The effects.of the s.pplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GDP)on the progres.ion of the s.s.emic and hepatic metabolic s.atus.of rats.having untreated type 1 diabetes.mellitus.T1DM)were *** Wis.a...
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The effects.of the s.pplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GDP)on the progres.ion of the s.s.emic and hepatic metabolic s.atus.of rats.having untreated type 1 diabetes.mellitus.T1DM)were *** Wis.ar diabetic rats.s.reptozotocin,60 mg/kg)were allotted to four groups.s.pplemented by gavage for thirty days.as.follows.control and diabetic receiving s.line;diabetic receiving GLN(248 mg/kg);and diabetic receiving GDP(400 mg/kg).Body weight,plas.atic parameters.and kidney function were *** hepatocytes.were us.d to as.es. gluconeogenic *** and kidney were us.d for morphological analys.s.T1DM decreas.d the number and increas.d the area of the hepatocytes.pos.ibly becaus. of the obs.rved enlargement of glycogen *** weight,glomerular area and proteinuria increas.d,and glomerular filtration rate decreas.d,in non-s.pplemented T1DM *** area and proteinuria were revers.d by both *** T1DM hepatocytes.releas.d les. glucos.,which could have been diverted to glycogen s.nthes.s.and s.condary glycogenos.s.obs.rved in T1DM;this.was.partially revers.d by the *** res.lts.point to a pos.ible beneficial effect of glutamine on the metabolic and hepatic impairments.of T1DM.
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