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RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops

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Horticulture Research 2020年第1期7卷 527-549页

作者： Amy F.Iezzoni Jim McFerson James luby Ksenija gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva linge Stijn Vanderzande Thomas M.Davis lise l.Mahoney Chad Finn cameron Peace Michigan State University East LansingMI 48824USA Washington State University WenatcheeWA 98801USA University of Minnesota St.PaulMN 55108USA Clemson University ClemsonSC 29634USA University of Florida WimaumaFL 33598USA USDA-ARS CorvallisOR 97333USA Washington State University PuyallupWA 98371USA Washington State University PullmanWA 99164USA Cedar lake Research group PortlandOR 97215USA University Queensland BrisbaneQLDAustralia Wageningen University and Research 6700 AA WageningenThe Netherlands University of New Hampshire DurhamNH 03824USA

The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the *** 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural ***,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in *** RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research *** was designed to enable the routine application of modern genomics and genetics technologies in *** crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural *** review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future *** technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic *** of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection *** chasm is now bridged,accelerating rosaceous crop genetic improvement.

关键词： breeding cultivar crops

Cummins QSK23型柴油机装用于Vossloh g6型液力传动调车机车

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国外内燃机车 2010年第4期 12-13页

作者： Ian cameron 苏明

基地在德国基尔的Vossloh机车公司最近与著名的发动机制造商Cummins公司联手推出一种新型调车机车.这种被Vossloh公司命名为g6的新型三轴液力传动调车内燃机车是该公司新的模块化机车系列中的第一种机车.

关键词： QSK23型柴油机 g6型机车结构特点技术参数

Clinicopathological features and surgical outcomes of resected functional pancreatic neuroendocrine tumors: a single institution experience

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Journal of Pancreatology 2019年第2期2卷 29-34页

作者： Ammar A.Javed Alina Hasanain Aleezay Haider george Jones Zunaira N.Javed Kevin Soares Richard A.Burkhart John l.cameron Matthew J.Weiss Christopher l.Wolfgang Jin He Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Background:Functional pancreatic neuroendocrine tumors(f-PanNETs)are rare tumors of the pancreas that are associated with excess hormone production.A majority of literature available on these tumors is limited to case reports and small series and discusses a particular ***,we report the clinicopathological features and outcomes of all f-PanNETs from a high-volume pancreatectomy ***:A prospectively maintained database was used to identify patients who underwent resection for f-PanNETs between January 1995 and December *** were stratified by the type of f-PanNET,and their clinicopathological features and outcomes were analyzed and ***:We identified 69 patients with a mean age of 52±16 years,and the majority were female(62%).The most common type of f-PanNET were insulinomas(70%)followed by gastrinomas(15%),and vasoactive intestinal peptidomas(VIPomas)(10%).There was considerable heterogeneity in the presenting *** with insulinomas presented with smaller tumors compared to the other *** disease was most frequent in patients with VIPomas(71%),and gastrinomas(50%).The median overall survival(OS)was 7.4 *** Ki-67 and age>65 years were associated with poorer *** was observed in 8 patients(12%)and was most frequent in patients with *** was associated with a poorer OS(P=.012).Conclusion:f-PanNETs are exceedingly rare and present with a wide variety of symptoms,histopathological findings,and *** resection can help achieve good long-term survival.

关键词： Functional tumor Outcome Pancreatic neuroendocrine tumor

Comparison of Pentax Hiline and Olympus lucera systems at screening colonoscopy

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World Journal of gastrointestinal Endoscopy 2013年第2期5卷 62-66页

作者： Alexey Chernolesskiy David Swain James C lee gareth D Corbett Ewen AB cameron Department of gastroenterology Addenbrooke's HospitalCambridge CB2 0QQUnited Kingdom

AIM:To compare the performance characteristics of Pentax Hiline(PHl)(with i-scan) and Olympus lucera(Ol) systems in a screening ***:Screening colonoscopies in asymptomatic guaiac faecal occult blood test-positive patients with PHl(n = 58) and Ol(n = 425) colonoscopes were *** procedures were performed by a single *** used white-light endoscopy(WlE) on scope insertion and contrast/surface enhancement(i-scan 1) on withdrawal,and Ol utilised WlE both on insertion and *** age,sex,instrument insertion and withdrawal times,nurse assessed patient comfort scores,midazolam and fentanyl doses,procedure completion and rates of lesion detection were recorded separately for each *** between the groups were made using either Fisher's exact test(for dichotomous variables) or Mann-Whitney U test(for ordinal and continuous variables).RESUlTS:Colonoscopy completion rates were similar in both groups:413/425(97.2%) for Ol and 55/58(94.9%) for PHl(P = 0.24).For complete colonoscopies,the two groups were well matched for age,sex,colonoscope insertion times(mean 11.1 min in Ol vs 11.6 min in PHl,P = 0.93) and normal colonoscopy withdrawal times(mean 15.6 min in Ol vs 14.7 min in PHl,P = 0.2).Patients in the PHl group experienced a small increase in discomfort(mean patient comfort scores were 0.49 in the Ol and 0.95 in the PHl group,P le Fentanyl doses required were similar between groups(mean 57.5 μg in Ol vs 61.4 μg in PHl,P = 0.13),slightly more Midazolam was required in the PHl group(mean 2.1 mg in Ol vs 2.4 mg in PHl,P = 0.035).There was no difference in polyp(58% in Ol vs 67% in PHl) or adenoma(49% in Ol vs 56% in PHl) detection rates between the *** the total number of polyps and adenomas,nor the characteristics of these(including size,location or presence of advanced features) were different between the two ***:This study suggests that there is no advantage of either colonoscop

关键词： Pentax Hiline i-scan Polyp Adenoma Colonoscopy

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世界上最深的水平井是怎样钻成的

石油石化节能与计量 1996年第7期 16-18+22页

作者： g．W．grimes,PaulE．cameronⅢ,Jaysalzer,李相正,杨凤敏大庆油田采油六厂大庆油田采油六厂

钻AustinChalk水平井已经在德克萨斯完成，但是，南露易斯安那时白垩地层提出新的待解决的问题、包括高达325F的井底温度及超过89001b／in2的压力。在BayouCountry增加钻井装备支持问题和不稳定的造斜率，使你面对一个挑战。

关键词：水平井设计打捞落物造斜率泥浆 MWD系统铣磨剖面完井替喷

Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion?Findings from the NCAA and Department of Defense CARE Consortium

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Journal of Sport and Health Science 2023年第3期12卷 379-387页

作者： Rany Vorn Christina Devoto Timothy B.Meier Chen lai Sijung Yun Steven P.Broglio Sara Mithani Thomas W.McAllister Christopher C.giza Hyung-Suk Kim Daniel Huber Jaroslaw Harezlak Kenneth l.cameron gerald Mcginty Jonathan Jackson Kevin M.guskiewicz Jason P.Mihalik Alison Brooks Stefan Duma Steven Rowson lindsay D.Nelson Paul Pasquina Michael A.McCrea Jessica M.gill the CARE Consortium Investigators Johns Hopkins School of Nursing and Medicine BaltimoreMD 21205USA National Institutes of Health BethesdaMD 20892USA Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Predictiv Care Inc.Mountain ViewCA 94086USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Department of Psychiatry Indiana University School of MedicineIndianapolisIN 46202USA Departments of Pediatrics and Neurosurgery University of California at Los Angeles(UCLA)Los AngelesCA 90024USA Department of Epidemiology and Biostatistics School of Public Health–Bloomington Indiana UniversityBloomingtonIN 47405USA John A.Feagin Sports Medicine Fellowship Keller Army Community HospitalWest PointNY 10996USA United States Air Force Academy Colorado SpringsCO 80840USA Mathew gfeller Center Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27514USA Department of Orthopedics Division of Sports MedicineSchool of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA Center for Neuroscience&Regenerative Medicine Uniformed Services UniversityBethesdaMD 20814USA 不详 Current affiliation:School of Nursing University of Texas Health Science Center San AntonioSan AntonioTX 78229USA

Background:Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or ***,more accurate diagnostic markers are needed for sport-related ***:This was a multicenter,prospective,case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association-Department of Defense Concussion Assessment,Research,and Education Consortium conducted between 2015 and *** blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute *** with concussion were divided into 6 h post-injury(0-6 h post-injury)and after 6 h postinjury(7-48 h post-injury)*** applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305proteins in plasma samples from athletes with and without sport-related ***:A total of 140 athletes with concussion(79.3%males;aged 18.71±1.10 years,mean±SD)and 21 non-concussed athletes(76.2%males;19.14±1.10 years)were included in this *** identified 338 plasma proteins that significantly differed in abundance(319 upregulated and 19 downregulated)in concussed athletes compared to non-concussed *** top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve(AUC)of 0.954(95%confidence interval:0.922-0.986).Specifically,after 6 h of injury,the individual AUC of plasma erythrocyte membrane protein band 4.1(EPB41)and alpha-synuclein(SNCA)were 0.956 and 0.875,*** combination of EPB41 and SNCA provided the best AUC(1.000),which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of ***:Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combina

关键词： Biomarkers College athletes Concussion Mild traumatic brain injury Sport injury

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世界上最深的水平井是怎样钻成的

国外油田工程 1996年第7期12卷 16-18,22页

作者： g.W.grimes PaulE.cameronⅢ Jaysalzer 李相正杨凤敏大庆油田采油六厂

关键词：水平井设计造斜率泥浆钻井

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影响十二指肠切除术后长期生存的主要因素

中国实用外科杂志 1992年第6期 330-330页

作者： John l.cameron ,张强中国医科大学第一临床学院

作者报道89例胰腺癌行胰十二指肠切除术的患者,其5年生存率为19%,中位生存期为11.9个月.对影响生存的有关因素分析结果表明,无淋巴结转移及血管浸润者,生存期较长.在无淋巴结受累组,中位生存期为55.8个月,而在淋巴结阳性组为11个月

关键词：中位生存期长期生存个月患者淋巴结血管淋巴组织切除术后小肠十二指肠

Modelling sulphate-enhanced cadmium uptake by Zea mays from nutrient solution under conditions of constant free Cd^(2+) ion activity

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Journal of Environmental Sciences 2010年第7期22卷 1080-1085页

作者： Ulrico J.lópez-Chuken Scott D.Young Division of Environmental Sciences School of ChemistryUniversidad Autónoma de Nuevo León Division of Agricultural & Environmental Sciences School of Biosciencesthe University of Nottingham

A controlled hydroponic experiment was undertaken to investigate Cd uptake in relation to the activity of Cd species in solution other than the free ion （Cd^2＋） by maintaining a constant Cd^2＋ activity under variable SO4^2- and Cl^- concentrations exposed to maize （Zea mays vat. cameron） plants. The objectives of these experiments were：（1） to distinguish and quantify the different uptake rates of free and inorganic-complexed Cd from nutrient solution, and （2） to model the uptake of Cd by maize with a Biotic ligand Model （BlM） in a system which facilitates the close examination of root characteristics. Results of the current experiments suggest that, in addition to the free ion, CdSO4^0 complexes are important factors in determining Cd uptake in nutrient solution by maize plants. Higher nominal SO4^2- concentrations in solution generally resulted in a greater Cd accumulation by maize plants than predicted by the Cd^2＋ activity. A better integration of the complete dataset for the 3 harvest times （6, 9 and 11 days after treatment） was achieved by including consideration of both the duration of Cd exposure and especially the root surface area to express Cd uptake. Similarly, the fit of the BlM was also improved when taking into account exposure time and expressing uptake in terms of root morphological parameters.

关键词： free ion activity model biotic ligand model root surface area Cd complexation metal exposure time hydroponics plant uptake