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TCMBank-the largest TCM database provides deep learningbased Chinese-Western medicine exclusion prediction

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1396-1398页

作者： Qiujie Lv Guanxing chen Haohuai He Ziduo Yang Lu Zhao Kang Zhang calvin yu-chian chen Artificial Intelligence Medical Research Center School of Intelligent Systems EngineeringSun Yat-sen UniversityGuangzhouChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouChina Center for Innovations and Biomedicine Faculty of MedicineMacao University of Science and TechnologyMacaoChina

Dear Editor,In the modernization of traditional Chinese medicine(TCM),two key aspects are determining the active ingredients in herbs and elucidating the mechanism of action between the active ingredients and *** construction of a comprehensive and highly-reliability TCM database is highly *** its establishment in 2011,our TCM Database@Taiwan1 has been used extensively and heavily cited,and it also has been included in the ZINC database.2 Using natural language processing,we set up a knowledge graph and molecular signaling pathways to establish a TCM database,TCMBank(https://***/),which extends from TCM Database@Taiwan and includes 9192 herbs,61,966 ingredients,15,179 targets,and 32,529 *** updated TCMBank expanded the number of herbal ingredients from 32,364 to 61,966(unduplicated),and two new data fields,targets,and diseases,have been *** number of herbs with connection information is 9010,and the average number of connection edges of herbs is *** number of ingredients with connection information is 54,676,and the average number of connection edges of herbs is 5.26.

关键词： TCM herbal database

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： chen-Xiao Huang Xiao-Dong Zhou calvin Q Pan Ming-Hua Zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

The Impact of Privatization on Terminal Efficiency: A Case Study of Tema Port

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Journal of Transportation Technologies 2024年第3期14卷 358-371页

作者： Bernard Kwei Tetteh calvin Elorm Atsunyo Alex Boateng College of Transport and Communications Shanghai Maritime University Shanghai China Department of Transport Regional Maritime University Accra Ghana

Port and terminal efficiency are of utmost importance to the container shipping industry due to their significance in enhancing the competitive advantage of ports within a region. Consequently, there have always been notable variations of studies around it. This paper analyzes the impact of privatization on terminal efficiency using the Port of Tema as a Case Study. The main objective of this paper is to analyze the efficiency trends of the public and private terminals in the port over the years. To achieve this objective, DEA-CCR methodology was employed to calculate the annual technical efficiency trends of the private and public terminals using four input variables and three output variables. The main results of the paper indicated that the public and private terminals were efficient for multiple years. However, the efficiency scores over the years demonstrated inconsistency, exhibiting notable fluctuations. The findings of this study will aid policymakers across the region on policies relating to the efficiency and ownership structure of ports and terminals.

关键词： Privatization Terminal Efficiency DEA Tema Port

以专业使命为本的行业——专访中国香港会计师公会会长梁思杰

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新理财（公司理财） 2024年第4期 73-75页

作者： Jemelyn Yadao calvin Sit(图) 不详

中国香港会计师公会新任会长梁思杰听取过许多会员的不同观点,在担任会长后的首次访谈中,他讲述着如何让会计师创造价值以及他们所担任的各种不同的角色如何成为大众焦点。会计师在各行各业发挥着正面的影响力,但人们往往未必能即时察... 详细信息

中国香港会计师公会新任会长梁思杰听取过许多会员的不同观点,在担任会长后的首次访谈中,他讲述着如何让会计师创造价值以及他们所担任的各种不同的角色如何成为大众焦点。会计师在各行各业发挥着正面的影响力,但人们往往未必能即时察觉到会计师为社会作出的贡献。

关键词：香港会计师公会会计师会长影响力

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Insight of Natural Compounds Halimane Diterpenoids against Mycobacterium tuberculosis: Virtual Screening, DFT, Drug-Likeness, and Molecular Dynamics Approach

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Computational Molecular Bioscience 2024年第2期14卷 35-58页

作者： Laurent Gael Eyia Andiga Boris Davy Bekono Désiré Mama Bikele Pie Pascal Onguéné Amoa Luc calvin Owono Owono Luc Léonard Mbaze Meva’a Department of Chemistry Faculty of Science University of Douala Douala Cameroon Department of Physics Ecole Normale Suprieure University of Yaound 1 Yaound Cameroon Center for Drug Discovery Faculty of Science University of Buea Buea Cameroon Department of Chemistry University of Yaound I Institute of Wood Technology Mbalmayo Cameroon CEPAMOQ Faculty of Science University of Douala Douala Cameroon

In the purpose to design novel antituberculosis (anti-TB) drugs agents against Mycobacterium tuberculosis (Mtb), we have built a molecular library around 42 Halimane Diterpenoids isolated from natural sources. Two Mtb enzymes drug targets (Mtb Mycothiol S-transferase and Mtb Homoserine transacetylase) have been adopted. The pharmacological potential was investigated through molecular docking, molecular dynamics simulation, density functional theory (gas phase and water) and ADMET analysis. Our results indicate that (2R,5R,6S)-1,2,3,4,5,6,7,8-octahydro-5-((E)-5-hydroxy-3-methylpent-3-enyl)-1,1,5,6-tetramethylnaphtha-lene-2-ol (compound 20) has displays higher docking score with each of the selected drug targets. In addition, this molecule exhibits a satisfactory drug potential activity and a good chemical reactivity. Its improved kinetic stability in the Mtb Mycothiol S-transferase enzyme reflects its suitability as a novel inhibitor of Mtb growth. This molecule has displayed a good absorption potential. Our results also show that its passive passage of the intestinal permeability barrier is more effective than that of first-line treatments (ethambutol, isoniazid). In the same way, this anti-TB druglikeness has shown to be able to cross the blood brain barrier.

关键词： Antituberculosis Druglikeness Density Functional Theory Halimane Diterpenoids Molecular Docking Molecular Dynamics Simulation

On an Algebra Structure on the Hochschild Homology of Simply Connected Topological Space

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Algebra Colloquium 2019年第3期26卷 425-436页

作者： calvin Tcheka Department of Mathematics and Computer Science Faculty of Sciences University of DschangCampus Box(237)67 DschangCameroon

In this note,we use the pairing induced by the interchange map in conjunction with the strongly homotopy commutative algebra structure to define products on the Eilenberg-Moore differential Tor and give a simplified proof of an improved outcome of Jsone's result due to Ndombol and *** a result,we establish an isomorphism of graded algebras between the Hochschild homology and the free loop space cohomology of a simply connected topological space.

关键词： semi-free resolution Hochschild homology free loop space coholomogy Eilenberg-Moore differential Tor strongly homotopy commutative algebra

Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits

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Synthetic and Systems Biotechnology 2023年第4期8卷 654-672页

作者： calvin Lam Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE68198USA.

The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible *** only would it further our understanding of native processes such as development and the immune response,but it would also have powerful applications in medical fields such as regenerative medicine and *** control is typically obtained by synthetic circuits that use synthetic receptors,but control remains *** synthetic juxtacrine receptors(SJRs)are widely used as they are fully modular and enable spatial control,but they have limited gene expression amplification and temporal *** these are integral facets to cell control,I therefore designed transcription factor based amplifiers that amplify gene expression and enable unidirectional temporal control by prolonging duration of target gene *** a validated in silico framework for SJR signaling,I combined these amplifiers with SJRs and show that these SJR amplifier circuits can direct spatiotemporal patterning and improve the quality of self-organization.I then show that these circuits can improve chimeric antigen receptor(CAR)T cell tumor killing against various heterogenous antigen expression *** amplifiers are flexible tools that improve control over SJR based circuits with both basic and therapeutic applications.

关键词： Synthetic biology Synthetic development Synthetic immunotherapy synNotch SNIPR Amplifiers Self-organization Temporal control Spatiotemporal control CAR T cell Synthetic receptors

A review of the geomechanics aspects of a double fatality coal burst at Austar Colliery in NSW,Australia in April 2014

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International Journal of Mining Science and Technology 2017年第1期27卷 3-7页

作者： Hebblewhite Bruce calvin Jim School of Mining Engineering UNSWSydney 2052Australia

A coal burst occurred on 15 April, 2014 at the Austar Coal Mine, located west of Newcastle, NSW,Australia. The burst resulted in fatal injuries to two men working as part of the mining crew at the development face. At the time, a continuous miner was being used to mine a longwall development gate road through heavily structured coal, at a depth of approximately 550 m. A number of pre-cursor bumps had occurred on previous shifts, emanating from the coal ribs of the roadway, in proximity to the coal *** paper reviews the geological, geotechnical and mining conditions and circumstances leading up to the coal burst event; and presents and discusses the available evidence and possible interpretations relating to the geomechanical behaviour mechanisms that may have been critical factors in this incident. The paper also discusses some key technical and operational considerations of ground support systems and mining practices and strategies needed for operating in such conditions in the future.

关键词： Underground coal mining Roadway development Strata controlCoal burst Coal geology Mine safety

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A classification system for tableting behaviors of binary powder mixtures

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 486-491页

作者： Changquan calvin Sun Pharmaceutical Materials Science and Engineering Laboratory Department of PharmaceuticsCollege of PharmacyUniversity of Minnesota

The ability to predict tableting properties of a powder mixture from individual components is of both fundamental and practical importance to the efficient formulation development of tablet products. A common tableting classification system(TCS) of binary powder mixtures facilitates the systematic development of new knowledge in this direction. Based on the dependence of tablet tensile strength on weight fraction in a binary mixture,three main types of tableting behavior are identified. Each type is further divided to arrive at a total of 15 sub-classes. The proposed classification system lays a framework for a better understanding of powder interactions during compaction. Potential applications and limitations of this classification system are discussed.

关键词： Powder Mixture Tensile strength Tabletability Classification system Compaction

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