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商业周刊（中文版） 2024年第7期 26-28页

作者： Zachary Fleming cam baker Andre Tartar Raeedah Wahid 晴川(译) 不详

企业在董事长称谓上一直在稳步转向性别中立语言。但而今,对多元平等包容政策的批评又卷土重来。今年2月,芯片制造商Advanced Micro Devices Inc.(简称AMD)就在批准其CEO苏姿丰奖金方案的前一天,从公司章程中去掉了董事长英文头衔中带... 详细信息

企业在董事长称谓上一直在稳步转向性别中立语言。但而今,对多元平等包容政策的批评又卷土重来。今年2月,芯片制造商Advanced Micro Devices Inc.(简称AMD)就在批准其CEO苏姿丰奖金方案的前一天,从公司章程中去掉了董事长英文头衔中带有性别指向的部分(译注:董事长的英文为chairman,其中man指男性)。该公司在一份监管文件中称,这是“技术化、现代化、明晰化且顺应潮流的一系列变化”中的一部分。

关键词：芯片制造商明晰化公司章程董事长技术化

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Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesis

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Bioactive Materials 2023年第2期20卷 306-317页

作者： Tianyu Yao Honglin Chen Rong Wang Rebeca Rivero Fengyu Wang Lilian Kessels Stijn M.Agten Tilman M.Hackeng Tim G.A.M.Wolfs Daidi Fan Matthew B.baker Lorenzo Moroni Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi’anShaanxi710069China Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineMaastricht UniversityMaastricht6229 ERthe Netherlands Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhou510080China Radboudumc Department of Dentistry-Regenerative BiomaterialsRadboud University Medical CenterPhilips van Leydenlaan 256525 EXNijmegenthe Netherlands School of Medicine South China University of TechnologyGuangzhou510006China Maastricht University Medical Center MUMC+ P.Debyelaan 256229 HXMaastrichtthe Netherlands Research School for Cardiovascular Diseases(CARIM) Maastricht UniversityUniversiteitssingel 506229ER Maastrichtthe Netherlands School for Oncology and Developmental Biology(GROW) Maastricht UniversityUniversiteitssingel 406229ER Maastrichtthe Netherlands

Vascular endothelial growth factor(VEGF)plays a vital role in promoting attachment and proliferation of endothelial cells,and induces *** recent years,much research has been conducted on the functionalization of tissue engineering scaffolds with VEGF or a VEGF-mimetic peptide to promote ***,most chemical reactions are nonspecific and require organic solvents,which can compromise control over functionalization and alter peptide/protein *** attractive alternative is the fabrication of functionalizable electrospun fibers,which can overcome these *** this study,we used thiol-ene chemistry for the conjugation of a VEGF-mimetic peptide to the surface of poly(ε-caprolactone)(PCL)fibrous scaffolds with varying amounts of a functional PCL-diacrylate(PCL-DA)polymer.30%PCL-DA was selected due to homogeneous fiber morphology.A VEGF-mimetic peptide was then immobilized on PCL-DA fibrous scaffolds by a light-initiated thiol-ene reaction.7-Mercapto-4-methylcoumarin,RGD-FITC peptide and VEGF-TAMRA mimetic peptide were used to validate the thiol-ene reaction on the fibrous *** strength and elastic modulus of the 30%PCL-DA fibrous scaffolds were significantly increased after the *** of the 30%PCL-DA fibrous scaffolds with the VEGF peptide increased the surface water wettability of the *** structures could be obtained after using a photomask on the fibrous ***,in vitro studies indicated that scaffolds functionalized with the VEGF-mimetic peptide were able to induce phosphorylation of the VEGF receptor and enhanced HUVECs survival,proliferation and adhesion.A chick chorioallantoic membrane(cam)assay further indicated that the VEGF peptide functionalized scaffolds were able to promote angiogenesis in *** results show that scaffold functionalization can be controlled via a simple polymer mixing approach,and that the functionalized VEGF peptide-scaffolds have potential for vascular

关键词： Electrospinning Fibrous scaffolds Thiol-ene reaction VEGF peptide

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