation

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Neural Regeneration Research 2018年第7期13卷 1253-1262页

作者： Travis B.Sullivan Litchfield c.Robert Patrick A.Teebagy Shannon E.Morgan Evan W.Beatty Bryan J.cicuto Peter K.Nowd Kimberly M.Rieger-christ David J.Bryan Department of Translational Research Lahey Hospital & Medical Center Tissue Engineering Laboratory Lahey Hospital & Medical Center Department of Plastic and Reconstructive Surgery Lahey Hospital & Medical Center

While the peripheral nervous system has regenerative ability,restoration of sufficient function remains a *** has been shown to be localized in axonal growth fronts and associated with nerve regeneration,including myelination,neuroplasticity,kinase signaling in nerve axoplasm,and cell migration;however,the mechanisms regulating its expression within Schwann cell（Sc） remain *** aim of this study was to profile the spatial and temporal expression profile of micro RNA（mi RNA） in a regenerating rat sciatic nerve after transection,and explore the potential role of mi R-138-5 p targeting vimentin in Sc proliferation and migration.A rat sciatic nerve transection model,utilizing a polyethylene nerve guide,was used to investigate mi RNA expression at 7,14,30,60,and 90 days during nerve *** levels of mi RNA expression were determined using microarray analysis and subsequently validated with quantitative real-time polymerase chain *** vitro assays were conducted with cultured Schwann cells transfected with mi RNA mimics and assessed for migratory and proliferative *** top seven dysregulated mi RNAs reported in this study have been implicated in cell migration elsewhere,and go and KEGG analyses predicted activities essential to wound *** of one of these,mi RNA-138-5 p,into Scs reduced cell migration and *** R-138-5 p has been shown to directly target vimentin in cancer cells,and the luciferase assay performed here in rat Schwann cells confirmed *** results detail a role of mi R-138-5 p in rat peripheral nerve regeneration and expand on reports of it as an important regulator in the peripheral nervous system.

关键词： non-coding RNA neural regeneration nerve guide sciatic nerve transection peripheral nerve injury wound healing Gene Ontology processes Kyoto Encyclopedia of Genes and Genomes pathways microarray luciferase assay

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脑室内肿瘤的在体质子MR波谱分析

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国际医学放射学杂志 2009年第5期32卷 519-519页

作者： c.Majós c.Aguilera M.cos A.camins A.P.candiota T.Delgado-goi 郭雪梅 Institut de Diagnòstic per la Imatge(IDI).centre Bellvitge Hospital Universitari de BellvitgeAutovia de Castelldefels km 2.708907 L’Hospitalet de LlobregatBarcelonaSpain

本研究的目的是评价质子MR波谱对脑室内肿瘤的诊断价值。从我们的数据库中选取分属于16种不同肿瘤类型的共52例脑室内肿瘤。所有病例均在1．5T设备上行单体素质子MR波谱分析，TE分别采用30ms和136ms。采用Mann-Whitney U检验探索每种肿... 详细信息

本研究的目的是评价质子MR波谱对脑室内肿瘤的诊断价值。从我们的数据库中选取分属于16种不同肿瘤类型的共52例脑室内肿瘤。所有病例均在1．5T设备上行单体素质子MR波谱分析，TE分别采用30ms和136ms。采用Mann-Whitney U检验探索每种肿瘤类型的最佳分类数据点。在一些分组内发现了特异性趋势：

关键词：脑肿瘤 MR波谱脑室内肿瘤

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龙头示范创意先行——江苏建筑工程设计创意产业园江苏建筑工程设计创意产业园建设背景

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建筑与文化 2009年第1期 32-35页

作者： A＋c 南京市鼓楼区发改局

江苏建筑工程设计创意产业园，位于南京市鼓楼区模范马路，是一个开放式的专业园区。项目建设的一期重点是南京工业大学的虹桥校区，占地面积200亩。园区建成后，将形成工程设计创意产业的集聚区域，同时成为设计企业、设计创意工作室... 详细信息

江苏建筑工程设计创意产业园，位于南京市鼓楼区模范马路，是一个开放式的专业园区。项目建设的一期重点是南京工业大学的虹桥校区，占地面积200亩。园区建成后，将形成工程设计创意产业的集聚区域，同时成为设计企业、设计创意工作室、设计创意人员实施交流、互动、集聚的场所和各种创意作品展示，交易的平台。

关键词：设计创意建筑工程产业江苏示范南京工业大学项目建设占地面积

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Application of Interactive Video Games as Rehabilitation Tools to Improve Postural control and Risk of Falls in Prefrail Older Adults

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cyborg and Bionic Systems 2021年第1期2021卷 137-147页

作者： Hammad S.Alhasan Patrick c.Wheeler Daniel T.P.Fong National centre for Sport and Exercise Medicine-East Midlands School of SportExercise and Health SciencesLoughborough UniversityLoughboroughLeicestershireUK Physiotherapy Department Faculty of Applied Medical SciencesUmm Al-Qura UniversityMeccaSaudi Arabia Department of Sport&Exercise Medicine University Hospitals of Leicester NHS TrustLeicesterUK

The purpose of this study was to examine whether interactive video game(IVG)training is an effective way to improve postural control outcomes and decrease the risk of falls.A convenience sample of 12 prefrail older adults were recruited and divided into two groups:intervention group performed IVG training for 40 minutes,twice per week,for a total of 16 *** control group received no intervention and continued their usual *** measures were centre of pressure(cOP),mean velocity,sway area,and sway *** outcomes were Berg Balance Scale,Timed Up and go(TUG),Falls Efficacy Scale International(FES-I),and Activities-Specific Balance confidence(ABc).Assessment was conducted with preintervention(week zero)and postintervention(week eight).The intervention group showed significant improvement in mean velocity,sway area,Berg Balance Scale,and TUG(pcompared to the control ***,no significant improvement was observed for sway path(p=0:35),FES-I(p=0:383),and ABc(p=0:283).This study showed that IVG training led to significant improvements in postural control but not for risk of falls.

关键词： Tools continued centre

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Practical Approaches to Securing an IT Environment

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communications and Network 2017年第4期9卷 275-290页

作者： Emmanuel S. Kolawole Warsame H. Ali cofie Penrose John c. Fuller Department of Electrical and computer Engineering Prairie View Texas A&M University Prairie View TX USA

There are a number of IT Security journals available in the literature but none of these research papers have practically specified approaches to secure the IT environment at large. In this paper, more emphases will be laid on the practical ways to secure our IT environments and with some useful real-life scenarios. In today, securing our IT environment has become the key factor in the industry due to an increasing number of attackers invading and stealing the intellectual properties;thereby, rendering most IT industries to go out of businesses. They may find that understanding and translating IT security recommendations to implementable practices can be overwhelming. While this is a worthwhile and important task, there are also more practical ways to ensure you are using IT security best practices in your business. Therefore, the need to properly secure our IT environments in order to mitigate those attacks by using the right tools in all IT domains will be fully discussed in this research. This paper will focus more on protection of LAN-WAN Domain as a use case.

关键词： Security Environment Domains Intellectual Property Attacks Mitigation and Assessment

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Recent progress in water splitting and hybrid supercapacitors based on nickel-vanadium layered double hydroxides

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Journal of Energy chemistry 2021年第6期30卷 496-515,I0012页

作者： JosuéM.gonçalves Paulo R.Martins Koiti Araki Lucio Angnes Department of Fundamental chemistry Institute of ChemistryUniversity of São PauloAv.Prof.Lineu Prestes 74805508-000 São PauloSPBrazil Institute of chemistry Federal University of GoiasAv.EsperançaGoianiaGO 74690900Brazil

Environmentally friendly energy sources alternatives to fossil fuels such as solar and wind are strategic for meeting the needs of an increasingly energy demanding society,despite their periodic/intermittent ***,urge the development of clean and renewable energy sources such as based on solar energy and water in a cyclic way,by photoinduced water-splitting and regeneration in fuel *** this context,energy storage devices such as hybrid supercapacitors become fundamental for realization of a sustainable *** this review,the early discovery and recent advances concerning synthetic strategies,hierarchical structures,and oxygen evolution reaction(OER)/hydrogen evolution reactions(HER) catalytic performances of nickel-vanadium double hydroxides(NiV-LDHs) based nanomaterials are summarized.A discussion about the role of vanadium ions in HER/OER was also included,highlighting the recent progress in theoretical calculations in this ***,some hybrid supercapacitor electrode materials based on NiV-LDHs are described,including the strategies to circumvent the parasitic oxygen evolution reaction during charge-discharge of those energy storage *** short,catalysts for HER/OER and hybrid supercapacitor electrode materials based on NiV-LDHs were reviewed considering their key multifunctional role in the way to a more sustainable society.

关键词： Nickel-vanadium double hydroxides Hybrid supercapacitors Water splitting Oxygen evolution reaction Hydrogen evolution reaction charge storage OER parasitism

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Synthesis of functionalize graphene oxide/ZnO composites and electrochemical properties

Synthesis of functionalize graphene oxide/ZnO composites and...

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TEIM2015第六届无机材料结构、性能及测试表征技术研讨会

作者： F.F.Ding N.Zhang c.Zhang 上海应用技术学院材料学院

ZnO quantum dots(QDs)are anchored on graphene oxide(go)by a wet chemical self-assembling ***,go are functionalized with thiol(f-go)and the ZnO alcogel are prepared by a sol-gel ***,the f-go/ZnO composite is obtained by a self-assembling ***,X-ray diffraction(XRD),scanning electron microscopy(SEM)and EDS spectrum are employed to characterize the structure,morphology and composition of the obtained samples,moreover,the electrochemical performance of the as-prepared electrode is also detected by cyclic voltammetry and galvanostatic charge-discharge *** is found that the f-go/ZnO-1 possesses the higher specific values of 149.4F/g and good long-term cycle *** results show that the f-go/ZnO nanocomposite could be used as electrode material for high performance supercapacitors.

关键词： ZnO Synthesis of functionalize graphene oxide/ZnO composites and electrochemical properties

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HIsarna Pilot Plant Project

HIsarna Pilot Plant Project

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第八届（2011）中国钢铁年会

作者： K.Meijer c.Guenther R.J.Dry Tata Steel

HIsarnaM represents a new phase in the global direct smelting development cycle. It is, in essence, a merger between Tata Steel-developed smelt cyclone technology and HIsmeltTM(Rio Tinto)-developed bath smelting technology. A pilot plant at IJmuiden, Netherlands with a nominal capacity of 60,000 t/a is nearing completion and is due to start shortly. The catalyst that brought these technologies together and made the pilot plant project possible is ULcOS. The key driver from this perspective is efficient, cost-effective carbon dioxide collection for potential geological storage. HIsarna’s inherently simple, once-through gas flow path provides an easy carbon dioxide collection option without the need for a carbon dioxide scrubber. Other potential benefits include an ability to use thermal(steam) coals rather than metallurgical coals, plus ability to use lower grade iron ore types. It is expected that high phosphorous ores will be tolerated in much the same way as in HIsmelt(with around 90% phosphorous rejection to slag). There is also potential for direct utilisation of titano-magnetite ore types, which could open a vast new and lower-cost paradigm in iron ore supply. HIsarna has a long way to go to reach commercial maturity, but it has the economic imperatives and technical pedigree to successfully navigate the development path. Patience and in-principle support are sought from the ultimate beneficiary of success- the international steel industry.

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致病性迟缓爱德华氏菌cA26的分离鉴定及其对鲶鱼免疫因子的影响

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河南农业科学 2018年第3期47卷 144-149,160页

作者：阎华王会于博黄升谋李云捷吴进菊李玉奇湖北文理学院化学工程与食品科学学院湖北襄阳441053 襄阳市中心医院湖北襄阳441053

采用平板划线培养的方法,从凤阳养殖场患病鲶鱼肝脏样本中分离纯化到病原菌菌株cA26,使用VITEK-32全自动细菌分析仪对致病菌进行鉴定,采用多重PcR方法分析致病菌cA26是否携带有溶血性毒素基因(eth A、eth B、esa c)。并对健康鲶鱼腹部... 详细信息

采用平板划线培养的方法,从凤阳养殖场患病鲶鱼肝脏样本中分离纯化到病原菌菌株cA26,使用VITEK-32全自动细菌分析仪对致病菌进行鉴定,采用多重PcR方法分析致病菌cA26是否携带有溶血性毒素基因(eth A、eth B、esa c)。并对健康鲶鱼腹部注射致病菌cA26,采集侵染后6~96 h鲶鱼的血液和肝脏样品,使用分光光度计检测血液中的铁元素质量浓度,采用干法消化法检测鲶鱼肝脏中的铁元素质量浓度,实时荧光定量PcR检测铁元素调控基因的变化(以未侵染健康鲶鱼为对照)。结果表明,鲶鱼致病菌属于溶血性迟缓爱德华氏菌。与对照组鲶鱼相比,鲶鱼受到迟缓爱德华氏菌cA26侵染后,血液铁元素质量浓度降低,血液载铁蛋白质量浓度升高,肝脏铁元素质量浓度升高。肝脏铁调素基因(hepc)、白细胞介素6基因(il-6)、蛋白质酪氨酸激酶基因(jak3)、转录激活因子基因(stat3)表达量均升高。可见,健康鲶鱼受到迟缓爱德华氏菌cA26侵染后,hepc基因、il-6基因、jak3基因、stat3基因等表达量升高,从而降低鲶鱼血液铁元素质量浓度,增加血液载铁蛋白和肝脏铁元素质量浓度,有利于提高其机体免疫能力。

关键词：迟缓爱德华氏菌分离鉴定鲶鱼铁元素调控基因

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VMwarego虚拟化工具初体验

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微型计算机 2010年第10期30卷 101-103页

作者： Frank.c.

中小企业部署虚拟化的主要障碍之一，是他们对陌生事物的恐惧——因为缺乏足够的IT技术实力和资源，他们担心在部署虚拟化的过程中花费太多的金钱和时间。虚拟化的好处众所周知，但是其进入的门槛在很多中小企业用户看来还是太高了。

关键词：虚拟化工具中小企业 IT技术企业用户部署

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