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The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes:findings from a prospective,nationwide,and multicenter registry

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Journal of Geriatric Cardiology 2024年第5期21卷 523-533页

作者： Rui FU Ying-Xuan ZHU Kong-Yong CUI Jin-Gang YANG Hai-Yan XU Dong YIN Wei-Hua SONG Hong-Jian WANG Cheng-Gang ZHU Lei FENG Wei WU Kai-HongCHEN Yan-Yan ZHAO Ye LU Ke-Fei DOU Yue-Jin YANG on behalf of the cami Registry Investigators Cardiometabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangzhou Traditional Chinese Medical College First Affiliated HospitalGuangdong ProvinceChina Department of Cardiology Longyan Hospital First HospitalFujian ProvinceChina 不详

OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPG)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism *** We selected 5,308 participants with AMI from the prospective,nationwide,multicenter cami registry,of which 2,081 were diabetic and 3,227 were *** were divided into high FPG and low FPG groups according to the optim-al cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts,*** primary endpoint was in-hospital *** Overall,94 diabetic patients(4.5%)and 131 nondiabetic patients(4.1%)died during hospitalization,and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,*** with individuals who had low FPG,those with high FPG were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1%vs.2.8%;odds ratio[OR]=3.862,95%confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4%vs.1.7%;HR=4.542,95%CI:3.041-6.782).After adjusting the potential confounders,this significant association was not ***-more,FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic *** FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic *** This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mor-tality in AMI patients with and without *** might be useful to stratify patients with AMI.

关键词： patients fasting infarction

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Clinical significance of diabetes on symptom and patient delay among patients with acute myocardial infarction——an analysis from China Acute Myocardial Infarction(cami) registry

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Journal of Geriatric Cardiology 2019年第5期16卷 395-400页

作者： Rui FU Si-Dong LI Chen-Xi SONG Jing-Ang YANG Hai-Yan XU Xiao-Jin GAO Yi XU Jian-Ping ZENG Jun-Nong LI Ke-Fei DOU Yue-Jin YANG on behalf of the cami Registry study group Beijing,China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina XiangTan Center Hospital XiangtanHunanChina Department of Cardiology Weinan Central HospitalWeinanShanxiChina 不详

Background Diabetes is frequently associated with poor prognosis among acute myocardial infarction(AMI)*** with these comorbidities often have atypical symptoms and subsequent delay in *** studies have reported detailed AMI symptoms in patients with *** study compared AMI symptoms and presentation characteristics between diabetics and *** We included patients from the China AMI registry diagnosed with AMI between January 2013 and September *** characteristics,symptomology,and delay in treatment were compared between diabetics and *** logistic regression analysis was used to explore independent predictors of atypical *** A total of 4450(20.2%)patients had *** were older,more often women,higher in body mass index,and more likely to have non-ST segment elevation myocardial *** diabetic patients presented with persistent precordial chest pain(63.1%vs.68%,P<0.0001),diaphoresis(60.1%vs.65.6%,P<0.0001),fatigue(16.7%vs.18.3%,P=0.0123),and incontinence(0.4%vs.0.7%,P=0.0093).Time to hospital presentation was longer among patients with diabetes than those *** multivariable analysis,diabetes was identified as an independent predictor of atypical symptoms(OR:1.112,95%CI:1.034?1.196).Conclusions Our study is the first large-scale study providing evidence that diabetics are less likely to present with typical chest pain and more likely to experience treatment delay when suffering from an *** results may increase clinician awareness of recognizing AMI patients rapidly to reduce diagnosis and treatment delay,particularly in the context of diabetes.

关键词： Acute myocardial infarction Diabetes Symptoms Patient delay

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Triglyceride glucose index predicts in-hospital mortality in patients with ST-segment elevation myocardial infarction who underwent primary angiography

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Journal of Geriatric Cardiology 2023年第3期20卷 185-194页

作者： Rui FU Yan-Yan ZHAO Kong-Yong CUI Jin-Gang YANG Hai-Yan XU Dong YIN Wei-Hua SONG Hong-Jian WANG Cheng-Gang ZHU Lei FENG Zhi-Fang WANG Qing-Sheng WANG Ye LU Ke-Fei DOU Yue-Jin YANG the cami Registry Investigators Cardiometabolic Medicine Center Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Xinxiang Central Hospitalthe Fourth Clinical College of Xinxiang Medical UniversityHenan ProvinceChina Department of Cardiology Qinhuangdao First HospitalHebei ProvinceChina

OBJECTIVES To assess the correlation between triglyceride glucose(TyG)index and in-hospital mortality in patients with ST-segment elevation myocardial infarction(STEMI).METHODS A total of 2190 patients with STEMI who underwent primary angiography within 12 h from symptom onset were selected from the prospective,nationwide,multicenter cami *** index was calculated with the formula:Ln[fasting triglycerides(mmol/L)×fasting glucose(mmol/L)/2].Patients were divided into three groups according to the tertiles of TyG *** primary endpoint was in-hospital *** Overall,46 patients died during hospitalization,in-hospital mortality was 1.5%,2.2%,2.6%for tertile 1,tertile 2,and tertile 3,***,TyG index was not significantly correlated with in-hospital mortality in single-variable logistic regression ***,after adjusting for age and sex,TyG index was significantly associated with higher mortality when regarded as a continuous variable(adjusted OR=1.75,95%CI:1.16-2.63)or categorical variable(tertile 3 *** 1:adjus-ted OR=2.50,95%CI:1.14-5.49).Furthermore,TyG index,either as a continuous variable(adjusted OR=2.54,95%CI:1.42-4.54)or categorical variable(tertile 3 *** 1:adjusted OR=3.57,95%CI:1.24-10.29),was an independent predictor of in-hospital mortality after adjusting for multiple confounders in multivariable logistic regression *** subgroup analysis,the pro-gnostic effect of high TyG index was more significant in patients with body mass index<18.5 kg/m2(P interaction=0.006).CONCLUSIONS This study showed that TyG index was positively correlated with in-hospital mortality in STEMI patients who underwent primary angiography,especially in underweight patients.

关键词： patients mortality angiography

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Astronomy ‘playne and simple’. The writing of science between 1700 and 1900. Including CD-Rom: A Corpus of English Texts on Astronomy (CETA)

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2012年

作者： Isabel Moskowich Begoña Crespo Isabel Moskowich Inés Lareo Gonzalo cami.a Rioboo Begoña Crespo

ISBN: (数字)9789027272508

ISBN: (纸本)9789027211941

This volume includes methodological considerations and descriptions of some of the texts compiled in The Corpus of English Texts on Astronomy (CETA), together with a number of pilot studies using these texts showing how the corpus can be used to investigate English Astronomy writing between 1700 and 1900, from a synchronic and a diachronic *** is part of the Coruña Corpus of English Scientific Writing (CC). Since the CC was designed in 2003 with a sampling method by which extracts of 10,000 words were selected, this method has been followed in CETA, with samples from 42 different authors both from Europe and North America. Some extralinguistic parameters, such as year of publication, sex, geographical provenance and text-types/genres have been considered for text selection. According to late Modern English text typology, the samples in CETA can be grouped in eight different categories and such categories, as well as some other metadata information, can be used to search the ***, together with the Coruña Corpus Tool purpose-designed software by IrLab, was originally made available with the volume on CD-rom. As of early 2019, these are also accessible online at the Repositorio Universidade Coruña: CCT at http://***/2183/21850 and CETA at http://***/2183/21848

关键词： Astronomy Technical writing English language

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Angiographic characteristics and in-hospital mortality among patients with ST-segment elevation myocardial infarction presenting without typical chest pain: an analysis of China Acute Myocardial Infarction registry

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Chinese Medical Journal 2019年第19期132卷 2286-2291页

作者： Chen-Xi Song Rui Fu Jin-Gang Yang Hai-Yan Xu Xiao-Jin Gao Chun-Yue Wang Yang Zheng Shao-Bin Jia Ke-Fei Dou Yue-Jin Yang on behalf of the cami Registry study group Coronary Heart Disease Center Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100037China Department of Cardiology The First Hospital of Jilin UniversityChangchunJilin 130031China Heart Center General Hospital of Ningxia Medical UniversityYinchuanNingxia 750004China 不详

Background:Patients with ST-segment elevation myocardial infarction(STEMI)who present without typical chest pain are associated with a poor ***,whether angiographic characteristics are related to a higher risk of mortality in this population is *** study aimed to investigate whether the higher mortality risk in patients with STEMI without chest pain could be explained by their"high-risk"angiographic ***:We used data of 12,145 patients with STEMI who was registered in China Acute Myocardial Infarction registry from January 2013 to September *** compared the infarct-related artery(IRA),thrombolysis in myocardial infarction(TIMI)flow grade in the IRA,and other angiographic characteristics between patients without and those with chest *** logistic regression model was used to identify independent risk factor of in-hospital ***:The 2922(24.1%)patients with STEMI presented without typical chest *** patients had a higher TIMI flow grade(mean TIMI flow grade:1.00 vs.0.94,P=0.02)and a lower rate of IRA disease of the left anterior descending artery(44.6%vs.51.2%,χ^2=35.63,P<0.01)than did those with typical chest *** without chest pain were older,more likely to have diabetes,longer time to hospital and higher Killip classification,and less likely to receive optimal medication treatment and primary percutaneous coronary intervention and higher In-hospital mortality(3.3%vs.2.2%,χ^2=10.57,P<0.01).After adjusting for multi-variables,presentation without chest pain was still an independent predictor of in-hospital death among patients with STEMI(adjusted odds ratio:1.36,95%confidence interval:1.02–1.83).Conclusions:Presentation without chest pain is common and associated with a higher in-hospital mortality risk in patients with acute myocardial *** results indicate that their poor prognosis is associated with baseline patient characteristics and delayed treatment,but not angiograp

关键词： Myocardial infarction Symptom assessment Coronary angiography Patient outcome assessment

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多发性硬化症不同临床亚型的TNF-α转化酶(TACE)蛋白表达

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 55-56页

作者： Comabella M. Romera C. cami.M. M.na Comabella 李青波 Dr.Unitat de Neuroimmunologia Clnica Hospital Universitari Vall d'HebronEscuela de Enfermeria 2a PlantaPsg Vall d'Hebron 119-12908035 BarcelonaSpain

Tumor necrosis factor(TNF)-αconverting enzyme(TACE,also called ADAM17)is a key sheddase that releases TNF-αfrom its inactive cell-bound *** protein expression levels in peripheral blood mononuclear cells were measured by Western blot analysis in 20 healthy controls and 80 multiple sclerosis(MS)patients before and after treatment with IFNβ[20 patients with primary progressive(PP)MS,20 patients with secondary progressive(SP)MS,and 40 patients with relapsing-remitting(RR)MS(20 patients during clinical remission and 20 patients in relapse)].TNF-αserum levels were also measured by enzyme-linked immunoassay in the MS patients and healthy *** protein expression levels were lower in healthy controls and PPMS patients compared with SPMS patients and RRMS patient during clinical *** differences in TACE protein levels were observed between RRMS patients in relapse and during *** protein levels were increased in PPMS patients treated with IFNβ.Serum TNFαlevels were higher in RRMS patients in relapse compared with RRMS patients during remission,and positive and negative correlations were found between TACE protein expression and serum TNF-αlevels in RRMS patients during relapse and during remission *** findings point to different regulatory mechanisms of the TACE-TNF-αpathway in the clinical MS subtypes and expand the role of TACE in MS pathogenesis.

关键词：多发性硬化症 TACE 蛋白表达 TNF 临床亚型转化酶蔗糖酶

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中国不同地域和级别医院急性心肌梗死诊疗资源配置情况调查

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中华心血管病杂志 2016年第7期44卷 565-569页

作者：孙慧杨跃进许海燕杨进刚高晓津吴元李卫王杨刘佳金辰宋雷中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病诊治中心 100037 代表中国急性心肌梗死注册研究项目组

目的调查中国不同地域和级别医院的急性心肌梗死（AMI）诊疗资源配置情况。方法中国AMI（cami）注册研究在全国范围内选取医院115家，其中北方医院61家，南方医院54家；东部医院52家，中部医院26家，西部医院37家；三级医院79家，二级医... 详细信息

目的调查中国不同地域和级别医院的急性心肌梗死（AMI）诊疗资源配置情况。方法中国AMI（cami）注册研究在全国范围内选取医院115家，其中北方医院61家，南方医院54家；东部医院52家，中部医院26家，西部医院37家；三级医院79家，二级医院36家；省部级医院34家、地市级医院46家，县级医院35家。2012年11月至2013年8月期间，向各医院的心内科医生进行问卷调查，了解其AMI诊疗资源配置情况。结果（1）北方医院年收治AMI数多于南方医院[220（120，400）例比220（80，350）例，P=0．033]，设有心脏监护病房（CCU）、开展溶栓治疗、经皮冠状动脉介入治疗（PCI）、急诊PCI和冠状动脉旁路移植术的比例差异均无统计学意义（P均〉0．05）。（2）东部、中部和西部地区医院年收治AMI数分别为295（150，501）、175（75，300）和170（50，250）例（P=0．007），设有CCU、开展溶栓治疗、PCI、急诊PCI和冠状动脉旁路移植术的比例差异均无统计学意义（P均〉0．05）。（3）三级医院床位数[104（70，152）张比47（30，52）张，P〈0．001]、年收治AMI数[300（200，460）例比80（47，135）例，P〈0．001]均多于二级医院。三和二级医院设有CCU的比例分别为97．5％（77／79）和75．0％（27／36），开展PCI的比例分别为98．7％（78／79）和27．8％（10／36），开展急诊PCI的比例分别为96．2％（76／79）和22．2％（8／36），开展冠状动脉旁路移植术的比例分别为81．0％（64／79）和11．1％（4／36），可使用主动脉内球囊反搏的比例分别为91．1％（72／79）和13．9％（5／36），差异均有统计学意义（P均〈0．001）。（4）省部级、地市级和县级医院年收治AMI数分别为400（250，600）、232（100，380）和80（50，162）例，设有CCU的比例分别为100％（34／34）、95．7％（44／46）和74．3％（26／35），开展溶栓治疗的比例分别为88．2％（30／34）、100％（46／46）和91．4％（32／35），开展PCI的比例分别为100％（34／34）、89．1％（41／46）和37．1％（13／35），开展急诊PCI的比例分别为100％（34／34）、84．8％（39／46）和31．4％（11／35），开展冠状动脉旁路移植术的比例分别为97．1％（33／34）、67．4％（31／46）和11．4％（4／35），差异均有统计学意义（P〈0．01或0．05）。结论我国不同地域医院在CCU设置及再灌注手段方面无显著差异。三级与二级医院以及省部级、地（市）级与县级医院之间的AMI诊疗配置存在较大的差别，可能会影响AMI患者的诊治效果。临床试验注册美国国立卫生研究院，注册号为NCT01874691。

关键词：心肌梗死资源配置诊断治疗

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急性ST段抬高型心肌梗死合并慢性闭塞病变的近远期预后分析

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中华心血管病杂志 2021年第6期49卷 586-592页

作者：王天杰董军乐王妍赵延延陈舸钱海燕袁建松宋雷乔树宾杨进刚杨伟宪杨跃进代表中国急性心肌梗死注册登记研究组中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心100037 不详

目的评估接受急诊介入治疗(PCI)的ST段抬高型心肌梗死(STEMI)患者同时合并慢性闭塞病变(CTO)时其近远期预后。方法研究纳入中国急性心肌梗死患者前瞻性注册研究中接受急诊PCI的11905例STEMI患者,根据造影结果分为合并CTO组和不合并CTO... 详细信息

目的评估接受急诊介入治疗(PCI)的ST段抬高型心肌梗死(STEMI)患者同时合并慢性闭塞病变(CTO)时其近远期预后。方法研究纳入中国急性心肌梗死患者前瞻性注册研究中接受急诊PCI的11905例STEMI患者,根据造影结果分为合并CTO组和不合并CTO组。收集2组的基线临床资料,并根据基线资料进行1∶3倾向评分匹配。对2组患者进行随访,主要研究终点为住院期间和术后1年死亡率,次要研究终点为1年时的总心血管不良事件率,包括死亡、再发心肌梗死、再次血运重建、心力衰竭(心衰)再入院、卒中、严重出血等。结果合并CTO的患者STEMI共931例,男性755例(81.1%),年龄(62.2±11.4)岁,占所有STEMI患者的7.8%。非合并CTO的STEMI患者共10974例,男性8829例(80.5%),年龄(60.0±11.8)岁。进行倾向评分匹配后STEMI合并CTO组纳入896例患者,STEMI不合并CTO组纳入2688例患者,与不合并CTO组相比,STEMI合并CTO组住院期间死亡率较高(4.2%比2.4%,P=0.006),随访1年期间全因死亡率(8.5%比4.4%,P<0.001)、心原性死亡率(5.3%比2.6%,P=0.001)和总MACE发生率(35.1%比23.3%,P<0.001)较高。多因素logistic回归分析提示合并CTO(HR=1.54,95%CI 1.06~2.22,P=0.022)、高龄(HR=1.06,95%CI 1.04~1.08,P<0.001)和既往存在心衰病史(HR=4.10,95%CI 1.90~8.83,P<0.001)是接受急诊PCI的STEMI患者术后1年死亡的独立危险因素。结论合并CTO的STEMI患者住院期间和1年死亡率较高,合并CTO、高龄和既往存在心衰病史是STEMI患者1年死亡的独立危险因素。

关键词：急性ST段抬高型心肌梗死经皮冠状动脉介入治疗慢性闭塞病变

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TIMI评分与GRACE评分对中国急性非ST段抬高型心肌梗死患者院内死亡率的预测价值

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中华心血管病杂志 2019年第4期47卷 297-304页

作者：吴超高晓津赵延延杨进刚杨跃进许海燕严若华吴元乔树宾王杨李卫孙毅金辰春语诗代表中国急性心肌梗死注册登记研究组中国医学科学院北京协和医学院国家心血管病中心阜外心血管病医院冠心病诊治中心100037 不详

目的比较心肌梗死溶栓治疗临床试验(TIMI)评分和全球急性冠状动脉事件注册(GRACE)评分对急性非ST段抬高型心肌梗死(NSTEMI)患者在院期间死亡率的预测价值。方法本研究全部数据均来自前瞻性、多中心的大规模临床注册研究——中国心肌梗... 详细信息

目的比较心肌梗死溶栓治疗临床试验(TIMI)评分和全球急性冠状动脉事件注册(GRACE)评分对急性非ST段抬高型心肌梗死(NSTEMI)患者在院期间死亡率的预测价值。方法本研究全部数据均来自前瞻性、多中心的大规模临床注册研究——中国心肌梗死注册登记研究。该研究在2013年1月至2014年9月共连续入选全国31个省、市和自治区107家医院的NSTEMI患者5 896例。对NSTEMI患者进行TIMI评分和GRACE评分,通过Mann-Whitney检验比较两种评分系统对NSTEMI患者院内死亡率的预测价值。结果在5 896例NSTEMI患者中,4 020例(68.2%)为男性,年龄为(65.4±12.1)岁,住院天数为10.0(7.0,13.0)d。住院死亡353例(6.0%);213例(3.6%)发生过院前心脏骤停;651例(11.0%)的患者接受了再灌注治疗,再灌注治疗时间为529.5(256.0,1 065.0)min,其中645例(10.9%)接受了急诊经皮冠状动脉介入治疗,6例(0.1%)接受了急诊冠状动脉旁路移植术。接受他汀、β受体阻滞剂、血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体阻滞剂、醛固酮受体拮抗剂的治疗比例分别为94.8%(5 587例)、71.7%(4 228例)、65.5%(3 864例)和26.0%(1 533例)。用受试者工作特征模型计算TIMI评分和GRACE评分对院内死亡率预测价值的曲线下面积分别为0.559(95%CI 0.532~0.586)和0.793(95%CI 0.768~0.818),二者比较差异有统计学意义(P<0.001)。结论 GRACE评分对中国NSTEMI患者院内死亡率的预测价值优于TIMI评分。

关键词：心肌梗死医院死亡率危险评分

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慢性闭塞病变合并急性非ST段抬高型心肌梗死的近远期预后分析

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中华内科杂志 2022年第4期61卷 384-389页

作者：王天杰董军乐闫森陈桂浩陈舸赵延延钱海燕袁建松宋雷乔树宾杨进刚杨伟宪杨跃进中国急性心肌梗死注册登记研究组中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心北京100037 中国医学科学院北京协和医学院国家心血管病中心阜外医院医学统计中心北京100037 不详

目的评估慢性闭塞病变(CTO)对接受急诊经皮冠状动脉介入治疗(PCI)的急性非ST段抬高型心肌梗死(NSTEMI)患者近远期预后的影响。方法研究纳入中国急性心肌梗死患者前瞻性注册研究中接受急诊PCI的2271例急性NSTEMI患者,根据造影结果分为合... 详细信息

目的评估慢性闭塞病变(CTO)对接受急诊经皮冠状动脉介入治疗(PCI)的急性非ST段抬高型心肌梗死(NSTEMI)患者近远期预后的影响。方法研究纳入中国急性心肌梗死患者前瞻性注册研究中接受急诊PCI的2271例急性NSTEMI患者,根据造影结果分为合并CTO组和非合并CTO组,主要研究终点为在院期间和术后2年病死率,次要研究终点为2年时的总心血管不良事件率,包括再次血运重建、死亡、再发心肌梗死、心力衰竭再入院、卒中、严重出血等。结果急性NSTEMI患者中有13.4%合并CTO,与非合并CTO患者相比,在院期间病死率(3.6%比1.4%,P<0.01)和2年随访病死率(9.0%比5.1%,P<0.01)明显增加。多因素回归分析提示慢性阻塞性肺疾病是接受急诊PCI患者住院期间死亡的独立危险因素(HR 7.28,95%CI 1.50~35.35,P=0.01),而高龄(HR 1.04,95%CI 1.01~1.07,P<0.01)和射血分数(EF)减低(HR 0.95,95%CI 0.93~0.98,P<0.01)是远期死亡的独立危险因素。CTO并未增加患者死亡风险,而是再次血运重建的独立危险因素(HR 1.67,95%CI 1.10~2.54,P=0.02)。结论尽管合并CTO的急性NSTEMI患者近远期病死率明显增加,但CTO并不是急性NSTEMI患者近远期死亡的独立危险因素,仅和再次血运重建增加相关,高龄和EF减低是接受急诊PCI的急性NSTEMI患者2年死亡的独立危险因素。

关键词：心肌梗死急性心肌血管重建术慢性闭塞病变预后

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