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Base excision repair accessory factors in senescence avoidance and resistance to treatments

cancer Drug Resistance 2022年第3期5卷 703-720页

作者： Elise Vickridge camila c.f.faraco Alain Nepveu Goodman cancer Institute McGill University1160 Pine avenue WestMontrealQuebec H3A 1A3Canada Departments of Biochemistry McGill University1160 Pine avenue WestMontrealQuebec H3A 1A3Canada Medicine McGill University1160 Pine avenue WestMontrealQuébec H3A 1A3Canada Oncology McGill University1160 Pine avenue WestMontrealQuébec H3A 1A3Canada

cancer cells,in which the RAS and PI3K pathways are activated,produce high levels of reactive oxygen species(ROS),which cause oxidative DNA damage and ultimately cellular *** process has been documented in tissue culture,mouse models,and human pre-cancerous *** this context,cellular senescence functions as a tumour suppressor *** rare cancer cells,however,manage to adapt to avoid senescence and continue to *** well-documented mode of adaptation involves increased production of antioxidants often associated with inactivation of the KEAP1 tumour suppressor gene and the resulting upregulation of the NRf2 transcription *** this review,we detail an alternative mode of adaptation to oxidative DNA damage induced by ROS:the increased activity of the base excision repair(BER)pathway,achieved through the enhanced expression of BER enzymes and DNA repair accessory *** proteins,exemplified here by the cUT domain proteins cUX1,cUX2,and SATB1,stimulate the activity of BER *** ensued accelerated repair of oxidative DNA damage enables cancer cells to avoid senescence despite high ROS *** a by-product of this adaptation,these cancer cells exhibit increased resistance to genotoxic treatments including ionizing radiation,temozolomide,and ***,considering the intrinsic error rate associated with DNA repair and translesion synthesis,the elevated number of oxidative DNA lesions caused by high ROS leads to the accumulation of mutations in the cancer cell population,thereby contributing to tumour heterogeneity and eventually to the acquisition of resistance,a major obstacle to clinical treatment.

关键词： Base excision repair reactive oxygen species DNA repair accessory factor oxidative DNA damage resistance to treatment tumour heterogeneity acquisition of resistance

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Stress tensors and quantification of fracture patterns to analyze connectivity and potential fluid flow in a mesa landform of the Northern Andes

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Journal of Mountain Science 2024年第1期21卷 271-291页

作者： GARcÍA-ARIAS Sergio VELANDIA francisco ALVAREZ Angélica SANABRIA-GÓMEZ JoséD TARAZONA Yessenia VARGAS María camila Escuela de Geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela de física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work applies stress tensors inversions and quantification of fracture patterns along the Mesa de Los Santos, in the Eastern cordillera of colombia, to better understand the potential fluid flow. It thus contributes to the conceptual hydrogeological model. The area was subdivided into three blocks, separated by the NW Potreros and the Los Santos faults, having minor inner faults of different orientations. This separation facilitates the analysis of the fractures measured in the field, which in general show high dip angles and a conjugate geometry in the northern block, tension fractures(Mode I) in the central block, and a random distribution in the southwestern block. WinTensor treatment of slickensides yielded a maximum horizontal stress(SHmax) of 111o, which coincides with the WNW-ESE tensor observed from the conjugate and tension joints. We then used frac Pa Q to generate interpolation maps of fracture intensity and density. The maps show the highest values in the central block and the lowest in the northern block,where the precipitation is higher, causing intensive rock weathering and homogenization of the fracture planes. Although the highest values of connectivity by line are found to the south of the mesa, we suggest the possibility of greater flow from the recharge zone(NE) along bedding planes and open NW-SE fractures.

关键词： Mesa de Los Santos colombia Win-Tensor fracPaQ Strike-slip faults fractured aquifers

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All-electron basis sets for H to Xe specific for ZORA calculations:Applications in atoms and molecules

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chinese Physics B 2024年第8期33卷 238-246页

作者： c.S.Gomes f.E.Jorge A.canal Neto Departamento de fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-ccSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–Hess Hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe ccSD(T)method atomic and molecular properties

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Effects of dust controls on respirable coal mine dust composition and particle sizes:case studies on auxiliary scrubbers and canopy air curtain

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International Journal of coal Science & Technology 2024年第3期11卷 86-101页

作者： f.Animah c.Keles W.R.Reed E.Sarver Department of Mining and Minerals Engineering Virginia Polytechnic Institute&State UniversityBlacksburgVAUSA National Institute of Occupational Safety and Health(NIOSH) PittsburghPAUSA

control of dust in underground coal mines is critical for mitigating both safety and health *** decades,the National Institute of Occupational Safety and Health(NIOSH)has led research to evaluate the effectiveness of various dust control technologies in coal *** studies have included the evaluation of auxiliary scrubbers to reduce respirable dust downstream of active mining and the use of canopy air curtains(cAcs)to reduce respirable dust in key operator *** detailed dust characterization was not a focus of such studies,this is a growing area of *** preserved filter samples from three previous NIOSH studies,the current work aims to explore the effect of two different scrubbers(one wet and one dry)and a roof bolter cAc on respirable dust composition and particle size *** this,the preserved filter samples were analyzed by thermogravimetric analysis and/or scanning electron microscopy with energy dispersive *** indicate that dust composition was not appreciably affected by either scrubber or the ***,the wet scrubber and cAc appeared to decrease the overall particle size *** an effect of the dry scrubber was not consistently observed,but this is probably related to the particular sampling location downstream of the scrubber which allowed for significant mixing of the scrubber exhaust and other return *** from the insights gained with respect to the three specific dust control case studies revisited here,this work demonstrates the value of preserved dust samples for follow-up investigation more broadly.

关键词： Respirable dust Dust control SEM–EDX Scrubber canopy air curtain Silica

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Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： N.IQBAL J.cHOI S.f.SHAH c.LEE S.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline Ni-rich LiNixMnyco_(z)O_(2)(x≥0.8)(NMc)particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary NMc particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the lower stiffness,higher ionic conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framework for calculating the chemo-mechanical responses of anisotropic electrode materials and fundamental insights into how the coating of NMc active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation Ni-rich LiNixMnyco_(z)O_(2)(x>0.8)(NMc)

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Adsorption of pharmaceutical pollutants on Zncl_(2)-activated biochar from corn cob:Efficiency,selectivity and mechanism

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Journal of Bioresources and Bioproducts 2024年第1期9卷 58-73页

作者： christian f.Varela L.c.Moreno-Aldana Yazmin Yaneth Agámez-Pertuz Department of chemistry National University of ColombiaAv.Carrera 30 No.45-03BogotáD.C.Colombia Department of Biology and chemistry University of the Llanoskm 12 road to Puerto LópezVillavicencioColombia

The occurrence of pharmaceuticals in water bodies and drinking water poses risks for the envi-ronment and human health,thus it is necessary to study methodologies that allow the efficient removal of these *** this work,corn cob-derived biochar was obtained by Zncl_(2)-activation,and subsequent carbonization at 700℃.The effect of contact time,temperature,pH,and initial concentration on the adsorption capacity of acetaminophen(AcE)and amoxicillin(AMX)was determined through batch *** addition,the kinetics,isotherms,and ther-modynamics parameters were *** activated biochar exhibited a maximum adsorp-tion capacity of 332.08 mg/g for AcE and 175.86 mg/g for *** adsorption kinetics and adsorption isotherm of AcE corresponded to the pseudo-second order and Langmuir model,***,pseudo-first-order kinetics and the freundlich isotherm model were well-fitted to AMX *** AcE and AMX co-adsorption had a synergistic effect on AMX but an antagonistic effect on AcE removal,achieving a maximum adsorption capacity of 193.51 and 184.58 mg/g,*** the other hand,fixed-bed column experiments showed that the adsorption capacity depends on the influent concentration,and the breakthrough curve fits the Thomas and Yoon-Nelson *** mechanism adsorption studies showed that surface inter-actions(hydrogen bonding formation and n-𝜋interactions)are the main driving forces for the adsorption process,and pore filling is the rate-limiting *** this way,the prepared biochar exhibits a high potential for the adsorption of pharmaceutical compounds from water.

关键词： Biochar Adsorption Acetaminophen Amoxicillin Wastewater treatment

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characterization of conception drawing in architecture to face technological mediations

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frontiers of Architectural Research 2024年第3期13卷 425-438页

作者： Hugo c.Gomez-Tone Javier f.Raposo Grau Departamento de Ideación Gráfica Arquitectónica Universidad Politécnica de MadridMadrid 28040Spain Departamento de Arquitectura Universidad Nacional de San Agustín de ArequipaArequipa 04001Peru

The conception drawing in architecture is that allows to initiate the architectural thinking,visualizing,and discovering the first *** drawing has traditionally been given as an act of linking and collaboration between thought,sight,and the movement of the hands with a *** and recognizing its characteristics will make it possible to deal with any mediation of information *** establish such characteristics,three case studies were carried *** analysis was made of the conception drawings and interviews by the Pritzker Prize laureates:Ando,Hadid and *** condition and four characteristics have been determined:drawing is a phenomenological action that produces haptic drawings;it is an undecided process that originates unformed drawings;it is a fast action that results in small and multiplied drawings;it is a perceptual act that generates redrawn and remarked drawings;and finally,it is an action that seeks to remember to resume the creative process at another moment,which produces rudimentary conventional *** these before any technological mediation will be an important pedagogical contribution that will allow future architects not to alter the cognitive processes that generate the first ideas in the initial moments of the architectural project.

关键词： conception drawing Architectural thinking Graphic ideation concept creativity

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comparisons of oxbow lake fish assemblages in relation to bigheaded carp establishment in the lower White River, Arkansas

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Ecological Processes 2024年第1期13卷 188-205页

作者： Michael A.Eggleton cody J.Salzmann Joseph E.Kaiser Shannon c.f.Smith Department of Aquaculture and fisheries University of Arkansas at Pine Bluff Arkansas Game and fish commission Virginia Institute of Marine Science

Background Since the late 1990s, bigheaded carps(largely silver carp [Hypophthalmichthys molitrix] but also bighead carp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we compared current(2017, “post-carp” establishment) fish assemblages to historical(2002, “pre-carp” establishment) fish assemblages. fish assemblages were comprehensively assessed using multiple gears, including boat electrofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indices of richness, diversity, evenness, and dominance were often greater(P carp period as reflected by boat electrofishing and experimental gill nets. However, all indices were generally similar(P > 0.05) between the pre-carp and post-carp period with fish assemblages depicted using mini-fyke nets. Nonmetric multidimensional scaling analyses indicated that fish assemblages differed structurally between pre-carp and post-carp periods. Assemblage differences were linked to both small and large abundance changes for more than 20 species. Abundances of gizzard shad(Dorosoma cepedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), crappies(Pomoxis spp.), bluegill(Lepomis macrochirus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) declined between the pre-carp and postcarp periods. conversely, abundances of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ictiobus spp.), and gars(Lepisosteus spp.) generally increased during the same *** Although not possible to conclude assemblage shifts were entirely related to bigheaded carps due to the absence of an appropriate reference system where carps did not establish, the wide establishment of these carps is one of the most pervasive changes to have occurred in the lower White

关键词： Bigheaded carp Silver carp Aquatic nuisance species fish assemblage Oxbow lake Large river

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Thermoluminescence characterization of natural and synthetic irradiated ce-monazites

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Journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.correcher c.Boronat J.Garcia-Guinea J.f.Benavente T.Rivera-Montalvo cIEMAT Av.Complutense 4028040MadridSpain MNcN-cSIc J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of synthetic and natural ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic cePO_(4):Nd_(0.20),La_(0.25)).The main differences appreciated in these complex TL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthetic monazite relies only on Nd and La).The behavior of the dose response in the range of 1-8 Gy is similar for both samples;the TL intensity increases linearly as the dose increases without changes in the position of the maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,ce3+?ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,frenkel defects,ODcs or NBOHcs).

关键词： Thermoluminescence Kineticparameters Phosphate ce-monazite Defects Rare earths

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Adsorption of yttrium(Y^(3+)) and concentration of rare earth elements from phosphogypsum using chitin and chitin aerogel

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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson S.dos Reis Diana Pinto Sabrina f.Lütke Eder c.Lima Luis f.O.Silva Irineu A.S.De Brum Guilherme L.Dotto Department of forest Biomaterials and Technology Biomass Technology centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad De La costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and catalytic Process Engineering(ENGEPAc) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin *** aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex *** complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths Sustainable material chitin powder chitin porous aerogel Yttrium adsorption and recovery

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