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Attention Model for Chronic Conditions:Blind Women and Their Sons

Health 2015年第6期7卷 747-753页

作者： Mariana Goncalves de Oliveira Aline Tomaz de Carvalho Lorita Marlena Freitag Pagliuca Ana Karina bezerra Pinheiro camila pontes bezerra Márcia Maria Tavares Machado Department of Nursing Universidade Federal do CearáFortalezaBrazil Centro Universitário Estácio do Ceará FortalezaBrazil Department of Community Health Universidade Federal do CearáFortalezaBrazil

It aimed to analyze the assistance to the blind woman during prenatal care, childbirth, and child-care in light of the Model of Attention to Chronic Conditions. This is a descriptive, qualitative study. A collection was done through semi-structured interview and analysis of the speeches, conducted by content technique proposed by Bardin, emerging from the screening process. Ten mothers aged between 21 and 42 years old participated in the study. Three categories were identified: prescriptive and focused attention on the disease;for collaborative and focused attention on the person;uniprofessional attention to the multidisciplinary attention;establishment of relationship between the family health strategy and the specialized outpatient care. The women experienced chronic conditions according to the Model in addition to blindness. Study results show that for blind women, attention in the health service has weaknesses in service, both in the prenatal period and childbirth, and in childcare. It deems necessary transformation in assisting the blind woman.

关键词： Blindness Nursing Women’s Health Child Health

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Antiasthmatic Effect of Eugenol （4-Allyl-2-Methoxyophenol） Mediated by Both Bronchodilator and Immunomodulatory Properties

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Journal of Pharmacy and Pharmacology 2014年第1期2卷 38-49页

作者： Campos Keina Maciele Teixeira Tatiane Oliveira Cerqueira-Lima Ana Tereza Costa Ryan Santos CarneiroTamires Cana Brasil Silva Darizy Faivia Barreto Mauricio Lima pontes-de-Carvalho Lain Carlos Alcantatara-Neves Neuza Maria Figueiredo camila Alexandrina Instituto de CiOncias da Saude Universidade Federal da Bahia Salvador Bahia 41110-100 Brazil lnstituto de Saftde Coletiva Universidade Federal de Bahia Rua Basilio da Gama s/n Canela Salvador Bahia 41110-040 Brazil Centro de pesquisa Gongalo Moniz Fundacao Oswaldo Cruz Salvador Bahia 40296-710 Brazil

Eugenol, an aromatic product, exhibits anti-inflammatory properties, however, little is known about its effect in allergic inflammation mediated by Th2-type cells and cytokines. We examined the pharmacological potential of this compound in a murine model of respiratory allergy to Bt (Blomia tropicalis). For this, AJ mice were sensitized (100 μg/animal s. c.) and challenged (10 μg/animal i. n.) with Bt mite extract. Sensitized animals were treated or not with eugenol (20, 40 or 80 mg/kg) and the following parameters were analyzed: number of total cells in BAL (bronchoalveolar lavage); EPO (eosinophil peroxidase activity) and histopathological changes in the lungs; serum level of specific IgE, IgG1 and IgG2a and; concentration of Th2 cytokines on BAL and spleen cultures. In addition, the capability of eugenol in relaxing tracheal smooth muscle was also evaluated. Our results showed that treatment with eugenol significantly reduced the airway inflammation, decreasing the cellular infiltrate, EPO and mucus in the lungs, as well as the production of Th2 cytokines. It was also demonstrated a dilator effect of eugenol observed by the relaxation of normal and hyper-reactivity isolated trachea upon carbachol stimulation. These results suggest that eugenol has potential as an anti-asthmatic drug by both bronchodilator and immunomodulatory properties.

关键词：药剂学药理学药学数学物理学化学

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DNA Vaccines Approach:From Concepts to Applications

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World Journal of Vaccines 2014年第2期4卷 50-71页

作者： Vanessa Bastos Pereira Meritxell Zurita-Turk Tessalia Diniz Luerce Saraiva camila Prosperi De Castro Bianca Mendes Souza Pamela Mancha Agresti Fernanda Alvarenga Lima Vanessa Nathalie Pfeiffer Marcela Santiago Pacheco Azevedo Clarissa Santos Rocha Daniela Santos pontes Vasco Azevedo Anderson Miyoshi Laboratorio de Genetica Celular e Molecular Instituto de Ciencias BiologicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteBrazil Universidade Estadual da Paraiba(UEPB) Joao PessoaBrazil

DNA vaccines are the third generation vaccines based on purified plasmid preparations containing transgenes that encode antigenic/therapeutic proteins or peptides capable of triggering an immune response against a wide range of diseases. This vaccine platform presents several attributes that confer distinct advantages over other vaccine technologies in terms of safety, ease of fabrication and stability. Many aspects, such as antigen expression and especially vector design, are under study because of their great influence on immunogenicity and efficacy of DNA vaccines. In this regard, with the attempt of improving the efficiency of DNA vaccines, co-expression of stimulatory sequences and diverse vector delivery systems are being optimized. With this in mind, this review aims to giving a conceptual approach of DNA vaccines, explaining their mechanisms of action and listing the already licensed veterinary DNA vaccines presented in the market.

关键词： DNA Vaccines Vector Design Delivery Systems Approved DNA Vaccines Bacterial Delivery

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SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

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Journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

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