检索结果-南通市图书馆

c-Met enforces proinflammatory and migratory features of human activated CD4^(+)T cells

Cellular & Molecular Immunology 2021年第8期18卷 2051-2053页

作者： Mahdia Benkhoucha Ngoc Lan Tran Gautier Breville Isis Senoner camilla jandus Patrice Lalive Department of Pathology and Immunology Faculty of MedicineUniversity of GenevaGenevaSwitzerland Department of Neurosciences Division of NeurologyUniversity Hospital of GenevaGenevaSwitzerland Ludwig Institute for Cancer Research Lausanne BranchLausanneSwitzerland

The receptor tyrosine kinase c-Met is essential for embryonic development and tissue regeneration,as it promotes cell survival,proliferation,migration,and angiogenesis[1,2].The HGF/c-Met axis modulates several inflammatory-mediated diseases by acting on a wide variety of cells[3].Nevertheless,studies on the role of c-Met in peripheral T cell functions are very limited,partly because we and others have reported negligible c-Met expression in naive T cells[2,4].

关键词： inflammatory diseases negligible

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Severe COVID-19 patients exhibit an ILC2 NKG2D^(+) population in their impaired ILC compartment

引用

Cellular & Molecular Immunology 2021年第2期18卷 484-486页

作者： Alejandra Gomez-Cadena Laurie Spehner Marie Kroemer Myriam Ben Khelil Kevin Bouiller Grégory Verdeil Sara Trabanelli Christophe Borg Romain Loyon camilla jandus Department of Pathology and Immunology University of GenevaGenevaSwitzerlandand Ludwig Institute for Cancer ResearchLausanneSwitzerland University of Bourgogne Franche-Comté INSERMEFS BFCUMR1098RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueF-25000BesançonFrance Department of Pharmacy University Hospital of BesançonF-25000BesançonFrance Department of Infectious Disease University Hospital of BesançonF-25000BesançonFrance UMR-CNRS 6249 Chrono-Environment UniversitéBourgogne Franche-ComtéF-25000BesançonFrance Department of Oncology UNIL-CHUVUniversity of Lausanne1066EpalingesSwitzerland Department of Medical Oncology University Hospital of BesançonF-25000BesançonFrance

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the current COVID-19 disease *** some patients,the symptoms are mild,and a fraction of SARS-CoV-2-infected individuals develop severe illness with a high fatality rate due to lung damage and acute respiratory distress syndrome.1 Innate lymphoid cells(ILCs)are a recently identified type of effector immune cells that rapidly sense environmental stimuli and participate in early immune responses by promptly secreting large amounts of cytokines.2 The ILC2 subpopulation was shown to mediate Type 2 responses and to recruit eosinophils during viral lung infections upon the release of alarmins(e.g.,IL-33)by damaged epithelial cells.3,4,5 ILC2s were also shown to participate in the termination of inflammatory responses and tissue repair by amphiregulin *** addition,ILC2s are critical in the early phases of allergic lung inflammation,including that induced by the protease allergen papain.6 Based on the essential function of the papain-like protease PLpro in regulating SARS-CoV-27(Fig.1a)and the severe lung damage caused by this virus,we sought to investigate the potential involvement of ILC2s in immune responses to COVID-19.

关键词： impaired patients acute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：