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A longitudinal analysis of the U.S. Air Force Reserve Officers’ Training Corps physical fitness assessment

military medical Research 2020年第2期7卷 166-173页

作者： cameron Smackey Jason mDe Freitas Applied Neuromuscular Physiology Laboratory Oklahoma State University192 CRCStillwaterOK 74078USA

Background:The *** Force physical fitness assessment(PFA)is used to determine the overall fitness of their *** is currently unknown to what extent the PFA scores of Reserve Officers’Training Corps(ROTC)cadets are affected by mandatory physical *** purpose of this investigation was to longitudinally examine the PFAs of ROTC cadets over a four-year period,evaluate the results across class ranks,and evaluate the sensitivity of the classification of the ***:Air Force ROTC cadets performed the PFAs(abdominal circumference,1-min pushups,1-min sit-ups,and a 1.5-mile run)in both the spring(n=26)and fall(n=22)*** were compiled over a four-year period(Spring 2014–Fall 2017)and were performed in accordance with Air Force Instruction 36–2905.A oneway repeated measures ANOVA was performed separately for the fall and spring groups for each dependent variable across the 4 ***,a one-way between groups ANOVA was performed for each dependent variable during the time point(fall 2015;n=46)with the most recorded cadets for each class ***:Longitudinal assessments revealed a main effect of time(P=0.010)on abdominal circumference;cadets had a smaller abdominal circumference in their freshman year than in their senior year.A main effect of time(P=0.006)was also observed on sit-up quantity;cadets performed more sit-ups in their junior year than in their freshman *** between class ranks during the same year(between-subjects ANOVA)revealed a main effect of class rank on sit-up quantity(P=0.003);the freshmen completed fewer repetitions than the sophomores(P=0.018)and the juniors did(P=0.001).Conclusions:The results indicated that only the sit-up component showed differences between class *** findings suggest that the Air Force PFA may not be sensitive enough to detect changes in physical fitness or distinguish between class ranks regarding physical performance,even after years of *** limitation may b

关键词： Class ranks Fitness assessment military Physical training ROTC

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Keratinized Nuptial Spines Are Used for male Combat in the Emei moustache Toad(Leptobrachium boringii)

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Asian Herpetological Research 2011年第3期2卷 142-148页

作者： cameron m. HUDSON Xianjin HE Jinzhong FU Department of Integrative Biology University of Guelph50 Stone Road East College of Life Science and Technology Southwest University for Nationalities

We describe the natural history and reproductive behaviour of the Emei moustache Toad(Leptobrachium boringii) with an emphasis on the development of keratinized nuptial spines in males and document combat behaviour for the first time in this species. Between February and march of 2011, 19 female and 43 male L. boringii from mount Emei UNESCO World Heritage Site, Sichuan, China were observed throughout the breeding season. This species exhibits male-biased sexual size dimorphism(SSD) with limited evidence of paternal care(nest guarding by males). Prior to the breeding season males grow 10 – 16 keratinized spines on their upper lip, which fall off once the season has ended. Throughout the breeding season males construct and defend aquatic nests where they produce advertisement calls to attract females. During this time we documented 14 cases involving a total of 22 males where males used their moustaches for aggressive interaction. Combat typically occurred at the beginning of the season when males would compete for a limited number of available nest sites. Neither male body size, nor body condition significantly affects the outcome of an aggressive interaction, suggesting that size may not be the only factor influencing an individual’s chance of victory. Our evidence for male competition and aggression, along with observed paternal care are potential mechanisms to explain the evolution of male-biased SSD observed in this species.

关键词： reproductive behaviour territoriality Leptobrachium boringii secondary sexual characters

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In vitro angiogenesis in response to biomaterial properties for bone tissue engineering:a review of the state of the art

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Regenerative Biomaterials 2023年第1期10卷 744-783页

作者： Else Ellermann Nima meyer Ruth E.cameron Serena m.Best Department of materials Science and metallurgy University of CambridgeCambridge CB30FSUK

Bone tissue engineering(BTE)aims to improve the healing of bone fractures using scaffolds that mimic the native extracellular *** successful bone regeneration,scaffolds should promote simultaneous bone tissue formation and blood vessel growth for nutrient and waste ***,a significant challenge in regenerative medicine remains the development of grafts that can be vascularized *** other things,optimization of physicochemical conditions of scaffolds is key to achieving appropriate angiogenesis in the period immediately following *** phosphates and collagen scaffolds are two of the most widely studied biomaterials for BTE,due to their close resemblance to inorganic and organic components of bone,respectively,and their bioactivity,tunable biodegradability and the ability to produce tailored *** various strategies exist to enhance vascularization of these scaffolds in vivo,further in vitro assessment is crucial to understand the relation between physicochemical properties of a biomaterial and its ability to induce *** mono-culture studies can provide evidence regarding cell-material interaction of a single cell type,a co-culture procedure is crucial for assessing the complex mechanisms involved in angiogenesis.A co-culture more closely resembles the natural tissue both physically and biologically by stimulating natural intercellular interactions and mimicking the organization of the in vivo ***,a co-culture is a complex system requiring optimization of various parameters including cell types,cell ratio,culture medium and seeding *** fundamental knowledge of the mechanism behind the bioactivity of biomaterials and understanding the contribution of surface and architectural features to the vascularization of scaffolds,and the biological response in general,can provide an invaluable basis for future optimization *** review gives an overview of the

关键词： angiogenesis collagen scaffolds hydroxyapatite co-culture architectural features physicochemical properties

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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife m O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead smith Deirdre mcNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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Whole Field Strain measurement of High Strength Steel Under Plain Strain Condition

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Journal of Iron and Steel Research International 2011年第S1期18卷 320-324页

作者： smith Lorenzo m Department of mechanical Engineering Oakland UniversityRochester 48309MIUnited States

Sheet metal undergoes different strain conditions during different forming *** investigation of mechanical properties under these conditions is very important in the forming *** metal is particularly liable to failure under plain strain *** and investigate the necking strain under plane strain condition is a particularly important study for sheet formability *** this study,material behavior of DP780 high strength steel sheet under plain strain condition was *** plane strain tensile tests were carried out on the mTS testing machine with a special designed specimen.A digital image correlation system was employed to measure the full-field strain distribution during plain strain tensile *** strain evolution during deformation was obtained and *** capability of the specimen for plane strain test was validated from the strain *** necking strain and fracture strain of DP780 high strength steel sheet were determined from the strain field and strain history results.

关键词： plain strain test strain history fracture high strength steel digital image correlation

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The omentum

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World Journal of Gastroenterology 2000年第2期6卷 169-176页

作者： cameron Platell Deborah Cooper John m.Papadimitriou John C.Hall Department of Surgery the University of Western Australia Departments of Pathology the University of Western Australia

INTRODUCTIONThe word omentum derives from the ancientEgyptians who,when embalming human bodies,used to assess their'omens'by looking at thevariations in what we recognise today as ***(128-199 AD)thought that therole of the omentum was to warm the *** was on the basis of a gladiator who had anomental resection after a stab injury and sufferedgreatly from cold for the rest of his life.A

关键词： omentum peritonitis macrophage neutrophil lymphocytes mesothelium adhesions omentectomy

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What we have learned from randomized trials of prostate cancer screening

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Asian Journal of Andrology 2011年第3期13卷 369-373,510页

作者： Richard m Hoffman Anthony Y smith medicine Service New Mexico VA Health Care System Albuquerque NM 87108 USA Department of medicine University of New Mexico School of Medicine Albuquerque NM 87108 USA Department of Surgery University of New Mexico School of Medicine Albuquerque NM 87108 USA

The introduction of prostate-specific antigen （PSA） for prostate cancer screening in the late 1980s led to an epidemic of prostate cancer, particularly in developed countries. However, the first valid reports from randomized controlled trials on the efficacy of screening were not published until 2009. men in the screening group in the European Randomized Study of Screening for Prostate Cancer were 20% less likely than those in the control group to die from prostate cancer. The absolute difference was only 0.7/1000, implying that over 1400 men needed to be screened to prevent one prostate cancer death. Screening was also associated with a 70% increased risk for being diagnosed with prostate cancer. The American Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial found no survival benefit for screening. Results were not conclusive because a substantial proportion of study subjects had previously undergone PSA testing, over half of the control group had PSA testing, follow-up was relatively short, and fewer than 100 subjects died from prostate cancer. Balancing the potential survival benefit from screening is the risk of overdiagnosis--finding cancers that would not otherwise cause clinical problems^and the risk of treatment complications, including urinary, sexual and bowel dysfunction. Prostate cancer screening efforts would benefit from improved biomarkers, which more readily identify clinically important cancers. Cancer control efforts might also need to include chemoprevention, though currently available agents are controversial. In the meantime, oatients need to be supoorted in achievine informed decisions on whether to be screened for orostate cancer.

关键词： cancer screening prostate-specific antigen prostatic neoplasms randomized controlled trials as topic

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microstructure segmentation with deep learning encoders pre-trained on a large microscopy dataset

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npj Computational materials 2022年第1期8卷 1905-1916页

作者： Joshua Stuckner Bryan Harder Timothy m.smith materials and Structures Division NASA Glenn Research Center21000 Brookpark RdClevelandOH44135USA

This study examined the improvement of microscopy segmentation intersection over union accuracy by transfer learning from a large dataset of microscopy images called *** neural network encoder architectures were trained on over 100,000 labeled microscopy images from 54 material *** pre-trained encoders were then embedded into multiple segmentation architectures including UNet and DeepLabV3+to evaluate segmentation performance on created benchmark microscopy *** to ImageNet pre-training,models pre-trained on microNet generalized better to out-of-distribution micrographs taken under different imaging and sample conditions and were more accurate with less training *** training with only a single Ni-superalloy image,pre-training on microNet produced a 72.2%reduction in relative intersection over union *** results suggest that transfer learning from large in-domain datasets generate models with learned feature representations that are more useful for downstream tasks and will likely improve any microscopy image analysis technique that can leverage pre-trained encoders.

关键词： union intersection image

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History and evaluation of national-scale geochemical data sets for the United States

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Geoscience Frontiers 2013年第2期4卷 167-183页

作者： David B.smith Steven m.smith John D.Horton U.S.Geological Survey.Denver Federal Center MS 973.DenverCO 80225USA

Six national-scale,or near national-scale,geochemical data sets for soils or stream sediments exist for the United *** earliest of these,here termed the ＇Shacklette＇ data set,was generated by a U.S. Geological Survey（USGS） project conducted from 1961 to *** project used soil collected from a depth of about 20 cm as the sampling medium at 1323 sites throughout the conterminous *** National Uranium Resource Evaluation Hydrogeochemical and Stream Sediment Reconnaissance（NUREHSSR） Program of the *** of Energy was conducted from 1975 to 1984 and collected either stream sediments,lake sediments,or soils at more than 378,000 sites in both the conterminous *** *** sampled area represented about 65%of the *** Natural Resources Conservation Service（NRCS）,from 1978 to 1982,collected samples from multiple soil horizons at sites within the major crop-growing regions of the conterminous *** data set contains analyses of more than 3000 *** National Geochemical Survey,a USGS project conducted from 1997 to 2009,used a subset of the NURE-HSSR archival samples as its starting point and then collected primarily stream sediments, with occasional soils,in the parts of the *** covered by the NURE-HSSR *** data set contains chemical analyses for more than 70,000 *** USGS,in collaboration with the mexican Geological Survey and the Geological Survey of Canada,initiated soil sampling for the North American Soil Geochemical Landscapes Project in *** of three horizons or depths at more than 4800 sites in the *** completed in 2010,and chemical analyses are currently *** NRCS initiated a project in the 1990s to analyze the various soil horizons from selected pedons throughout the *** data set currently contains data from more than 1400 *** paper（1） discusses each data set in terms of its purpose,sample collection protocols,and analytical methods;and（2） evaluates each data set in terms

关键词： Geochemical mapping National-scale geochemical data Geochemical baselines United States

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Adjusting the physico-chemical properties of collagen scaffolds to accommodate primary osteoblasts and endothelial cells

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Regenerative Biomaterials 2023年第1期10卷 590-602页

作者： Nima meyer Daniel V.Bax Jochen Beck Ruth E.cameron Serena m.Best Department of materials Science and metallurgy University of CambridgeCambridge CB30FSUK Geistlich Pharma AG Product DevelopmentWolhusenSwitzerland

Collagen-based biomaterials are used widely as tissue engineering scaffolds because of their excellent bioactivity and their similarity to the natural *** regeneration of healthy bone tissue requires simultaneous support for both osteoblasts and,where angiogenesis is intended,endothelial *** it is important to tailor carefully the biochemical and structural characteristics of the scaffold to suit the needs of each cell *** work describes for the first time a systematic study to gain insight into the cell type-specific response of primary human osteoblast(hOBs)and human dermal microvascular endothelial cells(HDmECs)to insoluble collagen-based *** behaviour was evaluated on both 2D films and 3D scaffolds,produced using *** collagen was cross-linked at various EDC/NHS concentrations and mono-cultured with hOBs and HDmECs to assess the effect of architectural features and scaffold stabilization on cell *** was observed that 3D scaffolds cross-linked at 30%of the standard conditions in literature offered an optimal combination of mechanical stiffness and cellular response for both cell types,although endothelial cells were more sensitive to the degree of cross-linking than *** features have a time-dependent impact on the cell migration profile,with alignment being the most influential parameter overall.

关键词： angiogenesis collagen scaffolds cell migration EDC/NHS cross-linking

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