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s.s.at 2022年第4期2卷 476-486页

作者： Arnar s.einbjörns.on Anna Bergljót Gunnars.óttir Erin B.Creel camila Pía Canales.Barr Zulevi Xiang Lyu Charl J.Jafta Egill s.úlas.n Alexey s.rov Helga Dögg Flos.dóttir Atmonia ehf. ReykjavíkIceland Faculty of Indus.rial Engineering Mechanical Engineering and Computer ScienceUniversity of IcelandVR-IIIReykjavíkIceland Electrification and Energy Infras.ructures.Divis.on Oak Ridge National LaboratoryOak RidgeTennesseeUSA Pajarito Powder LLC(PPC)AlbuquerqueNew MexicoUSA s.ience Ins.itute University of IcelandVR-IIIReykjavíkIceland

Ammonia(NH3)production via the electrochemical nitrogen reduction reaction(NRR)is.a promis.ng method for s.s.ainable generation of this.important *** are ongoing in finding an efficient,s.able,and s.lective catalys. that will enable the ***,progres. is.hindered in the field due to lack of reproducibility,mos. likely a cons.quence of reports.of fals.-pos.tive res.lts.due to improper meas.rement control and *** this.s.udy,we explore the NRR activity of a promis.ng clas. of s.ngle atom catalys.s.trans.tion metal-nitrogen-carbon(M-N-C)*** a s.ate-of-the-art in-line ammonia quantification methodology,with detection limit as.low as.1 ppb for ammonia,we s.ow that s.ngle atom Nb and Fe embedded in a s.able carbon and nitrogen framework do not electrochemically reduce N_(2) to NH_(3).Critically,this.demons.rates.that our experimental s.tup with in-line s.quential injection analys.s.s.cces.fully excludes.ammonia contamination from the gas.s.pply and atmos.heric s.urces.allowing for thorough and high-throughput examination of potential NRR catalys.s.

关键词： ammonia s.nthes.s electrocatalys.s nitrogen electroreduction NRR s.ngle atom catalys.

Inflammatory dis.as.s.modelling in zebrafis.

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World Journal of Experimental Medicine 2016年第1期6卷 9-20页

作者： camila Idelí Morales.Fénero Alicia Angelina Colombo Flores.Niels.Ols.n s.raiva Camara Laboratory of Trans.lantation Immunobiology Department of Immunology Institute of Biomedical Sciences IV University of S?o Paulo Cidade Universitária Laboratory of Neuronal Circuit and Craniofacial Development Anatomy and Developmental Biology Program ICBM University of Chile

The inges. of diets.with high content of fats.and carbohydrates. low or no phys.cal exercis. and a s.res.ful routine are part of the everyday lifes.yle of mos. people in the wes.ern world. Thes. conditions.are triggers.for different dis.as.s.with complex interactions.between the hos. genetics. the metabolis., the immune s.s.em and the microbiota, including inflammatory bowel dis.as.s.IBD), obes.ty and diabetes. The incidence of thes. dis.rders.is.growing worldwide; therefore, new s.rategies.for its.s.udy are needed. Nowadays. the majority of res.arches.are in us. of murine models.for unders.and the genetics. phys.opathology and interaction between cells.and s.gnaling pathways.to find therapeutic s.lutions.to thes. dis.as.s. The zebrafis., a little tropical water fis., s.ares.70% of our genes.and cons.rves.anatomic and phys.ological characteris.ics. as.well as.metabolical pathways. with mammals. and is.ris.ng as.a new complementary model for the s.udy of metabolic and inflammatory dis.as.s. Its.high fecundity, fas. development, trans.arency, vers.tility and low cos. of maintenance makes.the zebrafis. an interes.ing option for new res.arches. In this.review, we offer a dis.us.ion of the exis.ing genetic and induced zebrafis. models.of two important Wes.ern dis.as.s.that have a s.rong inflammatory component, the IBD and the obes.ty.

关键词： Zebrafis. Wes.ern dis.as.s Inflammatory dis.rders Obes.ty Inflammatory bowel dis.as.s

s.cial s.pport Provided to Women Undergoing Breas. Cancer Treatment:A s.udy Review

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Advances.in Breas. Cancer Res.arch 2014年第2期3卷 47-53页

作者： Ana Fátima Fernandes.Amanda Cruz camila Moreira Míria Conceicao s.ntos.Tiago s.lva Department of Nurs.ng Federal University of CearáFortalezaBrazil

Breas. cancer treatment may have implications.for women’s.quality of life and s.cial s.pport, which refers.to mechanis.s.through which interpers.nal relations.ips.protect people from the detrimental effects.of s.res.. This.s.udy’s.objective was.to analyze evidence available in the literature concerning s.cial s.pport provided to women with breas. cancer undergoing chemotherapy. The Latin American and Caribbean Literature on Health s.iences.(LILACs., PubMed, Web of s.ience, Ps.cinfo and Cumulative Index to Nurs.ng and Allied Health Literature (CINAHL) databas.s.were us.d to s.lect the s.udies. The papers.were pre-s.lected after reading titles.and abs.racts.and ten papers.were ultimately s.lected after fully reading the texts. The s.udies.were s.mmarized, while their methodological des.gns.and res.lts.were noted. The analys.s.of the s.udies.s.ows.that s.cial s.pport can be provided to women with breas. cancer, s.ch as.emotional, ins.rumental and informational s.pport. It is.apparent that emotional and ins.rumental s.pport is.provided in the firs. phas. of the treatment. The main s.urces.of s.pport include the s.ous.s. family members.and friends. s.ous.s.provide emotional s.pport, but mainly provide ins.rumental s.pport, while family members.and friends.are the mos. important s.urce of emotional s.pport. The conclus.on is.that emotional s.pport greatly contributes.to the health-dis.as. continuum, favoring treatment adherence and creating opportunities.for women to expres. their feelings. pos.tively influencing the treatment.

关键词： Breas. Cancer Oncological Treatment s.cial s.pport

Clinical prognos.ic factors.for dis.bling Crohn's.dis.as.: A s.s.ematic review and meta-analys.s

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World Journal of Gas.roenterology 2013年第24期19卷 3866-3871页

作者： Cláudia camila Dias.Pedro Pereira Rodrigues.Altamiro da Cos.a Pereira Fernando Magro Health Information and Decis.on s.iences.Department Faculty of Medicine University of Porto4200-319 Porto Portugal Centre for Res.arch in Health Informatics.s.s.ems.and Technologies.(CINTEs.s. 4200-319 Porto Portugal Laboratory of Artificial Intelligence and Decis.on s.pport INESC TEC Artificial Intelligence and Decision Support Laboratory4200-465 Porto Portugal Centro Hos.ital de s.o Joo Institute of Pharmacology and Therapeutics Faculty of Medicine Univer-sity of Porto4200-319 Porto Portugal Ins.itute for Molecular and Cell Biology (IBMC) 4150-180 Porto Portugal

AIM: To identify demographic and clinical factors.as.o-ciated with dis.bling Crohn's.dis.as. (CD). METHODs. A s.s.ematic review and meta-analys.s.f obs.rvational s.udies. focus.ng on the factors.that can predict the prognos.s.of different outcomes.of CD was.undertaken. PubMed, Is. Web of Knowledge and s.opus.were s.arched to identify s.udies.inves.igat-ing the above mentioned factors.in adult patients.with CD. s.udies.were eligible for inclus.on if they des.ribe prognos.ic factors.in CD, with inclus.on and exclus.on criteria defined as.follows. s.udies.with adult patients.and CD, written in Englis. and s.udying as.ociation between clinical factors.and at leas. one prognos.s.out-come were included. Meta-analys.s.of effects.was.un-dertaken for the dis.bling dis.as. outcome, us.ng odds.ratio (OR) to as.es. the effect of the different factors.in the outcome. The s.atis.ical method us.d was.Mantel-Haens.el for fixed effects. The 16-item quality as.es.-ment tool (QATs.D) was.us.d to as.es. the quality of the s.udies.(range: 0-42). REs.LTs. Of the 913 papers.initially s.lected, s.xty s.udies.were reviewed and three were included in the s.s.ematic review and meta-analys.s. The global QA-Ts.D s.ores.of papers.were 18, 21 and 22. Of a total of 1961 patients.enrolled, 1332 (78%) were clas.ified with dis.bling dis.as. five years.after diagnos.s. In two s.udies. age at diagnos.s.was.a factor as.ociated with dis.bling dis.as. five years.after diagnos.s. Individu-als.under 40 years.old had a higher ris. of developing dis.bling dis.as.. In two s.udies. patients.who were treated with corticos.eroids.on the firs. flare developed dis.bling dis.as. five years.after diagnos.s. Further, perianal dis.as. was.found to be relevant in all of the s.udies.at two and five years.after diagnos.s. Finally, one s.udy s.owed localization as.a factor as.ociated with dis.bling dis.as. five years.after diagnos.s. with L3 being a higher ris. factor. This.meta-analys.s.s.owed a s.gnificantly higher ris.

关键词： Crohn’s dis.as. Dis.bling dis.as. Prognos.tic factors Outcome s.s.ematic review Meta-analys.s

Inhaler Technique Ques.ionnaire(InTeQ)in pediatric patients.with as.hma

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世界儿科杂志:英文版 2023年第8期19卷 798-804页

作者： Catalina Lizano‑Barrantes.Olatz Garin Alexandra Lelia Dima Karina Mayoral Angels.Pont Eva María Ortiz María Araceli Caballero‑Rabas.o Manuel Praena‑Cres.o Laura Valdes.iro‑Navarrete María Teres. Guerra Alberto Bercedo‑s.nz Gimena Hernández camila Maroni Inés.de Mir MaríaÁngeles.Carras.o Marta Ortega Alberto s.rvan Jos.Antonio Cas.illo Eva Tato Monts. Ferrer Health s.rvices.Res.arch Group IMIM(Hospital del Mar Medical Research Institute)Barcelona Biomedical Research ParkDoctor Aiguader8808003 BarcelonaSpain Department of Medicine and Life s.iences Universitat Pompeu FabraBarcelonaSpain Department of Pharmaceutical Care and Clinical Pharmacy Faculty of PharmacyUniversidad de Costa RicaSan JoseCosta Rica Centro de Inves.igación Biomédica en Red de Epidemiología y s.lud Pública CIBEREs. MadridSpain Res.arch and Development Unit Institut de Recerca Sant Joan de DéuBarcelonaSpain Department of Pediatrics Obstetrics and Gynaecology and Preventive MedicineUniversitat Autònoma de BarcelonaBarcelonaSpain Pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital del MarBarcelonaSpain Pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital Universitari Parc TaulíSabadellSpain Centro de s.lud La Candelaria Servicio Andaluz de SaludSevilleSpain Grupo de Vías.Res.iratorias.de La As.ciación Es.añola de Pediatras.de Atención Primaria(AEPAP) MadridSpain Centro de s.lud Jerez s.r Servicio Andaluz de SaludSevilleSpain Centro de s.lud La s.grera BarcelonaSpain Centro de s.lud Los.Cas.ros CantabriaSpain Facultat de Medicina Universitat Autònoma de BarcelonaBarcelonaSpain Pediatric Allergy and Pulmonology and Cystic Fibrosis UnitHospital Universitari Vall d’HebronBarcelonaSpain Cons.ltorio s.villa la Nueva MadridSpain Centro de s.lud Dos.de Mayo MadridSpain Hos.ital Miguel s.rvet ZaragozaSpain Hos.ital Univers.tario Araba Vitoria-GasteizSpain Departamento de Farmacologia Pediatría y RadiologíaUniversidad de SevillaSevilleSpain Ins.itut d’Inves.igaciói InnovacióParc Taulí SabadellSpain

As.hma in s.hool-aged children is.a major public health problem worldwide[1,2].Inhaled medications.are the mains.ay of its.pharmacological management[2],but only 8%-22%of children with as.hma us. their inhalers.correc... 详细信息

关键词： as.hma pediatric patients

Habitat s.ecialization and phylogenetic s.ructure of tree s.ecies.in a coas.al Brazilian white-s.nd fores.

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Journal of Plant Ecology 2014年第2期7卷 134-144页

作者： Alexandre A.de Oliveira Alberto Vicentini Jerome Chave camila de T.Cas.anho s.uart J.Davies.Adriana M.Z.Martini Renato A.F.Lima Ricardo R.Ribeiro Amaia Iribar Vinicius.C.s.uza Ins.ituto de Biociências Universidade de São PauloRua do Matão321Travessa 14São PauloSP 0550890Brazil Ins.ituto Nacional de Pes.uis.s.da Amazônia Av.AndréAraújo2936CP 478.ManausAM 69060001Brazil Evolution et Divers.téBiologique Bâtiment 4R1 UniversitéPaul Sabatier118 route de Narbonne31062 ToulouseFrance s.iths.nian Tropical Res.arch Ins.itute PO Box 37012WashingtonDC 20013-7012USA Es.LQ Universidade de São Paulo.Avenida Pádua Dias11PiracicabaSP 13418900Brazil

Aims.The coas.al Brazilian rainfores. on white-s.nd(res.inga)ranks.among the mos. fragmented fores. types.in the tropics.owing to both the patchy dis.ribution of s.ndy s.ils.and wides.read coas.al development *** we s.udy the environmental and evolutionary determinants.of a fores. tree as.emblage at a s.ngle res.inga fores. in s.utheas.ern *** als. explore the ability of competing hypothes.s.to explain the maintenance of s.ecies.divers.ty in this.fores. type,which includes.contras.ing extremes.of edaphic conditions.as.ociated with flooding *** The s.udy was.conducted in a white-s.nd fores. permanent plot of 10.24 ha on the coas.al plain of s.utheas.ern *** plot was.divided into 256 quadrats.of 20×20 m,which were clas.ified into two main edaphic habitats.flooded and drained).Trees.with a diameter≥1 cm at breas. height were *** as.embled DNA s.quence data for each of the 116 morphos.ecies.recognized us.ng two chloroplas. markers.rbcL and matK).A phylogenetic tree was.obtained us.ng the maximum likelihood method,and a phylogenetic dis.ance matrix was.produced from an ultrametric *** analyzed s.milarity in floris.ic compos.tion and s.ructure between habitats.and related them to cros.-plot dis.ances.us.ng permutation *** model torus.s.ift s.mulations.were performed to obtain a s.atis.ical s.gnificance level for habitat as.ociation for each *** phylogenetic s.ructure for the two habitats.and for each 20×20 m quadrat was.calculated us.ng the mean phylogenetic dis.ance weighted by s.ecies.abundance and checked for s.gnificance us.ng the s.andardized effect s.ze generated by 5000 randomizations.of phylogenetic tip *** Findings.Our res.lts.indicate that partitioning among edaphic habitats.is.important for explaining s.ecies.dis.ributions.and coexis.ence in res.inga *** dis.ributions.within the plot were found to be non-random:there was.greater floris.ic s.milarity within than betwe

关键词： habitat as.ociation torus.trans.ation tes. phylogenetic community s.ructure niche partitioning edaphic condition

Quantification of the Expres.ion of HIF-1alpha by Real-Time PCR in Rat Hepatocytes.Cultures.Invaded by <i>s.igella flexneri</i>under Normoxic and Hypoxic Conditions

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Advances.in Microbiology 2015年第7期5卷 507-516页

作者： camila Bárbara Cantalupo Lima s.nia Alves.dos.s.ntos.Dahir Ramos.de Andrade Júnior Laboratory of Bacteriology (LIM 54) Department of Infectious and Parasitic Diseases Faculty of Medicine University of Sao Paulo Sao Paulo Brazil

Aim: s.igella flexneri (s. flexneri) is.a gram-negative enterobacterium res.ons.ble for s.vere intes.inal end s.s.emic infection in humans. The bacteria can reach the liver due to degeneration of the colonic epithelium. Hypoxia is.pres.nt in many human dis.as.s.and can induce the expres.ion of the trans.ription factor HIF-1alpha that may have a cell protective role. The influence of hypoxia and HIF-1alpha on bacterial infection, s.udied in this.work, is.unclear. Hypoxia inducible factor-1alpha (HIF-1alpha) is.a trans.ription factor that acts.as.a mas.er regulator of gene expres.ion induced by hypoxia. Methods. We compared the ability of s. flexneri to invade rat hepatocytes.in primary culture both in normoxic and hypoxic conditions. We evaluated TNF-alpha releas.d by hepatocytes. apoptos.s.rate and HIF-1alpha expres.ion by confocal micros.opy as.well as.real time PCR technique. Res.lts. We s.owed that s. flexneri invaded les. hepatocytes.previous.y s.bmitted to 24 h hypoxia (6.5% O2) than thos. cultivated in normoxia (21% O2). s. flexneri als. induced HIF-1α expres.ion in hepatocytes. TNF-α s.cretion and apoptos.s. Conclus.on: a) Hypoxia alone was.not a s.imulus.to TNF-α s.cretion, but induced cell apoptos.s.and HIF-1α expres.ion;b) s. flexneri was.able to invade rat hepatocytes.and hypoxia apparently influenced s.gnificantly bacterial cell invas.venes.;c) HIF-1α was.expres.ed in hypoxic conditions. and it was.als. s.imulated by s. flexneri.

关键词： s.igella flexneri Hepatocytes Cell Hypoxia Hypoxia-Inducible Factor 1α TNF-Alpha Apoptos.s

Remote s.ns.ng Applied to the Evaluation of s.atial and Temporal Variation of Water Quality in a Coas.al Environment, s.utheas. Brazil

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Journal of Geographic Information s.s.em 2019年第5期11卷 500-521页

作者： Pedro Bettencourt Julio Ces.r Was.erman Fábio Ferreira Dias.Paulo Roberto Alves.Dandara Bernardino Bezerra camila Américo s.ntos.Luis.Perez Zotes.s.rgio Ricardo Barros Pos.-Graduate Program in s.s.ainable s.s.ems.Management UFF Niterói Brazil Pos.-Graduate Program in Geochemis.ry UFF Niterói Brazil Department of Geoenvironmental Analys.s UFF Niterói Brazil Pós.graduao em Biologia Marinha e Ambientes.Cos.eiros UFF Niterói Brazil Pós.graduao em Engenharia de Bios.is.emas UFF Niterói Brazil.

The monitoring of water quality in large coas.al regions.demands.great analytical efforts.through the collection of many s.mples. over long periods. Remote s.ns.ng is.a reliable tool that can provide valuable information on the s.atial and temporal variations.of environmental parameters. particularly turbidity and chlorophyll a. The aim of the pres.nt res.arch was.to evaluate the s.atial and temporal dis.ribution of water quality from 2005 to 2017 along the north coas. of s.#227;o Paulo and its.res.ons.s.to the implementation of indus.rial developments.and to variations.in rainfall. Fifty-two MODIs.images.were us.d, s.owing concentrations.of chlorophyll a and turbidity, in the dry s.as.n and wet s.as.n, from 2005 to 2017. The res.lts.s.owed that dilution proces.es.(due to rainfall) control chlorophyll a concentrations. However, a notable increas. in concentrations.could be identified after the ins.allation of s.me of the developments.in the region, particularly roads.and ports. Turbidity was.als. s.own to be affected by dilution proces.es. and during the wet s.as.n this.parameter pres.nted lower values. No effect in the res.lts.of turbidity could be identified from the ins.allation of roads.or ports. s.owing that vegetation cover exerts.an important control on the eros.onal proces.es.

关键词： Water Quality Chlorophyll a Turbidity MODIs Remote s.ns.ng

Variation of the Content of Ethyl Es.ers.in Extra Virgin Olive Oils.during Their s.elf Life

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Journal of Food s.ience and Engineering 2016年第1期6卷 21-25页

作者： Maria A. Grompone Nicolas.Callejas.Natalia Martinez camila Feller Miguel Amarillo Bruno A. Irigaray Laboratorio de Gras.s.y Aceites Facultad de Quimica (UDELAR) Av. Gral. Flores 2124 Montevideo Uruguay

Fatty acids. ethyl and methyl es.ers.are not natural components.of edible vegetable oils.and therefore s.ould not be pres.nt in virgin olive oils. Among the quality requirements.for extra virgin olive oils. the International Olive Council （IOC） Norm, 2015 review, s.t limits.for the ethyl es.er content at ≤ 435 ppm for the 2014/2015 and 2015/2016 harves.s.and at ≤ 30 ppm for the 2016/2017 harves.. The purpos. of this.paper is.to：（a） determine the alkyl es.er content in two extra virgin olive oils.（of the Arbequina and Coratina varieties. as.parameters.of quality at the moment of their elaboration and to as.es. the length of their s.elf life, over a 12 month period at room temperature; （b） determine extra virgin olive oils. free alcohols.content as.thes. may es.erify due to the free fatty acids.pres.nt during s.orage. After 6 months.of s.orage, the Arbequina oil＇s.ethyl es.er content was.32 ppm, and the Coratina＇s.was.46 ppm. As.a res.lt, the s.elf life for both was.only about half a year （labeling us.ally indicates.it mus. be cons.med ＂before 1 year＂）. However, parameters.related to oxidation （peroxide index, K 232, K 270 and AK） remained within the limits.s.t by the International Olive Council （IOC） throughout the year. In conclus.on： ethyl es.er content is.a very fine parameter for as.es.ing the quality of extra virgin in an olive oil and determining the length of its.s.elf life.

关键词： Alkyl es.ers free alcohols olive oil s.elf life

Tracheal Intubation Difficulties. s.s.ematic Literature Review

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Journal of Bios.iences.and Medicines 2022年第5期10卷 95-104页

作者： Vanes.a Ferreira Dias.Duarte da Cos.a Mariana Ronches.l Barauna camila dos.s.ntos.Leite Os.ar Cés.r Pires Laboratory of Pharmacology and Phys.ology Medicine Department Taubaté University Taubaté Brazil Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francis.o Univers.ty Medical s.hool Bragan&ccedil a Paulis.a Brazil

Background: Tracheal intubation is.a common procedure in medical practice, being performed mainly in s.rgical centers.and emergencies.in trauma patients. Objective: This.s.s.ematic literature review aims.to unders.and the main difficulties.and complications.related to tracheal intubation. Methods. s.s.ematic literature review, conducted in the Virtual Health Library databas.s.between 2016 and 2021, res.ricted to articles.in Englis. and Portugues. with the des.riptors. Airway, Difficult intubation, and Complications. After reading the abs.racts. 34 articles.were found, and, after reading them, 9 articles.were s.lected. Res.lts. This.review analyzed 9 s.ientific s.udies.that rigorous.y met the previous.y es.ablis.ed characteris.ics.in the s.mple s.lection. The s.nthes.s.included the following as.ects.(author/year of publication, article title, objective, type of s.udy, and databas.. Dis.us.ion: s.veral factors.that influence the s.cces. of intubation were identified, s.ch as.technical, profes.ional, and patient is.ues. In addition, meas.res.to minimize the ris.s.involving the procedure were highlighted. Conclus.on: Tracheal intubation is.a common procedure in s.rgical centers.and emergencies. However, its.ris.s. while low, s.ould not be ignored. Uns.cces.ful procedures.can occur and have cons.quences.for the patient, s.ch as.trauma to the upper airway.

关键词： Airway Difficult Intubation Complications