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Built Heritage 2021年第3期5卷 159-170页

作者： camilla Mileto Fernando Vegas lópez‑Manzanares Valentina Cristini lidía García Soriano Polytechnic University of Valencia Camino de Vera s/n46022 ValenciaSpain

For more than a decade,a wide range of Spanish case studies,relating especially to rural inner or abandoned sites and areas,have been analysed by the authors as part of diferent research projects linked with traditional and monumen‑tal architecture,conservation strategies and earthen *** one hand the studies have been undertaken in the framework of a project concerning the conservation of rammed earth in the Iberian Peninsula,including criteria,techniques,results and perspectives and,on the other,by a project about the conservation and rehabilitation of tradi‑tional earthen architecture in the Iberian Peninsula,providing guidelines and tools for its sustainable *** all cases the researchers’eforts focused on enhancing new perspectives and opportunities for rural earthen buildings,analysing landscapes,contexts,constructive features,decay and *** fnal common aim of this research is to stress these crucial topics to improve tangible or intangible opportunities for conservation strategies.

关键词： Risk analysis Conservation strategies Constructive techniques Preservation tools RES-TAPIA SOS-TIERRA

Iron toxicity resistance strategies in tropical grasses:The role of apoplastic radicular barriers

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Journal of Environmental Sciences 2019年第4期31卷 257-266页

作者： Advanio Inacio Siqueira-Silva camilla Oliveira Rios Eduardo Gusmao Pereira Institute of Biological and Health Sciences Federal University of Vicosa (UFV)Campus Florestal Minas Gerais Brazil Federal University of Western Para (UFOPA) University Campus of JurutiPara Brazil Postgradute Program in Management and Conservation of Natural and Agrarian Ecosystems UFV Campus Florestal Florestal Minas Gerais Brazil

The revegetation of mined areas poses a great challenge to the iron ore mining *** initial recovery process in degraded areas might rely on the use of Fe-resistant *** grasses, such as Paspalum densum and Echinochloa crus-galli, show different resistance strategies to iron toxicity; however, these mechanisms are poorly *** Fe-resistance mechanisms and direct iron toxicity as a function of root apex removal were investigated. To achieve this purpose, both grass species were grown for up to 480 hr in a nutrient solution containing 0.019 or 7 mmol/l Fe-EDTA after the root apices had been removed or maintained. Cultivation in the presence of excess iron-induced leaf bronzing and the formation of iron plaque on the root surfaces of both grass species, but was more significant on those plants whose root apex had been removed. Iron accumulation was higher in the roots, but reached phytotoxic levels in the aerial parts as well. It did not hinder the biosynthesis of chloroplastidic pigments. No significant changes in gas exchange and chlorophyll a fluorescence occurred in either grass when their roots were kept intact; the contrary was true for plants with excised root apices. In both studied grasses, the root apoplastic barriers had an important function in the restriction of iron translocation from the root to the aerial plant parts, especially in E. crus-galli. Root apex removal negatively influenced the iron toxicity resistance mechanisms(tolerance in P. densum and avoidance in E. crus-galli).

关键词： Paspalum densum Echinochloa crus-galli Apoplastic barrier Iron toxicity

Widening socioeconomic disparity in lung cancer incidence among men in New South Wales, Australia, 1987–2011

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Chinese Journal of Cancer Research 2017年第5期29卷 395-401页

作者： Xue Qin Yu Qingwei luo Clare Kahn camilla Cahill Marianne Weber Paul Grogan Ahmedin Jemal Dianne l O'Connell Cancer Research Division Cancer Council NSW Sydney School of Public Health University of Sydney Sanofi Australia Cancer Council Australia Surveillance and Health Services Research American Cancer Society School of Medicine and Public Health University of Newcastle

Objective：We assessed the trends in lung cancer incidence over a 25-year period by socioeconomic groups for men in New South Wales（NSW）,***：Men diagnosed with lung cancer between 1987 and 2011 were divided into five quintiles according to an Index of Education and Occupation（IEO）.We assessed relative socioeconomic differences over time by calculating age-standardized incidence ratios（SIRs）by 5-year period of diagnosis,and estimated absolute differences by comparing the observed and expected numbers of cases using the highest IEO quintile as the ***：lung cancer incidence for men decreased from 1987 to 2011 for all IEO quintiles,with a greater rate of decline for men living in the highest IEO ***,the relative disparity increased significantly over the 25-year period（P=0.0006）.For example,the SIR for the lowest IEO quintile increased from 1.28 during 1987–1991 to 1.74during 2007–*** differences also increased with the proportion of＂potentially preventable＂cases doubling from 14.5% in 1987–1991 to 30.2% in 2007–***：Despite the overall decline in lung cancer incidence among men in NSW over the past 25 years,there was a significant increase in disparity across socioeconomic areas in both relative and absolute terms.

关键词： Australia lung cancer socioeconomic inequality temporal trends tobacco control tobacco smoking

Helicobacter pylori infection and drugs malabsorption

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World Journal of Gastroenterology 2014年第30期20卷 10331-10337页

作者： Edith lahner camilla Virili Maria Giulia Santaguida Bruno Annibale Marco Centanni Gastrointestinal Unit Department of Digestive and Liver Disease"Sapienza" University of Roma00189 RomaItaly Endocrinology Unit Department of Medico-Surgical Sciences and Biotechnologies"Sapienza" University of Roma04100 LatinaItaly

Drug absorption represents an important factor affecting the efficacy of oral drug *** secretion and motility seem to be critical for drug absorption.A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori(***)infection has been *** have been reported between poor bioavailability of l-thyroxine and l-dopa and *** *** to the Maastricht Florence Consensus Report on the management of *** infection,*** treatment improves the bioavailability of both these drugs,whereas the direct clinical benefits to patients still await to be *** strong seems the association between *** infection and other drugs malabsorption,such as delavirdine and *** exact mechanisms forming the basis of the relationship between *** infection and impaired drugs absorption and/or bioavailability are not fully *** infection may trigger a chronic inflammation of the gastric mucosa,and impaired gastric acid secretion often *** reduction of acid secretion closely relates with the wideness and the severity of the damage and may affect drug *** minireview focuses on the evidence of *** infection associated with impaired drug absorption.

关键词： Drug malabsorption Helicobacter pylori gastritis Gastric hypoacidity Thyroxine treatment Thyroxine malabsorption Human immunodeficiency virus Delavirdine l-dopa Parkinson's disease Ketaconazole

Autism spectrum disorder and personality disorders: Comorbidity and differential diagnosis

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World Journal of Psychiatry 2021年第12期11卷 1366-1386页

作者： camilla Rinaldi Margherita Attanasio Marco Valenti Monica Mazza Roberto Keller Adult Autism Center Department of Mental HealthASL Cittàdi TorinoTurin 10138Italy Department of Applied Clinical Sciences and Biotechnology University of L’AquilaL’Aquila 67100Italy Regional Centre for Autism Abruzzo Region Health SystemL’Aquila 67100Italy

BACKGROUND Differential diagnosis,comorbidities and overlaps with other psychiatric disorders are common among adults with autism spectrum disorder(ASD),but clinical assessments often omit screening for personality disorders(PD),which are especially common in individuals with high-functioning ASD where there is less need for *** To summarize the research findings on PD in adults with ASD and without intellectual disability,focusing on comorbidity and differential *** PubMed searches were performed using the key words“Asperger’s Syndrome”,“Autism”,“Personality”,“Personality disorder”and“comorbidity”in order to identify relevant articles published in *** literature was identified through searching Google *** literature reviews and reference sections of selected papers were also examined for additional potential *** search was restricted to studies published up to April *** review is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** The search found 22 studies carried out on ASD adults without intellectual disability that met the inclusion criteria:16 evaluated personality profiles or PD in ASD(comorbidity),five compared ASD and PD(differential diagnosis)and one performed both *** were significant differences in the methodological Cluster A and cluster C PD are the most frequent co-occurring PD,but overlapping features should be *** on differential diagnosis were only found with cluster A and cluster B *** ASD in high-functioning adults is associated with a distinct personality profile even if variability *** studies are needed to explore the complex relationship between ASD and PD.

关键词： Autism spectrum disorder Asperger’s Syndrome Personality disorder Adulthood Comorbidity Differential diagnosis

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使用临床流程图鉴别处方瀑布

英国医学杂志中文版 2020年第11期23卷 672-676页

作者： Katrina l Piggott Nishila Mehta camilla l Wong Paula A Rochon 闫雪莲(译) Department of Medicine and the Institute for Health Policy Management and Evaluation(IHPME)University of TorontoTorontoCanada Undergraduate Medicine Faculty of MedicineUniversity of TorontoTorontoCanada Division of Geriatric Medicine St Michael′s HospitalUniversity of TorontoTorontoCanada Women′s College Research Institute Women′s College HospitalUniversity of TorontoTorontoCanada 中国医学科学院北京协和医院药剂科

药物的不良反应可能"隐藏"于常见症状中。如1997年Rochon和Gurwitz在The BMJ所阐述,处方瀑布即医务人员将药物不良事件误认为是新出现的医疗状况,而开具新的药物来处理这个不良事件。这个概念已扩展至不必要的诊断性检查、使用医疗设备... 详细信息

药物的不良反应可能"隐藏"于常见症状中。如1997年Rochon和Gurwitz在The BMJ所阐述,处方瀑布即医务人员将药物不良事件误认为是新出现的医疗状况,而开具新的药物来处理这个不良事件。这个概念已扩展至不必要的诊断性检查、使用医疗设备和非处方药治疗等可能使患者暴露于风险和伤害的情况。目前还没有公认的方法来确定某一症状是否由一种药物所致,但是通过核查处方瀑布,临床医师可以减少不必要的药物、检查、会诊和伤害。

关键词：诊断性检查药物不良事件医疗状况临床医师常见症状医疗设备非处方药流程图

Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance

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Cancer Drug Resistance 2021年第4期4卷 984-995页

作者： Montserrat Estruch camilla Vittori Teresa Muñoz Montesinos Kristian Reckzeh Kim Theilgaard-Mönch The Finsen laboratory Rigshospitalet/National University HospitalFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Biotech Research and Innovation Centre Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Novo Nordisk Foundation Centre for Stem Cell Biology DanStemFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Department of Hematology Rigshospitalet/National University HospitalUniversity of CopenhagenCopenhagen DK-2200Denmark

Resistance of cancer patients to DNA damaging radiation therapy and chemotherapy remains a major problem in the *** current review discusses the molecular mechanisms of therapy resistance in acute myeloid leukemia(AMl)conferred by cooperative chemotherapy-induced DNA damage response(DDR)and mutational activation of PI3K/AKT *** addition,strategies to overcome resistance are discussed,with particular focus on studies underpinning the vast potential of therapies combining standard chemotherapy AMl regimens with small molecule inhibitors targeting key regulatory hubs at the interface of DDR and oncogenic signaling pathways.

关键词： DNA damage response PI3K/AKT chemotherapy resistance AMl

Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid

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World Journal of Gastroenterology 2005年第28期11卷 4367-4374页

作者： Asbjφrn Mohr Drewes Hariprasad Reddy camilla Staahl Jan Pedersen Peter Funch-Jensen lars Arendt-Nielsen Hans Gregersen Center for Biomechanics and Pain Department of Gastroenterology Aalborg HospitalAarhus University HospitalAalborgDenmark Department of Surgical Gastroenterology l Aarhus University Hospital AarhusDenmark Center for Sensory-Motor Interactions (SMI) Department of Health Science and Technology Aalborg UniversityAalborgDenmark

AIM: Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the *** current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after ***: Thirty healthy subjects were *** of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/l hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area,volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with ***: The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not ***: Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary *** new model can be used to study abnormal sensorymotor mechanisms in visceral organs.

关键词： Esophagus Mechanical Sensitization Motility Reflux Pain

Barley genome,Pan Genome and Its Application to Barley Breeding

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Barley genome,Pan Genome and Its Application to Barley Breed...