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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Adventures Beyond Amdahl's Law:How Power-Performance Measurement and Modeling at Scale Drive Server and Supercomputer Design

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Journal of Computer Science & Technology 2023年第1期38卷 80-86页

作者： Kirk W.cameron Computer Science Virginia TechWashington D.C.VA 24061U.S.A.

Amdahl’s Law painted a bleak picture for large-scale *** implication was that parallelism was limited and therefore so was potential *** Amdahl’s contribution was seminal and important,it drove others vested in parallel processing to define more clearly why large-scale systems are critical to our future and how they fundamentally provide opportunities for speedup beyond Amdahl’s *** the early 2000s,much like Amdahl,we predicted dire consequences for large-scale systems due to power *** our early work was often dismissed,the implications were clear to some:power would ultimately limit *** this retrospective,we discuss how power-performance measurement and modeling at scale led to contributions that have driven server and supercomputer design for more than a *** the influence of these techniques is now indisputable,we discuss their connections,limits and additional research directions necessary to continue the performance gains our industry is accustomed to.

关键词： Amdahl’s Law speedup power-aware computing power modeling performance modeling performance prediction power measurement

Solar surface magnetoconvection simulations: A brief review of solar dermatology

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1665-1669页

作者： cameron Robert Max-Planck-Institute fr Sonnensystemforschung Katlenburg-Lindau

Rapid improvement in the speed of computers has enabled realistic simulations of magnetoconvective processes in the surface layers of the Sun. The simulations now cover a wide range of features found in observations. In many cases a direct comparison with the observations is justified, and in all cases our understanding and interpretation of the observations is being improved. Current and future opportunities and difficulties will be discussed.

关键词： Sun photosphere magnetohydrodynamics

DNA-informed breeding of rosaceous crops: promises, progress and prospects

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Horticulture Research 2017年第1期4卷 335-347页

作者： cameron P Peace Department of Horticulture Washington State UniversityPO Box 646414Pullman99164-6414WAUSA

Crops of the Rosaceae family provide valuable contributions to rural economies and human health and *** solutions to production challenges and market demands can be met with genetically improved new *** rosaceous crop breeding is expensive and time-consuming and would benefit from improvements in efficiency and *** of DNA information is becoming conventional in rosaceous crop breeding,contributing to many decisions and operations,but only after past decades of solved challenges and generation of sufficient *** in deployment of DNA-based knowledge and tools have arisen when the‘chasm’between genomics discoveries and practical application is bridged *** steps are establishing breeder desire for use of DNA information,adapting tools to local breeding utility,identifying efficient application schemes,accessing effective services in DNA-based diagnostics and gaining experience in integrating DNA information into breeding operations and ***-informed germplasm characterization for revealing identity and relatedness has benefitted many programs and provides a compelling entry point to reaping benefits of genomics ***-informed germplasm evaluation for predicting trait performance has enabled effective reallocation of breeding resources when applied in pioneering ***-based diagnostics is now expanding from specific loci to genome-wide *** the full potential of this expansion will require improved accuracy of predictions,multi-trait DNA profiling capabilities,streamlined breeding information management systems,strategies that overcome plant-based features that limit breeding progress and widespread training of current and future breeding personnel and allied scientists.

关键词： breeding crops operations

Three trajectories for narrative visualisation

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Visual Informatics 2021年第2期5卷 26-40页

作者： cameron Edmond Tomasz Bednarz Expanded Perception&Interaction Centre(EPICentre) School of Art&DesignUNSWSydney NSWAustralia CSIRO’s Data61 Sydney NSWAustralia

Narrative Visualisation(NarVis)is the pairing of data visualisation with narrative *** to its interdisciplinary applications and scholarship,NarVis presentations often feature vastly different interpretations of"narrative"and"visualisation",which is echoed in NarVis authoring *** map the morphology of how the narratives of NarVis manifest,we identify three different trajectories for the *** trajectories are identified through an analysis of selected NarVis presentations and tools,with an emphasis on identifying how traditional narrative techniques are adopted,transposed or indeed challenged by NarVis *** then populate our categories with additional examples and tools,providing a foundational point of reference for NarVis scholars,authors and tool developers.

关键词： Visualisation Narrative techniques Communication Storytelling Interaction design

On embedding infinite cyclic covers in compact 3-manifolds

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Science China Mathematics 2017年第9期60卷 1575-1578页

作者： GORDON cameron McA. Department of Mathematics The University of Texas at AustinAustinTX 78712USA

We show that there are knots whose infinite cyclic covers do not embed in any compact 3-manifold,answering a question of Jiang et al.(2006).

关键词： knot infinite cyclic cover compact 3-manifold

Antimicrobial usage and resistance in beef production

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Journal of Animal Science and Biotechnology 2017年第2期8卷 249-270页

作者： Andrew cameron Tim A.McAllister Faculty of Veterinary Medicine University of CalgaryCalgaryABCanada Agriculture and Agri-Food Canada LethbridgeABCanada

Antimicrobials are critical to contemporary high-intensity beef production. Many different antimicrobials are approved for beef cattle, and are used judiciously for animal welfare, and controversially, to promote growth and feed efficiency. Antimicrobial administration provides a powerful selective pressure that acts on the microbial community, selecting for resistance gene determinants and antimicrobial-resistant bacteria resident in the bovine flora. The bovine microbiota includes many harmless bacteria, but also opportunistic pathogens that may acquire and propagate resistance genes within the microbial community via horizontal gene transfer. Antimicrobial-resistant bovine pathogens can also complicate the prevention and treatment of infectious diseases in beef feedlots,threatening the efficiency of the beef production system. Likewise, the transmission of antimicrobial resistance genes to bovine-associated human pathogens is a potential public health concern. This review outlines current antimicrobial use practices pertaining to beef production, and explores the frequency of antimicrobial resistance in major bovine pathogens. The effect of antimicrobials on the composition of the bovine microbiota is examined, as are the effects on the beef production resistome. Antimicrobial resistance is further explored within the context of the wider beef production continuum, with emphasis on antimicrobial resistance genes in the food chain, and risk to the human population.

关键词： Antibiotics Antimicrobial resistance Antimicrobial usage Beef production Bovine pathogens Bovine microbiota Cattle Enteropathogens Fecal bacteria Resistome

A longitudinal analysis of the U.S. Air Force Reserve Officers’ Training Corps physical fitness assessment

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Military Medical Research 2020年第2期7卷 166-173页

作者： cameron SMackey Jason MDe Freitas Applied Neuromuscular Physiology Laboratory Oklahoma State University192 CRCStillwaterOK 74078USA

Background:The *** Force physical fitness assessment(PFA)is used to determine the overall fitness of their *** is currently unknown to what extent the PFA scores of Reserve Officers’Training Corps(ROTC)cadets are affected by mandatory physical *** purpose of this investigation was to longitudinally examine the PFAs of ROTC cadets over a four-year period,evaluate the results across class ranks,and evaluate the sensitivity of the classification of the ***:Air Force ROTC cadets performed the PFAs(abdominal circumference,1-min pushups,1-min sit-ups,and a 1.5-mile run)in both the spring(n=26)and fall(n=22)*** were compiled over a four-year period(Spring 2014–Fall 2017)and were performed in accordance with Air Force Instruction 36–2905.A oneway repeated measures ANOVA was performed separately for the fall and spring groups for each dependent variable across the 4 ***,a one-way between groups ANOVA was performed for each dependent variable during the time point(fall 2015;n=46)with the most recorded cadets for each class ***:Longitudinal assessments revealed a main effect of time(P=0.010)on abdominal circumference;cadets had a smaller abdominal circumference in their freshman year than in their senior year.A main effect of time(P=0.006)was also observed on sit-up quantity;cadets performed more sit-ups in their junior year than in their freshman *** between class ranks during the same year(between-subjects ANOVA)revealed a main effect of class rank on sit-up quantity(P=0.003);the freshmen completed fewer repetitions than the sophomores(P=0.018)and the juniors did(P=0.001).Conclusions:The results indicated that only the sit-up component showed differences between class *** findings suggest that the Air Force PFA may not be sensitive enough to detect changes in physical fitness or distinguish between class ranks regarding physical performance,even after years of *** limitation may b

关键词： Class ranks Fitness assessment Military Physical training ROTC

WE ARE ALL STUDENTS OF GREEN DESIGN

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Journal of Green Building 2010年第3期5卷 30-42页

作者： Michael Andresen cameron Campbell 不详 Department of Architecture Iowa State University

The practice of architecture,the academic pursuit of architecture,and the sustainability issues in architecture converge in this project to create a unique opportunity for a didactic *** to this project is the notion that the laboratory itself is the object of direct experimentation-in other words,the design and experimentation take place in the space and the space itself is a laboratory for sustainable *** King Pavilion at Iowa State University for the College of Design specifically and purposefully provides this *** laboratory,a design studio housing freshman introductory design for all disciplines in the college and sophomore level design studios for the programs of architecture,landscape architecture,and interior design,serves the dual role of providing an environment that encourages creativity while acting as a learning lab for sustainable design.

关键词： sustainable education college sustainability flexible spaces performance planning evidence based design integrative thinking