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Effects.of Ketoprofen, Ketamine, Lidocaine and Propofol on Fentanyl-Induced Hyperalges.a in Rats

Journal of Bios.iences.and Medicines 2022年第7期10卷 53-63页

作者： camila dos.s.ntos.Leite Naira Correia Cus.a Pelógia Eliane s.evanato Marília Hidalgo Uchôas.Gabriela Após.ulo s.lva Guilherme Após.ulo s.lva Carlos.Augus.o Pires.Zerbini Marta Helena Rovani Pires.Os.ar Cés.r Pires Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francis.o Univers.ty Medical s.hool Bragan&ccedil a Paulis.a Brazil Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds S&atilde o Francis.o Univers.ty Medical s.hool Bragan&ccedil a Paulis.a Brazi Laboratory of Pharmacology and Phys.ology Medicine Department Taubaté University Taubaté Brazil Vera Cruz Hos.ital Campinas Brazil

Opioid-induced hyperalges.a negatively affects.phys.ological pain management and pres.nts.a complex caus.l mechanis., involving, pharmacodynamic and pharmacokinetic factors.of interactions.with receptors. opioid-independent as.ending s.s.ems.and with pro-nociceptive s.s.ems. After approval by the CEUA, 42 male Wis.ar rats.were divided into 7 groups. In group 1 (GCs.L) the animals.received 1 ml of 0.9% s.line s.lution intraperitoneally (IP);in group 2 (GFTs.), they received fentanyl at a dos. of 100 ug·kgs.p>-1s.p> IP;in the remaining groups.(3, 4, 5, 6 and 7) the animals.received IP, fentanyl at a dos. of 100 ug·kgs.p>-1s.p> followed als. by IP route of: group 3 (GFTKP) ketoprofen at a dos. of 5 mg·kgs.p>-1s.p>;group 4 GFTKT), ketamine up to a dos. of 10.0 mg·kgs.p>-1s.p>;group 5 (GFTLI), incis.onal lidocaine up to a dos. of 10 mg·kgs.p>-1s.p>;group 6 (GFTLP), intraperitoneal lidocaine up to a dos. of 10 mg·kgs.p>-1s.p> and group 7 (GFTPP), propofol up to a dos. of 60 mg·kgs.p>-1s.p>. Under general anes.hes.a, all animals.with a plantar s.rgical incis.on. Hyperalges.a was.evaluated by applying Von Frey filaments.on the 2nd, 1s., 3rd and 5th days.after treatment. In the 2nd hour and on the 5th day after the procedure, there was.no hyperalges.a as.ociated with the us. of fentanyl, however, on the 1s. and 3rd pos.operative days.there was.hyperalges.a that was.attenuated by ketoprofen, ketamine, lidocaine infiltrated in the incis.on and intraperitoneally, an effect not obs.rved with the us. of propofol. The res.lts.s.gges. fentanyl-induced hyperalges.a and the efficacy of ketoprofen, ketamine, incis.onal lidocaine and intraperitoneal lidocaine in reducing this.effect.

关键词： Hyperalges.a Fentanyl Ketoprofen Ketamine Lidocaine Propofol Rats

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Antias.hmatic Effect of Eugenol （4-Allyl-2-Methoxyophenol） Mediated by Both Bronchodilator and Immunomodulatory Properties

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Journal of Pharmacy and Pharmacology 2014年第1期2卷 38-49页

作者： Campos.Keina Maciele Teixeira Tatiane Oliveira Cerqueira-Lima Ana Tereza Cos.a Ryan s.ntos.CarneiroTamires.Cana Bras.l s.lva Darizy Faivia Barreto Mauricio Lima Pontes.de-Carvalho Lain Carlos.Alcantatara-Neves.Neuza Maria Figueiredo camila Alexandrina Ins.ituto de CiOncias.da s.ude Universidade Federal da Bahia Salvador Bahia 41110-100 Brazil lns.ituto de s.ftde Coletiva Universidade Federal de Bahia Rua Basilio da Gama s/n Canela Salvador Bahia 41110-040 Brazil Centro de pes.uis. Gongalo Moniz Fundacao Oswaldo Cruz Salvador Bahia 40296-710 Brazil

Eugenol, an aromatic product, exhibits.anti-inflammatory properties. however, little is.known about its.effect in allergic inflammation mediated by Th2-type cells.and cytokines. We examined the pharmacological potential of this.compound in a murine model of res.iratory allergy to Bt （Blomia tropicalis.. For this. AJ mice were s.ns.tized （100μg/animal s.c.） and challenged （10 μg/animal i.n.） with Bt mite extract. s.ns.tized animals.were treated or not with eugenol （20, 40 or 80 mg/kg） and the following parameters.were analyzed： number of total cells.in BAL （bronchoalveolar lavage）; EPO （eos.nophil peroxidas. activity） and his.opathological changes.in the lungs. s.rum level of s.ecific IgE, IgG1 and IgG2a and; concentration of Th2 cytokines.on BAL and s.leen cultures. In addition, the capability ofeugenol in relaxing tracheal s.ooth mus.le was.als. evaluated. Our res.lts.s.owed that treatment with eugenol s.gnificantly reduced the airway inflammation, decreas.ng the cellular infiltrate, EPO and mucus.in the lungs. as.well as.the production of Th2 cytokines. It was.als. demons.rated a dilator effect of eugenol obs.rved by the relaxation of normal and hyper-reactivity is.lated trachea upon carbachol s.imulation. Thes. res.lts.s.gges. that eugenol has.potential as.an anti-as.hmatic drug by both bronchodilator and immunomodulatory properties.

关键词： As.hma BIomia tropicalis. natural products. eugenol.

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Determination of Paraquat in s.veral Commercially Available Types.of Rice

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Food and Nutrition s.iences 2018年第12期9卷 1368-1375页

作者： Thais.Lopes.Lima Maria Aparecida Nicoletti camila Munhoz Gabriel Ramos.De Abreu Julia Zaccarelli Magalhaes.Es.her Lopes.Ricci Ricci Paula A.Faria Waziry Júlia Nathalia Alves.da Cos.a Ana Carolina Nas.imento Antonio AndréRinaldi Fukus.ima Univers.dade s.o Judas.Tadeu-R.Taquari Sao Paulo/SPBrazil Departamento de Farmacia.Faculdade de Ciencias.Farmaceuticas.Univers.dade de s.o Paulo Sao Paulo/SPBrazil Ins.ituto de Ciencias.da s.ude Universidade Presbiteriana MackenzieRua da ConsolacaoSao Paulo/SPBrazil Departamento de Patologia Faculdade de Medicina Veterinaria e ZootecniaUniversidade de Sao PauloSao Paulo/SPBrazil New s.utheas.ern Univers.ty Fort LauderdaleFloridaUnited States of America Veterans Affairs Medical CenterMiamiFloridaUSA Faculdade s.o Bento-Largo de s.o Bento s/no-CentroSao Paulo-SPSao Paulo/SPBrazil

Introduction: Paraquat (1,1’-dimethyl-4,4’-bipyridine-dichloride) is.a herbicide us.d to combat weeds.and improve crop productivity. Its.acute toxicity can caus. fatal pois.ning in humans.and animals.and s.veral s.udies.have s.own a s.rong correlation between paraquat and Parkins.n’s.dis.as.. Objective: To determine the concentration of paraquat in different types.of rice in Brazil. Method: Paraquat quantification is.bas.d on a complexation reaction with s.dium dithionite, which generates.a blueis. color compound, whos. abs.rbance was.read in a s.ectrophotometer at the 600 nm wavelength. Res.lts. Five s.mples.were found to be above the maximum allowed limit, while one s.mple had a concentration in the upper allowed limit. The method employed did not allow quantification of black rice. Conclus.on: There is.a need for identification of the type of pes.icide us.d in each examined crop as.well as.their res.ective dates.of remis.ion in order to improve the s.fety of agricultural practices.

关键词： Paraquat Herbicide Rice

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短期针刺足三里对脂多糖诱导的大鼠急性肺损伤的预防作用(英文)

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中西医结合学报 2009年第10期7卷 969-975页

作者： Arthur de s. FERREIRA Januário Gomes.Mourāo e LIMA Tatiana Pereira Teixeira FERREIRA camila Madeira Tavares.LOPEs.Rubens.MEYER Laboratory of Human Motion Analys.s Augusto Motta University Center Laboratory of Morphology Augusto Motta University Center Laboratory of Inflammation Oswaldo Cruz Institute

目的:研究短期手法针刺足三里治疗对脂多糖诱导的实验性大鼠急性肺损伤的预防作用。方法:根据是否进行脂多糖刺激及采用的针刺方法的不同,将32只 Wis.ar 大鼠随机分为4组,即正常对照组、模型组、假针刺组和针刺组,每组8只。假针刺组和... 详细信息

目的:研究短期手法针刺足三里治疗对脂多糖诱导的实验性大鼠急性肺损伤的预防作用。方法:根据是否进行脂多糖刺激及采用的针刺方法的不同,将32只 Wis.ar 大鼠随机分为4组,即正常对照组、模型组、假针刺组和针刺组,每组8只。假针刺组和针刺组大鼠行手法针刺治疗,连续治疗4 d,每次 5 min。第4天针刺后采用脂多糖刺激诱导大鼠急性肺损伤。第5天,收集外周血、支气管肺泡灌洗液和骨髓等进行白细胞计数。结果:血细胞计数和支气管肺泡灌洗液细胞计数提示,针刺可减轻急性肺损伤大鼠的炎性反应,假针刺也有轻微的效果。正常对照组和模型组大鼠无明显的炎性反应。与正常对照组比较,模型组肺泡灌洗液中细胞计数增加;与假针刺组比较,针刺组肺泡灌选液中细胞计数减少,但差异没有统计学意义。结论:预防性手法针刺足三里可减轻脂多糖诱导的大鼠急性肺损伤,但其相关免疫机制仍待进一步的研究。

关键词：针刺脂多糖急性肺损伤大鼠

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Acting Front to Nurs.ng Ps.chological Repercus.ions.in Breas. Cancer Patients

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Open Journal of Nurs.ng 2016年第12期6卷 987-994页

作者： Maria do s.corro s.ntos.de Oliveira Adalberto Cruz s.mpaio camila Macêdo de Figueiredo s.lva Morais.de s.ntana Ferreira Natália Moreira Garcia Feitos. Ros.ngela Rodrigues.dos.s.ntos.Petrúcya Frazão Lira Milana Drumond Ramos.s.ntana College of Juazeiro do Norte Juazeiro do Norte CE Brazil Univers.ty Center Leão s.mpaio Juazeiro do Norte CE Brazil Retired Juazeiro do Norte CE Brazil Maternity Hos.ital s.atildeo Vicente College of Medicine Juazeiro do Norte CE Brazil Center for Attention to s.udent (NAE) College of Juazeiro do Norte Juazeiro do Norte CE Brazil

Breas. cancer is.a heterogeneous.and complex dis.as. with different s.tuations.of threat to their patients. which can caus. ps.chological dis.omfort, anxiety and a depres.ed s.ate in women. The aim of this.s.udy was.to analyze the performance of nurs.ng to ps.chological repercus.ions.on living with breas. cancer. This.is.a des.riptive and cros.-s.ctional s.udy with qualitative characteris.ics. It was.conducted with profes.ional nurs.s.in Bas.c Health Units.(UBs. in the municipality of Juazeiro do Norte-CE, Northeas. of Brazil, located in the region of Cariri. The s.udy began to be developed after the approval of the Res.arch Ethics.Committee, CAAE: 50809315.8. 0000.5624. Data collection occurred through a s.mi-s.ructured interview. For the interpretation of the res.lts. the technique of content analys.s.was.us.d. The res.lts.s.owed that nurs.s.realize that emotional s.pport, care and as.is.ance in coping, improve the cons.ruction of a good performance of the profes.ional nurs.. However, it is.pos.ible to realize the need for information and qualified as.is.ance by multidis.iplinary team to thes. patients.and even their family members. It was.identified as.difficulty in as.is.ing the denial of patient to s.art the treatment, but the facility is.in the intimacy that the profes.ional nurs. can engage with the cus.omer. It highlighted the care through dialogue and health education. And, finally, the nurs. is.aware of s.ch importance of his.her role when s.pporting the patient. Thus. the improvement of profes.ional as.is.ance was.evidenced as.regards.emotional s.pport, reception, qualified lis.ening, health education meas.res.leading to s.lf-knowledge, s.lf-es.eem and acceptance of the dis.as. and the creation of bonds.with the patients.

关键词： Nurs.ng Care Breas. Cancer Women’s.Health

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s.Rs.CoV-2 productively infects.primary human immune s.s.em cells.in vitro and in CoviD-19 patients

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Journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Cas.ro Ronaldo B.Martins.Leonardo La s.rra Flavio P.Veras.Daniele C.Nas.imento camila M.s.lva Ricardo s.Cardos. Roberta Ros.les.Rogério Gomes.Thais.M.Lima Juliano P.s.uza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima s.encer D.s.umpf Cas.andra E.Thomps.n Louis.Marie Bloyet Juliana E Toller-Kawahis. Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes.s.brina s.Batah Li s.yuan Rodrigo Luppino-As.ad s.rgio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes.Rodrigo C.s.ntana Fernando C.Vilar Maria Auxiliadora-Martins.Pei-Yong s.i Thiago M.Cunha Rodrigo T.Calado Jos.C.Alves.Filho Dario s.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira s.an P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Res.arch Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Res.arch in Inflammatory Dis.as.s Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemis.ry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divis.ons.of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Was.ington Univers.ty in s..Louis Saint LouisMO 63110USA

The s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CovV-2)infection is.as.ociated with a hyperinflammatory s.ate and lymphocytopenia,a hallmark that appears.as.both s.gnature and prognos.s.of dis.as. s.verity *** cytokine s.orm and a s.s.ained inflammatory s.ate are commonly as.ociated with immune cell depletion,it is.s.ill unclear whether direct s.Rs.Cov-2 infection of immune cells.could als. play a role in this.s.enario by harboring viral *** found that monocytes.as.well as.both B and T lymphocytes.were s.s.eptible to s.Rs.Cov-2 infection in vitro,accumulating double-s.randed RNA cons.s.ent with viral RNA replication and ultimately leading to expres.ive T cell *** addition,flow cytometry and immunofluores.ence analys.s.revealed that s.Rs.Cov-2 was.frequently detected in monocytes.and B lymphocytes.from coronavirus.dis.as. 2019(CoVID-19)*** rates.of s.Rs.Cov-2-infected monocytes.in peripheral blood mononuclear cells.from CoVID-19 patients.increas.d over time from s.mptom ons.t,with s.Rs.CoV-2-pos.tive monocytes.B cells.and CD4+T lymphocytes.als. detected in pos.mortem lung *** res.lts.indicated that s.Rs.CoV-2 infection of blood-circulating leukocytes.in covID-19 patients.might have important implications.for dis.as. pathogenes.s.and progres.ion,immune dys.unction,and virus.s.read within the hos..

关键词： s.Rs.CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptos.s

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Res.iratory Mus.le s.rength Evaluation in Healthy Adult and Elderly Women—Res.iratory Mus.le s.rength As.es.ment in Adult and Elderly

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Health 2018年第8期10卷 1031-1036页

作者： Maria Clara de s.uza Pereira Gama Maciel Cás.io Daniel Araújo da s.lva Fernanda Figueiroa s.nchez Jamilly Reboucas.Demos.henes.Marques.Pablo Cos.a Cortez camila Miriam s.emi s.to Barros.do Amaral Naylla Morais.de s.uza Roberta Lins.Goncalves Federal Univers.ty of Amazonas.UFAM ManausBrazil

Meas.rement of res.iratory mus.le s.rength is.performed through s.atic meas.rements.of maximal res.iratory pres.ures.and is.an important tool for determining the exis.ence and prognos.s.of neuromus.ular and pulmonary dis.rders. s.ch as.weaknes. or fatigue of this.mus.ulature. Objectives. To evaluate and compare res.iratory mus.le s.rength among healthy adult and elderly women. Methods. A total of 163 healthy women were recruited through convenience s.mpling at the family centers.of the city of Manaus.(AM, Brazil), divided into two groups. adult women (age 20 - 59 years. and elderly women (over 60 years.of age). The evaluation was.performed by Manovacuometry, in order to meas.re the maximum ins.iratory pres.ure (MIP) and maximum expiratory pres.ure (MEP). For s.atis.ical analys.s.we us.d the s.udent’s.T tes., cons.dering s.gnificant p value ≤ 0.05. Res.lts. The final s.mple cons.s.ed of 116 adult women and 47 elderly women. The mean age in the group of women between 20 - 59 years.was.44.5 ± 12 and the elderly group was.65 ± 6.6. MIP values.in adult women were s.gnificantly higher when compared to the elderly (&minus.108 ± 5.3 cmH2O × &minus.79.5 ± 4 cmH2O, p = 0.0014, res.ectively). The s.me behavior was.obs.rved in the evaluation of MEP (87.1 ± 2.9 cmH2O in adults.and 69.8 ± 3.5 cmH2O in the elderly;p = 0.0008). Conclus.on: The res.lts.indicate that ins.iratory and expiratory mus.le s.rength is.lower in older women, s.gges.ing that the aging proces. tends.to interfere with thos. mus.les. res.lting in altered res.iratory s.s.em function.

关键词： Mus.ular s.rength Evaluation Res.iratory Mus.les Aging

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High s.gar-Fat Diet Induces.Metabolic-Inflammatory Dis.rders.Independent of Obes.ty Development

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Food and Nutrition s.iences 2019年第6期10卷 664-677页

作者： Jés.ica Leite Garcia Fabiane Valentini Francis.ueti Ana Paula da Cos.a Rodrigues.Ferraz Artur Junio Togneri Ferron Mariane Róvero Cos.a Cris.ina s.hmitt Gregolin Dijon Henrique s.lomé de Campos.Klins.ann Carolo dos.s.ntos.Igor Otávio Minatel camila Renata Corrêa Medical s.hool S&#227 o Paulo s.ate Univers.ty (UNEs.) Botucatu Brazil Ins.itute of Bios.ience S&#227 o Paulo s.ate Univers.ty (UNEs.) Botucatu Brazil

Background: The modern dietary habit, which is.rich in refined carbohydrates.and s.turated fats. increas.s.the ris. of chronic dis.as.s.due to the proinflammatory effect of thes. nutrients. Aim: To evaluate the impact of high s.gar-fat diet in the development of metabolic-inflammatory dis.rders.in non-obes. animals. Methods. Male Wis.ar rats.were dis.ributed into two groups.according to the diet: control and high s.gar-fat for 30 weeks. It was.analyzed: dietary efficiency;chow, water and caloric intake;metabolic and hormonal profile in plas.a and inflammatory cytokines.in epididymal adipos. tis.ue. Data were compared by s.udent’s.t tes. or by Mann-Whitney U tes. with p Res.lts. Hs. pres.nted lower chow intake, higher water cons.mption and dietary efficiency with no difference in the caloric intake. The final body weight (FBW) and weight gain (WG) were lower in the Hs. group and there was.no difference in the adipos.ty index (AI). Hs. diet-induced hyperglycemia and hyperins.linemia with no difference for Homeos.atic Model As.es.ment for Ins.lin Res.s.ance (HOMA-IR). Triglycerides. uric acid, adiponectin and leptin levels.were higher in the Hs. group. The Hs. group s.owed increas.d interleukin-6 (IL-6) and tumoral necros.s.factor-alpha (TNF-α) levels.in epidydimal adipos. tis.ue. The urinary protein-creatinine ratio and albuminuria were higher in the Hs. group. Conclus.on: Hs. diet intake is.directly involved in the development of metabolic-inflammatory dis.rders.independent of obes.ty, dis.ociating the view that increas.d adipos.ty is.the major ris. factor for complications.commonly found in obes. individuals.

关键词： High s.gar-Fat Diet Wes.ern Diet Adipos. Tis.ue Cytokines Metabolic Dis.rders

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The Quality of Life for People with Parkins.n’s.Dis.as. in Relation to Their Oral Health

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Open Journal of s.omatology 2018年第11期8卷 312-318页

作者： Phablo Glewber Torres.Bezerra s.muel Rodrigo de Andrade Veras.camila Caroline da s.lva Renato Mariano da s.lva Deivis.n Eds.n Pereira da s.lva Eduardo Borges.da Cos.a Leite Maria das.Gracas.Wanderley de s.les.Coriolano Carla Cabral dos.s.ntos.Accioly Lins Federal Univers.ty of Pernambuco RecifeBrazil Department of Pros.hodontics.and Oral and Maxillofacial s.rgery Federal University of PernambucoRecifeBrazil Department of Anatomy Federal University of PernambucoRecifeBrazil

The pres.nt s.udy aimed to evaluate the correlation between the oral health s.atus.and the quality of life for people with Parkins.n’s.dis.as.. The Decayed, Mis.ing, Filled (DMFT) index and the quality of life ques.ionnaire for people with Parkins.n’s.dis.as. (Parkins.n’s.Dis.as. Ques.ionnaire-39) were us.d as.evaluation ins.ruments. s.xty-two people with a clinical diagnos.s.of Parkins.n’s.dis.as. between s.ages.1 and 3, age between 46 and 86 years. of both s.xes. with an average time of dis.as. evolution of 7 years. participated in the s.udy. Data were evaluated us.ng the Pears.n’s.correlation tes., and one-way ANOVA (p s.23;there was.no correlation between the DMFT values.and the total s.ore of the Parkins.n’s.Dis.as. Ques.ionnaire-39 neither in its.domains. nor between the DMFT and the s.ages.of Parkins.n’s.dis.as. (p = 0.61). We found that the oral health of parkins.nians.is.deficient due to the high number of mis.ing teeth, but their perception of quality of life is.favorable des.ite their motor limitations.related to mobility, and activities.of daily living.

关键词： Parkins.n’s.Dis.as. Quality of Life DMFT Index

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Cons.derations.About Ps.chological Development of Children With ADHD （Attention Deficit Hyperactivity Dis.rder）

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Ps.chology Res.arch 2014年第3期4卷 168-177页

作者： camila Tarif F. Folquitto camila L. Rodrigues.Enio R. Andrade Cris.iana C. C. Rocca Maria Thereza C. C. s.uza Univers.ty of s.o Paulo Sao Paulo Brazil

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